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| 1 | Platelet function monitoring guided antiplatelet therapy in patients receiving high-risk coronary interventions显示文摘 | Xu Li Wang Lefeng Yang Xinchun Li Kuibao Sun Hao Zhang Dapeng Wang Hongshi Li Weiming Ni Zhuhua Xia Kun Liu Yu | 2014 | Chinese Medical Journal2014，，19： | 8 |
| 2 | Overview of Research and Development Status of Brushless Doubly-Fed Machine System显示文摘The brushless doubly-fed machine(BDFM)has been widely used due to its advantages of robustness,reliable operation,ease of maintenance,adjustable power factor,small converter capacity and low cost.BDFM is attractive for use in many applications such as variable frequency speed regulation systems and variable speed constant frequency generation systems.Hence,there is a rapidly growing interest in design and control of BDFM.In this paper,the origin and development of BDFM are reviewed,the structural characteristics of BDFM are discussed at length,the principles of operation and design are analyzed,and the different control methods used for BDFM are overviewed and compared in detail.Finally,challenges and opportunities of BDFM are concluded. | Fengge Zhang Siyang Yu Hao Wang Yutao Wang Dapeng Wang | 2016 | Chinese Journal of Electrical Engineering2016，2，2： | 4 |
| 3 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 4 | Equilibrium Phase Constituents and Discontinuous Precipitation Behavior of Al-Zn-Cu Alloy with Symmetrical Composition显示文摘Through microstructure observation and X-ray diffraction analysis, the equilibrium phase constituents of Al-Zn alloythat contains 2 at. pct Cu at room temperature have been determined as Al-based solid solution (α), Zn-based solidsolution and Al4Cu3Zn phase (T′-phase), which are different from α phase, Zn phase and CuZn4 phase originallybelieved. It is determined that the products of discontinuous precipitation transformation below 277℃ are not theequilibrium phase constituents, but the metastable phases made up of α phase, Zn phase and CuZn4 phase. Thephase constituents after discontinuous precipitation of AlZn-2Cu alloy would transform to the ones in equilibriumstatus: Al-based solid solution (c) in fcc structure, Zn-based solid solution in hcp structure and Al4Cu3Zn phase(T′-phase) ultimately through plastic deformation at room temperature and re-heating treatment below 277℃. | Shiming HAO, Yuping REN, Hua DING, Dapeng WANG, Gang ZHAO and Hongxiao LISchool of Materials and Metallurgy, Northeastern University, Shenyang 110004, China | 2003 | Journal of Materials Science & Technology2003，19，5： | 3 |
| 5 | Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/β-catenin/c-Myc/cyclin A2 signaling pathway显示文摘Skin epidermal stem cells(EpSCs)play an important role in wound healing.Quercetin is a phytoestrogen reported to accelerate skin wound healing,but its effect on EpSCs is unknown.In this study,we investigated the effect of quercetin on human EpSC proliferation and explored the underlying mechanisms.We found that quercetin at 0.1~1μM significantly promoted EpSC proliferation and increased the number of cells in S phase.The pro-proliferative effect of quercetin on EpSCs was confirmed in cultured human skin tissue.Mechanistic studies showed that quercetin significantly upregulated the expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.Inhibitor forβ-catenin or c-Myc significantly inhibited quercetin-induced EpSC proliferation.Theβ-catenin inhibitor XAV-939 suppressed quercetin-induced expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.The c-Myc inhibitor 10058-F4 inhibited the upregulation of c-Myc and cyclin A2 by quercetin.Pretreatment of EpSCs with estrogen receptor(ER)antagonist ICI182780,but not the G protein-coupled ER1 antagonist G15,reversed quercetin-induced cell proliferation and upregulation ofβ-catenin,c-Myc,and cyclin A2.Collectively,these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation ofβ-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.As EpSCs are used not only in clinic to treat skin wounds but also as seed cells in skin tissue engineering,quercetin is a useful reagent to expand EpSCs for basic research,skin wound treatment,and skin tissue engineering. | Zhaodong Wang Guangliang Zhang Yingying Le Jihui Ju Ping Zhang Dapeng Wan Qiang Zhao Guangzhe Jin Hao Su Jinwei Liu Jiaxuan Feng Yi Fu Ruixing Hou | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 3 |
