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| 1 | Blood-testis barrier and spermatogenesis: lessons From genetically-modified mice显示文摘血睾丸障碍(BTB ) 在它在生精的试管为 meiotic 和 postmeiotic 细菌房间的发展和成熟创造唯一的微型环境的睾丸在邻近的 Sertoli 房间之间被发现。它是复合 proteinous 结构,包括紧密的连接(TJ ) 的房间连接的几种类型镇静,粘附连接和差距连接(GJ ) 。一些 junctional 蛋白质作为 BTB 的结构的蛋白质工作,一些有规章的角色。删除或编码这些蛋白质的基因的功能的 silencing 可以破坏 BTB,它可以引起到 meiotic 和 postmeiotic 房间的免疫学的或另外的损坏并且最终导致 spermatogenic 拘捕和不孕。在这评论,我们将在 BTB 结构上总结调查结果并且从遗传上修改的老鼠模型工作并且讨论未来观点。 | Xiao-Hua Jiang Ihtisham Bukhari Wei Zheng Shi Yin Zheng Wang Howard J Cooke Qing-Hua Shi | 2014 | Asian Journal of Andrology2014，16，4： | 9 |
| 2 | COVID-19疫苗:Pfizer/BioNTech和Moderna疫苗生物学、药理学特性和不良反应的比较显示文摘2019-nCoV所致的COVID-19已在世界范围内引起一场具有挑战性和威胁性的大流行,给人类健康和经济造成了巨大损失。美国食品和药品监督管理局(Food and Drug Administration,FDA)已经批准Pfizer/BioNTech和Moderna COVID-19疫苗的紧急使用许可。许多人对特定的食物、药物或疫苗有明显的过敏史;因此,世界各国都对这两种疫苗极为关注。本文比较了这两种疫苗的药理学、适应症、禁忌症和不良反应。 | Meo SA Bukhari IA Akram J 吕新军(编译) | 2021 | 中华实验和临床病毒学杂志2021，35，3： | 8 |
| 3 | Therapeutic Efficacy of Neurostimulation for Depression:Techniques, Current Modalities, and Future Challenges显示文摘Depression is the most prevalent debilitating mental illness; it is characterized as a disorder of mood,cognitive function, and neurovegetative function. About one in ten individuals experience depression at some stage of their lives. Antidepressant drugs are used to reduce the symptoms but relapse occurs in *20% of patients. However,alternate therapies like brain stimulation techniques have shown promising results in this regard. This review covers the brain stimulation techniques electroconvulsive therapy,transcranial direct current stimulation, repetitive transcranial magnetic stimulation, vagus nerve stimulation, and deep brain stimulation, which are used as alternatives to antidepressant drugs, and elucidates their research and clinical outcomes. | Hafsah Akhtar Faiza Bukhari Misbah Nazir Muhammad Nabeel Anwar Adeeb Shahzad | 2016 | Neuroscience Bulletin2016，32，1： | 8 |
| 4 | Nitrogen(N) metabolism related enzyme activities,cell uitrastructure and nutrient contents as affected by N level and barley genotype显示文摘Development of the new crop cultivars with high yield under low nitrogen(N) input is a fundamental approach to enhance agricultural sustainability,which is dependent on the exploitation of the elite germplasm.In the present study,four barley genotypes(two Tibetan wild and two cultivated),differing in N use efficiency(NUE),were characterized for their physiological and biochemical responses to different N levels.Higher N levels significantly increased the contents of other essential nutrients(P,K,Ca,Fe,Cu and Mn),and the increase was more obvious for the N-efficient genotypes(ZD9 and XZ149).The observation of ultrastructure showed that chloroplast structure was severely damaged under low nitrogen,and the two high N efficient genotypes were relatively less affected.The activities of the five N metabolism related enzymes,i.e.,nitrate reductase(NR),glutamine synthetase(GS),nitrite reductase(NiR),glutamate synthase(GOGAT) and glutamate dehydrogenase(GDH) all showed the substantial increase with the increased N level in the culture medium.However the increased extent differed among the four genotypes,with the two N efficient genotypes showing more increase in comparison with the other two genotypes with relative N inefficiency(HXRL and XZ56).The current findings showed that a huge difference exists in low N tolerance among barley genotypes,and improvement of some physiological traits(such as enzymes) could be helpful for increasing N utilization efficiency. | Jawad Munawar Shah Syed Asad Hussain Bukhari ZENG Jian-bin QUAN Xiao-yan Essa Ali Noor Muhammad ZHANG Guo-ping | 2017 | Journal of Integrative Agriculture2017，16，1： | 4 |
