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| 1 | Neoadjuvant radiotherapy for rectal cancer management显示文摘Thirty per cent of all colorectal tumours develop in the rectum.The location of the rectum within the bony pelvis and its proximity to vital structures presents significant therapeutic challenges when considering neoadjuvant options and surgical interventions.Most patients with early rectal cancer can be adequately managed by surgery alone.However,a significant proportion of patients with rectal cancer present with locally advanced disease and will potentially benefit from down staging prior to surgery.Neoadjuvant therapy involves a variety of options including radiotherapy,chemotherapy used alone or in combination.Neoadjuvant radiotherapy in rectal cancer has been shown to be effective in reducing tumour burden in advance of curative surgery.The gold standard surgical rectal cancer management aims to achieve surgical removal of the tumour and all draining lymph nodes,within an intact mesorectal package,in order to minimise local recurrence.It is critically important that all rectal cancer cases are discussed at a multidisciplinary meeting represented by all relevant specialties.Pre-operative staging including CT thorax,abdomen,pelvis to assess for distal disease and magnetic resonance imaging to assess local involvement is essential.Staging radiology and MDT discussion are integral in identifying patients who require neoadjuvant radiotherapy.While Neoadjuvant radiotherapy is potentially beneficial it may also result in morbidity and thus should be reserved for those patients who are at a high risk of local failure,which includes patients with nodal involvement,extramural venous invasion and threatened circumferential margin.The aim of this review is to discuss the role of neoadjuvant radiotherapy in the management of rectal cancer. | Gerard Feeney Rishabh Sehgal Margaret Sheehan Aisling Hogan Mark Regan Myles Joyce Michael Kerin | 2019 | World Journal of Gastroenterology2019，25，33： | 28 |
| 2 | Role of self-expanding metal stents in the management ofvariceal haemorrhage:Hype or hope?显示文摘Despite the advances of medical,endoscopic and radiological therapy over recent years the mortality rates of acute variceal haemorrhage are still 16%-20% and the medium term outcome has not improved in the last 25 years. Early transjugular intrahepatic portosystemic shunt has proved to be an effective therapy for selected groups of patients with a high risk of re-bleeding and moderate liver disease. However,there is an unmet need for a therapy that can be applied in patients with a high risk of re-bleeding and advanced liver disease either as definitive therapy or as a bridge to permanent therapy. Selfexpanding metal stents can be placed without the need for endoscopic or fluoroscopic control and,once in place,will provide effective haemostasis and allow a route for oral fluids and nutrition. They can remain in place whilst liver function recovers and secondary prophylaxis is initiated. We review the results of 6 case series including a total of 83 patients and the first randomised controlled trial of self-expanding metal stents vs balloon tamponade(BT) in the management of refractory variceal haemorrhage. We report that self-expanding metal stents provide effective haemostasis and perform better than BT in refractory bleeding,where they are associated with fewer complications. Whilst the most effective place for self-expanding metal stents in the management algorithm needs to be determined by further randomised controlled trials,currently they provide an effective alternative to BT in selected patients. | Brian J Hogan James P O’Beirne | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，1： | 5 |
