|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | TRICHOMEAND ARTEMISININ REGULATOR 1 Is Required for Trichome Development and Artemisinin Biosynthesis in Artemisia annua显示文摘毛状体,许多植物种类的表面上的小伸出,能生产并且存储各种各样的第二等的新陈代谢的产品。Artemisinin,最著名并且为疟疾的有势力药,被综合,存储,并且由 Artemisia annua 毛状体藏匿了。然而,糟糕在 A.annua 遗体调整 artemisinin 的生合成和毛状体的发展的分子的基础理解。这里,我们报导那一个 AP2 抄写因素,毛状体和 ARTEMISININ 管理者 1 (TAR1 ) ,在在 A.annua 调整毛状体的发展和 artemisinin 的生合成起关键作用。TAR1,编码特殊位于原子核的蛋白质,主要在年轻叶子,花芽,和一些毛状体被表示。在 TAR1-RNAi 线,毛状体的形态学和表皮的蜡的作文被改变,并且 artemisinin 内容戏剧性地被减少它能被 TAR1 oeverexpression 显著地增加。当 TAR1 是 silenced 或 overexpressed 时,涉及 artemisinin 生合成的几关键基因的表示层次被改变。由 electrophoretic 活动性移动,酵母一个混血儿和短暂转变 -glucuronidase 试金,我们证明广告和 CYP71AV1,在 artemisinin 的生合成小径的二关键基因,是可能的 TAR1 的直接目标。一起拿,我们的结果显示 TAR1 是在 A.annua 调整毛状体开发和 artemisinin 生合成的分子的网络的一个关键部件。 | Hexin Tan Ling Xiao Shouhong Gao Qing Li Junfeng Chen Ying Xiao Qian Ji Ruibing Chen Wansheng Chen Lei Zhang | 2015 | Molecular Plant2015，8，9： | 37 |
| 2 | The Post-meiotic Deficicent Anther1 (PDA1) gene is required for post-meiotic anther development in rice显示文摘To understand the molecular mechanism of male reproductive development in the model crop rice,we isolated a complete male sterile mutant post-meiotic deficient anther1 (pda1) from a γ-ray-treated rice mutant library.Genetic analysis revealed that the pda1 mutant was controlled by a recessive nucleus gene.The pda1 mutant anther seemed smaller with white appearance.Histological analysis demonstrated that the pda1 mutant anther undergoes normal early tapetum development without obvious altered meiosis.However,the pda1 mutant displayed obvious defects in postmeiotic tapetal development,abnormal degeneration occurred in the tapetal cells at stage 9 of anther development.Also we observed abnormal lipidic Ubisch bodies from the tapetal layer of the pda1 mutant,causing no obvious pollen exine formation.RT-PCR analysis indicated that the expression of genes involved in anther development including GAMYB,OsC4 and Wax-deficient anther1 (WDA1) was greatly reduced in the pda1 mutant anther.Using map-based cloning approach,the PDA1 gene was finely mapped between two markers HLF610 and HLF627 on chromosome 6 using 3,883 individuals of F2 population.The physical distance between HLF610 and HLF627 was about 194 kb.This work suggests that PDA1 is required for post-meiotic tapetal development and pollen/microspore formation in rice. | Lifang Hu Hexin Tan Wanqi Liang Dabing Zhang | 2010 | Journal of Genetics and Genomics2010，37，1： | 8 |
| 3 | MicroRNAs in pathogenesis of breast cancer:Implications in diagnosis and treatment显示文摘MicroR NAs(miR NAs) are small non-coding RNAs generated by a two-step complex process and are post transcriptional negative regulators of their target m RNAs. Dysregulation of many of these miR NAs has been associated with tumorigenesis in various cancers including breast cancer. Aberrantly high expression of specific mi RNAs in breast cancer cells is demonstrated to be linked with inhibition of tumor suppressor genes and promote tumorigenesis. They are classified as oncogenic miR NAs. However, the tumor suppressor miR NAs are downregulated in breast cancer cells, since their major targets are oncogenic m RNAs. Understanding mechanism of action of specific miR NAs in breast cancer cells can be utilized to develop newer anti-cancer therapies. Recently, newer techniques are also developed to detect abundance of specific miR NA in the blood plasma samples and can be used in early diagnosis or prognosis in breast cancer. In this review article, we have discussed several mi RNAs dysregulated in breast cancer and their therapeutic potential. | Nirav R Shah Hexin Chen | 2014 | World Journal of Clinical Oncology2014，5，2： | 8 |
