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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 4 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 5 | Low-cost all-polymer integrated circuits 显示文摘 | Drury C J Mutsaers C M J Hart C M | 1998 | Applied Physics Letters1998，73，： | 2 |
| 6 | Community-level physiological profiles of bacteria and fungi: plate type and incubation temperature influences on contrasting soils显示文摘 | Aimée T Classen Sarah I Boyle Kristin E Haskins Steven T Overby Stephen C Hart | | FEMS Microbiology Ecology0，，： | 2 |
| 7 | Hantaviruses 显示文摘 | McMAUGHEY C HART C | 2000 | Med Microbiol2000，49，7： | 1 |
| 8 | High rates of nitrification and nitrate turnover in undisturbed coniferous forests显示文摘 | Stark J M Hart S C | 1997 | Nature1997，385，： | 1 |
| 9 | The fortune at the bottom of the pyramid 显示文摘 | Prahalad C K Hart S L | 2002 | Strategy + Business2002，26，： | 1 |
| 10 | Creating wealth in organizations: The role of strategic leadership 显示文摘 | Brush C Greene P Hart M | 2001 | Academy of Management Executive2001，15，1： | 1 |
| 11 | 13C andl5N natural abundance of the soil microbial biomass显示文摘 | Dijkstra P Ishizu A Doucett R Hart S C Schwartz E Menyailo O V Hungate B A | 2006 | Soil Biology & Biochemistry2006，38，： | 1 |
| 12 | 3 ' ,4' -dihydroxyflavonol re- duces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries显示文摘 | Leo C H Hart J L Woodman 0 L | 2011 | PLoS One2011，6，20： | 1 |
| 13 | Apramycin-resistant Escheriehia coli isolated from pigs and a stockman显示文摘 | Hunter J E B Bennett M Hart C A | 1994 | Epidemiol infect1994，112，： | 1 |
| 14 | Childhood mental ability and blood pressure at midlife: linking the Scottish mental survey 1932 and the midspan studies显示文摘 | Starr J M Taylor M D Hart C L | 2004 | J Hypertens2004，22，5： | 1 |
| 15 | Post-cesarean delivery analgesia显示文摘 | Gadsden J Hart S Santos A C | 2005 | Anesth Analg2005，101，5： | 1 |
| 16 | Evalution of the airtraq and macintosh laryngoscopes in patients at increased risk for difficult tracheal intubation 显示文摘 | MAHARAJ C H COSTELLO J F HARTE B H | 2008 | Anaesthesia2008，63，2： | 1 |
| 17 | Re: Citation System for Patent Office显示文摘 | Hart H C | 1949 | Journal of the Patent Office Society1949，31，： | 1 |
| 18 | Application of the Australian river bioassessmentsystem ( AUSRIVAS) in the Brantas River, East Java,Indonesia 显示文摘 | Hart B T Davies P E Humphrey C L | | Journal of Environmental Management0，，： | 1 |
| 19 | Oral anticoagulants vs as- pirin in nonvalvular atrial fibrillation An individual patient meta-a- nalysis显示文摘 | WaIraven C Hart RG Singer DE | 2002 | JAMA2002，288，19： | 1 |
| 20 | Pregnancy affects cellular activity,but not tissue mechanical properties,in the healing rabbit medial collateral ligament显示文摘 | Hart DA Reno C Frank CB | 2000 | J Orthop Res2000，18，3： | 1 |
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