| 5 | Synergistic effects of combined therapy of curcumin and Fructus Ligustri Lucidi for treatment of osteoporosis: cellular and molecular evidence of enhanced bone formation显示文摘Objective: The present study explored the effects of the combined herbal therapy consisting of curcumin(CUR) and Fructus Ligustri Lucidi(FLL) on aspects of bone regeneration.Methods: Prior to analyzing the ability of this novel combined herbal therapy to promote aspects of bone regeneration, its cytotoxicity was determined using MC3 T3-E1 cells(pre-osteoblast model). Cell proliferation was evaluated using phase-contrast microscopy and cell differentiation was estimated using alkaline phosphatase activity. The effect of the combined herbal therapy(CUR + FLL) was also assessed in terms of mineralization in the extracellular matrix(ECM) of cultured cells. Further, to explore the molecular mechanisms of bone formation, time-dependent expression of bone-regulating protein biomarkers was also evaluated.Results: Combined herbal therapy(CUR + FLL) significantly upregulated the viability, proliferation and differentiation of MC3 T3-E1 cells compared to the monotherapy of CUR or FLL. The magnitude of ECM mineralization(calcium deposition) was also higher in MC3 T3-E1 cells treated with combined therapy.The time-dependent expression of bone-forming protein biomarkers revealed that the tendency of expression of these bone-regulating proteins was remarkably higher in cells treated with combined therapy.Conclusion: The co-administration of CUR and FLL had superior promotion of elements of bone regeneration in cultured cells, thus could be a promising alternative herbal therapy for the management of bone erosive disorders such as osteoporosis. | Syed Nasir Abbas Bukhari Fahad Hussain Hnin Ei Thu Zahid Hussain | 2019 | Journal of Integrative Medicine2019，17，1： | 4 |
| 6 | Bioassay-guided isolation of novel and selective urease inhibitors from Diospyros lotus显示文摘Two new dimeric naphthoquinones, 5′,8′-dihydroxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone(1; Di-naphthodiospyrol D) and 5′,8′-dihydroxy-5,8-dimethoxy-6,6′-dimethyl-7,3′-binaphthyl-1,4,1′,4′-tetraone(2; Di-naphthodiospyrol E), along with known naphthoquinones diospyrin(3) and 8-hydroxy diospyrin(4) were isolated from the chloroform fraction of extract of Diospyros lotus roots. Their structures were elucidated by advanced spectroscopic analyses, including HSQC, HMBC, NOESY, and J-resolved NMR experiments. The fractions and compounds 1-4 were evaluated for urease activity and phosphodiesterase-Ⅰ, carbonic anhydrase-Ⅱ and α-chymotrypsin enzyme inhibitory activities. Compounds 1 and 2 and their corresponding fractions showed significant and selective inhibitory effects on urease activities. The IC_(50) values of 1 and 2 were 260.4 ± 6.37 and 381.4 ± 4.80 μmol·L-1, respectively, using thiourea(IC_(50) = 21 ± 0.11 μmol·L^(-1)) as the standard inhibitor. This was the first report demonstrating that the naphthoquinones class showed urease inhibition. | Abdur Rauf Ghias Uddin Bina S. Siddiqui Ajmal Khan Umar Farooq Farhan A. Khan Syed Majid Bukhari Sher Bahadar Khan | 2017 | Chinese Journal of Natural Medicines2017，15，11： | 2 |