| 6 | Highly sensitive piezoresistive pressure sensors based on laser-induced graphene with molybdenum disulfide nanoparticles显示文摘Wearable pressure sensors have drawn significant attention because of their extensive applications in motion detection, tactile sensing, and health monitoring. However, the complex manufacturing process and high cost of active materials make low-cost,large-scale production elusive. In this work, we report a flexible piezoresistive pressure sensor assembled with two 3D laserinduced graphene(LIG) foam electrodes on a polyimide thin film from a simple laser scribing process in the ambient environment. The design of the air gap between the two foam electrodes allows the sensor to showcase a low limit of detection of 0.274 Pa, which provides favorable sensing performance in motion detection and wrist pulse monitoring. The addition of spherical MoS2 nanoparticles between the two foam electrodes further enhances the sensitivity to 88 k Pa-1 and increases the sensing range to significantly outperform the previous literature reports. The demonstrated LIG pressure sensors also exhibit fast response/recovery rates and excellent durability/repeatability. | HAO DaPeng YANG RuoXi YI Ning CHENG HuanYu | 2021 | Science China(Technological Sciences)2021，64，11： | 2 |
| 7 | HIV-1 Vif suppresses antiviral immunity by targeting STING显示文摘HIV-1 infection-induced cGAS–STING–TBK1–IRF3 signaling activates innate immunity to produce type I interferon(IFN).The HIV-1 nonstructural protein viral infectivity factor(Vif)is essential in HIV-1 replication,as it degrades the host restriction factor APOBEC3G.However,whether and how it regulates the host immune response remains to be determined.In this study,we found that Vif inhibited the production of type I IFN to promote immune evasion.HIV-1 infection induced the activation of the host tyrosine kinase FRK,which subsequently phosphorylated the immunoreceptor tyrosine-based inhibitory motif(ITIM)of Vif and enhanced the interaction between Vif and the cellular tyrosine phosphatase SHP-1 to inhibit type I IFN.Mechanistically,the association of Vif with SHP-1 facilitated SHP-1 recruitment to STING and inhibited the K63-linked ubiquitination of STING at Lys337 by dephosphorylating STING at Tyr162.However,the FRK inhibitor D-65495 counteracted the phosphorylation of Vif to block the immune evasion of HIV-1 and antagonize infection.These findings reveal a previously unknown mechanism through which HIV-1 evades antiviral immunity via the ITIM-containing protein to inhibit the posttranslational modification of STING.These results provide a molecular basis for the development of new therapeutic strategies to treat HIV-1 infection. | Yu Wang Gui Qian Lingyan Zhu Zhuo Zhao Yinan Liu Wendong Han Xiaokai Zhang Yihua Zhang Tingrong Xiong Hao Zeng Xianghui Yu Xiaofang Yu Xiaoyan Zhang Jianqing Xu Quanming Zou Dapeng Yan | 2022 | Cellular & Molecular Immunology2022，19，1： | 2 |
