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| 1 | 胃肠道癌:中国、美国和欧洲显示文摘胃肠道癌包括结直肠癌、胃癌和食管癌,给全球带来了沉重的医疗和经济负担,无论是每年新发病例数还是死亡例数,均居癌症首位。食管癌和胃癌多见于发展中国家,而结直肠癌则是西方国家的主要胃肠道恶性肿瘤。然而,一些经济转型的发展中国家,其胃肠道癌谱正在发生巨大转变,同时,在西方国家,由于某些危险因素的暴露增加,食管癌和胃癌也有抬头的趋势。所有胃肠道癌的发生发展均与生活习惯密切相关,而且都能通过癌前病变予以识别。因此,这些胃肠道癌都非常适宜早期筛查。本文中,我们综述了胃肠道癌在中国、美国、欧洲的流行病学特点,总结其主要危险因素以及这些危险因素在上述地区的分布情况,并对当前的筛查策略进行了探讨。 | Yumo Xie Lishuo Shi Xiaosheng He Yanxin Luo | 2021 | Gastroenterology Report2021，9，2： | 16 |
| 2 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 3 | Classification and Facies Sequence Model of Subaqueous Debris Flows显示文摘Objective Debris flows are cohesive sediment gravity flows which occur in both subaerial and subaqueous settings.Compared to subaerial debris flows which have been well studied as a geological hazard,subaqueous debris flows showing complicated sediment composition and sedimentary processes were poorly understood.The main objective | XIAN Benzhong LIU Jianping DONG Yanlei LU Zhiyong HE Yanxin WANG Junhui | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 6 |
| 4 | The associated killing of hepatoma cells using multilayer drug-loaded mats combined with fast neutron therapy显示文摘Chemotherapeutic and radiation therapy have emerged as two most important treatment strategies to treat cancer in clinical practice;however,to improve anticancer efficacy,combination chemotherapy still remains challenge.Dichloroacetate(DCA)could produce significant cytotoxic effects in certain tumor cells through its distinct mechanism.Radiation therapy with fast neutrons(FNT)has high relative biolgical effectiveness compared to other radiotherapeutics.Herein,we reported the combination chemotherapy with FNT for effective tumor growth inhibition with the assistance of a multilayered nanofiber loading DCA and DCA derivatives.We first synthesized a biodegradable polylysine to condense DCA with negative charge,or to conjugate DCA by condensing synthesis,to obtain Ion-DCA and Co-DCA,respectively.DCA,Ion-DCA or Co-DCA was then loaded into fibers to form multilayer drug-loaded mats.Upon adhesion on the surface of subcutaneous and orthotopic liver tumors,the multilayer drug-loaded mats realized a controllable release of DCA,which reversed the Warburg effect and inhibited cancer cell proliferation.Meantime,irradiation of fast neutrons could seriously damage DNA structure.Combination of the controllable release of DCA and FNT resulted in synergistic cell apoptosis in vitro,and the tumor inhibition in vivo.This study thus provides a new approach to integrate chemotherapy and FNT with the assistance of biocompatible nanofiber for synergistic tumor therapy. | Yanxin Qi Shiwei Jing Shasha He Hejian Xiong Guohua Yang Yubin Huang Ningyi Jin | 2021 | Nano Research2021，14，3： | 2 |
| 5 | Effect of organicloading rate on aerobic granulation I:Reactorperformance显示文摘 | Tay J H Pan Shun He Yanxin | 2004 | Journal of Environmental Engineering2004，130，10： | 1 |
| 6 | Recovery of iron oxide concentrate from high-sulfur and low-grade pyrite cinder using an innovative beneficiating process显示文摘 | Binbin He Xike Tian Yan Sun Chao Yang Yanglin Zeng Yanxin Wang Suxin Zhang Zhenbang Pi | 2010 | Hydrometallurgy2010，，2： | 1 |
| 7 | Effect of Co element on microstructure and mechanical properties of FeCo_x NiCuAl alloys显示文摘FeCox NiCuAl (x values in molar ratio, x=0.2, 0.5, 1, 1.5, 2 and 3) alloys were prepared using a suck-casting method. The effect of Co element on phase constituents, microstructure and mechanical properties of the FeCox NiCuAl alloys was investigated using X-ray diffraction, scanning electron microscopy, optical microscopy and compressive tests. It was found that the Co addition has a significant influence on the structure and properties of the FeCox NiCuAl alloys. The alloys have typical dendrite microstructure, and are composed of a simple fcc structure and bcc structure. The addition of Co promotes the formation of fcc phase in the alloys, retards the compressive strength and hardness of the alloys, and enhances the plasticity of the alloys. | Yanxin ZHUANG Wenjie LIU Pengfei XING Fei WANG Jicheng HE | 2012 | Acta Metallurgica Sinica(English Letters)2012，25，2： | 1 |
