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| 1 | 长江中下游地区铜金(钼)矿Re-Os年龄测定及其对成矿作用的指示显示文摘长江中下游是中国东部一个重要的Cu-Au-Fe-Mo矿成矿带。笔者等在5个夕卡岩-斑岩Cu-Au-Mo矿区采集了11件辉钼矿样品,在铜陵地区大团山层控夕卡岩Cu-Au-Mo矿体采集了5件辉钼矿样品进行Re-Os同位素年龄测定。在对16件样品进行ICP-MS方法测定的同时,还利用NTIMS方法对其中9件样品进行了精测,两种方法测定的结果基本吻合。16件辉钼矿的Re-Os同位素模式年龄为134.7±2.3~143.7±1.6Ma(2σ)。其中大团山铜矿区的5件样品的模式年龄更为接近,分布范围为 138.0± 3.2~140.8±2.0 Ma,平均 139.3±2.6Ma,其等时线年龄为 139.1±2.7Ma,初始Os为0.7±8.1(MSWD=0.29)。这些结果清楚地反映出夕卡岩-斑岩Cu-Au-Fe-Mo矿床与层控夕卡岩Cu-Au-Mo矿床为同一时代形成,属于同一成矿系统。作为中国东部大规模成矿作用的组成部分,长江中下游地区铜钼金矿床的形成与岩石圈构造体制大转换之地球动力学事件相耦合,为中生代第二期大规模成矿作用的产物。 | 毛景文 Holly STEIN 杜安道 周涛发 梅燕雄 李永峰 藏文栓 李进文 | 2004 | 地质学报2004，78，1： | 275 |
| 2 | 生态旅游概念识别及其比较研究——对中外40个生态旅游概念的定量分析显示文摘伴随着生态旅游的快速发展而涌现出的大量生态旅游概念使旅游研究者和旅游利益相关者对生态旅游概念产生了困惑。这种困惑使生态旅游的核心标准和规则在实际的应用中被扭曲和误用。本文运用内容分析的方法,通过对中外当代近10-15年内40个有影响力的生态旅游概念的分析,提炼出生态旅游概念架构所遵循的8个标准规则,它们是:以自然为基础、对保护的贡献、当地社区受益、环境教育、道德规范与责任、可持续性、旅游享受体验和文化。并以这些标准规则为基础,对中外生态旅游的概念进行比较,得出中国未来的生态旅游研究应更加关注旅游目的地管理的结论。 | 卢小丽 武春友 Holly Donohoe | 2006 | 旅游学刊2006，21，2： | 72 |
| 3 | 基于内容分析法的生态旅游内涵辨析显示文摘随着生态旅游的流行与快速发展对生态旅游这个术语的概念也不断的增长扩散。由于缺乏对其内涵的科学认知和梳理,生态旅游概念的应用具有泛化的危险。不断涌现出的大量有关生态旅游的概念给学术研究和旅游管理带来了许多困惑。运用内容分析的方法对中外旅游文献近10~15a内有影响力的40个生态旅游概念进行了分析,提炼出生态旅游概念中最频繁出现的能代表其内涵的6个标准,它们是:以自然为基础、对保护的贡献、当地社区受益、环境教育、道德规范与责任和可持续性。通过对这些标准的识别,结合先前的生态旅游概念,本文对生态旅游的概念在操作层面上进行了重新架构,将生态旅游这一术语定义为:生态旅游是以可持续旅游和伦理道德规范原则为指导,在旅游过程中强调环境教育、影响管理和社区受益,并为其所依赖的环境保护做贡献的负责任的自然之旅。 | 卢小丽 武春友 Holly Donohoe | 2006 | 生态学报2006，26，4： | 38 |
| 4 | 税费改革对农户收入增长的影响:实证与解释--以长三角15村跟踪观察农户为例显示文摘本文利用长三角地区15个村庄连续11年固定观察数据构建固定效应模型,考察税费改革对这一地区农户收入的影响。研究表明:在控制了农户个体特征、创收能力和社会地位等变量后,税费改革对农户收入具有显著的正效应,平均使农户人均收入提高6.82%。该效应远大于税费减免所带来的直接收入增加。同时,本文还从动态的角度考察了税费改革对农户收入的影响。本文发现:在改革前3年,税费改革对农户收入增长具有显著的正效应。另外,本文利用农业生产函数,讨论了税费改革对农户生产性资本和劳动投入决策的影响。结果表明:税费改革后农户并没有显著增加对农业生产的资本投入和劳动投入。最后,本文基于C—D生产函数讨论了税费改革对农户生产投入要素效率的影响。研究发现:税费改革后,资本和土地的产出弹性显著增加。 | 徐翠萍 史清华 Holly Wang | 2009 | 中国农村经济2009，，2： | 27 |
| 5 | Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies显示文摘Nuclear factor kappa B(NF-κB) has an established role in the regulation of innate immunity and inflammation.NF-κB is also involved in critical mechanisms connecting inflammation and cancer development.Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal,gastric and colorectal cancers.This review will explore NF-κB's function in inflammation-associated gastrointestinal malignancies,highlighting its oncogenic contribution to each step of carcinogenesis.NF-κB's role in the inflammation-to-carcinoma sequence in gastrointestinal malignancies warrants stronger emphasis upon targeting this pathway in achieving greater therapeutic efficacy. | Sahil Gambhir Dinesh Vyas Michael Hollis Apporva Aekka Arpita Vyas | 2015 | World Journal of Gastroenterology2015，21，11： | 24 |
| 6 | Safety of the long-term use of proton pump inhibitors显示文摘The proton pump inhibitors (PPIs) as a class are remarkably safe and effective for persons with peptic ulcer disorders. Serious adverse events are extremely rare for PPIs, with case reports of interstitial nephritis with omeprazole, hepatitis with omeprazole and lansoprazole, and disputed visual disturbances with pantoprazole and omeprazole. PPI use is associated with the development of fundic gland polyps (FGP); stopping PPIs is associated with regression of FGP. In the absence of Helicobacter pylori infection, the long-term use of PPIs has not been convincingly proven to cause or be associated with the progression of pre-existing chronic gastritis or gastric atrophy or intestinal metaplasia. Mild/modest hypergastrinemia is a physiological response to the reduction in gastric acid secretion due to any cause. The long-term use of PPIs has not been convincingly proven to cause enterochromaff in-like cell hyperplasia or