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| 1 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 2 | Oxidative Rearrangement of Isatins with Arylamines Using H2O2 as Oxidant: A Facile Synthesis of Quinazoline-2,4-diones and Evaluation of Their Antibacterial Activity显示文摘 | Guanghao Shi Xinwei He Yongjia Shang Cheng Yang Liwei Xiang | 2017 | Chinese Journal of Chemistry2017，35，12： | 3 |
| 3 | Ferrocenyl-isoxazole Derivative: a Novel Electrochemical, Colorimetric and Fluorescent Multiple Signal Probe for Highly Selective Recognition of Cu2+ Ions显示文摘 | ZHANG Zhiqin HE Xinwei SHANG Yongjia YU Zhiyu WANG Sufan WU Fuli | 2017 | Chemical Research in Chinese Universities2017，33，1： | 3 |
| 4 | ERROR ANALYSIS IN DIFFERENTIAL QUADRATURE METHOD显示文摘Error estimation for the differential quadrature (DQ)with various sets of grid spacing is presented. A general formula is given to compute the weighting coefficients directly. It is found that the maximum error of the Do method with roots of Chebyshev polynomials including two end POints (-1 and + 1 ) is the smallest among the several sets of grid spacing investigated herein. | He Beiqing(College of Science,NUAA 29 Yudao Street,Nanjing 210016,P.R.China)Wang Xinwei(Department of Aircraft Engineering ,NUAA 29 Yudao Street,Nanjing 210016,P.R.China) | 1994 | Transactions of Nanjing University of Aeronautics and Astronautics1994，11，2： | 3 |
| 5 | Contrasting physical properties of the trilayer nickelates Nd4Ni3O10 and Nd4Ni3O8显示文摘We report the crystal structures and physical properties of trilayer nickelates Nd4Ni3O10and Nd4Ni3O8.Measurements of magnetization and electrical resistivity display contrasting behaviors in the two compounds.Nd4Ni3O10shows a paramagnetic metallic behavior with a metal-to-metal phase transition(T^*)at about 162 K,as revealed by both magnetic susceptibility and resistivity.Further magnetoresistance and Hall coefficient results show a negative magnetoresistance at low temperatures and the carrier type of Nd4Ni3O10is dominated by hole-type charge carriers.The significant enhancement of Hall coefficient and resistivity below T*suggests that effective charge carrier density decreases when cooling through the transition temperature.In contrast,Nd4Ni3O8 shows an insulating behavior.In addition,this compound shows a paramagnetic behavior with the similar magnetic moment as that of Nd4Ni3O10derived from the Curie-Weiss fitting.This may suggest that the magnetic moments in both systems are contributed by Nd^3+ ions.By applying pressures up to about 49 GPa,the insulating behavior is still present and becomes even stronger under a high pressure.Our results suggest that the different Ni configurations(Ni^1+/2+ or Ni^2+/3+)and the changes of coordination environment of Ni sites may account for the contrasting behaviors in trilayer nickelates Nd4Ni3O10and Nd4Ni3O8. | Qing Li ChengPing He XiYu Zhu Jin Si XinWei Fan Hai-Hu Wen | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，2： | 2 |
| 6 | The black pottery coating of longshan times from Taosi Site显示文摘Taosi is an archaeological site in Xiangfen county, Shanxi province. It is considered as a capital city site with the rudiment of an early country in Longshan Times. In this work, the black pottery coating was found on the surface of black and grey pottery of Longshan times and confirmed by scientific studies for the first time. It filled in the blank of pottery coating study in this time period at the Yellow River Valley, as well as supplied a new study method of 'black skin pottery' besides the carburization craft. In addition, according to the archaeological materials, we inferred that the wares with this pottery coating might be only used by the nobility at that time. | LU XiaoKe LI WeiDong LUO HongJie HE Nu LI XinWei | 2011 | Science China(Technological Sciences)2011，54，7： | 2 |
