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| 1 | Colorectal liver metastases: Current management and future perspectives显示文摘The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and Histopathology.Patient management is based on assessment of sophisticated clinical,radiological and biomarker information.Despite incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure.To this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant liver.Liver resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected patients.For unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability.Currently evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation. | Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet | 2020 | World Journal of Clinical Oncology2020，11，10： | 5 |
| 2 | 过瘤胃蛋氨酸、赖氨酸和组氨酸对泌乳奶牛生产性能的影响显示文摘试验旨在研究饲料中单独添加或综合添加过瘤胃(RP)蛋氨酸、赖氨酸和组氨酸及可代谢蛋白(MP)对泌乳后期奶牛生产性能的影响。试验选取72头荷斯坦奶牛,随机分为6组,试验期9周。奶牛随机分配到6个试验组中,2周作为1个变量周期:MPA组,根据美国国家科学研究委员会(2001)标准,在饲料中添加调节MP到243 g·d-1;MPD组,不添加MP,MP含量低于标准量54 g·d-1;MPDM组,在MPD组的基础上加入RP蛋氨酸;MPDL组,在MPD组的基础上加入RP赖氨酸;MPDH组,在MPD组的基础上加入组氨酸;MPDMLH组,在MPD组的基础上加入RP蛋氨酸、RP赖氨酸和RP组氨酸。试验结果表明,与MPA组对比,MPD组的干物质采食量(DMI)、产奶量、乳成分(乳脂肪、乳蛋白和乳糖)及能量校正的牛乳(ECM)、ECM饲料利用效率、牛奶和血浆中的N均降低。在MPD基础上补充RP赖氨酸可使乳蛋白率、血浆中葡萄糖浓度增加,且牛奶中N元素含量有增加的趋势;补充RP组氨酸可使DMI、牛奶浓缩蛋白增加,且乳脂肪、乳蛋白和ECM显著增加;补充3种RP氨基酸时,增加了乳蛋白率,使DMI和乳脂率有增加趋势,也提高了乳脂肪、乳蛋白含量和ECM及ECM饲料利用效率。与MPA相比,MPD组牛奶中N的含量有降低趋势,且血浆中必需氨基酸(除赖氨酸和蛋氨酸)浓度均降低。补充RP赖氨酸、RP蛋氨酸和RP组氨酸提高了血浆中蛋氨酸(除MPDM组)、赖氨酸和组氨酸浓度。饲喂MPD的奶牛血红蛋白浓度降低,血浆生长素含量高于MPA组。MPD组牛奶中总饱和脂肪酸浓度有高于MPA和MPDMLH组的趋势。MPD组的多元不饱和脂肪、牛奶中奇链与支链脂肪酸含量与MPA组相比,有降低趋势。试验结果表明,对于饲料中缺乏MP的奶牛,在饲料中添加组氨酸和添加3种RP氨基酸(赖氨酸、蛋氨酸和组氨酸)均有提高牛奶产量和牛奶组分含量的可能性。 | Giallongo F Harper M T Oh J Lopes J C Lapierre H Patton R A Parys C Shinzato I Hristov A N | 2016 | 饲料博览2016，0，7： | 4 |
| 3 | Mobile Agent and Security显示文摘 | Greenberg M S Byington L C Harper D G | 1998 | IEEE Communication Magazine1998，36，7： | 2 |
| 4 | Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial 显示文摘 | Harper DM Franco EL Wheeler C | 2004 | Lancet2004，364，9447： | 1 |
| 5 | Early po~stoperative gastrointestinal activity显示文摘 | ROTHNIE N C HARPER R A K CATCHPOLE B N | 1963 | Lancet1963，2，： | 1 |
| 6 | Communication with calcium显示文摘 | Sanders D Brownlee C Harper J F | 1999 | Plant Cell1999，11，： | 1 |
| 7 | Magnetocaloric effect in NiMnGa particles produced by spark erosion显示文摘 | TANG Y J SOLOMON V C SMITH D J HARPER H BERKOWITZ A E | 2005 | J Appl Phys2005，97，309： | 1 |
| 8 | Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial显示文摘 | Harper DM Franco EL Wheeler C | 2004 | Lancet2004，364，9447： | 1 |
| 9 | Structural basis of a phololropinlight switch显示文摘 | Harper S M Neil L C Gardner K H | 2003 | Science2003，301，5639： | 1 |
| 10 | Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women :a randomised controlled trial 显示文摘 | Harper DM Franco EL Wheeler C | 2004 | Lancet2004，364，9447： | 1 |
| 11 | Alkylammonium montmorillonites as adsorbents for organic vapors from air 显示文摘 | PURNELL C J | 1990 | Environ Sci Technol1990，24，1： | 1 |
| 12 | Efficacy of a bi- valent L1 virus-like particle vaccine in prevention of in- fection with human papillomavirus types 16 and 18 in young women : a randomised controlled trial 显示文摘 | Harper DM Franco EL Wheeler C | 2004 | Lancet2004，364，9447： | 1 |
| 13 | Mycoplmgous grazing and food preference of Proisotoma minuta ( Collembola: Isotomidae) and Onychiurus encarpatus (Collembola: Onychiuridae) 显示文摘 | Lartey R T Curl E E Peterson C M Harper J D | 1989 | Environmental Entomology1989，，18： | 1 |
| 14 | Communica-ting with calcium显示文摘 | Sanders D Brownlee C Harper J F | 1999 | Plant Cell1999，11，： | 1 |
| 15 | Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo:implications for psoriasis pathogenesis 显示文摘 | Harper EG Guo C Rizzo H | 2009 | J Inves Dermatol2009，129，9： | 1 |
| 16 | Axonal growth of embryon- ic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats显示文摘 | Harper JM Krishnan C Darman JS | 2004 | Proc Natl Acad Sci USA2004，101，18： | 1 |
| 17 | Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats显示文摘 | Harper JM Krishnan C Darman JS | 2004 | Proc Natl Acad Sci USA2004，101，18： | 1 |
| 18 | Curtin industrial safety trial:Managerial behavior and program effectiveness 显示文摘 | Harper A C Cordery J L De Klerk N H Sevastos P Geelhoed E Gunson C Robinson L Sutherland M Osbom D Colquhoun J | 1996 | Safety Science1996，24，3： | 1 |
| 19 | Origin of microsalellite instability in gastric cancer显示文摘 | Halling K C Harper J Moskaluk C A | 1999 | Am J Pathol1999，155，1： | 1 |
| 20 | Expression profiling of gastric adenocarcinoma using cDNA array显示文摘 | El-Rifai W Frierson H F Harper J C | 2001 | IntJCancer2001，93，： | 1 |
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