carcinoid tumors. PPIs increase the risk of community acquired pneumonia, but not of hospital acquired (nosocomial) pneumonia. There is no data to support particular care in prescribing PPI therapy due to concerns about risk of hip fracture with the long-termuse of PPIs. Long-term use of PPIs does not lead to vitamin B12 def iciencies, except possibly in the elderly, or in persons with Zollinger-Ellison Syndrome who are on high doses of PPI for prolonged periods of time. There is no convincingly proven data that PPIs increase the risk of Clostridium difficile-associated diarrhea in persons in the community. The discontinuation of PPIs may result in rebound symptoms requiring further and even continuous PPI use for suppression of symptoms. As with all medications, the key is to use PPIs only when clearly indicated, and to reassess continued use so that long-term therapy is used judiciously. Thus, in summary, the PPIs are a safe class of medications to use longterm in persons in whom there is a clear need for the maintenance of extensive acid inhibition. | Alan BR Thomson Michel D Sauve Narmin Kassam Holly Kamitakahara | 2010 | World Journal of Gastroenterology2010，16，19： | 20 |
| 7 | Micro RNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity显示文摘Over the past decade, research has shown that aberrant expression of micro RNA(mi RNA) is involved in colorectal cancer development and progression. Micro RNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific mi RNA may display the effects of a tumor suppressor or oncogene. Altered mi RNA expression is found in colorectal cancer(CRC) and patterns of mi RNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum mi RNA and fecal mi RNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of mi RNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC. | Michael Hollis Kavitha Nair Arpita Vyas Lakshmi Shankar Chaturvedi Sahil Gambhir Dinesh Vyas | 2015 | World Journal of Gastroenterology2015，21，27： | 19 |
| 8 | 护士长/护理管理团队在护士克服工作倦怠和培养心理韧性中的作用显示文摘目的:探讨护士长/护理管理团队在护士克服工作倦怠和培养心理韧性中的作用。方法:采用便利抽样法,对某三级甲等医院内科专业护士进行描述性问卷调查。结果:通过内容分析发现,可以降低护士职业倦怠的护士长/护理管理团队的管理行为包括:多鼓励少批评,榜样的作用,及时沟通,营造良好的科室氛围,增加业务培训及外出学习交流的机会,缩短考试与检查及非工作时间会议等。结论:培养护士的工作韧性是护士长/护理领导团队构建健康的工作环境和维护稳定的护士队伍的重要因素;鼓励性的认可,心理疏导和工作支持可以减轻护士工作倦怠。尽管护士工作倦怠是一个很严重的问题,但此项调查显示,护士长对减轻护士工作倦怠起不可忽略的作用。 | 房芳 李晓娟 魏丽丽 刘敏 Holly Wei | 2019 | 齐鲁护理杂志2019，25，5： | 13 |
| 9 | 辽宁省农户参与农业保险意愿的实证研究显示文摘辽宁省位于中国的东北地区,主要生产粮食和饲料.对辽宁省农户的保险意愿调查问卷进行了统计分析.结果表明:性别、受教育程度、收入、灾害损失和对保险的了解程度对农户在农业保险意愿上有影响.女性相对于男性,更不愿意参加农业保险;教育程度高和贫穷的农户不愿意参保.以往受灾损失大的农户也不愿意参保,这样,如果政府不能合理的设定保险品种和保险价格可能会出现逆向选择问题. | 聂荣 Holly H.Wang | 2011 | 数学的实践与认识2011，41，4： | 12 |
| 10 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 11 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 12 | Genetic and molecular changes in ovarian cancer显示文摘Epithelial ovarian cancer represents the most lethal gynecological malignancy in the developed world, and can be divided into five main histological subtypes: high grade serous, endometrioid, clear cell, mucinous and low grade serous. These subtypes represent distinct disease entities, both clinically and at the molecular level. Molecular analysis has revealed significant genetic heterogeneity in ovarian cancer, particularly within the high grade serous subtype. As such, this subtype has been the focus of much research effort to date, revealing molecular subgroups at both the genomic and transcriptomic level that have clinical implications.However, stratification of ovarian cancer patients based on the underlying biology of their disease remains in its infancy. Here, we summarize the molecular changes that characterize the five main ovarian cancer subtypes, highlight potential opportunities for targeted therapeutic intervention and outline priorities for future research. | Robert L Hollis Charlie Gourley | 2016 | Cancer Biology & Medicine2016，13，2： | 8 |