| 8 | Effect of Cu on Discontinuous Precipitation of a Symmetrical AlZn Alloy显示文摘The effect of Cu additions on discontinuous precipitation of AlZn alloy were studied with optical microscopy, scanning electron microscopy and X-ray diffraction. It is found that the effect of addition of 2 at. pct Cu on cellular nucleation site is not remarkable, while the effect of aging temperature on cellular nucleation site of AlZn and AlZn-2Cu alloys is fairly obvious. The cell growth rate of discontinuous precipitation of AlZn alloy is remarkably accelerated with the addition of 2 at. pct Cu. The discontinuous precipitation microstructure of AlZn alloy is not apparently affected with the addition of 2 at. pct Cu and the cellular front is still fine microstructure of spinodal decomposition. The phase constituents consist of a fcc Al-rich phase, a hcp Zn-rich phase and a CuZn4 phase. The transformation rate of discontinuous precipitation of AlZn alloy is remarkably accelerated with the addition of 2 at. pct Cu. | Shiming HAO, Yuping REN, Dapeng WANG, Danyang DONG and ffongxiao LI College of Materials and Metallurgy, Northeastern University, Shenyang 110004, China | 2005 | Journal of Materials Science & Technology2005，21，2： | 2 |
| 9 | Development of a direct ELISA based on carboxy-terminal of penicillin-binding protein BlaR for the detection of β-lactam antibiotics in foods显示文摘 | Juan Peng Guyue Cheng Lingli Huang Yulian Wang Haihong Hao Dapeng Peng Zhenli Liu Zonghui Yuan | 2013 | Analytical and Bioanalytical Chemistry2013，，27： | 1 |
| 10 | Discriminative dictionary learning via Fisher discrimination K-SVD algorithm显示文摘 | ZHENG Hao and TAO Dapeng | 2015 | Neurocomputing2015，2015，162： | 1 |
| 11 | Nonreciprocal coherent coupling of nanomagnets by exchange spin waves显示文摘Nanomagnets are widely used to store information in non-volatile spintronic devices.Spin waves can transfer information with low-power consumption as their propagations are independent of charge transport.However,to dynamically couple two distant nanomagnets via spin waves remains a major challenge for magnonics.Here we experimentally demonstrate coherent coupling of two distant Co nanowires by fast propagating spin waves in an yttrium iron garnet thin film with sub-50 nm wavelengths.Magnons in two nanomagnets are unidirectionally phase-locked with phase shifts controlled by magnon spin torque and spin-wave propagation.The coupled system is finally formulated by an analytical theory in terms of an effective non-Hermitian Hamiltonian.Our results are attractive for analog neuromorphic computing that requires unidirectional information transmission. | Hanchen Wang Jilei Chen Tao Yu Chuanpu Liu Chenyang Guo Song Liu Ka Shen Hao Jia Tao Liu Jianyu Zhang Marco A.Cabero Z Qiuming Song Sa Tu Mingzhong Wu Xiufeng Han Ke Xia Dapeng Yu Gerrit E.W.Bauer Haiming Yu | 2021 | Nano Research2021，14，7： | 1 |
| 12 | Stabilization and optimi- zation of PLUS factorization and its application in image coding显示文摘 | Yang Lei Hao Pengwei Wu Dapeng | 2011 | Journal of Visual Communication & Image Repre- sentation2011，22，： | 1 |
| 13 | Engineering of a NIR-activable hydrogel-coated mesoporous bioactive glass scaffold with dual-mode parathyroid hormone derivative release property for angiogenesis and bone regeneration显示文摘Osteogenesis,osteoclastogenesis,and angiogenesis play crucial roles in bone regeneration.Parathyroid hormone(PTH),an FDA-approved drug with pro-osteogenic,pro-osteoclastogenic and proangiogenic capabilities,has been employed for clinical osteoporosis treatment through systemic intermittent administration.However,the successful application of PTH for local bone defect repair generally requires the incorporation and delivery by appropriate carriers.Though several scaffolds have been developed to deliver PTH,they suffer from the weaknesses such as uncontrollable PTH release,insufficient porous structure and low mechanical strength.Herein,a novel kind of NIR-activable scaffold(CBP/MBGS/PTHrP-2)with dual-mode PTHrP-2(a PTH derivative)release capability is developed to synergistically promote osteogenesis and angiogenesis for high-efficacy bone regeneration,which is fabricated by integrating the PTHrP-2-loaded hierarchically mesoporous bioactive glass(MBG)into the N-hydroxymethylacrylamide-modified,photothermal agent-doped,poly(N-isopropylacrylamide)-based thermosensitive hydrogels through assembly process.Upon on/off NIR irradiation,the thermoresponsive hydrogel gating undergoes a reversible phase transition to allow the