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| 1 | Aberrant gene methylation in the peritoneal fluid is a risk factor predicting peritoneal recurrence in gastric cancer显示文摘AIM:To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer patients.METHODS: The gene methylation of CHFR (checkpoint with forkhead and ring finger domains), p16, RUNX3 (runt-related transcription factor 3), E-cadherin, hMLH1 (mutL homolog 1), ABCG2 (ATP-binding cassette, sub-family G, member 2) and BNIP3 (BCL2/adenovirus E1B 19 kDa interacting protein 3) were analyzed in 80 specimens of PF by quantitative methylation-specific polymerase chain reaction (PCR). Eighty patients were divided into 3 groups; Group A (n=35):the depth of cancer invasion was less than the muscularis propria; Group B (n=31): the depth of cancer invasion was beyond the muscularis propria. Both group A and B were diagnosed as no cancer cells in peritoneal cytology and histology; Group C (n=14): disseminated nodule was histologically diagnosed or cancer cells were cytologically defi ned in the peritoneal cavity.RESULTS: The positive rates of methylation in CHFR, E-cadherin and BNIP3 were significantly different among the 3 groups and increased in order of group A, B and C (0%,0% and 21% in CHFR, P<0.05; 20%, 45% and 50% in E-cadherin, P<0.05;26%,35% and 71% in BNIP3, P<0.05). In addition, the multigene methylation rate among CHFR, E-cadherin and BNIP3 was correlated with group A, B and C (9%,19% and 57%, P<0.001). Moreover, the prognosis was analyzed in group B, excluding 3 patients who underwent a non-curative resection. Two of the 5 patients with multigene methylation showed peritoneal recurrence after surgery, while those without or with a single gene methylation did not experience recurrence (P<0.05).CONCLUSION: This study suggested that gene methylation in the PF could detect occult neoplastic cells in the peritoneum and might be a risk factor for peritoneal metastasis. | Masatsugu Hiraki Yoshihiko Kitajima Seiji Sato Jun Nakamura Kazuyoshi Hashiguchi Hirokazu Noshiro Kohji Miyazaki | 2010 | World Journal of Gastroenterology2010，16，3： | 20 |
| 2 | Spatial Spillovers from Foreign Direct Investment: Evidence from the Yangtze River Delta in China显示文摘这份报纸在国内公司上从外国直接投资检验空间外表皮。用为 2004 的中国公司级的数据,并且在为一个 endogeneity 问题的财务以后,我们发现外国公司在类似的县和工业在国内公司的地区性的生产率上产生显著地积极的溢出效果。估计一个 spatial-autoregressive 模型,我们推进如此的本地溢出能在国内公司之中通过相互作用在另外的县和工业传给国内公司的表演。然而,这些空间更多样地,效果与距离衰退,从而减少外国直接投资溢出在远地点为国内公司完成。 | Kiyoyasu Tanaka Yoshihiro Hashiguchi | 2015 | China & World Economy2015，23，2： | 12 |
| 3 | Systematic review of laparoscopic vs open surgery for colorectal cancer in elderly patients显示文摘AIM: To verify the safety and validity of laparoscopic surgery for the treatment of colorectal cancer in elderly patients.METHODS: A meta-analysis was performed of a systematic search of studies on an electronic database. Studies that compared laparoscopic colectomy(LAC) in elderly colorectal cancer patients with open colectomy(OC) were retrieved, and their short and long-term outcomes compared. Elderly people were defined as 65 years old or more. Inclusion criteria were set at: Resection of colorectal cancer, comparison between laparoscopic and OC and no significant difference in backgrounds between groups.RESULTS: Fifteen studies were identified for analysis. LAC was performed on 1436 patients, and OC performed on 1810 patients. In analyses of short-term outcomes, operation time for