| 7 | Empirical Likelihood Based Diagnostics for Heteroscedasticity in Semiparametric Varying-Coefficient Partially Linear Models with Missing Responses显示文摘This paper proposes an empirical likelihood based diagnostic technique for heteroscedasticity for semiparametric varying-coefficient partially linear models with missing responses. Firstly, the authors complement the missing response variables by regression method. Then, the empirical likelihood method is introduced to study the heteroscedasticity of the semiparametric varying-coefficient partially linear models with complete-case data. Finally, the authors obtain the finite sample property by numerical simulation. | LIU Feng GAO Weiqing HE Jing FU Xinwei KANG Xinmei | 2021 | Journal of Systems Science & Complexity2021，34，3： | 2 |
| 8 | Autoantibodies targeting to GPER1 promote monocyte cytokines production and inflammation in systemic lupus erythematosus显示文摘Dear Editor,Systemic lupus erythematosus(SLE),one of the most common autoimmune diseases in reproductive females,is a multifactorial disease involving genetic,environmental,and hormonal factors.1 It occurs at a 9:1 female-to-male ratio,and the sex predisposition suggests that the estrogen system plays an essential role in the developing of SLE.The effects of estrogen have traditionally been attributed to the classical nuclear estrogen receptors(ERs),ERα,and ERβ,which predominantly regulate transcription.Guanine nucleotide-binding protein-coupled estrogen receptor 1(GPER1)is a transmembrane receptor for estrogen that mediates several rapid cellular effects of estrogen.2 Large amounts of autoantibodies characterize SLE,and anti-estrogen receptor autoantibodies are likely to affect the function of immune cells in SLE but are not yet fully understood. | Xinwei Zhang Hongyan Qian Yangchun Chen Yuanhui Wu Yuechi Sun Yan He Shiju Chen Guixiu Shi Yuan Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 9 | Synthesis and optical properties of novel anthracene-based stilbene derivatives containing an 1,3,4-oxadiazole unit显示文摘 | Xinwei Li Daohang He | 2012 | Dyes and Pigments2012，93，13： | 1 |
| 10 | Auxin signaling module OsSK41-OsIAA10-OsARF regulates grain yield traits in rice显示文摘Auxin is an important phytohormone in plants, and auxin signaling pathways in rice play key roles in regulating its growth, development, and productivity. To investigate how rice grain yield traits are regulated by auxin signaling pathways and to facilitate their application in rice improvement, we validated the functional relationships among regulatory genes such as OsIAA10, OsSK41, and OsARF21 that are involved in one of the auxin(OsIAA10) signaling pathways. We assessed the phenotypic effects of these genes on several grain yield traits across two environments using knockout and/or overexpression transgenic lines.Based on the results, we constructed a model that showed how grain yield traits were regulated by OsIAA10 and OsTIR1, OsAFB2, and OsSK41 and OsmiR393 in the OsSK41-OsIAA10-OsARF module and by OsARF21 in the transcriptional regulation of downstream auxin response genes in the OsSK41-OsIAA10-OsARF module. The population genomic analyses revealed rich genetic diversity and the presence of major functional alleles at most of these loci in rice populations. The strong differentiation of many major alleles between Xian/indica and Geng/japonica subspecies and/or among modern varieties and landraces suggested that they contributed to improved productivity during evolution and breeding. We identified several important aspects associated with the genetic and molecular bases of rice grain and yield traits that were regulated by auxin signaling pathways.We also suggested rice auxin response factor(OsARF) activators as candidate target genes for improving specific target traits by overexpression and/or editing subspecies-specific alleles and by searching and pyramiding the ‘best' gene allelic combinations at multiple regulatory genes in auxin signaling pathways in rice breeding programs. | Fuying Ma Fan Zhang Yu Zhu Dengyong Lan Peiwen Yan Ying Wang Zejun Hu Xinwei Zhang Jian Hu Fuan Niu Mingyu Liu Shicong He Jinhao Cui Xinyu Yuan Ying Yan Shujun Wu Liming Cao Hongwu Bian Jinshui Yang Zhikang Li Xiaojin Luo | 2023 | Journal of Integrative Plant Biology2023，65，7： | 1 |
