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| 1 | One hundred and one over-the-scope-clip applications forsevere gastrointestinal bleeding,leaks and fistulas显示文摘AIM: To investigate the efficacy and clinical outcome of patients treated with an over-the-scope-clip(OTSC) system for severe gastrointestinal hemorrhage, perforations and fistulas.METHODS: From 02-2009 to 10-2012, 84 patients were treated with 101 OTSC clips. 41 patients(48.8%) presented with severe upper-gastrointestinal(GI) bleeding, 3(3.6%) patients with lower-GI bleeding, 7 patients(8.3%) underwent perforation closure, 18 patients(21.4%) had prevention of secondary perforation, 12 patients(14.3%) had control of secondary bleeding after endoscopic mucosal resection or endoscopic submucosal dissection(ESD) and 3 patients(3.6%) had an intervention on a chronic fistula. RESULTS: In 78/84 patients(92.8%), primary treatment with the OTSC was technically successful. Clinical primary success was achieved in 75/84 patients(89.28%). The overall mortality in the study patients was 11/84(13.1%) and was seen in patients with life threatning upper GI hemorrhage. There was no mortality in any other treatment group. In detail OTSC application lead to a clinical success in 35/41(85.36%) patients with upper GI bleeding and in 3/3 patients with lower GI bleeding. Technical success of perforation closure was 100% while clinical success was seen in 4/7 cases(57.14%) due to attendant circumstances unrelated to the OTSC. Technical and clinic success was achieved in 18/18(100%) patients for the prevention of bleeding or perforation after endoscopic mucosal resection and ESD and in 3/3 cases of fistula closure. Two application-related complications were seen(2%).CONCLUSION: This largest single center experience published so far confirms the value of the OTSC for GI emergencies and complications. Further clinical experience will help to identify optimal indications for its targeted and prophylactic use. | Edris Wedi Susana Gonzalez Detlev Menke Elena Kruse Kai Matthes Juergen Hochberger | 2016 | World Journal of Gastroenterology2016，22，5： | 28 |
| 2 | Modular architecture for fully non-blocking silicon photonic switch fabric显示文摘Integrated photonics offers the possibility of compact,low energy,bandwidth-dense interconnects for large port count spatial optical switches,facilitating flexible and energy efficient data movement in future data communications systems.To achieve widespread adoption,intimate integration with electronics has to be possible,requiring switch design using standard microelectronic foundry processes and available devices.We report on the feasibility of a switch fabric comprised of ubiquitous silicon photonic building blocks,opening the possibility to combine technologies,and materials towards a new path for switch fabric design.Rather than focus on integrating all devices on a single silicon chip die to achieve large port count optical switching,this work shifts the focus towards innovative packaging and integration schemes.In this work,we demonstrate 1×8 and 8×1 microring-based silicon photonic switch building blocks with software control,providing the feasibility of a full 8×8 architecture composed of silicon photonic building blocks.The proposed switch is fully non-blocking,has path-independent insertion loss,low crosstalk,and is straightforward to control.We further analyze this architecture and compare it with other common switching architectures for varying underlying technologies and radices,showing that the proposed architecture favorably scales to very large port counts when considering both crosstalk and architectural footprint.Separating a switch fabric into functional building blocks via multiple photonic integrated circuits offers the advantage of piece-wise manufacturing,packaging,and assembly,potentially reducing the number of optical I/O and electrical contacts on a single die. | Dessislava Nikolova David M.Calhoun Yang Liu Sébastien Rumley Ari Novack Tom Baehr-Jones Michael Hochberg Keren Bergman | 2017 | Microsystems & Nanoengineering2017，3，1： | 3 |
