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| 1 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 2 | Frequency dependent polarization analysis of ambient seismic noise recorded at a broadband seismometer in the central United States显示文摘We present a new approach to polarization analysis of seismic noise recorded by three-component seismometers.It is based on statistical analysis of frequency-dependent particle motion properties determined from a large number of time windows via eigenanalysis of the 3-by-3,Hermitian,spectral covariance matrix.We applied the algorithm to continuous data recorded in 2009 by the seismic station SLM,located in central North America.A rich variety of noise sources was observed.At low frequencies (<0.05 Hz) we observed a tilt-related signal that showed some elliptical motion in the horizontal plane.In the microseism band of 0.05-0.25 Hz,we observed Rayleigh energy arriving from the northeast,but with three distinct peaks instead of the classic single and double frequency peaks.At intermediate frequencies of 0.5-2.0 Hz,the noise was dominated by non-fundamental-mode Rayleigh energy,most likely P and Lg waves.At the highest frequencies (>3 Hz),Rayleigh-type energy was again dominant in the form of Rg waves created by nearby cultural activities.Analysis of the time dependence of noise power shows that a frequency range of at least 0.02-1.0 Hz (much larger than the microseism band) is sensitive to annual,meteorologically induced sources of noise. | Keith D. Koper Veronica L. Hawley | 2010 | Earthquake Science2010，23，5： | 13 |
| 3 | Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress显示文摘AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, depending on the degree of elevation of cellular AMP, distinct compartmentalized pools of AMPK are activated, phosphorylating different sets of targets. Low glucose activates AMPK exclusively through the AMP-independent, AXIN-based pathway in lysosomes to phosphorylate targets such as ACC1 and SREBP1c, exerting early anti-anabolic and pro-catabolic roles. Moderate increases in AMP expand this to activate cytosolic AMPK also in an AXIN-dependent manner. In contrast, high concentrations of AMP, arising from severe nutrient stress, activate all pools of AMPK independently of AXIN. Surprisingly, mitochondrion-localized AMPK is activated to phosphorylate ACC2 and mitochondrial fission factor (MFF) only during severe nutrient stress. Our findings reveal a spatiotemporal basis for hierarchical activation of different pools of AMPK during differing degrees of stress severity. | Yue Zong Chen-Song Zhang Mengqi Li Wen Wang Zhichao Wang Simon A. Hawley Teng Ma Jin-Wei Feng Xiao Tian Qu Qi Yu-Qing Wu Cixiong Zhang Zhiyun Ye Shu-Yong Lin Hai-Long Piao D. Grahame Hardie Sheng-Cai Lin | 2019 | Cell Research2019，29，6： | 8 |
| 4 | 妊娠期高血压疾病与后代在儿童中期的心血管代谢健康的关系:Viva项目调查结果显示文摘暴露于先兆子痫或妊娠期高血压疾病与后代收缩压较高有关,但与其他心脏代谢风险标志物的相关性研究较少。该研究收集Viva研究项目中在1999-2002年出生的1097名儿童资料。从产前记录先兆子痫或妊娠期高血压疾病的发生情况,及产前、孕早期、孕中期、孕晚期的平均收缩压水平。 | 刘莉 叶鹏 Tripathi RR Rifas-Shiman SL Hawley N Hivert MF Oken E | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 5 | Variable change in renal function by hypertonic saline显示文摘AIM: To investigate the effects of hypertonic saline in the neurocritical care population.METHODS: We retrospectively reviewed our hospital's use of hypertonic saline(HS) since March of 2005, and prospectively since October 2010. Comparisons were made between admission diagnoses, creatinine change(Cr), and HS formulation(3% Na Cl, 3% Na Cl/sodium acetate mix, and 23.4% Na Cl) to patients receiving normal saline or lactated ringers. The patients(n = 1329) of