| 11 | The status and development on the technology of safety relief for pressure vessels in China显示文摘 | Li Zhiyi Ding Xinwei and He Kuangguo | 1989 | Chemical Engineering & Machnery(in Chinese)1989，16，4： | 1 |
| 12 | Rh-Catalyzed Formal[3+2]Cyclization for the Synthesis of 5-Aryl-2-(quinolin-2-yl)oxazoles and Its Applications in Metal lons Probes显示文摘Main observation and conclusion A facile and efficient strategy for the synthesis of 5-aryl-2-(quinolin-2-yl)oxazoles via rhodium-catalyzed formal[3+2]cyclization of 4-aryl-1-tosyl-1H-1,2,3-triazoles with quinoline-2-carbaldehydes has been described.The protocol employs mild conditions and offers good yields of diverse 2,5-aryloxazole derivatives with a broad reaction scope.It is amenable to gram-scale synthesis and easily transformation.Moreover,this 5-aryl-2-(quinolin-2-yl)oxazole skeleton is indeed a new fluorophore and its applications in metal ions probes are also investigated and showed fluorescent responses to mercury ion. | Tongtong Zhou Xinwei He Youpeng Zuo Yuhao Wu Wangcheng Hu Shiwen Zhang Jiahui Duan Yongjia Shang | 2021 | Chinese Journal of Chemistry2021，39，3： | 1 |
| 13 | Study on Effects of Organic Nutrient Solution on Amino Acid Contents in Litchi (Litchi chinensis Sonn.) Fruit显示文摘[Objectives] This study was conducted to investigate the effect of organic nutrient solution on litchi quality. [Methods] Different concentrations of organic nutrient solutions were sprayed on litchi leaves to study their effects on amino acid contents in the fruit of litchi cultivar 'Qinzhouhongli'. [Results] The results showed that the organic nutrient solution could significantly promote the growth of litchi fruit at various development stages and improve fruit quality by spraying the organic nutrient solution for 3 times with a dilution concentration of 500-1 500 times during fruit development(at an interval of 15 d) of litchi. It could increase the total essential amino acid, total semi-essential amino acid, lysine, phenylalanine, threonine, methionine, valine, leucine, histidine, arginine, aspartic acid, glycine, serine, proline, alanine and tyrosine contents. Spraying the organic nutrient solution with a dilution concentration of 1 000 times achieved the best effect of promoting the growth and improving quality of litchi fruit. [Conclusions] This study provides a theoretical basis for high-quality production and nutritional quality evaluation of litchi and the development of functional processed litchi products. | Yingyi DENG Chanchan QIN Hui WANG Xinwei CHEN Jiechun PAN Jiongzhi XU Jianan HE Guorui HU Xiao QU | 2019 | Agricultural Biotechnology2019，8，2： | 1 |
| 14 | Spectroscopic investigation of defects mediated oxidization of single-layer MoS_(2)显示文摘Due to the extremely large surface to bulk ratio,the properties of single layer(SL)MoS_(2)are largely determined by its interaction with environment.One critical interaction process that has been intensively investigated is the oxidation process of MoS_(2).Despite numerous previous explorations,the detailed mechanism regarding how MoS_(2)reacts with oxygen is still not well understood.In this work,we systematically investigate the impact of intrinsic and pre-created defects on the oxidation process of SL MoS_(2).For pristine SL MoS_(2),the oxidation is found to initiate near point defects and grain boundaries,leading to the formation of triangle pits in the basal plane and cracks