LAC was longer than for OC(mean difference = 34.4162, 95%CI: 17.8473-50.9851, P < 0.0001). The following clinical parameters were lower in LAC than in OC: Amount of estimated blood loss(mean difference =-93.3738, 95%CI:-132.3437 to-54.4039, P < 0.0001), overall morbidity(OR = 0.5427, 95%CI: 0.4425-0.6655, P < 0.0001), incisional surgical site infection(OR = 0.6262, 95%CI: 0.4310-0.9097, P = 0.0140), bowel obstruction and ileus(OR = 0.6248, 95%CI: 0.4519-0.8638, P = 0.0044) and cardiovascular complications(OR = 0.4767, 95%CI: 0.2805-0.8101, P = 0.0062). In analyses of long-term outcomes(median follow-up period: 36.4 mo in LAC, 34.3 mo in OC), there was no significant difference in overall survival(mean difference = 0.8321, 95%CI: 0.5331-1.2990, P = 0.4187) and disease specific survival(mean difference = 1.0254, 95%CI: 0.6707-1.5675, P = 0.9209). There was also no significant difference in the number of dissected lymph nodes(mean difference =-0.1360, 95%CI:-4.0553-3.7833, P = 0.9458).CONCLUSION: LAC in elderly colorectal cancer patients had benefits in short-term outcomes compared with OC except operation time. The long-term outcomes and oncological clearance of LAC were similar to that of OC. These results support the assertion that LAC is an effective procedure for elderly patients with colorectal cancer. | Shoichi Fujii Mitsuo Tsukamoto Yoshihisa Fukushima Ryu Shimada Koichi Okamoto Takeshi Tsuchiya Keijiro Nozawa Keiji Matsuda Yojiro Hashiguchi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 10 |
| 4 | Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma显示文摘AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus(HCV)related hepatocellular carcinoma(HCC).METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective study.All patients had chronic liver disease(CLD) due to infection with HCV.Thirty patients with HCV-related HCC,34 with HCV-related CLD without HCC(non-HCC),and 20 healthy volunteers(HVs) were enrolled.Possible associations between serum manganese superoxide dismutase(MnSOD) and thioredoxin(TRX) levels and clinical parameters or patient prognosis were analyzed over a mean follow-up period of 31.7 mo.RESULTS:The serum MnSOD levels were significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.03) or HVs(P < 0.001).Similarly,serum TRX levels were also significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.04) or HVs(P < 0.01).However,serum levels of MnSOD and TRX were not correlated in patients with HCC.Among patients with HCC,the overall survival rate(OSR) was lower in patients with MnSOD levels ≥ 110 ng/mL than in patients with levels < 110 ng/mL(P = 0.01),and the OSR tended to be lower in patients with TRX levels < 80 ng/mL(P = 0.05).In addition,patient prognosis with HCC was poorest with serum MnSOD levels ≥ 110 ng/mL and serum TRX levels < 80 ng/mL.Furthermore,a multivariate analysis using a Cox proportional hazard model and serum levels of five factors(MnSOD,prothrombin time,serum albumin,serum α-fetoprotein(AFP),and serum des-γ-carboxy prothrombin) revealed that MnSOD levels ≥ 110 ng/mL(risk ratio:4.12,95% confidential interval:1.22-13.88,P = 0.02) and AFP levels ≥ 40 ng/mL(risk ratio:6.75;95% confidential interval:1.70-26.85,P < 0.01) were independent risk factors associated with a poor patient prognosis.CONCLUSION:Serum MnSOD and TRX levels are potential clinical biomarkers that predict patient prognosis in HCV-related HCC. | Tsutomu Tamai Hirofumi Uto Yoichiro Takami Kouhei Oda Akiko Saishoji Masashi Hashiguchi Kotaro Kumagai Takeshi Kure Seiichi Mawatari Akihiro Moriuchi Makoto Oketani Akio Ido Hirohito Tsubouchi | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 5 | Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathologicalsignificance显示文摘 | Yojiro Hashiguchi Naohiro Nishida Koshi Mimori Tomoya Sudo Fumiaki Tanaka Kohei Shibata Hideshi Ishii Hidetaka Mochizuki Kazuo Hase Yuichiro Doki Masaki Mori | 2012 | International Journal of Oncology2012，，5： | 2 |
