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| 1 | Enhanced metastasis in RNF13 knockout mice s mediated by a reduction in GM-CSF levels显示文摘 | He Cheng Aodi Wang Jiao Meng Yong Zhang Dahai Zhu | 2015 | Protein & Cell2015，6，10： | 3 |
| 2 | Overexpression of miR-101 suppresses collagen synthesis by targeting EZH2 in hypertrophic scar fibroblasts显示文摘Background:MicroRNA-101(miR-101)is a tumor suppressor microRNA(miRNA)and its loss is associated with the occurrence and progression of various diseases.However,the biological function and target of miR-101 in the pathogenesis of hypertrophic scars(HS)remains unknown.Methods:We harvested HS and paired normal skin(NS)tissue samples from patients and cultured their fibroblasts(HSF and NSF,respectively).We used quantitative reverse transcriptase polymerase chain reaction(qRT-PCR),fluorescence in situ hybridization(FISH),enzyme-linked immunosorbent assays(ELISA)and Western blot analyses to measure mRNA levels and protein expression of miR-101,enhancer of zeste homolog 2(EZH2),collagen 1 and 3(Col1 and Col3)andα-smooth muscle actin(α-SMA)in different in vitro conditions.We also used RNA sequencing to evaluate the relevant signaling pathways and bioinformatics analysis and dual-luciferase reporter assays to predict miR-101 targets.We utilized a bleomycin-induced fibrosis mouse model in which we injected miR-101 mimics to evaluate collagen deposition in vivo.Results:We found low expression of miR-101 in HS and HSF compared to NS and NSF.Overexpressing miR-101 decreased Col1,Col3 andα-SMA expression in HSF.We detected high expression of EZH2 in HS and HSF.Knockdown of EZH2 decreased Col1,Col3 andα-SMA in HSF.Mechanistically,miR-101 targeted the 3-untranslated region(3UTR)of EZH2,as indicated by the decreased expression of EZH2.Overexpressing EZH2 rescued miR-101-induced collagen repression.MiR-101 mimics effectively suppressed collagen deposition in the bleomycin-induced fibrosis mouse model.Conclusions:Our data reveal that miR-101 targets EZH2 in HS collagen production,providing new insight into the pathological mechanisms underlying HS formation. | Jie Li Yan Li Yunchuan Wang Xiang He Jing Wang Weixia Cai Yanhui Jia Dan Xiao Jian Zhang Ming Zhao Kuo Shen Zichao Li Wenbin Jia Kejia Wang Yue Zhang Linlin Su Huayu Zhu Dahai Hu | 2021 | Burns & Trauma2021，9，1： | 3 |
| 3 | A new coordinated backup protection scheme for distribution network containing distributed generation显示文摘This paper proposes a new backup protection scheme,named coordinated backup protection(CBP)scheme,for distribution networks containing distributed generation.The proposed protection scheme takes into account the issues faced by traditional backup protection,such as difficulty in setting parameters and complex cooperation,and considers the features of distribution networks,such as changeable power flow because of high penetration of distributed generation sources and insufficient measuring quantities.The CBP scheme includes two aspects:coordinated substation protection and regional master substation protection,who also work as nearby backup protection and remote backup protection respectively.The two protections support each other by local information coordination and regional information sharing,in order to improve the reliability of fault identification.The configuration principles and performances of the proposed backup protection scheme are addressed in the paper.Different fault conditions in the IEEE 14-node system have been used to illustrate and verify the feasibility of the CBP scheme. | Jinghan He Lin Liu Fanfan Ding Changcheng Li Dahai Zhang | 2017 | Protection and Control of Modern Power Systems2017，2，1： | 3 |
| 4 | Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells显示文摘转变生长因素 --(TGF-) 在恶意的细胞的各种各样的类型上施加 apoptotic 效果,包括肝癌症细胞。然而, TGF- 由导致 apoptosis 的精确机制仍然保持糟糕已知。在现在的学习,我们显示出那 threonine 32 (Thr32 ) FoxO3 的残余是批评的让 TGF- 在 hepatocarcinoma Hep3B 房间经由 Bim 导致 apoptosis。我们的数据证明 TGF- 在 Thr32 通过特定的 de-phosphorylation 导致了 FoxO3 激活。TGF -- 激活的 FoxO3 与 Smad2/3 合作了调停 Bim 起来规定和 apoptosis。在 Thr32 的 FoxO3 (de ) phosphorylation 被酷蛋白 kinase 调整我 --(CKI-) 。由小分子 D4476 的 CKI 抑制能废除 TGF -- 导致的 FoxO/Smad 激活,反向的 Bim 起来规定,和块顺序的 apoptosis。更重要地, CKI- 和 p32FoxO3 的 deregulated 层次在人的恶意的肝纸巾被发现。一起拿,我们的调查结果建议可能有 FoxO3 的 Thr32 为 TGF 是枢轴的一台 CKI-FoxO/Smad-Bim 在引擎 -- 导致的 apoptosis,为肝癌症治疗使它成为一个潜在的治疗学的目标。 | Xiangxuan Zhao Yong Liu Lei Du Leya He Biyun Ni Junbo Hu Dahai Zhu Quan Chen | 2015 | Protein & Cell2015，6，2： | 3 |
| 5 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 6 | A Sliding Wear Tester for Overhead Wires and Current Collectors in Light Rail Systems显示文摘 | He Dahai Manory R Sinkis H | 2000 | Wear2000，239，： | 1 |