| 8 | Sound speed profile inversion using a horizontal line array in shallow water显示文摘It is better to use a simple configuration to enhance the applicability of ocean environment inversion in shallow water.A matched-field inversion method based on a horizontal line array(HLA)is used to retrieve the variation of sound speed profile.The performance of the inversion method is verified in the South China Sea in June,2010.An HLA laid at bottom was used to receive signals from a bottom-mounted transducer.Inverted mean sound speed profiles from 9-hour long acoustic signals are in good agreement with measurements from two temperature chains at the sites of the source and receiver.The results show that an HLA can be used to monitor the variability of shallow-water sound speed profile. | LI ZhengLin HE Li ZHANG RenHe LI FengHua YU YanXin LIN Peng | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，1： | 1 |
| 9 | The surface properties of Malan loess and its application to removing Cr(Ⅲ) from contaminated water显示文摘Loess has unique compositions and structural characteristics and can be used for environmental protection.Differences between the surface characteristics of the Malan loess from the suburbs of Taiyuan,Shanxi Province before and after reaction with Cr(Ⅲ) solution were studied by SEM/EDS,IR and XRD.The results showed that the Malan loess has a strong ability to remove Cr(Ⅲ) from the solution.The surface characteristics of loess include an effect on Cr(Ⅲ) in solution,as supported by the strong test evidence including the disappearance of Cr peak in the EDS spectrum,the disappearance of carbonate characteristic peaks in the infrared spectrogram,and the positive correlation between Fe and Cr peaks. | MA Teng WANG Yanxin LUO Wei HUANG Zheng HE Xin HE Jun TIAN Chunyan | 2010 | Chinese Journal Of Geochemistry2010，29，1： | 1 |
| 10 | Synergistic enhancement of immunological responses triggered by hyperthermia sensitive Pt NPs via NIR laser to inhibit cancer relapse and metastasis显示文摘The combination of tumor ablation and immunotherapy is a promising strategy against tumor relapse and metastasis.Photothermal therapy(PTT)triggers the release of tumor-specific antigens and damage associated molecular patterns(DAMPs)in-situ.However,the immunosuppressive tumor microenvironment restrains the activity of the effector immune cells.Therefore,systematic immunomodulation is critical to stimulate the tumor microenvironment and augment the anti-tumor therapeutic effect.To this end,polyethylene glycol(PEG)-stabilized platinum(Pt)nanoparticles(Pt NPs)conjugated with a PD-L1 inhibitor(BMS-1)through a thermo-sensitive linkage were constructed.Upon near-infrared(NIR)exposure,BMS-1 was released and maleimide(Mal)was exposed on the surface of Pt NPs,which captured the antigens released from the ablated tumor cells,resulting in the enhanced antigen internalization and presentation.In addition,the Pt NPs acted as immune adjuvants by stimulating dendritic cells(DCs)maturation.Furthermore,BMS-1 relieved T cell exhaustion and induced the infiltration of effector T cells into the tumor tissues.Thus,Pt NPs can ablate tumors through PTT,and augment the anti-tumor immune response through enhanced antigen presentation and T cells infiltration,thereby preventing tumor relapse and metastasis. | Jie Yu Sha Liu Yupeng Wang Xidong He Qingfei Zhang Yanxin Qi Dongfang Zhou Zhigang Xie Xiaoyuan Li Yubin Huang | 2022 | Bioactive Materials2022，7，1： | 0 |
| 11 | Resistive switching performance improvement of In GaZnO-based memory device by nitrogen plasma treatment显示文摘With the demand of flat panel display development,utilizing the non-volatile memory devices based on indium-gallium-zinc-oxide(IGZO)film may be integrated with IGZO thin film transistors(TFTs)to accomplish system-on-panel applications.In this work,1×1μm^2 via hole structure IGZO based memory device was fabricated and the resistive switching(RS)behavior was investigated.By inserting a nitrogen doping layer IGZO:N by plasma treatment in Pt/IGZO/Ti N device,highly improved RS performance including lower forming voltage,remarkable uniformity,large memory window of 102,retention property of 10^4 s at 125℃,excellent pulse endurance of 10^7 cycles were achieved.The X-ray photoelectron spectroscopy analysis indicates that plasma doping method can evenly dope nitrogen and induce more non-lattice oxygen in the IGZO film.It is deduced that the N atoms of the inserting layer can influence the random formation of oxygen vacancy type conducting filaments,which results in more stable and uniform performance. | Li Zhang Zhong Xu Jia Han Lei Liu Cong Ye Yi Zhou Wen Xiong Yanxin Liu Gang He | 2020 | Journal of Materials Science & Technology2020，47，14： | 0 |