the retrospective portion were identified. The data presented represents the first 230 patients with data. RESULTS: Significant differences in Acute Physiology and Chronic Health Evaluation Ⅱ scores and GlasgowComa Scale scores occurred between different saline formulations. No significant correlation of Cl- or Na+ with Cr, nor with saline types, occurred. When dichotomized by diagnosis, significant correlations appear. Traumatic brain injury(TBI) patients demonstrated moderate correlation between Na+ and Cr of 0.45. Stroke patients demonstrated weak correlations between Na+ and Cr, and Cl- and Cr(0.19 for both). Patients receiving HS and not diagnosed with intracerebral hemorrhage, stroke, subarachnoid hemorrhage, or TBI demonstrated a weak but significant correlation between Cl- and Cr at 0.29.CONCLUSION: Cr directly correlates with Na+ or Cl- in stroke, Na+ in TBI, and Cl- in other populations. Prospective comparison of HS and renal function is needed. | Jesse J Corry Panayiotis Varelas Tamer Abdelhak Stacey Morris Marlisa Hawley Allison Hawkins Michelle Jankowski | 2014 | World Journal of Critical Care Medicine2014，3，2： | 3 |
| 6 | 用可调式涡轮增压技术降低排放并改善扭矩特性显示文摘目前,欧洲80%的轿车柴油机已采用涡轮增压。随着排放标准的日益严格,在不久的将来,涡轮增压机型有望接近100%。目前的一个主要热点是在高速柴油机上采用可调式涡轮增压技术(VGT)。在一台1.8L直喷式柴油机上做了大量的稳态试验研究,旨在对可调式涡轮增压发动机与配置带放气阀增压器的基准发动机进行比较,以观其潜在的益处。在欧洲试验循环中对排放产物十分重视的部分负荷工况下,分别控制可调增压器的叶片位置和废气再循环(EGR)阀的位置,以优化排放指标。在不牺牲固定式增压发动机的燃油耗、烟度的前提下,在一些间断工况点测得的NO_X减少到45%。在满足最高爆发压力、烟度和涡轮前温度限制条件下,可调增压发动机与装有固定增压基准发动机相比最大扭矩提高了10%。 | Hawley J G Wallace F J Cox A 栾敏 董复兴 | 2000 | 国外内燃机2000，，3： | 3 |
| 7 | Measurement of the temperature profile during shear band formation in steels deforming at high strain rates显示文摘 | Hartley K A Duffy J Hawley R H | 1987 | Journal of the Mechanics and Physics of Solids1987，35，1： | 2 |
| 8 | PET and18 F-FDG in oncology:a clinical update显示文摘 | Conti PS Lilien DL Hawley K | 1996 | Nucl Med Biol1996，23，： | 1 |
| 9 | Solid insulators in vacuum-areview显示文摘 | Hawley R | 1968 | Vacuum1968，18，7： | 1 |
| 10 | Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism 显示文摘 | Bruce CR Carey AL Hawley JA | 2003 | Diabetes2003，52，9： | 1 |
| 11 | Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca^2+ in T lymphocytes显示文摘 | Tamas P Hawley S A Clarke R G | 2006 | J Exp Med2006，203，7： | 1 |
| 12 | AMPK:a nutrient and energy sensor that maintains energy homeostasis显示文摘 | HARDIE D G ROSS F A HAWLEY S A | 2012 | Nature Reviews Molecular Cell Biology2012，13，4： | 1 |
| 13 | AMP-activated protein Kinase-development of the energy Sensor concept显示文摘 | Hardie DG Hawley SA Scott JW | 2006 | Physiol2006，574，1： | 1 |
| 14 | AMP-activated protein kinase:development of the energy sensor concept显示文摘 | Hardie DG Hawley SA Scott JW | 2005 | J Physiol2005，547，： | 1 |
| 15 | Solid insulators in vacuum-a review显示文摘 | Hawley R | 1968 | Vacuum1968，18，7： | 1 |
| 16 | Somatic stem cell plasticity:to be or not to be显示文摘 | Hawley R G Sobieski D A | 2002 | Stem Cells2002，20，： | 1 |
| 17 | Attenuation of Sound in Suspensions and Enumsions:Theory and Experiments显示文摘 | Alligra J R Hawley S A | 1972 | J Acoust Soc Am1972，51，5： | 1 |
| 18 | Surface soil moisture varia- tion on small agricultural watersheds显示文摘 | Hawley M E Jackson T ] Mccuen R H | 1983 | Journal of Hydrology1983，62，： | 1 |
| 19 | Predictors and outcomes of fungal peritonitis in peritoneal dialysis patients显示文摘 | Miles R Hawley CM McDonald SP | 2009 | Kidney Int2009，76，： | 1 |
| 20 | P selectin and leukocyte microparticles are associated with venous thrombogenesis显示文摘 | Myers DD Hawley AE Farris DM el al | 2003 | J Vasc Surg2003，38，5： | 1 |
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