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| 1 | Human umbilical cord mesenchymal stem cells as treatment of adjuvant rheumatoid arthritis in a rat model显示文摘AIM:To investigate the effect of human umbilical cord stem cells,both mesenchymal and hematopoietic(CD34+),in the treatment of arthritis.METHODS:Mesenchymal stem cells(MSCs) and hematopoietic(CD34+) stem cells(HSC) were isolated from human umbilical cord blood obtained from the umbilical cord of healthy pregnant donors undergoing fullterm normal vaginal delivery.MSC,HSC,methotrexate(MTX) and sterile saline were injected intra-articularly into the rat hindpaw with complete freunds adjuvant(CFA) induced arthritis after the onset of disease(day 34),when arthritis had become well established(arthritis score ≥ 2).Arthritic indices were evaluated and the levels of interleukin(IL)-1,tumor necrosis factor(TNF)-α and interferon(IFN)-γ and anti-inflammatory cytokine IL-10 in serum were determined using enzyme-linked immunosorbent assay.Animals of all groups were sacrificed 34 d after beginning treatment,except positive control(PC) which was sacrificed at 10,21 and 34 d for microscopic observation of disease progression.We used hematoxylin,eosin and Masson's trichrome stains for histopathological examination of cartilage and synovium.RESULTS:The mean arthritis scores were similar in all groups at 12 and 34 d post immunization,with no statistical significant difference.Upon the injection of stem cells(hematopoietic and mesenchymal),the overall arthritis signs were significantly improved around 21 d after receiving the injection and totally disappeared at day 34 post treatment in MSC group.Mean hindpaw diameter(mm) in the MSC rats was about half that of the PC and MTX groups(P = 0.007 and P = 0.021,respectively) and 0.6 mm less than the HSC group(P = 0.047),as indicated by paw swelling.Associated with these findings,serum levels of TNF-α,IFN-γ and IL-1 decreased significantly in HSC and MSC groups compared to PC and MTX groups(P < 0.05),while the expression of IL-10 was increased.Histopathological examination with H and E stain revealed that the MTX treated group showed significant reduction of leucocytic infiltrate and hypertrophy of the synovial tissue with moderate obliteration of the joint cavity.Stem cells treated groups(both hematopoietic CD34+ and mesenchymal),showed significant reduction in leucocytic infiltrate and hypertrophy of the synovial tissue with mild obliteration of the joint cavity.With Masson's trichrome,stain sections from the PC group showed evidence of vascular edema of almost all vessels within the synovium in nearly all arthritic rats.Vacuoles were also visible in the outer vessel wall.The vessel became hemorrhagic and finally necrotic.In addition,there was extensive fibrosis completely obliterating the joint cavity.The mean color area percentage of collagen in this group was 0.324 ± 0.096,which was significantly increased when compared to the negative control group.The mean color area percentage of collagen in hematopoietic CD34+ and mesenchymal groups was 0.176 ± 0.0137 and 0.174 ± 0.0197 respectively,which showed a marked decrement compared to the PC group,denoting a mild increase in synovial tissue collagen fibers.CONCLUSION:MSC enhance the efficacy of CFAinduced arthritis treatment,most likely through the modulation of the expression of cytokines and amelioration of pathological changes in joints. | Sahar Greish Noha Abogresha Zeinab Abdel-Hady Eman Zakaria Mona Ghaly Mohamed Hefny | 2012 | World Journal of Stem Cells2012，4，10： | 17 |
| 2 | 岩石动力学中离散元程序处理波幅的新方法显示文摘顺应日益更新的计算机硬件及其外部设施,结合离散元程序UDEC,MATLAB和EX-CEL,提出了一种在UDEC中全面处理各节点或单元中心波幅的数据处理新方法.该方法涉及修改UDEC源程序以扩展时间历程及表格上限、应用UDEC中的内嵌语言FISH在建模文件中自动记录波的时间历程以及在MATLAB中处理各节点或单元中心波的幅值.给出了该方法在岩石动力学中波动问题研究的应用实例,结果表明:该方法优点多,在岩石动力学研究中具有较高的实用价值. | 雷卫东 Ashraf Mohamed Hefny 赵坚 赵晓豹 | 2005 | 中国矿业大学学报2005，34，2： | 7 |
| 3 | Verification of Numerical Modeling in 2-D Wave Propagation in Rock显示文摘Compressional harmonic wave propagation from a cylindrical tunnel or borehole in an intact rock is the basis for investigation of the practical explosion waves in a fractured rock mass. The amplitudes of the radial stress wave obtained from the universal distinct element code (UDEC) were compared with the analytical solutions for two cases with different conditions. Good agreements between the UDEC results and the analytical solutions have been achieved. It indicates that UDEC can model 2-D dynamic problems at a high degree of accuracy. | LEI Wei-dong HEFNY Ashraf TENG Jun ZHAO Jian SONG Hong-wei | 2005 | Journal of China University of Mining and Technology2005，15，4： | 6 |