| 7 | Wear of railway contact wires against current collector materials显示文摘 | Dahai He Rafael R Manory Norm Grady | 1998 | Wear1998，215，： | 1 |
| 8 | Study on Reaction Types and Environment in Different Regions of Diesel Deep Hydrodesulfurization Reactor显示文摘In this work,the influence of reaction conditions on hydrocarbon distribution and product quality was tested to obtain the rule of variation with different residence time.A semi-experience and semi-mechanism dynamics model was established and modified.Based on the simulation results,the hydrogenation reactor is divided into five regions:the upper two regions are mainly saturated with most of tri-cyclic and bi-cyclic aromatics,and 90%of nitrides are converted,while all simple sulfide and some 4,6-DMDBT compounds undergo transformation reactions.In the lower three regions,the reaction rate of HDS and HDN slows down,while the rate of monocyclic aromatic saturation increases.The HDS,HDN and HDA rates of the optimized catalyst grading scheme are significantly increased. | Dai Meng Li Shicai Li Yang Xu Dahai Ding He Chen Guang Guo Rong | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，1： | 1 |
| 9 | Extraction Difficulty of Lithium Ions from Various Crystal Planes of Lithium Titanate显示文摘To study the extraction difficulty of lithium ions from various crystal planes of Li_2 TiO_3, according to the first principle, four representative crystal surfaces of Li_2TiO_3(precursor),(-133),(-206),(002) and(-131), were selected to establish a model and to calculate the surface energy, bond length and population using Materials Studio 5.5(MS 5.5). The results demonstrate that there is no direct relationship between the surface energy and the order of disappearance of the four diffraction peaks when lithium titanate is treated with hydrochloric acid, instead, the difficulty of Li^+ extraction from various crystal faces corresponds to the Li-O bond strength. Lithium ion is easy to remove from(-133) and(-206) due to the relatively weak Li-O bond strength. In contrast, Li+ extraction requires a longer time for(002) and(-131). | 张理元 ZHOU Jiabei HE Gang ZHOU Dali TANG Dahai WANG Fahou | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，5： | 1 |
| 10 | A novel electric contact material with improved self-lubrication for railway current collectors 显示文摘 | He Dahai Rafael Manory | 2001 | Wear2001，249，： | 1 |
| 11 | Wear of railway contact wires against current collector materials显示文摘 | He Dahai Rafael Manory Norm Grady | 1998 | Wear1998，215，： | 1 |
| 12 | A novel electrical contact material with improved self-lubrication for railway current collectors显示文摘 | He Dahai Rafael Manory | 2001 | Wear2001，249，7： | 1 |
| 13 | Wear of railway contact wires against current collector materials显示文摘 | He Dahai Manory R Grady N | 1998 | Wear1998，215，： | 1 |
| 14 | Wear of railway contact wires against current collector materials显示文摘 | He DaHai Manory Rafael R Norm Grady | 1998 | Wear1998，15，： | 1 |
| 15 | A novel electrical contact material with improved self-lubrication for railway current collectors 显示文摘 | He Dahai | 2001 | Wear2001，249，： | 1 |
| 16 | Isotope effect of the phonons mean free path in graphene by micro-Raman measurement显示文摘The isotope labeled graphene was synthesized in the concentration of 13 C carbon atom in 1%, 25%, 50%, 75% and 99%. The isotope effect on the phonon behavior in graphene was investigated based on the micro-Raman analysis of 13 C isotope labeled graphene samples. We found that the phonon scattering is affected by the isotopic carbon atom as a point defect. Based on the experiment results, the Klemens-Callaway model and uncertainty principle were used to obtain the mean free path of the G and D phonons. The results agree with the thermal conductivity measurement by non-contact optical method and with other theoretical calculations. | ZHANG CanKun LI QiongYu TIAN Bo HUANG ZhiYi LIN WeiYi LI HongYang HE DaHai ZHOU YingHui CAI WeiWei | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，10： | 1 |
| 17 | A sliding wear tester for overhead wires and current collectors in light rail systems显示文摘 | HE Dahai Manory R Sinkis H | 2000 | Wear2000，239，： | 1 |
| 18 | Wear of railway contact wires against current collector materials显示文摘 | He Dahai Manory R R Grady N | 1998 | Wear1998，215，12： | 1 |
| 19 | A novel electrical contact material with improved self-lubrication for railway current collectors 显示文摘 | HE Dahai MANORY R | 2001 | Wear2001，249，： | 1 |
| 20 | A sliding wear tester for overhead wires and current collectors in light rail systems 显示文摘 | MANORY R SINKIS H | 2000 | Wear2000，239，： | 1 |
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