| 4 | Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis显示文摘Berberine has been shown to reduce acute liver injury although the underlying mechanism is not fully understood. Because of the anatomic connection, the liver is constantly exposed to gut-derived bacterial products and metabolites. In this study, we showed that berberine has beneficial effects on both hepatotoxicity and intestinal damage in a rat model of chronic or acute liver injury. Microbiota transplantation from the rats with chronic hepatotoxicity could aggravate acute hepatotoxicity in mice treated with diethylnitrosamine(DEN). In rat models with gut homeostasis disruption induced by penicillin or dextran sulfate sodium(DSS), their fecal microbiota could also cause an enhanced hepatotoxicity of recipient mice. When treated with berberine,the DSS-induced enteric dysbacteriosis could be mitigated and their fecal bacteria were able to reduce acute hepatotoxicity in recipient mice. This study indicates that berberine could improve intestinal dysbacteriosis, which reduces the hepatotoxicity caused by pathological or pharmacological intervention. Fecal microbiota transplantation might be a useful method to directly explore homeostatic alteration in gut microbiota. | Chenjie Qin Huilu Zhang Linghao Zhao Min Zeng Weijian Huang Gongbo Fu Weiping Zhou Hongyang Wang Hexin Yan | 2018 | Science China(Life Sciences)2018，61，12： | 8 |
| 5 | Artemisia annua glandular secretory trichomes: the biofactory of antimalarial agent artemisinin显示文摘Artemisinin, the key ingredient of first-line antimalarial drugs, has large demand every year. The native plant, which produces small quantities of artemisinin, remains as its main source and thus results in a short supply of artemisinin. Intensified efforts have been carried out to elevate artemisinin production. However, the routine metabolic engineering strategy, via overexpressing or down-regulating genes in artemisinin biosynthesis branch pathways, was not very effective as desired. Glandular secretory trichomes, sites of artemisinin biosynthesis on the surface of Artemisia annua L.(A. annua), are the new target for increasing artemisinin yield. In general, the population and morphology of glandular secretory trichomes in A. annua(Aa GSTs) are often positively correlated with artemisinin content. Improved understanding of Aa GSTs will shed light on the opportunities for increasing plant-derived artemisinin. This review article will refresh classification of trichomes in A. annua and provide an overview of the recent achievements regarding Aa GSTs and artemisinin. To have a full understanding of Aa GSTs,factors that are associated with trichome morphology and density will have to be further investigated, such as genes,micro RNAs and phytohormones. The purpose of thisreview was to(1) update the knowledge of the relation between Aa GSTs and artemisinin, and(2) propose new avenues to increase artemisinin yield by harnessing the potential biofactories, Aa GSTs. | Ling Xiao Hexin Tan Lei Zhang | 2016 | Science Bulletin2016，61，1： | 7 |
| 6 | First demonstration of an on-chip quadplexer for passive optical network systems显示文摘An on-chip quadplexer is proposed and demonstrated with four wavelength-channels of 1270, 1310, 1490, and 1577 nm. The present quadplexer consists of four cascaded filters based on multimode waveguide grating(MWG), which are composed of a two-mode(de)multiplexer and an MWG. For the fabricated quadplexer on silicon, all four wavelength channels have flat-top responses with low excess losses of <0.5 dB as well as the desired bandwidths, which are about 16, 38, 19, and 6 nm, respectively. The cross-talk for both upstream channels and downstream channels is less than -24 dB. Moreover, the data transmission of 10 Gb∕s of the present silicon quadplexer is also successfully demonstrated. | DAJIAN LIU LONG ZHANG HEXIN JIANG DAOXIN DAI | 2021 | Photonics Research2021，9，5： | 4 |
