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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Field - amplified sample stacking in capillary electrophoresis for the determination of clozapine, clozapine N - oxide, anddesmethylclozapine in schizophrenics' plasma显示文摘 | Ho Y H Ko W K Kou W S | 2004 | Journal of Chromatography B2004，809，： | 1 |
| 3 | Cognitive Profilingand Preliminary Subtyping in Chinese Developmental Dys-lexia显示文摘 | HO C S CHAN D W LEE S H etal | 2004 | Cognition2004，91，1： | 1 |
| 4 | Generalized survivable network 显示文摘 | HO K S CHEUNG K W | 2007 | IEEE/ACM Transactions on Networking2007，15，4： | 1 |
| 5 | An incremental method for studying the steady state performance of induction motors using time stepping finite Transactions on Magnetics, element model显示文摘 | S L Ho W N Fu | 1997 | IEEE1997，33，2： | 1 |
| 6 | A qualitative and quanti- tative review of antecedents of counterproductive behav- ior in organizations 显示文摘 | Lau V S Au W T & Ho J C | 2003 | Journal of Business and Psy- chology2003，18，1： | 1 |
| 7 | Characterization of tea catechins-loaded nanoparticles prepared from chitosan and an edible polypeptide显示文摘 | Tang D W Yu S H Ho Y C | | 0，，01： | 1 |
| 8 | Controlling carbon emissions in China显示文摘 | Garbaccio R F Ho M S Jorgenson D W | 1999 | Environment and Development Economics1999，，04： | 1 |
| 9 | Relationships between explanatory style, posttraumatic growth and posttraumatic stress disorder symptoms among Chinese breast cancer patients显示文摘 | Ho S M Y Chart M W Y Yau T K | 2011 | Psychology and Health2011，，3： | 1 |
| 10 | Tuning of PID controllers based on gain and phase margin specifications 显示文摘 | Ho W K Hang C C Cao L S | 1995 | Automatica1995，31，3： | 1 |
| 11 | herative learning control with initial rectifying action for nonlinear continuous systems 显示文摘 | Li X D Ho J K L Chow T W S | 2009 | lET Proc Control Theory and Applications2009，3，1： | 1 |
| 12 | Human Oviductal Cells Produce a Factor(s) That Maintains the Motility of Human Spermatozoa in Vitro显示文摘 | YAO Yuan-qing Ho P C Yeung W S B | 2000 | Fertil Steril2000，73，3： | 1 |
| 13 | Psychometric properties of the Chinese version of the mini-mental adjustment to cancer (MINI-MAC) scale显示文摘 | Ho S M Y Kam Fung W Chan C L W | 2003 | Psycho Oncol2003，12，6： | 1 |
| 14 | Facilitated transport of olefins in Ag^+ -containing polymer membranes 显示文摘 | Ho W S Dalrymple D C | | J Membr Sci0，91，： | 1 |
| 15 | Analysis of the M/G/1 queue with n-policy and multiple vacations显示文摘 | Ho W L Soon S L | 1994 | Journal of Applied Probabality1994，31，： | 1 |
| 16 | A power-balanced time-stepping finite element method for transient magnetic field computation显示文摘 | S L Ho S X Niu W N Fu | 2012 | IEEE Transactions on Magnetics2012，48，2： | 1 |
| 17 | Optimization of permanent magnet surface shapes of electric motors for minimization of cogging torque using FEM显示文摘 | Chen Ningning Ho S L Fu W N | 2010 | IEEE Transactions on Magnetics2010，46，6： | 1 |
| 18 | OPSO:Orthogonal particle swarm optimization and its application to task assignment problems显示文摘 | Ho S Y Lin H S Liauh W H | 2008 | IEEE Transactions on Systems Man and Cybernetics Part A: System and Humans2008，38，2： | 1 |
| 19 | Ion-beam-induced chemical changes in the oxyanions (Moyn-) and oxides (Mox) where M = chromium, molybdenum, tungsten, vanadium, niobium and tantalum 显示文摘 | Ho S F Contarini S Rabalais J W | 1987 | Journal of Physi- cal Chemistry1987，91，18： | 1 |
| 20 | Overexpression of cellular glutathione peroxidase does not affect expres- sion of plasma glutathione peroxidase or phospholipid hydroperoxide glutathione peroxidase in mice offered diets adequate or deficient in selenium显示文摘 | Cheng W H Ho Y S Ross DA | 1997 | The Journal of nutrition1997，127，5： | 1 |
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