near the grain boundaries.The pre-created defects introduced by ion irradiation are found to serve as the oxidation center,resulting in a more uniform oxidation process.The oxidation is found to introduce p-type doping in the SL MoS_(2),leading to the blue shift of Raman and photoluminescence(PL)spectra.The shift is found to be more for the region near the grain boundary and for the samples with more pre-created defects.Our results suggest that the presence of defects can strongly promote the oxidation reaction of SL MoS_(2)in ambient condition,which significantly affects the stability and functionality of materials. | HE ZuYun GUO Zheng ZHONG Xiao CHEN XiaoFei XUE JianMing WANG XinWei CHEN Yan | 2021 | Science China(Technological Sciences)2021，64，3： | 1 |
| 15 | Syntheses of N-sulfonyl-N,N-disubstituted amidines via a three-component free-radical coupling reaction of tertiary amines and arenesulfonyl azides with terminal alkynes显示文摘A facile and efficient synthesis of N-sulfonyl-N,N-disubstituted amidines has been achieved via a CuI-catalyzed three-component free-radical coupling reaction of tertiary amines and arenesulfonyl azides with terminal alkynes in the presence of azodiisobutyronitrile(AIBN).The reaction mechanism of this reaction has also been studied. | HE XinWei SHANG YongJia HU JinSong JU Kai JIANG Wei WANG SuFang | 2012 | Science China Chemistry2012，55，2： | 1 |
| 16 | A new model of fractured horizontal well coupling with the tight gas reser- voir at unsteady state 显示文摘 | Xu MengYa Liao XinWei He YiFan | 2012 | Petroleum Science and Tech- nology2012，30，24： | 1 |
| 17 | LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury显示文摘Dear Editor,ATP-binding cassette(ABC)-ATPase(RAD50),together with meiotic recombination 11 homolog 1(MRE11)subunits,to form MRE11-RAD50 complex,plays important roles in recognition of double-stranded DNA(dsDNA)and initiation of consequent inflammatory cascade1.Acute lung injury(ALI)and acute respiratory destress syndrome(ARDS)are systemic uncontrolled inflammation and life-threatening.However,the function of the DNA sensor in ALI/ARDS remains poorly defined.Here we investigated functions of RAD50 using mouse primary macrophages and conditionally RAD50 knockout mice in vitro and in a lipopolysaccharide(LPS)-induced lung injury model. | Xueqin Zhan Rui Cui Xinwei Geng Jiaqian Li Yunlian Zhou Lulu He Chao Cao Chao Zhang Zhimin Chen Songmin Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 0 |
| 18 | Status of transjugular intrahepatic portosystemic shunt for portal hypertension in China:A national survey analysis显示文摘Aim:The transjugular intrahepatic portosystemic shunt(TIPS)procedure has been performed in China for 30 years,but our understanding of the status and difficulties associated with the use of TIPS for portal hypertension is incomplete.This study aims to investigate the current situation of the use of TIPS for portal hypertension,which should aid the development of TIPS in China.Methods:This study involved a questionnaire survey,initiated by the China Portal Hypertension Alliance(CHESS)to investigate the use of TIPS for portal hypertension in China.Questionnaires were released on the Internet between August 16,2022 and September 16,2022.Detailed information was collected from 545 hospitals contracted by the CHESS in China,which performed TIPS surgery in 2021.Results:The 545 hospitals covers the majority of hospitals in China that conduct TIPS intervention.In the survey,a total of 13,527 TIPS interventions were carried out with 94.1%(498/545)of them had a system of routine follow‐up after TIPS.The majority(42.6%[232/545])believed that the main indication of TIPS was the control of acute bleeding.Overall,48.1%(262/545)carried out early or pre‐emptive TIPS,53.0%(289/545)carried out TIPS for cavernous transformation of the portal vein,and 81.0%(441/545)chose