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| 1 | Diagnosis and treatment of diabetes mellitus in chronic pancreatitis显示文摘Diabetes secondary to pancreatic diseases is commonly referred to as pancreatogenic diabetes or type 3c diabetes mellitus.It is a clinically relevant condition with a prevalence of 5%-10%among all diabetic subjects in Western populations.In nearly 80%of all type 3c diabetes mellitus cases,chronic pancreatitis seems to be the underlying disease.The prevalence and clinical importance of diabetes secondary to chronic pancreatitis has certainly been underestimated and underappreciated so far.In contrast to the management of type 1 or type2 diabetes mellitus,the endocrinopathy in type 3c is very complex.The course of the disease is complicated by additional present comorbidities such as maldigestion and concomitant qualitative malnutrition.General awareness that patients with known and/or clinically overt chronic pancreatitis will develop type 3c diabetes mellitus(up to 90%of all cases)is rather good.However,in a patient first presenting with diabetes mellitus,chronic pancreatitis as a potential causative condition is seldom considered.Thus many patients are misdiagnosed.The failure to correctly diagnose type 3 diabetes mellitus leads to a failure to implement an appropriate medical therapy.In patients with type 3c diabetes mellitus treating exocrine pancreatic insufficiency,preventing or treating a lack of fat-soluble vitamins(especially vitamin D)and restoring impaired fat hydrolysis and incretin secretion are key-features of medical therapy. | Nils Ewald Philip D Hardt | 2013 | World Journal of Gastroenterology2013，19，42： | 23 |
| 2 | Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases显示文摘AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific probes.RESULTS:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy population.In NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver disease.However,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory alterations.The linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of NAFLD.CONCLUSION:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis. | Johannes W Rey Andrea Noetel Aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans Peter Dienes Uta Drebber Margarete Odenthal | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 3 | Endoscopic sphincterotomy in patients with stenosis of ampulla of Vater:Three-year follow-up of exocrine pancreatic function and clinical symptoms显示文摘AIM: To investigate retrospectively the long-term effect of endoscopic sphincterotomy (ES) including exocrine pancreatic function in patients with stenosis of ampulla of Vater. METHODS: After diagnostic endoscopic retrograde cholangiopancreatography (ERCP) and ES because of stenosis of the ampulla of Vater (SOD Type Ⅰ), follow-up examinations were performed in 60 patients (mean follow-up time 37.7 mo). Patients were asked about clini-cal signs and symptoms at present and before interven-tion using a standard questionnaire. Before and after ES exocrine pancreatic function was assessed by determina-tion of immunoreactive fecal elastase 1. Serum enzymes indicating cholestasis as well as serum lipase and amy-lase were measured. RESULTS: Eighty percent of patients reported an im-provement in their general condition after ES. The fecal elastase 1 concentrations (FEC) in all patients increased significantly after ES. This effect was even more marked in patients with pathologically low concentrations (< 200 μg/g) of fecal elastase prior to ES. The levels of serum lipase and amylase as well as serum alcaline phosphatase (AP) and gamma-glutamyltranspeptidase (GGT) decreased signifi-cantly after ES. CONCLUSION: The results of this study demonstrate that patients with stenosis of the ampulla of Vater can be successfully treated with endoscopic sphincterotomy. The positive effect is not only indicated by sustained improvement of clinical symptoms and cholestasis but also by improvement of exocrine pancreatic function. | Nils Ewald Axel Michael Marzeion Reinhard Georg Bretzel Hans Ulrich Kloer Philip Daniel Hardt | 2007 | World Journal of Gastroenterology2007，13，6： | 5 |
