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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | The fortune at the bottom of the pyramid 显示文摘 | Prahalad C K Hart S L | 2002 | Strategy + Business2002，26，： | 1 |
| 4 | 3 ' ,4' -dihydroxyflavonol re- duces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries显示文摘 | Leo C H Hart J L Woodman 0 L | 2011 | PLoS One2011，6，20： | 1 |
| 5 | Childhood mental ability and blood pressure at midlife: linking the Scottish mental survey 1932 and the midspan studies显示文摘 | Starr J M Taylor M D Hart C L | 2004 | J Hypertens2004，22，5： | 1 |
| 6 | Application of the Australian river bioassessmentsystem ( AUSRIVAS) in the Brantas River, East Java,Indonesia 显示文摘 | Hart B T Davies P E Humphrey C L | | Journal of Environmental Management0，，： | 1 |
| 7 | The great leap: driving innovation from the base of the pyramid 显示文摘 | Hart S L Christensen C M | 2002 | MIT Sloan Management Review2002，44，1： | 1 |
| 8 | Evaluation of analytical methods for determining pesticides in baby foods and adult duplicate-diet samples 显示文摘 | Chuang J C Hart K Chang J S Boman L E Van Emon J M Reed A W | 2001 | Analytica Chimica Acta2001，444，1： | 1 |
| 9 | Analysis for partially penetrating sand drains显示文摘 | HART E G KONDNER R L BOYER W C | 1958 | Journal of Soil Mechanics and Foundation Division Proceedings of ASCE1958，1812，： | 1 |
| 10 | State feedback controller design of networked control systems 显示文摘 | Yue D Hart Q L Peng C | 2004 | IEEE Transactions on Circuits and Systems Ⅱ: Express Briefs2004，51，11： | 1 |
| 11 | A population- based study of the long-term risks associated with atrial fibrillation: 20-year follow-up of the renfrew/paisley study 显示文摘 | STEWART S HART C L HOLE D J | 2002 | AmJned2002，113，5： | 1 |
| 12 | The greal leap:Driving innova tion from the base of the pyramid显示文摘 | Hart S L and Christensen C | 2002 | Sloan Management Re view2002，44，1： | 1 |
| 13 | Narcissism and hostility显示文摘 | Hart P L Joubert C E | 1996 | Psychological Reports1996，79，1： | 1 |
| 14 | The profitable art of service recovery显示文摘 | Hart C W Heskett J L Sasser Jr W E | 1990 | Harvard business review1990，68，4： | 1 |
| 15 | Mechanisms of action of probiotics:recent advances显示文摘 | NG S C HART A L KAMM M A | 2009 | Inflamm Bowel Dis2009，15，2： | 1 |
| 16 | The great disruption 显示文摘 | Christensen C M Craig T Hart S L | 2001 | Foreign Policy2001，80，2： | 1 |
| 17 | Hypoxia-inducible factor-lalpha-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5' -nucleotidase (CD73) and the A2B adenosine receptor 显示文摘 | HART M L GRENZ A GORZOLLA I C | 2011 | J Immtmol2011，186，7： | 1 |
| 18 | 4-META use in dentistry:A literature review显示文摘 | CHANG J C HURST T L HART D A | 2002 | The Journal of Prosthetic Dentistry2002，87，2： | 1 |
| 19 | The profitable art of service recovery显示文摘 | Hart C W L Heskett L J Sasser W E | 1990 | Harvard Business Review1990，，7： | 1 |
| 20 | The fortune at the bottom of the pyramid显示文摘 | Prahalad C K Hart S L | 2002 | Strategy + Business2002，，26： | 1 |
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