routine embolization of collateral circulation during operation.Most used coils(97.0%[475/490])and biological glue(72.0%[353/490])as embolic materials,and 78.5%(428/545)routinely performed intraoperative portal pressure gradient measurements.When selecting TIPS stents,57.1%(311/545)chose viator‐specific stents,and 57.2%(312/545)chose conventional anticoagulation after TIPS.Conventional anticoagulation after TIPS is over a time interval of 3–6 months(55.4%[173/312]).The limitation of TIPS surgery is mainly its cost(72.3%[394/545])and insufficient understanding of the procedure by doctors in other related departments(77.4%[422/545]).Most of the hospital teams accept the use of domestic instruments in TIPS surgery(92.7%[505/545]).Conclusions:This survey shows that TIPS is an essential part of the treatment of portal hypertension in China.TIPS is widely used in Chinese patients with portal hypertension,and this survey presents a more comprehensive picture of the options and difficulties encountered in the implementation of TIPS.In the future,it is necessary to promote TIPS technology and further standardize surgical indications,routine operations,and instrument application. | Haibo Shao Xinwei Han Jianbo Zhao Junhui Sun Zhuting Fang Bin Xiong Xiaoli Zhu Weixin Ren Min Yuan Shiping Yu Meng Niu Weifu Lv Xueqiang Zhang Chunqing Zhang Lei Li Xuefeng Luo Yusheng Song Yilong Ma Tong Dang Hua Xiang Yun Jin Hui Xue Guiyun Jin Xiao Li Jiarui Li Shi Zhou Changlu Yu Song He Lei Yu Hongmei Zu Jun Ma Yanming Lei Ke Xu Xiaolong Qi | 2023 | Portal Hypertension & Cirrhosis2023，2，1： | 0 |
| 19 | A highly efficient protein corona-based proteomic analysis strategy for the discovery of pharmacodynamic biomarkers显示文摘The composition of serum is extremely complex,which complicates the discovery of new pharmacodynamic biomarkers via serum proteome for disease prediction and diagnosis.Recently,nanoparticles have been reported to efficiently reduce the proportion of high-abundance proteins and enrich lowabundance proteins in serum.Here,we synthesized a silica-coated iron oxide nanoparticle and developed a highly efficient and reproducible protein corona(PC)-based proteomic analysis strategy to improve the range of serum proteomic analysis.We identified 1,070 proteins with a median coefficient of variation of 12.56%using PC-based proteomic analysis,which was twice the number of proteins identified by direct digestion.There were also more biological processes enriched with these proteins.We applied this strategy to identify more pharmacodynamic biomarkers on collagen-induced arthritis(CIA)rat model treated with methotrexate(MTX).The bioinformatic results indicated that 485 differentially expressed proteins(DEPs)were found in CIA rats,of which 323 DEPs recovered to near normal levels after treatment with MTX.This strategy can not only help enhance our understanding of the mechanisms of disease and drug action through serum proteomics studies,but also provide more pharmacodynamic biomarkers for disease prediction,diagnosis,and treatment. | Yuqing Meng Jiayun Chen Yanqing Liu Yongping Zhu Yin-Kwan Wong Haining Lyu Qiaoli Shi Fei Xia Liwei Gu Xinwei Zhang Peng Gao Huan Tang Qiuyan Guo Chong Qiu Chengchao Xu Xiao He Junzhe Zhang Jigang Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 0 |
| 20 | 乙酰化抑制cGAS激活并控制DNA诱导的自身免疫显示文摘文章简介该工作揭示了乙酰化修饰控制DNA感受器c GAS激活的关键机制,并进一步发现阿司匹林可以通过直接乙酰化c GAS抑制DNA介导的自身免疫反应。该发现为阿卡迪综合征(AGS)等c GAS相关疾病的治疗提供了新的策略选择。细胞质内的DNA出现通常被认为是微生物感染的一个重要信号,会迅速被胞内DNA感受器c GAS识别并诱导抗感染免疫应答。 | 戴江 黄怡娇 何新华 Ming Zhao Xinzheng Wang Zhao-Shan Liu Wen Xue Hong Cai Xiao-Yan Zhan Shao-Yi Huang Kun He Hongxia Wang Na Wang Zhihong Sang Tingting Li Qiu-Ying Han Jie Mao Xinwei Diao Nan Song Yuan Chen Wei-Hua Li Jiang-Hong Man Ai-Ling Li Tao Zhou Zheng-Gang Liu 张学敏 李涛 | 2020 | 科学新闻2020，，2： | 0 |
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