| 4 | Numerical simulation of rock fragmentation process induced by two TBM cutters and cutter spacing optimization显示文摘 | Q.M. Gong J. Zhao A.M. Hefny | 2006 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2006，，3： | 4 |
| 5 | Numerical study on maximum rebound ratio in blasting wave propagation along radian direction normal to joints显示文摘In the process of 2-D compressional wave propagation in a rock mass with multiple parallel joints along the radian direction normal to the joints, the maximum possible wave amplitude corresponding to the points between the two adjacent joints in the joint set is controlled by superposition of the multiple transmitted and the reflected waves, measured by the maximum rebound ratio. Parametric studies on the maximum rebound ratio along the radian direction normal to the joints were performed in universal distinct element code. The results show that the maximum rebound ratio is influenced by three factors, i.e., the normalized normal stiffness of joints, the ratio of joint spacing to wavelength and the joint from which the wave rebounds. The relationship between the maximum rebound ratio and the influence factors is generalized into five charts. Those charts can be used as the prediction model for estimating the maximum rebound ratio. | 雷卫东 滕军 HEFNY A 赵坚 关炯 | 2006 | Journal of Central South University of Technology2006，13，6： | 3 |
| 6 | Rock dynamics research related to cavern development for ammunition storage显示文摘 | Zhao J Zhou Y X Hefny A M | 1999 | Tunnelling and Underground Space Technology1999，14，4： | 1 |
| 7 | Effect of large excavation on deformation of adjacent MRT tunnels显示文摘 | SHARMA J S HEFNY A M ZHAO J | 2001 | Tunnelling and Underground Space Technology2001，16，2： | 1 |
| 8 | Effect of large excava- tion on deformation of adjacent MRT tunnels 显示文摘 | harma J S Hefny A M Zhao J | 2001 | Tunnel- ling and Underground Space Technology2001，，16： | 1 |
| 9 | Parametric Studies on the Interaction Between Existing and New Bored Tunnels显示文摘 | Hefny A M Chua H C Zhao J | 2004 | Tunnelling and Underground Space Technology2004，19，45： | 1 |
| 10 | Effect of large excavation on deformation of adjacent MRT tunnels 显示文摘 | SHARMA J S HEFNY A M ZHAO J | 2001 | Tunnelling and Underground Space Technology2001，16，2： | 1 |
| 11 | Epidural dexam- ethasone for post-operative analgesia in patients undergo- ing abdominal hysterectomy: A dose ranging and safety evaluation study显示文摘 | Hefni AF Mahmoud MS A1 Alim AA | 2014 | Saudi Journal of Anaesthesia2014，8，3： | 1 |
| 12 | Morbidity associated with posterior intravaginal slingplasty for uterovaginal and vault prolapse显示文摘 | Hefni M Yousri N El-Toukhy T | 2007 | Arch Gynecol Obstet2007，276，5： | 1 |
| 13 | Long-term outcome of vaginal sacrospinous colpopexy for marked uterovaginal and vault prolapse 显示文摘 | Hefni MA E1-Toukhy TA | 2006 | Eur J Obstet Gynecol Reprod Biol2006，127，2： | 1 |
| 14 | Numerical simulation of rock fragmentation process induced by two TBM cutters and cutter spacing optimization<!-- doi='10.1016/j.tust.2005.12.124' aid='937.14'-->显示文摘 | Q.M. Gong J. Zhao A.M. Hefny | 2006 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2006，，3： | 1 |
| 15 | Parametric studies on the interactions between existing and new bored tunnels显示文摘 | HEFNY A M CHUA H C ZHAO J | 2004 | Tunnel and undergroud space technology2004，19，19： | 1 |
| 16 | Management of mesenteric ascular occlusion显示文摘 | Hefny AF Ahmed I Branicki FJ | 2008 | Singapore Med J2008，49，4： | 1 |
| 17 | Effect of Iarge Excavation on Deformation of Adjacent MRT Tunnels显示文摘 | Sharma J S Hefny A M | 1972 | Tunneling and Underground Space Technology1972，，7： | 1 |
| 18 | The effect of different types of hysterectomy on urinary and sexual functions : a prospec- tive study显示文摘 | E1-Toukhy TA Hefni M Davies A | 2004 | J Obstet Gynaecol2004，24，4： | 1 |
| 19 | Folate content in foods commonly consumed in Egypt显示文摘 | HEFNI M (O)HRVIK V TABEKHA M | | 0，，02： | 1 |
| 20 | Effect of Large Excavation on Deformation of Adjacent MRT Tunnels显示文摘 | Sharma J S Hefny A M Zhao J | 2001 | Tunneling and Underground Space Technology2001，16，2： | 1 |
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