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| 1 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 2 | Early cessation of triptorelin in in vitro fertilization:a double-blind,randomized study 显示文摘 | Arnold H M Henny J M Alex P E | 2005 | Fertil Steril2005，83，4： | 1 |
| 3 | Heat transfer and pressure drop characteristic of angled spiraling tape inserts in a heat exchanger annulus显示文摘 | Hennie C Leon L Josua P M | 2003 | Heat Transfer Engineering2003，24，6： | 1 |
| 4 | Dyschromatosis universalis hereditaria:evidence for autosomal recessive inheritance and identification of a new locus on chromosome 12q21-q23 显示文摘 | Stuhrmann M Hennies HC Bukhari IA | 2008 | Clin Genet2008，73，6： | 1 |
| 5 | Preoperative exercise capacity in adult inflammatory bowel disease sufferers,determined by cardiopulmonary exercise testing显示文摘 | Otto J M O'Doherty A F Hennis P J | 2012 | Int J Colorectal Dis2012，27，11： | 1 |
| 6 | Vitellogenin in Carp (Cyprinus carpio) and Perch (Perca 显示文摘 | HENNIES M WIESMANN M ALLNER B | 2003 | Science of the Total Environment2003，309，： | 1 |
| 7 | Modern methods for cancer external radiation therapies显示文摘 | Giraud P Henni M Housset M | 2008 | Rev Prat2008，58，15： | 1 |
| 8 | Study of liquids absorption and retention capacities of new cellulosic materials and sodiumcellulose carboxylmethylate prepared from posidonia显示文摘 | Khiari R Ferchichi I M’henni M F | 2010 | Fibers and Polymers2010，11，4： | 1 |
| 9 | Critical hematocritininstestinal tissue oxygenation during severe normovolemic hemodilution显示文摘 | Van Bommel J Siegemund M Henny C P | 2001 | Anesthesilogy2001，94，： | 1 |
| 10 | Dyschromatosis universalis hereditaria: evidence for autosomal recessive inheritance and identification of a new locus on chromosome 12q21-q23显示文摘 | Stuhrmann M Hennies HC Bukhari IA | 2008 | Clin Genet2008，73，6： | 1 |
| 11 | Surprising behav-ioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease显示文摘 | Hennis M R Marvin M A Taylor C M 2nd | 2014 | Neurobiol Dis2014，62，： | 1 |
| 12 | Dense ceramic mem branes for methane conversion显示文摘 | HENNY J M | 2003 | Catalysis Today2003，82，： | 1 |
| 13 | Folate, homocysteine and neural tube defects: an overview 显示文摘 | Nathalie M J Henny WM Frans JM | 2001 | Exp Biol Med2001，226，4： | 1 |
| 14 | Comparison of the mieronucleus and chromosome aberration techniques for the documentation of cytogenetic damage in radiochemotherapy- treated patients with rectal cancer 显示文摘 | Wolff H A Hennies S Herrmann M K etal | 2011 | Strahlenther Onkol2011，187，1： | 1 |
| 15 | Comparative ass-ociation analysis reveals that corneodesmosin is more closely associated with psoriasis than HLA-Cw * 0602-B * 5701 in German families 显示文摘 | Schmitt-Egenolf M Windemuth C Hennies HC | 2001 | Tissue Antigens2001，57，5： | 1 |
| 16 | Stroke epidemiology, prevention, and management strategies at a regional level: Latin America and the CaribBean 显示文摘 | Lavados P M Hennis A J Fernandes J G | 2007 | LancetNeuml2007，6，： | 1 |
| 17 | Dysehrom- atosis universalis hereditaria: evidence for autosomal re- cessive inheritance and identification of a now locus on chromosome12q21-q23 显示文摘 | Stuhrmann M Hennies HC Bukhari IA | 2008 | CIin Genet2008，73，6： | 1 |
| 18 | Competition for sorption between added phenanthrene and in situ PAHs in two sediments显示文摘 | Henny H Noort P C M | 2003 | Chemosphere2003，53，： | 1 |
| 19 | Biosurfactant from Lactococcus lactis 53 inhibits microbial adhesion on silicone rubber显示文摘 | Ligia R Henny M Jose AT | 2004 | Applied Microbiology and Biotechnology2004，66，3： | 1 |
| 20 | Dyschroma-tosis universalis hereditaria:evidence for autosomal reces-sive inheritance and identification of a new locus onchro-mosome 12q21-q23显示文摘 | Stuhrmann M Hennies HC Bukhari IA | | 0，，06： | 1 |
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