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| 1 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 2 | CeCl_3·7H_2O as an efficient catalyst for one-pot synthesis of β-amino ketones by three-component Mannich reaction显示文摘Cerium trichloride heptahydrate(CeCl_3·7H_2O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with acetophenone.This protocol has advantages of high yield,no environmental pollution,mild condition,and simple work-up procedure. | Yan Dai Chun Xu Lü | 2010 | Chinese Chemical Letters2010，21，1： | 10 |
| 3 | Ozone vertical variations during a typhoon derived from the OMI observations and reanalysis data显示文摘Typhoon is considered to play a key role in the dynamical exchange processes taking place between the troposphere and stratosphere.In this paper,the impact of typhoon on the ozone distribution in the upper troposphere and middle stratosphere is investigated using ozone profiles measured by Aura’s Ozone Monitoring Instrument and meteorological fields from reanalysis data.During the passage of Typhoon Hai-Tang in 2005 over the western North Pacific,low values of ozone column above 200 hPa and ozone mixing ratio between the upper troposphere and the middle stratosphere(from 200 to 50 hPa)are observed right above the typhoon’s track,a result due to the strong upward propagation of air associated with overshooting convection in typhoon.A comparative analysis of different stages of Hai-Tang suggests that in the region where typhoon has higher intensity the troposphere-to-stratosphere transport is enhanced.These results indicated that the typhoon has a significant impact on the ozone variation in the upper troposphere and the middle stratosphere. | FU YunFei XIAN Tao Lü DaRen LIU GuoSheng HENG ZhiWei SUN Liang LIU Qi WANG Yu YANG YuanJian | 2013 | Chinese Science Bulletin2013，58，32： | 5 |
| 4 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 5 | A proteomics study to explore the role of adsorbed serum proteins for PC12 cell adhesion and growth on chitosan and collagen/chitosan surfaces显示文摘The aim of this article is to apply proteomics in the comparison of the molecular mechanisms of PC12 cell adhesion and growth mediated by the adsorbed serum proteins on the surfaces of chitosan and collagen/chitosan films.First,the chitosan and the collagen/chitosan films were prepared by spin coating;and their surface morphologies were characterized by scanning electron microscopy,X-ray energy dispersive spectroscopy,contact angle measurement and Fourier transform infrared spectroscopy.Subsequently,cell proliferation experiments on two materials were performed and the dynamic curves of protein adsorption on their surfaces were measured.Then,proteomics and bioinformatics were used to analyze and compare the adsorbed serum proteins on the surfaces of two biomaterials;and their effects on cell adhesion were discussed.The results showed that the optimum concentration of chitosan film was 2%w/v.When compared with chitosan film,collagen/chitosan film promoted the growth and proliferation of PC12 cells more significantly.Although the dynamic curves showed no significant difference in the total amount of the adsorbed proteins on both surfaces,proteomics and bioinformatics analyses revealed a difference in protein types:the chitosan surface adsorbed more vitronectin whereas collagen/chitosan surface adsorbed more fibronectin 1 and contained more cell surface receptor binding sites and more Leu-Asp-Val sequences in its surface structure;the collagen/chitosan surface were more conducive to promoting cell adhesion and growth. | Xiaoying Lü Heng Zhang Yan Huang Yiwen Zhang | 2018 | Regenerative Biomaterials2018，5，5： | 2 |
| 6 | Mechanical Behavior and Failure Mechanism of 2.5D(Shallow Bend-joint, Deep Straight-joint) and 3D Orthogonal UHWMPE Fiber/Epoxy Composites by Vacuum-assistant-resin-infused显示文摘Ultra-high molecular weight polyethylene(UHMWPE) fiber/epoxy composites were fabricated by a vacuum assisted resin infused(VARI) processing technology. The curing condition of composites was at a cure temperature of 80 ℃ for 3h in a drying oven. The characteristics of 2.5D(shallow bend-joint and deep straight-joint) structure and 3D orthogonal structure were compared. The failure behavior, flexural strength, and microstructures of both composites were investigated. It was found that the flexural property was closely related to undulation angle θ. The flexural strength of 3D orthogonal structure composite was superior to the other two structures composites with the same weave parameters and resin. | 赵晓琳 DU Jianhua YANG Hongwei JIA Chengchang GAO Heng WANG Dafeng Lü Yingying | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，6： | 2 |
| 7 | Use of the FAO CROPWAT model in deficit irrigation studies显示文摘 | Smith M Kivumbi D Heng L K | | Defieit Irrigation Practices0，22，： | 1 |
| 8 | An optical bio- sensor for dichlovos using stacked sol - gel films contai- ning acetylcholinesterase and a lipophilic chromoionophore 显示文摘 | Wong F C M Ahmad M Heng L Y | 2006 | Talanta2006，69，4： | 1 |
| 9 | Reliable GPS-based timing for power systems显示文摘 | Heng L Chou D Gao G X | 2014 | Inside GNSS2014，，6： | 1 |
| 10 | Cross sectional echocardiography, 3: analysis of mathematic models for quantifying volume of symmetric and asymmetric left ventricles显示文摘 | WYATT H L MEERBAUM S HENG M K | 1980 | Am Heart J1980，100，： | 1 |
| 11 | Strategies for directing the differentiation of stem cells into the osteogenic lineage in vitro显示文摘 | Heng B C Cao T Sranton L W | | 0，，： | 1 |
| 12 | Para ganglioma of the urinary bladder: can biologic poten tialbe predicted? 显示文摘 | C heng L Leibovich B C Cheville J C | 2000 | Cancer2000，88，4： | 1 |
| 13 | Job performance dimensions for improving final project outcomes显示文摘 | Eddie W L Cheng L Heng Faul F | 2007 | Journal of Construction Engineering and Management2007，，8： | 1 |
| 14 | Isosurface computation for approximating boundary surfaces in 3D images显示文摘 | Wang L Bai J Heng P A | 2007 | Journal of Electronic Imaging2007，16，1： | 1 |
| 15 | Construction Partnering Process and Associated Critical Success Factors: Quantitative Investigation显示文摘 | Eddie W L Cheng Heng Li | 2002 | Journal of Management in Engineering2002，18，4： | 1 |
| 16 | Cross-linking mechanisms of calci- um and zinc in production of alginate miCrospheres 显示文摘 | Chan L Jin Y Heng P | 2002 | IntJ Pharm2002，242，12： | 1 |
| 17 | Cooperative GNSS authentication: reliability from unreliable peers 显示文摘 | Heng L Work D B Gao G X | 2013 | Inside GNSS2013，，5： | 1 |
| 18 | High resolution free ehromatin/DNA fiber fluorescent in situ hybridization显示文摘 | Heng H H Tsui L C | 1998 | J Chromatogr A1998，806，1： | 1 |
| 19 | Composite structural components under blast loading显示文摘 | HENG L | 2001 | Structures under Shock and Impact2001，，： | 1 |
| 20 | Thermal decomposition of high-nitrogen energetic compounds-dihydrazido-s-tetrazine salts 显示文摘 | Jimmie C Oxley James L Smith Heng Chen | 2002 | Thermochimica Acta2002，384，： | 1 |
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