| 13 | The discovery and reporting of internal control deficiencies prior to SOX-mandated audits显示文摘 | Hollis Ashbaugh-Skaife Daniel W. Collins William R. Kinney | 2006 | Journal of Accounting and Economics2006，，1： | 8 |
| 14 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 15 | Genomic Analyses Yield Markers for Identifying Agronomically Important Genes in Potato显示文摘野土豆种类有实质的 phenotypic 和生理的差异。这里,我们基于茄属节 Petota 的 201 就职的 genomic 分析报导对野、栽培的土豆种类的一个全面评价。我们定序这 201 就职的染色体并且识别了 6 ? 487 ? 从在 clade 的 167 就职的 006 高质量的单个核苷酸多型性(SNP ) 4 茄属节 Petota,包括 146 野并且有宽广地理分布的 21 栽培双土豆就职。染色体宽的基因变化分析比栽培土豆,和在农学地重要的疾病抵抗的高得多的基因差异,基因在野土豆被观察的证明野土豆的差异高。由关于已知的量的特点 loci (QTL ) 利用信息,而且,我们在选择下面识别了 609 基因,包括那些在 tubers 与痛苦的损失相关,那些在 tuberization 包含了,土豆的二个主要驯养的特点。种系发生的分析在 clade 揭示了所有种类的一个纵贯的部门 4,不是就那些在 S.? brevicaule 建筑群,和进一步支持的 S。是的 candolleanum 栽培土豆和在南部的秘鲁的栽培土豆的 monophyletic 起源的祖先。另外,我们分析了 S. 的染色体 ? candolleanum 并且鉴别 529 基因在栽培土豆输了。一起,在这研究产生的分子的标记为为土豆繁殖有用的农学地重要的基因的鉴定提供一个珍贵资源。 | Yangping Li Christophe Colleoni Junjie Zhang Qiqi Liang Yufeng Hu Holly Ruess Reinhard Simon Yinghong Liu Hanmei Liu Guowu Yu Eric Schmitt Ghloe Ponitzki Guangjian Liu Huanhuan Huang Feilong Zhan Lin Chen Yubi Huang David Spooner Binquan Huang | 2018 | Molecular Plant2018，11，3： | 8 |
| 16 | The pig as a preclinical traumatic brain injury model:current models,functional outcome measures,and translational detection strategies显示文摘Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the development of functional impairments. However, there are currently no effective therapeutic interventions that improve brain outcomes following TBI. As a result, a number of experimental TBI models have been developed to recapitulate TBI injury mechanisms and to test the efficacy of potential therapeutics. The pig model has recently come to the forefront as the pig brain is closer in size, structure, and composition to the human brain compared to traditional rodent models, making it an ideal large animal model to study TBI pathophysiology and functional outcomes. This review will focus on the shared characteristics between humans and pigs that make them ideal for modeling TBI and will review the three most common pig TBI models–the diffuse axonal injury, the controlled cortical impact, and the fluid percussion models. It will also review current advances in functional outcome assessment measures and other non-invasive, translational TBI detection and measurement tools like biomarker analysis and magnetic resonance imaging. The use of pigs as TBI models and the continued development and improvement of translational assessment modalities have made significant contributions to unraveling the complex cascade of TBI sequela and provide an important means to study potential clinically relevant therapeutic interventions. | Holly A.Kinder Emily W.Baker Franklin D.West | 2019 | Neural Regeneration Research2019，14，3： | 7 |
| 17 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 18 | Gastric cancer in Alaska Native people: A cancer health disparity显示文摘AIM To evaluate recent trends in gastric cancer incidence, response to treatment, and overall survival among Alaska Native(AN) people. METHODS A retrospective analysis of the Alaska Native Medical Center patient database was performed. Patient history, clinical, pathological, response to treatment and patient outcomes were collected from one-hundred and thirty-two AN gastric cancer patients. The Surveillance, Epidemiology and End Result database 18 was used to collect comparison