| 12 | Impact of surface-reflected seismic waves on the seismic isolation performance of circular tunnel isolation layers显示文摘Seismic isolation is an effective strategy to mitigate the risk of seismic damage in tunnels.However,the impact of surface-reflected seismic waves on the effectiveness of tunnel isolation layers remains under explored.In this study,we employ the wave function expansion method to provide analytical solutions for the dynamic responses of linings in an elastic half-space and an infinite elastic space.By comparing the results of the two models,we investigate the seismic isolation effect of tunnel isolation layers induced by reflected seismic waves.Our findings reveal significant differences in the dynamic responses of the lining in the elastic half-space and the infinitely elastic space.Specifically,the dynamic stress concentration factor(DSCF)of the lining in the elastic half-space exhibits periodic fluctuations,influenced by the incident wave frequency and tunnel depth,while the DSCF in the infinitely elastic space remain stable.Overall,the seismic isolation application of the tunnel isolation layer is found to be less affected by surface-reflected seismic waves.Our results provide valuable insights for the design and assessment of the seismic isolation effect of tunnel isolation layers. | LU Jiahui LUO Junjie HUANG Xiangyun HONG Junliang HE YanXin ZHOU Fulin | 2024 | Journal of Mountain Science2024，21，3： | 0 |
| 13 | Strength and deformation characteristics of irregular columnar jointed rock mass: A combined experimental and theoretical study显示文摘The irregularity of jointed network poses a challenge to the determination of field mechanical param-eters of columnar jointed rock mass(CJRM),and a reasonable prediction of deformation and strength characteristics of CJRM is important for engineering construction.The Voronoi diagram and three-dimensional printing technology were used to make an irregular columnar jointed mold,and the irregular CJRM(ICJRM)specimens with different dip directions and dip angles were prepared.Uniaxial compression tests were performed,and the anisotropic strength and deformation characteristics of ICJRM were described.The failure modes and mechanisms were revealed in accordance with the final appearances of the ICJRM specimens.Based on the model test results,the empirical correlations for determining the field deformation and strength parameters of CJRM were derived using the dip angle and modified joint factor.The proposed empirical equations were used in the Baihetan Project,and the calculated mechanical parameters were compared with the field test results and those obtained from the tunneling quality index method.Results showed that the deformation parameters determined by the two proposed methods are all consistent with the field test results,and these two methods can also estimate the strength parameters effectively. | Xiangcheng Que Zhende Zhu Yanxin He Zihao Niu Haonan Huang | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，2： | 0 |
| 14 | Quaternary Intrusions from the Zhongjiannan Basin,South China Sea:Their Relationship with the Hainan Mantle Plume and Influence on Hydrocarbon Reservoirs显示文摘The transportation of magma in sedimentary basins often occurs through extensive dyke-sill networks.The role of sills on the plumbing system in rifted margins and the impact of sills on hydrocarbon reservoirs of prospective sedimentary basins has long been an area of great industrial interest and scientific debate.Based on 2D seismic reflection,we present data on how the sills emplaced to form a magmatic plumbing system of the volcanic system for the Zhongjiannan Basin(ZJNB).The results show that sixty-nine sills and fourteen forced folds have been identified.The distribution and geometry of the sills suggest that magma flowed from west to east and then ascended to near the surface.The onlap relationship of the forced folds indicates that the timing of magmatic activities can be constrained at ca.0.2 Ma.The spatial and temporal occurrences of intrusions imply that the strong post-rift magmatism in ZJNB was associated with the Hainan mantle plume arising from the core-mantle boundary.Furthermore,these forced folds could produce several types of hydrocarbon traps,due to accommodation through bending and uplift of the overlying rock and free surface,but it is critical to evaluate the effect of such emplacement when setting exploration targets. | HE Yanxin LIU Jianping WANG Lei TIAN Wei | 2023 | Acta Geologica Sinica(English Edition)2023，97，1： | 0 |
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