| 6 | Serum levels of vascular endothelial growth factor dependent on the stage progression of lung cancer显示文摘 | Matsuyama W Hashiguchi T Mizoguchi A | | 0，，04： | 2 |
| 7 | Short-term results of a randomized study between laparoscopic and open surgery in elderly colorectal cancer patients显示文摘 | Shoichi Fujii Atsushi Ishibe Mitsuyoshi Ota Shigeru Yamagishi Kazuteru Watanabe Jun Watanabe Amane Kanazawa Yasushi Ichikawa Mari Oba Satoshi Morita Yojiro Hashiguchi Chikara Kunisaki Itaru Endo | 2014 | Surgical Endoscopy2014，，2： | 2 |
| 8 | Mechanical requirement and structures of cyclic plasticity显示文摘 | | 1993 | International Journal of Plasticity1993，9，6： | 1 |
| 9 | Topical application of cream-emulsified CD86 siRNA ameliorates allergic skin disease by targeting cutaneous dendritic cells显示文摘 | Ritprajak P Hashiguchi M Azuma M | 2008 | Mol Ther2008，16，7： | 1 |
| 10 | Dietary D-psicose,a C-3epimer of D-fructose,suppresses the activity of hepatic lipogenic enzymes in rats显示文摘 | Matsuo T Baba Y Hashiguchi M | 2001 | Asia Pac J Clin Nutr2001，10，： | 1 |
| 11 | Second-line chemoth- erapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature 显示文摘 | Funakoshi S Hashiguchi A Teramoto K | 2013 | Oncol Lett2013，5，1： | 1 |
| 12 | Construction of an L-isoleucine overproducing strain of Escherichia coli K-12显示文摘 | Hashiguchi K I Takesada H Suzuki E | 1999 | Bioscience Biotechnology and Biochemistry1999，63，4： | 1 |
| 13 | Expression and function of the B and T lymphocyte attenuator( BTLA/CD272 ) on human T cells 显示文摘 | Otsuki N Kamimura Y Hashiguchi M | 2006 | Biochem Biophys Res Cornmun2006，344，： | 1 |
| 14 | Human Fc epsilon Rlalpha - specific human single - chain Fv (scFv) antibody with antagonistic activity toward IgE/Fc epsilan RIalpha - binding显示文摘 | HASHIGUCHI S NAKASHIMA T NITANI A | 2003 | J Biochem2003，133，1： | 1 |
| 15 | Serum level of vascular endothelial growth factor dependent on the stage progression of lung cancer 显示文摘 | Matsuyama W Hashiguchi T Mizoguchi T | 2000 | Chest2000，118，4： | 1 |
| 16 | Stress Rate-elastic Stretching Relations in Elastoplastic Constitutive Equations for Soils显示文摘 | Hashiguchi K Collins I F | 2001 | Soils and Foundations2001，41，2： | 1 |
| 17 | Foundamentals in constitutive equation:continuity and smoothness conditions and loading criterion显示文摘 | | 2000 | Soils and Foundations2000，40，4： | 1 |
| 18 | Study of biochemical gene markers in the Mongolian gerbil (Meriones ungaliculatus)显示文摘 | Okumura K Maeda Y and Hashiguchi T | 1995 | Exp Anita (tokyo)1995，43，： | 1 |
| 19 | D- psicose is a rare sugar that provides no energy to growing rats 显示文摘 | Matsuo T Suzuki H Hashiguchi M | 2002 | Journal of Nutrition Science Vitaminol2002，48，1： | 1 |
| 20 | Relationship be- tween HPV typing and abnormality of G1 cell cycle regulators in cervical neoplasm显示文摘 | Tsuda H Hashiguchi Y Nishimum S | 2003 | Gynecoi Oncol2003，91，： | 1 |
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