| 7 | Key Recovery Against 3DES in CPU Smart Card Based on Improved Correlation Power Analysis显示文摘The security of CPU smart cards,which are widely used throughout China,is currently being threatened by side-channel analysis.Typical countermeasures to side-channel analysis involve adding noise and filtering the power consumption signal.In this paper,we integrate appropriate preprocessing methods with an improved attack strategy to generate a key recovery solution to the shortcomings of these countermeasures.Our proposed attack strategy improves the attack result by combining information leaked from two adjacent clock cycles.Using our laboratory-based power analysis system,we verified the proposed key recovery solution by performing a successful correlation power analysis on a Triple Data Encryption Standard(3DES)hardware module in a real-life 32-bit CPU smart card.All 112 key bits of the 3DES were recovered with about 80 000 power traces. | Yanting Ren Liji Wu Hexin Li Xiangyu Li Xiangmin Zhang An Wang Hongyi Chen | 2016 | Tsinghua Science and Technology2016，21，2： | 3 |
| 8 | Preparation of Cu(In,Ga)Se_2 thin film by sputtering from Cu(In,Ga)Se_2 quaternary target显示文摘Cu(In,Ga)Se2 (CIGS) thin films were prepared by directly sputtering Cu(In,Ga)Se2 quaternary target consisting of Cu:In:Ga:Se 25:17.5:7.5:50 at%. The composition and structure of CIGS layers have been investigated after annealing at 550 ℃ under vacuum and a Se-containing atmosphere. The results show that recrystallization of the CIGS thin film occurs and a chalcopyrite structure with a preferred orientation in the (112) direction was obtained. The CIGS thin film annealed under vacuum exhibits a loss of a portion of Se, while the film annealed under Se-containing atmosphere reveals compensation of Se. Several solar cells with three different absorber thicknesses were fabricated using a soda lime glass/Mo/CIGS/CdS/i-ZnO/ZnO:Al/Al grid stack structure. The highest conversion efficiency of 9.65% with an open circuit voltage of 452.42 mV, short circuit current density of 32.16 mA cm2 and fill factor of 66.32% was obtained on a 0.755 cm2 cell area. | Jiang Liu Daming Zhuang Hexin Luan Mingjie Cao Min Xie Xiaolong Li | 2013 | Progress in Natural Science:Materials International2013，23，2： | 2 |
| 9 | Do multiple cycles of aeolian deposit-pedogenesis exist in the reticulate red clay sections in southern China?显示文摘The Xiangyang reticulate red clay section was newly sampled in high-resolution. The viewpoints different from the previous studies[17] are put forward after studying Munsell color values, weathering degrees, magnetic parame-ters and stable carbon isotopic compositions of the section. They are as follows: (1) The curves of hue, DCB extracted iron (Fed), DCB extracted iron/total iron ratio (Fed/Fet), weathering index (BA) of the section show that the redness is not significantly correlated with the weathering degree of the layers though the uppermost yellow-brown-colored layer is relatively weakly weathered. The variation in hues of the section is possibly attributed to the change of hematite and goethite contents. It is insufficient to determine the existence of the multiple deposit-pedogenesis cycles in the section, like the loess-paleosol sequence in Chinese Loess Plateau, only by the color variation. (2) Magnetic susceptibility (c) values in the non-reticulate and weakly reticulate layers are high; but are quite low in the reticulate red clay layer. The former are more than ten times higher than the latter because of the leaching and collapse of superparamagnetic (SP) and stable single domain (SSD) magnetic particles during the plinthitic processes. Hence, c values in the section are not controlled by weathering and pedogenic processes, and no longer have clear paleoclimatic implication. It is not correct to prove the existence of the multiple deposit-pedogenesis cycles in the section using c curves. (3) The organic d 13C curve of the section illustrates the reduction of forests and increasing of C4 plants in the study area since the late stage of the Qua-ternary period. It could not prove the existence of the multi-ple deposit-pedogenesis cycles in the section either. (4) As a matter of fact, it is difficult to prove the existence of the mul-tiple deposit-pedogenesis cycles in the Xiangyang section like the loess-paleosol sequence in Chinese Loess Plateau using the evidence available currently. | Xuefeng Hu Tianfan Cheng Hexin Wu | 2003 | Chinese Science Bulletin2003，48，12： | 2 |