precise control of on-demand pulsatile and long-term slow release of PTHrP-2 from MBG mesopores.Such NIR-activated dual-mode delivery of PTHrP-2 by this scaffold enables a well-maintained PTHrP-2 concentration at the bone defect sites to continually stimulate vascularization and promote osteoblasts to facilitate and accelerate bone remodeling.In vivo experiments confirm the significant improvement of bone reparative effect on critical-size femoral defects of rats.This work paves an avenue for the development of novel dual-mode delivery systems for effective bone regeneration. | Shi Liu Zhengzhe Han Ji-Na Hao Dapeng Zhang Xianglong Li Yuanyuan Cao Jinghuan Huang Yongsheng Li | 2023 | Bioactive Materials2023，，8： | 1 |
| 14 | Polyether-grafted SnO2 nanoparticles designed for solid polymer electrolytes with long-term stability 显示文摘 | Xiong Huanming Liu Dapeng Zhang Hao | 2004 | J Mater Chem2004，14，18： | 1 |
| 15 | Single-cell transcriptome analysis reveals a cancer-associated fibroblast marker gene signature in hepatocellular carcinoma that predicts prognosis显示文摘Background and aims:Hepatocellular carcinoma(HCC)is one of the leading causes of cancer death.Multi-pathway combination therapy is used to treat HCC,and immunotherapy is also a routine part of treatment.As a major component of the tumor microenvironment(TME),cancer-associated fibroblasts(CAFs)actively participate in cancer progression through complex functions.However,because CAFs dynamically change during cancer development,most of the current treatment strategies targeting CAFs fail.We created a prognostic CAF marker gene signature(CAFMGS)to investigate the utility of CAFs as a prognostic factor and therapeutic target.Methods:Gene Expression Omnibus(GEO)single-cell RNA sequencing(Sc-RNA-seq)data were analyzed to identify CAF marker genes in HCC.The Cancer Genome Atlas(TCGA)database was used as a training cohort to construct the CAFMGS model and the International Cancer Genome Consortium(ICGC)dataset was used to validate the CAFMGS.Results:Marker genes in the CAFMGS model were(0.0001-SPP1),(0.0084-VCX3A),(0.0015-HMGA1),(0.0082-PLOD2),and(0.0075-CACYBP).The CAFMGS_score was separated into high-risk and low-risk groups based on the median of the patients’OS.Univariate and multivariate analyses confirmed that CAFMGS_score was an independent prognostic factor in the training group.CAFMGS_score was a more accurate prognostic indicator compared with clinicopathological score and tumor mutational burden score.Conclusion:CAFMGS offers a fresh perspective on stromal cell marker genes in HCC prognosis and expands our knowledge of CAF heterogeneity and functional diversity,perhaps paving the way for CAF-targeted immunotherapy in HCC patients. | Hao Chi Dapeng Chen Yuliang Zhang Zilin Cui Yi Bai Yamin Zhang | 2023 | iLIVER2023，2，1： | 0 |
| 16 | Construction and characterization of a humanized anti-human CD3 monoclonal antibody 12F6 with effective immunoregulation functions显示文摘 | Bohua Li Hao Wang Jianxin Dai Junjie Ji Weizhu Qian Dapeng Zhang Sheng Hou Yajun Guo | 2006 | 中国生物学文摘2006，20，1： | 0 |
| 17 | Effect of riboflavin deficiency on intestinal morphology,jejunum mucosa proteomics,and cecal microbiota of Pekin ducks显示文摘This study was to determine the effects of riboflavin deficiency(RD)on intestinal development,jejunum mucosa proteome,cecal short-chain fatty acids(SCFA)profiling,and cecal microbial diversity and community of starter Pekin ducks.Male white Pekin ducks(1 d old,n=240)were allocated into 2 groups,with 12 replicates and 10 birds per replicate in each group.For 21 d,all ducks had ad libitum access to either an RD or a riboflavin adequate(control,CON)diet,formulated by supplementing a basal diet with 0 or 10 mg riboflavin per kg of diet,respectively.Compared to the CON group,growth retardation,high mortality,and poor riboflavin status were observed in the RD group.Furthermore,RD reduced the villus height and the ratio of villus height to crypt depth of