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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics显示文摘 | Fang B Zheng C Liao L Han Q Sun Z Jiang X Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 3 |
| 3 | Slurry phase Fischer-Tropsch synthesis over manganese-promoted iron ultrafine particle catalyst显示文摘 | BAI L XIANG H W LI Y W HAN Y Z ZHONG B | 2002 | Fuel2002，81，1112： | 1 |
| 4 | Value of soluble TREM-1 ,procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bac- teremia among sepsis patients with new fever in intensive care units : a prospective cohort study 显示文摘 | Su L Han B Liu C | 2012 | BMC Infect Dis2012，12，： | 1 |
| 5 | B io a v a ila b ility andpopulation pharm acokinetics o f voriconazole in lungtransplant recipien ts 显示文摘 | Han K C apitano B B ies R et a l | 2010 | Antimicrob Agents Chemother2010，54，10： | 1 |
| 6 | Association between MTHFD1 polymorphisms and neural tube defect susceptibility显示文摘 | Meng J Han L Zhuang B | 2015 | J Neurot Sci2015，348，12： | 1 |
| 7 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 8 | ART-KOHONEN neural network for fault diagnosis of rotating machinery显示文摘 | YANG B S HAN T AN J L | 2004 | Mechanical Systems and Signal Processing2004，18，3： | 1 |
| 9 | Flywheel energy and power storage systems显示文摘 | BJORN B HANS B MATS L | 2007 | Renewable and Sustainable Energy Reviews2007，11，： | 1 |
| 10 | Innovative food packaging solutions 显示文摘 | Brody A L Bugusu B Han J H | 2008 | Scientific Status Summary2008，73，8： | 1 |
| 11 | Distribution and pathogenicity of bacteria species carried by Bursaphelenchus xylophilus in China显示文摘 | Zhao B G Wang H L Han S F | 2003 | Nematology2003，5，6： | 1 |
| 12 | High-efficiency-sensitized solar cell with a novel co-adsorbent显示文摘 | Han L Y Islam A Chen H Malapaka C Chiranjeevi B Zhang S F Yang X D Yanagida M | | 0，，03： | 1 |
| 13 | Evaluation of management strategies for the operation of high-speed railways in China显示文摘 | Wong W G Han B M Ferreira L | 2002 | Transporta tion Research Part A2002，36，： | 1 |
| 14 | Microwave -assisited extraction of flawnoids from Radix Astragali 显示文摘 | XIAO W H HAN L J SHI B | 2008 | Separation and Purification Technology2008，62，： | 1 |
| 15 | Identification and characterization of Bphl4, a gene conferring resistance to brown planthopper in rice 显示文摘 | Du B Zhang W Liu B Hu J Wet Z Shi Z He R Zhu L Chen R Han B He G | 2009 | Proceedings of the National Academy of Sciences2009，106，22： | 1 |
| 16 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 17 | ART-KOHONEN Neural Network for Fault Diagnosis of Rotating Machinery显示文摘 | Yang B S Han T An J L | | 0，，03： | 1 |
| 18 | ln vitro inhibitory effect of triterpenoidal saponinsfrompatycodiradixonpancreaticlipase 显示文摘 | Xu B J Han L K Zheng Y n | 2005 | Arch PharmRes2005，28，2： | 1 |
| 19 | Modification and testing of a commercial sprayer with PWM solenoids for precision spraying显示文摘 | Han S Hendrickson L L Ni B | 2001 | Applied Engineering in Agriculture2001，17，5： | 1 |
| 20 | Attitudes toward making babies with a deceased partner's cryopreserved gametes显示文摘 | Hans J D l~)oley B | 2014 | Death Stud2014，38，610： | 1 |
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