| 3 | Bacterial microcosms obey Taylor’s law:effects of abiotic and biotic stress and genetics on mean and variance of population density显示文摘Introduction:According to the empirical regularity called Taylor’s law,the variance of population density in samples of populations is a power of the mean population density.The exponent is often between 1 and 2.Our experiments investigated how genetics,evolution,and environment shape Taylor’s law.Methods:Genetically different strains(wild type and hypermutator)of the bacterium Pseudomonas fluorescens evolved and were assayed under different environmental conditions(with and without antibiotic rifampicin and bacteriophage SBW252,separately and in combination).Results:Experimental treatments altered the exponent b,but not the power law form,of the relation between variance and mean population density.Bacterial populations treated only with rifampicin had a narrow range of mean population densities and exponent b=5.43.Populations exposed to rifampicin plus phage had b=1.51.In ancestral,control,and phage-exposed populations,mean abundance varied widely and b was not significantly different from 2.Evolutionary factors(mutation rate,selection)and ecological factors(abiotic,biotic)jointly influenced b.Conclusions:Taylor’s power law relationship accurately and robustly described variance as a function of mean population density,with overall exponent b=1.89.These and other experiments with different factors acting on bacterial population size support the relevance of models that predict‘universal’patterns of fluctuation scaling. | Oliver Kaltz Patricia Escobar-Páramo Michael E Hochberg Joel E Cohen | 2012 | Ecological Processes2012，1，1： | 3 |
| 4 | The Effect of Finasteride on the Expression of Vascular Endothelial Growth Factor and Microvessel Density: A Possible Mechanism for Decreased Prostatic Bleeding in Treated Patients显示文摘 | GYAN PAREEK MARIA SHEVCHUK NOEL A. ARMENAKAS LJILJANA VASJOVIC DAVID A. HOCHBERG JAY B. BASILLOTE JOHN A. FRACCHIA | 2003 | The Journal of Urology2003，，1： | 3 |
| 5 | Prevention of growth deceleration after withdrawal of growth hormone therapy in idiopathic short stature 显示文摘 | Lampit M Hochberg Z | 2002 | J Clin Endocrinol Metab2002，87，8： | 1 |
| 6 | Neuronal ensemble control of prosthetic devices by a human with tetraplegia 显示文摘 | HOCHBERG L R SERRUYA M D FRIECHS G M | 2006 | Nature2006，442，7099： | 1 |
| 7 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythe-matosus 显示文摘 | Hochberg M C | 1997 | Arthritis Rheum1997，40，9： | 1 |
| 8 | Neuronal ensemble control of prosthetic devices by a human with tetraplegia 显示文摘 | Hochberg LR Serruya MD Friehs GM | 2006 | Science2006，442，7099： | 1 |
| 9 | Prevention and management of gout 显示文摘 | Star VL Hochberg MC | 1993 | Drugs1993，45，2： | 1 |
| 10 | Optical mod- ulation and detection in slotted silicon waveguides 显示文摘 | BAEHR J T HOCHBERG M WANG G | 2005 | Opt Express2005，13，： | 1 |
| 11 | Venture Capital and Corporate Governance in the Newly Public Firm显示文摘 | Hochberg Yael V | 2011 | Review of Finance2011，16，2： | 1 |
| 12 | Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis显示文摘 | MATOUK I J ABBASI I HOCHBERG A | 2009 | Eur J Gastroenterol Hepatol2009，21，6： | 1 |
| 13 | Growth hormone and insulin-like growth factor I increase macrophage uptake and begradation of low-density lipoprotein显示文摘 | Hochberg Z Hertz P Maor G | 1992 | Endocrinol1992，131，： | 1 |
| 14 | Direct antifungal effect of femtosecond laser on Trichophyton rubrum onychomycosis显示文摘 | Manevitch Z Lev D Hochberg M | 2010 | Photochem Photobiol2010，86，2： | 1 |
| 15 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus显示文摘 | Hochberg MC | 1997 | Arthritis Rheum1997，40，9： | 1 |
| 16 | An evaluation of three signal-detection algorithms using a highly inclusive refer- ence event database显示文摘 | Hochberg AM Hauben M Pearson RK | 2009 | Drug Saf2009，32，6： | 1 |
| 17 | Whom you know matters? venture capital networks and investment performance显示文摘 | HOCHBERG Y V LJUNGQVIST A LU Y | 2007 | Journal of Finance2007，62，1： | 1 |
| 18 | Determinants of pain severity in knee osteoarthritis: effect of demographic and psychosocial variable susing 3 pain measures显示文摘 | Creamer P Lethbridge-Cejku M Hochberg MC | 1999 | J Rheumatol1999，26，8： | 1 |
| 19 | Updating the American College of Rheumatolegy revised criteria for the classification of systemic lupus erythe- matosus 显示文摘 | Hochberg MC | 1997 | Arthritis Rheum1997，40，9： | 1 |
| 20 | Health-related quality of life after total hip replacement 显示文摘 | Towheed TE Hochberg MC | 1996 | Semin Arthritis Rheum1996，26，1： | 1 |
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