| 3 | 食管扩张——一种胃食管反流触发机制显示文摘目的 :明确食管扩张时下食管括约肌发生松弛状态下胃食管反流的发生率。方法 :12例健康志愿者在餐前和餐后同时检测食管压力和 pH ,食管扩张是通过快速和缓慢的气体注射诱发。 结果 :引起完全的下食管扩约肌松弛的气体阈值量平均为 (11 0± 1 0 )ml。只有极少的松弛伴有继发蠕动。快速注气下食管括约肌的松弛时间为(13.0± 1.5 )s;慢速注射时食管括约肌的松弛时间是 (16 0± 2 0 )s。由快速阈值量气体注射引起LES松弛并伴有胃食管反流率 ,在餐后为 (2 2± 6 ) % ;缓慢注射时为 (2 3± 10 ) %。对于快速食管扩张 ,单独的下食管括约肌松弛伴随反流的百分比显著高于伴有继发蠕动的下食管括约肌松弛时出现的胃食管反流情况。结论 :(1)胃食管反流可以发生在由食管扩张引起的下食管括约肌松弛期内 ;(2 )食管扩张可以引起不伴随继发蠕动的单纯下食管括约肌松弛 ;(3)单纯下食管括约肌松弛时的胃食管反流发生率显著高于伴有继发蠕动的情况。 | 谢鹏雁 Eytan Bardan Junlong Ren Walter J Hogan Reza Shaker | 2000 | 北京医科大学学报2000，32，2： | 5 |
| 4 | Total hepatectomy and liver transplantation as a two-stage procedure for fulminant hepatic failure: A safe procedure in exceptional circumstances显示文摘AIM: To evaluate the outcomes of two-stage liver transplant at a single institution, between 1993 and March 2015.METHODS: We reviewed our institutional experience with emergency hepatectomy followed by transplantation for fulminant liver failure over a twenty-year period. A retrospective review of a prospectively maintained liver transplant database was undertaken at a national liver transplant centre. Demographic data, clinical presentation, preoperative investigations, cardiocirculatory parameters, operative and postoperative data were recorded.RESULTS: In the study period, six two-stage liver transplants were undertaken. Indications for transplantation included acute paracetamol poisoning(n = 3), fulminant hepatitis A(n = 1), trauma(n = 1) and exertional heat stroke(n = 1). Anhepatic time ranged from 330 to 2640 min. All patients demonstrated systemic inflammatory response syndrome in the first post-operative week and the incidence of sepsis was high at 50%. There was one mortality, secondary to cardiac arrest 12 h following re-perfusion. Two patients required re-transplantation secondary to arterial thrombosis. At a median follow-up of 112 mo, 5 of 6 patients are alive and without evidence of graft dysfunciton.CONCLUSION: Two-stage liver transplantation represents a safe and potentially life-saving treatment for carefully selected exceptional cases of fulminant hepatic failure. | Rebeca Sanabria Mateos Niamh M Hogan Dimitri Dorcaratto Helen Heneghan Venkatesh Udupa Donal Maguire Justin Geoghegan Emir Hoti | 2016 | World Journal of Hepatology2016，8，4： | 3 |
| 5 | Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice显示文摘 | Hogan SP Koskinen A Matthaei KI | 1998 | Am J Respir Crit Care Med1998，157，： | 3 |
| 6 | 过氧化苯甲酰的致癌性及变应原性显示文摘过氧化苯甲酰目前被广泛用于治疗痤疮,亦用于皮肤溃疡的治疗。动物试验证明过氧化苯甲酰是一种致癌物质(促肿瘤生长剂)。但在人类尚未见因用过氧化苯甲酰治疗引起肿瘤的报告。过氧化苯甲酰具有强的刺激作用,亦可致皮肤接触过敏。过敏反应常发生于治疗下腿溃疡,在痤疮患者却不多见,而斑贴反应的阳性率却较高,但不影响继续用药。 | Hogan DJ 李惠民 丁明伟 | 1992 | 国外医学(皮肤性病学分册)1992，18，3： | 2 |
| 7 | Transcription factor of the NFAT family:regulation and function 显示文摘 | Rao A Luo C Hogan PG | 1997 | Annu Rev Immonol1997，15，： | 2 |
| 8 | CsBi4Te6: A high-performance thermoelectric material for low-temperature applications 显示文摘 | Chung D Y Hogan Tim Brazis Paul | 2000 | Science2000，1，1287： | 2 |
| 9 | Clinical and radiographic subtypes of vascular cognitive impairment in a clinic-based cohort study显示文摘 | Kenneth Rockwood Sandra E. Black Xiaowei Song David B. Hogan Serge Gauthier Chris MacKnight Robert Vandorpe Antonio Guzman Patrick Montgomery Andrew Kertesz Remi W. Bouchard Howard Feldman | 2005 | Journal of the Neurological Sciences2005，，1： | 2 |