United States non-Hispanic White(NHW) and AN gastric cancer patient data between 2006-2014.RESULTS AN gastric cancer patients have a higher incidence rate, a poorer overall survival, and are diagnosed at a significantly younger age compared to NHW patients. AN patients differ from NHW patients in greater prevalence of non-cardia, diffuse subtype, and signet ring cell carcinomas. AN females were more likely to be diagnosed with later stage cancer, stage IV, compared to AN males. Diminished overall survival was observed among AN patients with increasing stage, O+ blood type, < 15 lymph nodes examined at resection, and no treatment. This study is the first report detailing the clinicopathologic features of gastric cancer in AN people with outcome data.CONCLUSION Our findings confirm the importance of early detection, treatment, and surgical resection for optimizing AN patient outcomes. Further research on early detection markers are warranted. | Holly A Martinson Nancy J Shelby Steven R Alberts Matthew J Olnes | 2018 | World Journal of Gastroenterology2018，24，25： | 6 |
| 19 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 20 | New insights into the vitamin D requirements during pregnancy显示文摘Pregnancy represents a dynamic period with physical and physiological changes in both the mother and her developing fetus. The dramatic 2–3 fold increase in the active hormone 1,25(OH)2 D concentrations during the early weeks of pregnancy despite minimal increased calcium demands during that time of gestation and which are sustained throughout pregnancy in both the mother and fetus suggests an immunomodulatory role in preventing fetal rejection by the mother. While there have been numerous observational studies that support the premise of vitamin D's role in maintaining maternal and fetal well-being, until recently, there have been few randomized clinical trials with vitamin D supplementation. One has to exhibit caution,however, even with RCTs, whose results can be problematic when analyzed on an intent-to-treat basis and when there is high non-adherence to protocol(as if often the case), thereby diluting the potential good or harm of a given treatment at higher doses. As such, a biomarker of a drug or in this case 'vitamin' or pre-prohormone is better served. For these reasons, the effect of vitamin D therapies using the biomarker circulating 25(OH)D is a far better indicator of true 'effect.' When pregnancy outcomes are analyzed using the biomarker 25(OH)D instead of treatment dose, there are notable differences in maternal and fetal outcomes across diverse racial/ethnic groups, with improved health in those women who attain a circulating25(OH)D concentration of at least 100 nmol · L-1(40 ng · m L-1). Because an important issue is the timing or initiation of vitamin D treatment/supplementation, and given the potential effect of vitamin D on placental gene expression and its effects on inflammation within the placenta, it appears crucial to start vitamin D treatment before placentation(and trophoblast invasion); however, this question remains unanswered.Additional work is needed to decipher the vitamin D requirements of pregnant women and the optimal timing of supplementation, taking into account a variety of lifestyles, body types, baseline vitamin D status,and maternal and fetal vitamin D receptor(VDR) and vitamin D binding protein(VDBP) genotypes.Determining the role of vitamin D in nonclassical, immune pathways continues to be a challenge that once answered will substantiate recommendations and public health policies. | Bruce W Hollis Carol L Wagner | 2017 | Bone Research2017，5，3： | 5 |
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