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| 1 | Ethnicity association of Helicobacter pylori virulence genotype and metronidazole susceptibility显示文摘AIM:To characterise the cag pathogenicity island in Helicobacter pylori(H.pylori) isolates by analysing the strains' vacA alleles and metronidazole susceptibilities in light of patient ethnicity and clinical outcome.METHODS:Ninety-five H.pylori clinical isolates obtained from patients with dyspepsia living in Malaysia were analysed in this study.Six genes in the cagPAI region(cagE,cagM,cagT,cag13,cag10 and cag67) andvacA alleles of theH.pylori isolates were identified by polymerase chain reaction.The isolates' metronidazole susceptibility was also determined using the E-test method,and the resistant gene was characterised by sequencing.RESULTS:More than 90% of the tested isolates had at least one gene in the cagPAI region,and cag67 was predominantly detected in the strains isolated from the Chinese patients,compared with the Malay and Indian patients(P < 0.0001).The majority of the isolates(88%) exhibited partial deletion(rearrangement) in the cagPAI region,with nineteen different patterns observed.Strains with intact or deleted cagPAI regions were detected in 3.2% and 8.4% of isolates,respectively.The prevalence of vacA s1m1 was significantly higher in the Malay and Indian isolates,whereas the isolates from the Chinese patients were predominantly genotyped as vacA s1m2(P = 0.018).Additionally,the isolates from the Chinese patients were more sensitive to metronidazole than the isolates from the Malay and Indian patients(P = 0.047).Although we attempted to relate the cagPAI genotypes,vacA alleles and metronidazole susceptibilities to disease outcome,no association was observed.The vacA alleles were distributed evenly among the strains with intact,partially deleted or deleted cagPAI regions.Interestingly,the strains exhibiting an intact cagPAI region were sensitive to metronidazole,whereas the strains with a deleted cagPAI were more resistant.CONCLUSION:Successful colonisation by different H.pylori genotypes is dependent on the host's genetic makeup and may play an important role in the clinical outcome. | Hanafiah Alfizah Awang Hamat Rukman Ahmad Norazah Razlan Hamizah Mohamed Ramelah | 2013 | World Journal of Gastroenterology2013，19，8： | 2 |
| 2 | Direct ethoxylation of fatty methylester over Al-Mg composite oxide catalyst显示文摘 | Hamat Okamoto Hidaie Yamada Y | 1997 | Journal of the American Oil Chemists''Society1997，74，： | 1 |
| 3 | 显示文摘 | Brown P R Takechi K Hamat P V | 2008 | Phys Chern C2008，112，12： | 1 |
| 4 | Finite-element simulation of the elliptical cup deep drawing process by sheet hydroforming显示文摘 | HAMAT HATAKEYAMA T ASAKAWA M | 2007 | Finite Elements in Analysis and Design2007，43，3： | 1 |
| 5 | Ignition and detonation of solid explosives: A micromechanical burn model显示文摘 | Hamate Y Horie Y | 2006 | Shock Waves2006，16，2： | 1 |
| 6 | Nitrate reductase induction and molecular characterization in rice (Oryza sativa L.)显示文摘 | Halim B. Hamat Andris Kleinhofs Robert L. Warner | 1989 | MGG Molecular & General Genetics1989，，1： | 1 |
| 7 | Extremely high prevalence of an- tiseptic resistant Quaternary Ammonium Compound E gene among clinical isolates of multiple drug resistant Acinetobactcr baumannii in Malaysia显示文摘 | Babaei M Sulong A Hamat R | 2015 | Ann Clin Microbiol Antimicrob2015，14，1： | 1 |
| 8 | Hybrid fiber-to-the-x and free space optics for high bandwidth access networks显示文摘 | Anas S.B Ahmad Hamat F.H Hitam S | | 0，，01： | 1 |
| 9 | Methicillin-susceptible and -resistant Staphylococcus aureus with high-level antiseptic and low-level mupirocin resistance in Malaysia显示文摘 | GHASEMZADEH-MOGHADDAM H VAN BELKUM A HAMAT RA | 2014 | Microb Drug Resist2014，20，5： | 1 |
| 10 | High prevalence of qacA/B carriage among clinical isolates of meticillinresistant Staphylococcus aureus in Malaysia显示文摘 | Shamsudin MN Alreshidi MA Hamat RA | 2012 | J Hosp Infect2012，81，3： | 1 |
| 11 | Apoptosis in target organs ofhypertention显示文摘 | Hamat P Richard L Dam TV | 1995 | Hypertention1995，26，4： | 1 |
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