| 7 | 南极假丝酵母在纳米聚苯乙烯上的共价固载及其在微波辅助酯化反应中的应用(英文)显示文摘Nanopolystyrene was used as a solid support for the covalent immobilization of Candida antarctica lipase B(Cal B) using the photoreactive reagent 1‐fluoro‐2‐nitro‐4‐azido benzene(FNAB) as a cou‐pling reagent. The obtained derivative was then used as a biocatalyst in a microwave assisted ester‐ification experiment. Factors such as contact time, pH, and enzyme concentration were investigated during immobilization. The hydrolytic activity, thermal, and operational stability of immobi‐lized‐Cal B were determined. The maximum immobilized yield(218 μg/mg support) obtained at pH 6.8 exhibited optimum hydrolytic activity(4.42 × 103 mU p‐nitrophenol/min). The thermal stability of Cal B improved significantly when it was immobilized at pH 10, however, the immobilized yield was very low(93.6 μg/mg support). The immobilized‐Cal B prepared at pH 6.8 and pH 10 retained 50% of its initial activity after incubation periods of 14 and 16 h, respectively, at 60 °C. The opera‐tional stability was investigated for the microwave assisted esterification of oleic acid with metha‐nol. Immobilized‐Cal B retained 50% of its initial activity after 15 batch cycles in the micro‐wave‐assisted esterification. The esterification time was notably reduced under microwave irradia‐tion. The combined use of a biocatalyst and microwave heating is thus an alternative total green synthesis process. | Attaullah Bukhari Ani Idris Madiha Atta Teo Chee Loong | 2014 | 催化学报2014，35，9： | 2 |
| 8 | 一种实心针静电纺丝装置的场强模拟及优化(英文)显示文摘提出一种实心针静电纺丝方法,采用实心针作为静电发射极,并将其置于由绝缘材料制成的导液棒轴心,导液棒处于储液盒底部的圆锥沉头通孔内部并可以做升降运动以控制供液量,需要时还可以起到通流的作用,有效地解决了多针头静电纺丝堵塞和无针头静电纺丝开放式供液的问题.利用COMSOL有限元分析软件对影响场强大小及分布的各参数进行场强模拟,研究增大场强并减小边缘效应的改进方法,并采用研发的不完全齿轮横动机构纺丝头做往复横动进行纺丝实验,验证了实心针静电纺丝装置有效降低了能耗和边缘效应,避免了针头堵塞及溶剂挥发问题. | 刘健 刘延波 BUKHARI Samman hassan 任倩 韦春华 蒋秀明 | 2017 | 高等学校化学学报2017，38，6： | 2 |
| 9 | Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis显示文摘Two new sesquiterpenes, trivially named ricinusoids A(1) and ricinusoids B(2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including 1 D-and 2 D-NMR, UV, IR spectroscopy, and mass spectrometry. The compounds(1-2) were also assessed for in-vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5, 10, and 20 mg·kg^(–1) i.p. Pretreatment of both test compounds caused significant(P ≤ 0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics. Both compounds(1-2) possessed marked sedative and antinociceptive effects in animal models. | Umar Farooq Ajmal Khan Sadia Naz Abdur Rauf Haroon Khan Afsar Khan Irfan Ullah Syed Majid Bukhari | 2018 | Chinese Journal of Natural Medicines2018，16，3： | 2 |
| 10 | Intelligent Islanding Detection of Multi-distributed Generation Using Artificial Neural Network Based on Intrinsic Mode Function Feature显示文摘The integration of distributed energy resources(DERs) into distribution networks is becoming increasingly important, as it supports the continued adoption of renewable power generation, combined heat and power plants, and storage systems. Nevertheless, inadvertent islanding operation is one of the major protection issues in distribution networks connected to DERs. This study proposes an intelligent islanding detection method(IIDM) using an intrinsic mode function(IMF)feature-based grey wolf optimized artificial neural network(GWO-ANN). In the proposed IIDM, the modal voltage signal is pre-processed by variational mode decomposition