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| 1 | Current oncologic applications of radiofrequency ablation therapies显示文摘Radiofrequency ablation (RFA) uses high frequency alternating current to heat a volume of tissue around a needle electrode to induce focal coagulative necrosis with minimal injury to surrounding tissues. RFA can be performed via an open, laparoscopic, or image guided percutaneous approach and be performed under general or local anesthesia. Advances in delivery mechanisms, electrode designs, and higher power generators have increased the maximum volume that can be ablated, while maximizing oncological outcomes. In general, RFA is used to control local tumor growth, prevent recurrence, palliate symptoms, and improve survival in a subset of patients that are not candidates for surgical resection. It's equivalence to surgical resection has yet to be proven in large randomized control trials. Currently, the use of RFA has been well described as a primary or adjuvant treatment modality of limited but unresectable hepatocellular carcinoma, liver metastasis, especially colorectal cancer metastases, primary lung tumors, renal cell carcinoma, boney metastasis and osteoid osteomas. The role of RFA in the primary treatment of early stage breast cancer is still evolving. This review will discuss the general features of RFA and outline its role in commonly encountered solid tumors. | Dhruvil R Shah Sari Green Angelina Elliot John P McGahan Vijay P Khatri | 2013 | World Journal of Gastrointestinal Oncology2013，5，4： | 33 |
| 2 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 3 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 4 | Polysulphide pulping of two Canadian softwood blend显示文摘 | Green R P Prusas Z C | 1975 | Pulp Paper Can1975，76，9： | 2 |
| 5 | 肥大细胞特异性受体介导神经源性炎症和疼痛显示文摘肥大细胞被激活时可释放炎性细胞因子和趋化因子参与天然免疫细胞募集,作为神经系统和免疫系统联系的桥梁,肥大细胞的空间优势使其能够靠近外周神经末梢附近,在感觉神经纤维激活后率先做出反应。该研究发现肥大细胞特异性受体Mrgprb2通过在损伤部位招募天然免疫细胞,参与了炎症性机械痛和热痛觉过敏;肥大细胞可通过神经肽P物质激活Mrgprb2从而释放趋化因子,促使免疫细胞迁移;P物质激活人类肥大细胞上的MRGPRX2(Mrgprb2的同源基因)后也能释放多种促炎细胞因子和趋化因子;P物质介导的炎症反应独立于神经激肽-1受体(NK-1R)。结果表明Mrgprb2/X2参与了神经免疫调节,是治疗炎性痛的潜在靶点。 | Green Dustin P 刘彤彤(译) 唐宗湘(校) | 2020 | 中国疼痛医学杂志2020，26，7： | 2 |
| 6 | Computing dirichlet tessellations in the plane 显示文摘 | Green P J Sibson R | 1978 | Commputer Journal1978，21，2： | 2 |
| 7 | Human aortic valve allografts elicit a donor-specific immune response 显示文摘 | Hogan P Duplock L Green M | 1996 | J Thorac Cardiovasc Surg1996，112，6： | 2 |
| 8 | Effect of Endostatin on Spontaneous Tumorigenesis of Mammary Adenocarcinomas in a Transgenic Mouse Model显示文摘 | Yokoyama Y Green J E Sukhatme V P | 2000 | Cancer Res2000，60，16： | 1 |
| 9 | Computing dirichlet tessellations in the plane 显示文摘 | Green P J Sibson R R | 1978 | The Computer Journal1978，21，： | 1 |
| 10 | The Career Reasons of Minority Nascent Entrepreneurs 显示文摘 | Canner N M Gartner W B Greene P G | 2003 | Academy of Management Proceeding2003，18，1： | 1 |
| 11 | Mechanisms of Disease: the Myeloprolife Rative Disorders显示文摘 | Campbell P J Green A R | 2006 | N Engl J Med2006，355，： | 1 |
| 12 | Thermal annealing of fission tracks in apatite:A quantitative analysis显示文摘 | Lastett G M Green P F Duddy I R | 1987 | Chemical Geology1987，73，25： | 1 |
| 13 | Characterization of the bovine pregnancy-associated glycoprotcin gone family-analysisof gene sequences, regulatory regions within the promoter and expression of selected genes 显示文摘 | Telugu B P Walker A M Green J A et el | 2009 | BMC Genomics2009，10，： | 1 |
| 14 | On Use of the EM Algorithm for Penalized Likelihood Estimation显示文摘 | Green P J | 1990 | Journal of the Royal Statistical Society Series B (Methodological)1990，52，： | 1 |
| 15 | Effect of using Threadrin Shad as forage for channel catfish fed daily or every third day 显示文摘 | Green B Perschbacher P Ludwing G | 2009 | N Am J Aquacult2009，71，1： | 1 |
| 16 | Creating wealth in organizations: The role of strategic leadership 显示文摘 | Brush C Greene P Hart M | 2001 | Academy of Management Executive2001，15，1： | 1 |
| 17 | 显示文摘 | Green M L Schenck P K | 2009 | Microeleetronic Engi- neering2009，86，： | 1 |
| 18 | Global water resources:Vulnerability from climate change arid population growth显示文摘 | Vorosmarty C J Green P Salisbury J | 2000 | Science2000，289，： | 1 |
| 19 | The prevalence of nascent entrepreneurs in the United States: evidence from the panel study of entrepreneurial dynandler显示文摘 | Reynolds P D N M Carter W B Gartner P G Greene | 2004 | Small Business Economics2004，23，： | 1 |
| 20 | Thining and opening of carbon nanotubes by oxidation using carbon dioxide 显示文摘 | Tsang S C Harris P J F Green M L H | 1993 | Nature1993，362，： | 1 |
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