| 10 | Alzheimer’s disease:a tale of two diseases?显示文摘Sporadic late-onset Alzheimer’s disease(SLOAD)and familial early-onset Alzheimer’s disease(FEOAD)associated with dominant mutations in APP,PSEN1 and PSEN2,are thought to represent a spectrum of the same disorder based on near identical behavioral and histopathological features.Hence,FEOAD transgenic mouse models have been used in past decades as a surrogate to study SLOAD pathogenic mechanisms and as the gold standard to validate drugs used in clinical trials.Unfortunately,such research has yielded little output in terms of therapeutics targeting the disease’s development and progression.In this short review,we interrogate the widely accepted view of one,dimorphic disease through the prism of the Bmi1+/–mouse model and the distinct chromatin signatures observed between SLOAD and FEOAD brains. | Eleonora Nardini Ryan Hogan Anthony Flamier Gilbert Bernier | 2021 | Neural Regeneration Research2021，16，10： | 2 |
| 11 | Factors that influence induction of gastroesophageal reflux in normal human subjects显示文摘 | John Dent MD Wylie J. Dodds MD Walter J. Hogan MD James Toouli MD | 1988 | Digestive Diseases and Sciences1988，，3： | 2 |
| 12 | Overview of the progress on haploidentical hematopoietic transplantation显示文摘Allogeneic hematopoietic stem cell transplant(HSCT) remains the only potentially curative option for variety of hematologic disorders. Lack of a suitable fully HLAmatched donor limits this option for many patients. Without a suitable related or unrelated HLA-matched donor,umbilical cord blood and haploidentical family members provide a potential source of stem cells. Timely donor availability makes haploidentical donors an attractive alternative donor source. Initial attempts at haploidentical HSCT was associated with significantly increased mortality owing to high rates of graft rejection and severe graftversus-host disease caused by major donor-recipient HLAdisparity. However, over the past decade, outcomes of haploidentical HSCT have improved significantly. Here, we review the advantages and challenges of haploidentical transplantation. We also discuss new developments to attempt to overcome the challenges to a successful haploidentical transplantation. | Nosha Farhadfar William J Hogan | 2016 | World Journal of Transplantation2016，6，4： | 2 |
| 13 | Human aortic valve allografts elicit a donor-specific immune response 显示文摘 | Hogan P Duplock L Green M | 1996 | J Thorac Cardiovasc Surg1996，112，6： | 2 |
| 14 | How often do office blood pressure measurements fail to identify true hypertension? An exploration of white-coat normotension显示文摘 | Hogan BE Linden W | 2000 | Arch Fam Med2000，9，： | 1 |
| 15 | The effect of enclosure size on social interactions and daily activity patterns of the captive Asiatic wild horse (Equus przewalskii)显示文摘 | Hogan E S Houpt K A Sweeney K | 1988 | Applied Animal Behaviour Science1988，21，12： | 1 |
| 16 | Sitosterol-D-glucoside as primer for cellulose synthesis in plants显示文摘 | Peng LC Kawagoe Y Hogan P | 2002 | Science2002，295，5552： | 1 |
| 17 | Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igt2r) gene compared with embryonic stem (ES) cell lines 显示文摘 | Labosky PA Barlow DP Hogan BL | 1994 | Development1994，120，： | 1 |
| 18 | Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture显示文摘 | Matsui Y Zsebo K Hogan B L | 1992 | Cell1992，70，： | 1 |
| 19 | Enforcement of Implicit Employment Contracts through Unionization显示文摘 | Hogan C | 2001 | Journal of Labor Economics2001，，1： | 1 |
| 20 | Day 3 serum inhibin-B is predi ctive of assisted reproductive technologies outcome显示文摘 | Seifer DB Lamber MG Hogan JW | 1997 | Fertil Steril1997，67，： | 1 |
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