followed by Hilbert transform on each IMF to derive highly involved features. Then, the energy and standard deviation of IMFs are employed to train/test the GWO-ANN model for identifying the islanding operations from other non-islanding events. To evaluate the performance of the proposed IIDM, various islanding and non-islanding conditions such as faults, voltage sag, linear and nonlinear load and switching, are considered as the training and testing datasets. Moreover, the proposed IIDM is evaluated under noise conditions for the measured voltage signal. The simulation results demonstrate that the proposed IIDM is capable of differentiating between islanding and non-islanding events without any sensitivity under noise conditions in the test signal. | Samuel Admasie Syed Basit Ali Bukhari Teke Gush Raza Haider Chul Hwan Kim | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，3： | 2 |
| 11 | Fabrication of Electrospun Levodopa-Carbidopa Fixed-Dose Combinations显示文摘Introduction Parkinson’s disease(PD)is a disabling disorder that signifi-cantly affects a patient’s quality of life[1].Treatments are available,but only 10%of PD patients fully adhere to their treatment regimens[2].Non-adherence is a serious problem linked to worsening symptoms and increased motor fluc-tuations[3-5].Levodopa(LD)remains the most effective treatment for PD[6].However,a single dosing treatment is only effective in the early phase of the disease.In the severe phase,4-5 years after diagnosis,the therapeutic window of dopamine becomes narrow,and due to its short half-life of between 0.7 and 1.4 h dosing of LD will be required every 2 h[7-9].One way to ameliorate this issue is to co-admin-ister LD with carbidopa(CD),which can increase LD’s oral bioavailability to 40-70%[10]. | Haitham Bukhary Gareth R.Williams Mine Orlu | 2020 | Advanced Fiber Materials2020，2，4： | 2 |
| 12 | Ground water coagula-tion using soluble stainless steel electrodes显示文摘 | ABUZAID N S BUKHARI A A AL-HAMOUS Z M | 2002 | Advances in EnviornmentalResearch2002，6，3： | 1 |
| 13 | Emergence of Methicilifn- resistant Staphylococcus aureus as a community parhogen显示文摘 | Bukharie HA Abdelhadi MS Saeed IA et aI | 2001 | Diagn Microbio] infect Dis2001，40，1： | 1 |
| 14 | Synthesis,characterization and antioxidant activity copper-quercetin complex显示文摘 | Bukhari S B Memon S Mahroof T M | | 0，，： | 1 |
| 15 | Gut modulator effects of Conyza bonariensis explain its traditional use in constipation and diarrhea显示文摘 | BUKHARI IA SHAH A J KHAN RA | 2013 | Eur Rev Med Pharmacol Sci2013，17，4： | 1 |
| 16 | Association of phosphodiesterase 4D gene with ischemic stroke in a pakistani population显示文摘 | Bukhari S Haider SR | 2005 | Stroke2005，36，： | 1 |
| 17 | anti inflammato ry trends of 1,3-Diphenyl-2-propen-1 one derivatives 显示文摘 | Bukhari S N A Jantan I Jasamai M | 2013 | Mini-Reviews in Medicinal Chemistry2013，13，1： | 1 |
| 18 | Emergence of methicillin-resistant Staphylococcus aureus as a community pathogen显示文摘 | Bukharie HA Abdelhadi MS Saeed IA etal | 2001 | Diagn Microbiol Infect Dis2001，40，122： | 1 |
| 19 | Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice显示文摘 | Fujisaka S Usui I Bukhari A | 2009 | Diabetes2009，58，11： | 1 |
| 20 | Dyschromatosis universalis he- reditaria as an autosomal recessive disease in five members of one family 显示文摘 | Bukhari IA El-Harith EA Stuhrmann M | 2006 | J Eur Acad Dermatol V enereol2006，20，5： | 1 |
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