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| 1 | Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry显示文摘瞄准:为颜色检测新浆液简历标记由浆液蛋白质与提高表面的激光解吸附作用 ionisation 介绍的表面的癌症(CRC )-- 飞行团分光术(SELDI-TOF MS ) 的时间。方法:二个独立浆液样品集合与 ProteinChip 技术独立被分析(集合 A:40 CRC+49 健康控制;集合 B:37 CRC+31 健康控制) ,有一个弱阳离子的使用的芯片交换一半和缓冲区 pH 5。差别的歧视的力量表示了蛋白质与一个分类树算法被估计。产生分类树的敏感和特性被盲目地从集合 B 并且反过来也如此从集合 A 把数据用于产生的树获得。CRC 浆液蛋白质侧面也与从胸的那些相比,卵巢,前列腺,和非小的房间肺癌症。结果:Mass-to-charge 比率(m/z ) 3.1x10 (3 ) , 3.3x10 (3 ) , 4.5x10 (3 ) , 6.6x10 (3 ) 和 28x10 (3 ) 在最好执行的分类树上被用作分类器。树敏感和特性在 65% 和 90% 之间。大多数这些歧视的 m/z 价值在调查的另外的瘤类型也是不同的。M/z 3.3x10 (3 ) ,在大多数树上的主要分类器,是 6.6x10 (3 ) 的一种二倍地控告的形式 -Da 蛋白质。后者作为 apolipoprotein C-I 被识别。M/z 3.1x10 (3 ) 作为 apolipoprotein A-I 作为白朊,和 m/z 28x10 (3 ) 的 N 终端碎片被识别。结论:分类树模式分析跟随的 SELDI-TOF MS 是为为 CRC 发现新浆液标记的一种合适的技术。Biomarkers 能与高敏感和特性在独立样品集合被识别并且 reproducibly 检测了。尽管为 CRC 不特定,这些简历标记在监视的疾病和治疗有一个潜在的角色。 | Judith YMN Engwegen Helgi H Helgason Annemieke Cats Nathan Harris Johannes MG Bonfrer Jan HM Schellens Jos H Beijnen | 2006 | World Journal of Gastroenterology2006，12，10： | 45 |
| 2 | Chemoprevention of lung cancer by non-steroidal inflammatory drugs among cigarette smokers 显示文摘 | Harris RE Beebe-Donk J Schuller HM | 2002 | Oncol Rep2002，9，4： | 1 |
| 3 | A comparison between Mohs micrographic surgery and wide surgical excision for the treatment of dermatoflbrosarcoma protuberans显示文摘 | Gloster HM Jr Harris KR Roenigk RK | 1996 | J Am Acad Dermatol1996，35，1： | 1 |
| 4 | Lifetime risk of suicide for affective disorder,alcoholism and schizophrenia显示文摘 | Inskip HM Harris EC Barraclough B | 1998 | Br J Psychiatry1998，172，： | 1 |
| 5 | Acute intraoperative in- tracranial hypertension in neurosurgical patients:mechanical and phar- macologic factors显示文摘 | Shapiro HM Wyte SR Harris AB | 1972 | Anesthesiology1972，37，4： | 1 |
| 6 | Spontaneous perforation of the colon显示文摘 | HM Olnick and CM Harris | 1980 | South Med J1980，73，3： | 1 |
| 7 | 显示文摘 | Harries HM | 2001 | Toxicol in vitro2001，15，： | 1 |
| 8 | Hepatic macrophages promote the neutrophil-dependent resolution of fibrosis in repair- ing cholestatic rat livers显示文摘 | Harry MW Papa EF Huddleston HM | 2008 | Surgery2008，143，： | 1 |
| 9 | Chemoprevention of lung cancer by non-steroidal anti-inflammatory drugs among cigarette smokers显示文摘 | Harris RE Beebe-Donk J Schuller HM | 2002 | Oncol Rep2002，9，4： | 1 |
| 10 | Permissive recognitio n of amycobacterial T-cell epitope: localization of overlapping epitope core s equencesrecognized in association with multiple major histocompatibility comple x class I-Amolecules显示文摘 | Harris DP Vordermeier HM Arya A | 1995 | Immunol1995，84，： | 1 |
| 11 | Copepod hatching success in marine ecosystems with high diatom concentrations 显示文摘 | Irigoien X Harris RP Verheye HM Joly P Runge J Starr M Pond D Campbell R Shreeve R Ward P Smith AN Dam HG Peterson W Tirelli V Koski M Smith T Harbour D Davidson R | 2002 | Nature2002，419，： | 1 |
| 12 | A comparison between Mohs micrographic surgery and wide surgical excision for treatment of dermatofibrosarcom protuberans显示文摘 | Gloster HM Harris KR Roenigk RK | 1996 | J Am Acad Dermatol1996，35，： | 1 |
| 13 | Chemopreventive of breast cancer in rats by celexib, a cyclooxygenase-2 inhibitor显示文摘 | Harris RE Alshafie GA Abou-Issa HM | 2000 | Cancer Res2000，60，8： | 1 |
| 14 | Chemopreventive of breast cancer in rats by celecoxib, a cyclooxygense-2 inhibitor显示文摘 | Harris RE Alshafie GA Abou-Issa HM | 2000 | Cancer Res2000，60，8： | 1 |
| 15 | Chemopreventive of breast cancer in rats by celecoxib,a cyclooxygenase-2 inhibitor 显示文摘 | Harris RE Alshafie GA Abou-Issa HM | 2000 | Cancer Res2000，60，8： | 1 |
| 16 | Chemoprevention of lung cancer by non-steroidal anti-inflammatory drugs among cigarette smokers显示文摘 | Harris RE Beebe DJ Schuller HM | 2002 | Oncol Rep2002，9，4： | 1 |
| 17 | The in vitro growth and maturation of follicles显示文摘 | Picton HM Harris SE Muruvi W | 2008 | Reproduction2008，136，6： | 1 |
| 18 | Leukemia arising out of paroxysmal nocturnal hemoglobinuria显示文摘 | Harris JW Koscick R Lazarus HM | 1999 | Leuk Lymphoma1999，32，56： | 1 |
| 19 | Chemoprevention of lung cancer by non-steroidal inflammatory drugs among cigarette smokers显示文摘 | Harris RE Beebe-Donk J Schuller HM | 2002 | Onclo Rep2002，9，4： | 1 |
| 20 | Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetie relationships masked by current clinical typing显示文摘 | Harris SR Clarke IN Seth-Smith HM | 2012 | Nat Genet2012，44，4： | 1 |
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