| 4 | Treatment of small coronary arteries with a paclitaxel-coated balloon catheter显示文摘 | Martin Unverdorben Franz X. Kleber Hubertus Heuer Hans-Reiner Figulla Christian Vallbracht Matthias Leschke Bodo Cremers Stefan Hardt Michael Buerke Hanns Ackermann Michael Boxberger Ralf Degenhardt Bruno Scheller | 2010 | Clinical Research in Cardiology2010，，3： | 2 |
| 5 | Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure显示文摘 | Britta Vogel Andreas Keller Karen S. Frese Petra Leidinger Farbod Sedaghat-Hamedani Elham Kayvanpour Wanda Kloos Christina Backe Ann Thanaraj Thomas Brefort Markus Beier Stefan Hardt Eckart Meese Hugo A. Katus Benjamin Meder | 2013 | European Heart Journal2013，，： | 2 |
| 6 | 老年人群胰腺外分泌功能不全的发病和决定因素:一项大样本人群研究结果 | Rothenbacher D. Lw M. Hardt P.D. 杨媛 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，11： | 2 |
| 7 | A Single Standard for Memory: the Case for Reconsolidation 显示文摘 | Karim Naderl Oliver Hardt | 2009 | Nature Reviews Neuroscience2009，，10： | 1 |
| 8 | Narcotrend-assisted propofoVremifentanil anaesthesia vs clinical practice: does it make a difference 显示文摘 | Rundshagen I Hardt T Cortina K | 2007 | Br J Anaesth2007，99，5： | 1 |
| 9 | Passive micromixer for applications in the microreactor andμTAS fields显示文摘 | HARDT S DRESE K S HESSEL F | 2005 | Microfluidics and Nanofluidics2005，1，2： | 1 |
| 10 | Mininal alteration in the ratio of circulatory fetal DNA to fetal corticotropin--releasing hormone mRNA level in preeelampsia 显示文摘 | Zhong XY Holzqreve W Geb Hardts | 2006 | Fetal Diagn Therapy2006，21，3： | 1 |
| 11 | Tumor M2-pyruvate kinase: a promising tumor marker in the diagnosis of gastrointestinal cancer显示文摘 | Ngoumou BK Rupp J | 2000 | Anticancer Res2000，20，6： | 1 |
| 12 | Outcome of implant therapy in relation to experienced loss of periodontal bone support:a retrospective 5-year study显示文摘 | Hardt CR Grondahl K Lekholm U | 2002 | Clin Oral Implants Res2002，13，： | 1 |
| 13 | Gaschromatographic enantiomer separation of agrochemicalsand polychlorinated biphenyls(PCBs)using modified cy-clodextrins显示文摘 | Ingo H Hardt Christian Wolf Barbel Gehrcke | 1994 | J High Resolut Chromatogr1994，17，12： | 1 |
| 14 | A five body--Three dimensional dynamic analysis of walking 显示文摘 | Hardt D E Mann R W | 1980 | Journal of Biomechanics1980，13，5： | 1 |
| 15 | Bojanc- zyk, Member, IEEE, The hyperbolic singular value decompositi -on and applications 显示文摘 | Ruth Onn Student Member IEEE Allan Stein- hardt Senior Member IEEE and Adam W | 1991 | IEEE Transac- tion On Singal Processing1991，39，7： | 1 |
| 16 | The dynamie voltage/current characteristics of vacuum arcs after breakdown at currents in the lower kHz-range显示文摘 | HARDT N HEIMBACH M BOHME H | 2002 | European Transactions on Electrical Power2002，12，5： | 1 |
| 17 | Narcotrend-assisted pmpofol/remifentanil anaesthesia vs clinical practice:does it make a difference 显示文摘 | Rundshagen I Hardt T Cortina K | 2007 | Br J Anaesth2007，99，5： | 1 |
| 18 | Immediate and chronic effects of AV delay optimization in patients with cardiac resynchronization therapy 显示文摘 | HARDT S E YAZDI S H BAUER A | 2007 | Int J Cardiol2007，115，： | 1 |
| 19 | Tumor M2 - pyruvate kinase : a promising tumor marker in the diagnosis of gastro - intestinal cancer显示文摘 | Hardt PD Ngoumou BK Rupp J | 2000 | Anticancer Res2000，20，： | 1 |
| 20 | Global analysis of genes regulated by HOXA10 in decidualization reveals a role in cell proliferation显示文摘 | La Z Hardt J Kim JJ | 2008 | Mol Hum Reprod2008，14，6： | 1 |
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