jejunum and ileum(P<0.05),indicating morphological alterations of the small intestine.In addition,dietary RD enhanced relative cecum weight and decreased cecal SCFA concentrations(P<0.05),including propionate,isobutyrate,butyrate,and isovalerate.The jejunum mucosa proteomics showed that 208 proteins were upregulated and 229 proteins were downregulated in the RD group compared to those in the CON group.Among these,RD mainly suppressed intestinal absorption and energy generation processes such as glycolysis and gluconeogenesis,fatty acid beta oxidation,tricarboxylic acid cycle,and oxidative phosphorylation,leading to impaired ATP generation.In addition,RD decreased the community richness and diversity of the bacterial community in the cecum of ducks.Specifically,RD reduced the abundance of butyrate-producing bacteria in the cecum(P<0.05),such as Eubacterium coprostanoligenes,Prevotella and Faecalibacterium.Dietary RD resulted in growth depression and intestinal hypofunction of Pekin ducks,which could be associated with impaired intestinal absorption and energy generation processes in intestinal mucosa,as well as gut microbiota dysbiosis.These findings contribute to our understanding of the mechanisms of intestinal hypofunction due to RD. | Yaxi Xu Bo Zhang Rui Zhao Kexin Gao Suyun Liang Yongbao Wu Yongsheng Hao Dapeng Liu Zhanbao Guo Jian Hu Zhengkui Zhou Ming Xie Jing Tang | 2023 | Animal Nutrition2023，，1： | 0 |
| 18 | Preparation of Quaternary FeCoMoCu Metal Oxides for Oxygen Evolution Reaction显示文摘Molybdenum doping is an effective way to improve the oxygen evolution reaction(OER)properties of catalysts,which can efficiently improve the electronic conductivity,mass transport process,and intrinsic activity of transition metal oxides or hydroxides,especially for those multi-component oxides with more abundant active sites.Herein,we have prepared a quaternary FeCoMoCu metal oxide on Cu foam(FeCoMoCuO_(x)@Cu)as an efficient OER catalyst.As expected,FeCoMoCuO_(x)@Cu could exhibit a low overpotential(252 mV at the current density of 10 mA/cm^(2))and exceptional stability(10000 cycles of CV scans or constant electrolysis for 48 h). | HAO Zhimin LIU Dapeng GE Huaiyun ZUO Xintao FENG Xilan SHAO Mingzhe YU Haohan YUAN Guobao ZHANG Yu | 2022 | Chemical Research in Chinese Universities2022，38，3： | 0 |
| 19 | Engineering nano-structures with controllable dimensional features on micro-topographical titanium surfaces to modulate the activation degree of M1 macrophages and their osteogenic potential显示文摘Modulating the activation state and degree of macrophages still remains as a challenge for the topographical design of Ti-based implants.In this work,micro/nano-structured coatings were prepared on Ti substrates by micro-arc oxidation(MAO)and subsequent hydrothermal(HT)treatment.By varying the HT conditions,plate-like nano-structures with an average length of 80,440 or 780 nm were obtained on MAO-prepared micro-topographical surfaces.Depending on the dimensional features of nano-plates,the specimens were noted as Micro,Micro/Nano-180,Micro/Nano-440 and Micro/Nano-780,respectively.The in vitro results showed that the activation state and degree of macrophages could be effectively modulated by the micro/nano-structured surfaces with various dimensional features.Compared to the Micro surface,the Micro/Nano-180 surface activated both M1 and M2 phenotype in macrophages,while the Micro/Nano-440 and Micro/Nano-780 surfaces polarized macrophages to their M1 phenotype.The activation degree of M1 macrophages followed the trend:Micro | Luxin Liang Qianli Huang Hong Wu Hao He Guanghua Lei Dapeng Zhao Kun Zhou | 2022 | Journal of Materials Science & Technology2022，，1： | 0 |
| 20 | Structure basis for the unique specificity of medaka enteropeptidase light chain显示文摘 | Jin Xu Shi Hu Xiaoze Wang Ziye Zhao Xinyue Zhang Hao Wang Dapeng Zhang Yajun Guo | 2014 | Protein & Cell2014，5，3： | 0 |
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