| 10 | Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase显示文摘 | Hong Nian Wei Zhang Hexin Shi Qingzhen Zhao Qi Xie Shangying Liao Yan Zhang Zhuqiang Zhang Chen Wang Chunsheng Han | 2008 | Cell Research2008，18，7： | 2 |
| 11 | Oxycarbonylation of methanol over modified CuY: Enhanced activity by improving accessibility of active sites显示文摘CuY zeolite is a promising catalyst in the field of manufacturing dimethyl carbonate(DMC) through oxidative carbonylation of methanol. Cu^+ exchanged with Br?nsted acid sites are supposed to be active for this reaction. However, the location of Cu^+ in small cages can not interact with reactants because of steric hindrance, which lead to a waste of Cu species. In this work, NH_4F solution was used to modify the pore structure of zeolite Y by etching the framework T atoms. Physical and chemical adsorption of probe molecules with different size are used to determine the changes of porosity as well as the accessibility of Cu^+ sites. At an optimized etching time, the small cages were opened with maintained zeolitic framework. As a result, more Cu^+ species located in small cages become accessible to reactants, which contributes to the enhanced activity in this reaction. | Hexin Zhou Shengping Wang Baowei Wang Xinbin Ma Shouying Huang | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 12 | Removal of disinfection by-products formation potential by biologically intensified process显示文摘The removal of disinfection by-products formation potential(DBPFP) in artificially intensified biological activated carbon(IBAC) process which is developed on the basis of traditional ozone granular activated carbon was evaluated. By IBAC removals of 31% and 68% for THMFP and HAAFP were obtained respectively. Under identical conditions, the removals of the same substances were 4% and 32% respectively only by the granular activated carbon(GAC) process. Compared with GAC, the high removal rates of the two formed potential substances were due to the increasing of bioactivity of the media and the synergistic capabilities of biological degradation cooperating with activated carbon adsorption of organic compounds. A clear linear correlation(R 2=0.9562 and R 2=0.9007) between DOC HAAFP removal rate and Empty Bed Contact Time(EBCT) of IBAC process was observed, while that between THMFP removal rate and EBCT of GAC was R 2=0.9782. In addition certain linear correlations between THMFP, HAAFP and UV 254 (R 2=0.855 and R 2=0.7702) were found for the treated water. For IBAC process there are also more advantages such as long backwashing cycle time, low backwashing intensity and prolonging activated carbon lifetime and so on. | ANDong LIWei-guang CUIFu-yi HEXin ZHANGJin-song | 2005 | Journal of Environmental Sciences2005，17，2： | 2 |
| 13 | An Improved Method of Detecting Edge Direction for Spatial Error Concealment显示文摘 | Yan Zhao Hexin Chen Shigang Wang Moncef Gabbouj | 2012 | Journal of Multimedia2012，，3： | 1 |
| 14 | Morphology and Properties of PP In-reactor Alloys Prepared with a MgCl2/TiCl4/Diisobutyl Phthalate/Phosphate Tris-methylphenyl Ester Catalyst System显示文摘 | ZHANG Chunyu DONG Bo ZHANG Hexin HU Yanming ZHANG Xuequan | 2018 | Chemical Research in Chinese Universities2018，34，1： | 1 |
| 15 | Association between Metabolic Dysfunction-associated Fatty Liver Disease and Cognitive Impairment显示文摘Background and Aims:Metabolic dysfunction-associated fatty liver disease(MAFLD)is a newly proposed term based on modified criteria.Although nonalcoholic fatty liver disease(NAFLD)has been well-documented as a multisystem dis-ease,research on the correlation of MAFLD and extra-hepatic diseases is limited.This study aimed to clarify the association of MAFLD,as well as NAFLD status with cognitive function.Methods:A total of 5,662 participants 20-59 years of age who underwent cognitive tests and liver ultrasonography in the Third National Health and Nutrition Examination Survey were included in the analysis.Cognitive function was evalu-ated using three computer-administered