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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Developmental changes in in vitro testoster-one production by dispersed Leydig cells during fetal life in rats显示文摘 | Habert R Brignaschi P | 1991 | Arch Androl1991，27，2： | 1 |
| 3 | Falling-film evaporation on tube bundle with plain and enhanced tubes - Part I: Experimental results显示文摘 | Habert M Thome J R | 2010 | Experimental Heat Transfer2010，23，4： | 1 |
| 4 | Developmental changes in in vitro testosterone production by dispersed Leydig cells during fetal life in rats显示文摘 | Habert R Brignaschi P | 1991 | Arch Androl1991，27，2： | 1 |
| 5 | Origin, proliferation and differ- entiation of Leydig cells 显示文摘 | Lejeune H Habert R Saez JM | 1998 | J Mol Endocrinol1998，20，1： | 1 |
| 6 | Development of fetal testicular cells in androgen receptor deficient mice 显示文摘 | Merlet J Moreau E Habert R | 2007 | Cell Cycle2007，6，18： | 1 |
| 7 | Adverse effects of endocrine disruptors on the foetal testis development : focus on the phthalates显示文摘 | Habert R Muczynski V Lehraiki A | 2009 | Folia Histochem Cytobiol2009，47，5： | 1 |
| 8 | Expression of type Ⅰ and type Ⅱ receptors for transforming growth factor beta in the adult rat testis显示文摘 | PAIRAULT C HABERT R | 1998 | Histochem Cell Biol1998，110，6： | 1 |
| 9 | Adverse effects of endocrine disruptors on the foetal testis development: focus on the phthalates显示文摘 | Habert R Muczynski V Lehraiki A | 2009 | Folia Histochem Cytobiol2009，47，5： | 1 |
| 10 | Expression of type Ⅰ and Ⅱ receptors for transforming growth factor beta in the adult rat testis显示文摘 | Olaso R Pairault C Habert R | 1998 | Histochem Cell Biol1998，110，： | 1 |
| 11 | Development of the foe- tal and neonatal testis显示文摘 | Rouiller-Fabre V Levacher C Habert R | 2003 | Andrologia2003，35，1： | 1 |
| 12 | Estrogen effects on fetal and neonatal testicular development 显示文摘 | Delb~s G Levacher C Habert R | 2006 | Reproduction2006，132，4： | 1 |
| 13 | Ontogenesis of thein vitro response of rat testis to gonadotropin-releasing hor-mone 显示文摘 | Habert R Devif I Gangnerau M N | 1991 | Mol Cell EndocrinoU1991，82，23： | 1 |
| 14 | Estrogen effects on fetal and neonatal testicular development 显示文摘 | Delbe's G Levache C Habert R | 2006 | Reproduction2006，132，： | 1 |
| 15 | Retinoid receptors involved in the effects of retinoic acid on rat testis development显示文摘 | Livera G Rouiller-Fabre V Habert R | 2001 | Biol Reprod2001，64，： | 1 |
| 16 | Effects of estrogens on the development of the testis during fetal and neonatal life 显示文摘 | Habert R Delbes G Duquenne C | 2006 | Gyn cologie Obst trique & Fertilit2006，34，： | 1 |
| 17 | Nutrient removal in the reed bed system显示文摘 | Habert R Perfler R | 1991 | Wat Sci Tech1991，23，46： | 1 |
| 18 | Time- and dose-related effects of estradiol and diethylstilbestrol on the morphology and function of the fetal rat testis in culture 显示文摘 | LASSURGUt~RE J LIVERA G HABERT R | 2003 | ToxicolSci2003，73，1： | 1 |
| 19 | Developmental changes in in vitro testosterone production by dispersed Leydig cells during fetal life in rats显示文摘 | Habert R Brignaschi P | 1991 | Arch Androl1991，27，2： | 1 |
| 20 | Regulation of the proliferation of cocultured gonocytes and sertoli cells by retinoids,triiodothyronine,and intracellular signaling factors:differences between fetal and neonatal cells显示文摘 | Boulogne B Habert R Levacher C | | 0，，02： | 1 |
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