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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Cement production technology improvement compared to factor 4 objectives显示文摘 | Habert G Billard C Rossi P | | 0，，05： | 1 |
| 3 | Development of a HTRF kinase assay for determination of Syk activ- ity显示文摘 | HABERT C MARSHALL J SOH S | 2008 | Curr ChemGenomics2008，，1： | 1 |
| 4 | Cement production technology improvement compared to factor 4 objectives显示文摘 | Habert G Billard C Rossi P | 2010 | Cement and Concrete Research2010，40，5： | 1 |
| 5 | Membrane formation mechanism based on precipitation kinetics and membrane morphology: flat and hollow fiber polysulfone membranes显示文摘 | Habert A C Borges C P 1999 | 1999 | J Membr Sci1999，155，： | 1 |
| 6 | Membrane formation mechanism based on precipitation kinetics and membrane morphology:Flat and hollow fiber polysulfone membranes显示文摘 | Machado P S T Habert A C Borges C P | 1999 | JMembr Sci1999，155，： | 1 |
| 7 | Membrane formation mechanism based on precipitation kinetics and membrane morphology:flat and hollow fiber polysulfone membranes显示文摘 | Machado P S T Habert A C Borges C P | 1999 | J Membrane Sci1999，155，2： | 1 |
| 8 | Expression of type Ⅰ and type Ⅱ receptors for transforming growth factor beta in the adult rat testis显示文摘 | PAIRAULT C HABERT R | 1998 | Histochem Cell Biol1998，110，6： | 1 |
| 9 | Expression of type Ⅰ and Ⅱ receptors for transforming growth factor beta in the adult rat testis显示文摘 | Olaso R Pairault C Habert R | 1998 | Histochem Cell Biol1998，110，： | 1 |
| 10 | Membrane formation mechanism based on precipitation kinetics and membrane morpholo- gy: fiat and hollow fiber polysulfone membranes显示文摘 | MACHADO P S T HABERT A C BORGES C P | 1999 | J Membr Sci1999，155，2： | 1 |
| 11 | Development of the foe- tal and neonatal testis显示文摘 | Rouiller-Fabre V Levacher C Habert R | 2003 | Andrologia2003，35，1： | 1 |
| 12 | Estrogen effects on fetal and neonatal testicular development 显示文摘 | Delb~s G Levacher C Habert R | 2006 | Reproduction2006，132，4： | 1 |
| 13 | Membrane formation mechanism based on precipitation kinetics and membrane morphology 显示文摘 | Machado P S T Habert A C Borges C P | 1999 | J Membr Sci1999，155，： | 1 |
| 14 | An insertion/deletion polymorphism in the angiotensin Ⅰ-converting enzyme gene accounting for half the variance of serum enzyme levels显示文摘 | RIGAT B HABERT C ALHENC-GELAS F | 1990 | JClinlnvest1990，86，4： | 1 |
| 15 | Estrogen effects on fetal and neonatal testicular development 显示文摘 | Delbe's G Levache C Habert R | 2006 | Reproduction2006，132，： | 1 |
| 16 | Effects of estrogens on the development of the testis during fetal and neonatal life 显示文摘 | Habert R Delbes G Duquenne C | 2006 | Gyn cologie Obst trique & Fertilit2006，34，： | 1 |
| 17 | Regulation of the proliferation of cocultured gonocytes and sertoli cells by retinoids,triiodothyronine,and intracellular signaling factors:differences between fetal and neonatal cells显示文摘 | Boulogne B Habert R Levacher C | | 0，，02： | 1 |
| 18 | compounds recovery of tropical fruit juice by pervaporaticn:Membrane material selection and process evaluation 显示文摘 | Pereira C C Rufino J R M Habert A C | 2005 | J Food Eng2005，66，1： | 1 |
| 19 | Optimizing the managementof depression:primary care experience显示文摘 | CAMERON C HABERT J ANAND L | 2014 | Psychiatry Res2014，220，1： | 1 |
| 20 | Membrane formation mechanism based on precipitation kinetics and membrane morphology:flat and hollow fiber polysulfone membranes显示文摘 | Machado P S T Habert A C Borges C P | 1999 | Journal of Membrane Science1999，155，2： | 1 |
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