tests,the serial dig-it learning test(SDLT),the simple reaction time test(SRTT)and the symbol digit substitution test(SDST).Results:Par-ticipants with MAFLD had significantly poorer performance on the SRTT[odds ratio(OR)1.47,95%confidence interval(CI):1.14-1.89)].MAFLD with moderate-severe liver stea-tosis was associated with higher risks of scoring low in the SDLT(OR 1.37,95%CI:1.04-1.82)and SRTT(OR 1.55,95%CI:1.19-2.02).NAFLD combined with metabolic dys-function,instead of NAFLD without metabolic disorders,was associated an increased risk of a low SRTT score(OR 1.44,95%CI:1.10-1.82).MAFLD patients had a high probability of fibrosis,prediabetes,and diabetes and were also signifi-cantly associated with increased risks based on the SDST or SRTT score.Conclusions:MAFLD was significantly associ-ated with increased risk of cognitive impairment,especially among MAFLD patients with a high degree of liver fibrosis,moderate-severe steatosis,or hyperglycemia. | Qiang Yu Ruixin He Haowen Jiang Ji Wu Zhifeng Xi Kang He Yongbo Liu Tao Zhou Mingxuan Feng Ping Wan Hexin Yan Qiang Xia | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 1 |
| 16 | Control of molecular weight distribution for polypropylene obtained by a commercial Ziegler-Natta catalyst: effect of a cocatalyst and hydrogen显示文摘 | Zhang Hexin Lee Y-J Park J-R | 2011 | Journal of Applied Polymer Science2011，120，1： | 1 |
| 17 | Exact analytic solution for a finite width strip with a single edge crack显示文摘 | Fan Tianyou Yang Xiaochun Li Hexin | 1999 | Chin Phy Lett1999，16，1： | 1 |
| 18 | Structural basis of interaction between protein tyrosine phosphatase PCP-2 and β-catenin显示文摘PCP-2 is a member of receptor-like protein tyrosine phosphatase of the MAM do- main family. To investigate which part of PCP-2 was involved in its interaction with β-catenin, we constructed various deletion mutants of PCP-2. These PCP-2 mutants and wild-type PCP-2 were co-transfected into BHK-21 cells with β-catenin individually. An in vivo binding assay revealed that the expression of wild-type PCP-2, PCP-2 ?C1C2 (deleted PCP-2 without both PTP domains) and PCP-2 ?C2 (deleted PCP-2 without the second PTP domain) could be immunoprecipitated by anti-catenin antibody in every co-transfection, but PCP-2 EXT (deleted PCP-2 without the juxtamembrane region and both PTP domains) was missing, which implied that PCP-2 and β-catenin could associate directly and the juxtamembrane region in PCP-2 was sufficient for the process. | HE Yaqin YAN Hexin DONG Hui ZHANG Peng TANG Liang QIU Xiuhua WU Mengchao WANG Hongyang | 2005 | Science China(Life Sciences)2005，48，2： | 1 |
| 19 | Exact Analytic Solutions for a Finite width Strip with a Single Edge Crack 显示文摘 | Fan Tianyou Yang Xiaochun Li Hexin | 1999 | Chin Phys Lett1999，16，1： | 1 |
| 20 | An Overview of Reverse Logistics显示文摘Until recently, investment in logistics has focused mainly on the flows from companies to markets. Growing concerns for the environment and conserving resources have created new logistical approaches to more effectively manage the distribution function, and make better use of the resources available to an organization. One such approach is reverse logistics, which uses various methods to give scope for a back-load of finished products, components, waste, reusable packing, etc. from consumer to manufacturer. Back-loads allow manufacturers to reduce costs by using the distribution vehicle′s return journey to create income or added value. This basic concept is now being developed to create novel solutions to the problems of reducing pollution, costs and vehicle movements, whilst maintaining high customer service levels. In this paper, the idea of reverse logistics is presented; motivations for it are analyzed, several successful practices are demonstrated and some important truths regarding successful reverse logistics are identified, trend of reverse logistics is provided. | WANGJia-xiang HEXin | 2005 | International Journal of Plant Engineering and Management2005，10，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员