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| 1 | A tale of worldwide success:Behind the scenes of Carex(Cyperaceae)biogeography and diversification显示文摘The megadiverse genus Carex(c.2000 species,Cyperaceae)has a nearly cosmopolitan distribution,displaying an inverted latitudinal richness gradient with higher species diversity in cold-temperate areas of the Northern Hemisphere.Despite great expansion in our knowledge of the phylogenetic history of the genus and many molecular studies focusing on the biogeography of particular groups during the last few decades,a global analysis of Carex biogeography and diversification is still lacking.For this purpose,we built the hitherto most comprehensive Carex-dated phylogeny based on three markers(ETS-ITS-matK),using a previous phylogenomic Hyb-Seq framework,and a sampling of two-thirds of its species and all recognized sections.Ancestral area reconstaiction,biogeographic stochastic mapping,and diversification rate analyses were conducted to elucidate macroevolutionary biogeographic and diversification patterns.Our results reveal that Carex originated in the late Eocene in E Asia,where it probably remained until the synchronous diversification of its main subgeneric lineages during the late Oligocene.E Asia is supported as the cradle of Carex diversification,as well as a< | Santiago Martin-Bravo Pedro Jimenez-Mejias Tamara Villaverde Marcial Escudero Marlene Hahn Daniel Spalink Eric H.Roalson Andrew L.Hipp the Global Carex Group Carmen Benitez-Benitez Leo P.Bruederle Elisabeth Fitzek Bruce A.Ford Kerry A.Ford Mira Gamer Sebastian Gebauer Matthias H.Hoffmann Xiao-Feng Jin Isabel Larridon Etienne Ldveilld-Bourret Yi-Fei Lu Modesto Luceno Enrique Maguilla Jose Ignacio Marquez-Corro Monica Miguez Robert Naczi Anton A.Reznicek Julian R.Starr | 2019 | Journal of Systematics and Evolution2019，57，6： | 6 |
| 2 | Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases显示文摘Excessive release of neutrophil extracellular traps(NETs)is associated with disease severity and contributes to tissue injury,followed by severe organ damage.Pharmacological or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models,indicating that NETs are potential therapeutic targets.Here,we demonstrate using a preclinical basket approach that our therapeutic anti-citrullinated protein antibody(tACPA)has broad therapeutic potential.Treatment with tACPA prevents disease symptoms in various mouse models with plausible NET-mediated pathology,including inflammatory arthritis(IA),pulmonary fibrosis,inflammatory bowel disease and sepsis.We show that citrulline residues in the N-termini of histones 2A and 4 are specific targets for therapeutic intervention,whereas antibodies against other N-terminal post-translational histone modifications have no therapeutic effects.Because citrullinated histones are generated during NET release,we investigated the ability of tACPA to inhibit NET formation.tACPA suppressed NET release from human neutrophils triggered with physiologically relevant human disease-related stimuli.Moreover,tACPA diminished NET release and potentially initiated NET uptake by macrophages in vivo,which was associated with reduced tissue damage in the joints of a chronic arthritis mouse model of IA.To our knowledge,we are the first to describe an antibody with NET-inhibiting properties and thereby propose tACPA as a drug candidate for NET-mediated inflammatory diseases,as it eliminates the noxious triggers that lead to continued inflammation and tissue damage in a multidimensional manner. | Renato G.S.Chirivi Jos W.Gvan Rosmalen Maarten van der Linden Maximilien Euler Gonny Schmets Galina Bogatkevich Konstantinos Kambas Jonas Hahn Quinte Braster Oliver Soehnlein Markus H.Hoffmann Helmuth H.Gvan Es Jos M.H.Raats | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 3 | A framework infrageneric classification of Carex (Cyperaceae) and its organizing principles显示文摘Phylogenetic studies of Carex L.(Cyperaceae)have consistently demonstrated that most subgenera and sections are para-or polyphyletic.Yet,taxonomists continue to use subgenera and sections in Carex classification.Why?The Global Carex Group(GCG)here takes the position that the historical and continued use of subgenera and sections serves to(i)organize our understanding of lineages in Carex,(ii)create an identification mechanism to break the~2000 species of Carex into manageable groups and stimulate its study,and(iii)provide a framework to recognize morphologically diagnosable lineages within Carex.Unfortunately,the current understanding of phylogenetic relationships in Carex is not yet sufficient for a global reclassification of the genus within a Linnean infrageneric(sectional)framework.Rather than leaving Carex classification in its current state,which is misleading and confusing,we here take the intermediate steps of implementing the recently revised subgeneric classification and using a combination of informally named clades and formally named sections to reflect the current state of our knowledge.This hybrid classification framework is presented in an order corresponding to a linear arrangement of the clades on a ladderized phylogeny,largely based on the recent phylogenies published by the GCG.It organizes Carex into six subgenera,which are,in turn,subdivided into 62 formally named Linnean sections plus 49 informal groups.This framework will serve as a roadmap for research on Carex phylogeny,enabling further development of a complete reclassification by presenting relevant morphological and geographical information on clades where possible and standardizing the use of formal sectional names. | Eric H.Roalson Pedro Jiménez-Mejías Andrew L.Hipp Carmen Benítez-Benítez Leo P.Bruederle Kyong-Sook Chung Marcial Escudero Bruce A.Ford Kerry Ford Sebastian Gebauer Berit Gehrke Marlene Hahn Muhammad Qasim Hayat Mathias H.Hoffmann Xiao-Feng Jin Sangtae Kim Isabel Larridon Étienne Léveillé-Bourret Yi-Fei Lu Modesto Luceño Enrique Maguilla Jose IgnacioMárquez-Corro Santiago Martín-Bravo Tomomi Masaki Mónica Míguez Robert F.C.Naczi Anton A.Reznicek Daniel Spalink Julian R.Starr Uzma Tamara Villaverde Marcia J.Waterway Karen L.Wilson and Shu-Ren Zhang | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
| 4 | 贯穿于生产过程中的有效的流程仿真显示文摘作为支持制定企业计划的手段,仿真显得越来越重要。通过在项目中的应用,成功的流程仿真使用者可以使投资总额节约5%~10%。改进计划质量显著地提高了计划的可靠性。 | N.Griffel H.Hoffmann 李亮 | 1999 | 工业工程与管理1999，4，5： | 2 |
| 5 | 查看详情显示文摘 | H.Rehage H.Hoffmann | | 0，，： | 1 |
| 6 | 两亲分子溶液聚集体结构的冷冻刻饰电子显微镜研究显示文摘利用冷冻刻饰电子显微镜(FF-TEM)技术研究了两亲分子溶液不同有序聚集体的结构,特别对一些两亲分子溶液体系形成的泡囊结构进行了详细的研究,探讨了聚集体结构的演变规律。对无剪切力下化学反应诱导L_3-相(海绵相)到层状Lα-相,手振荡层状Lα-相到多双层泡囊相及高剪切力作用下多双层泡囊相到单双层泡囊相的结构演变进行了冷冻刻饰电子显微镜追踪研究。首次报道了Zn^(2+)诱导的单链长表面活性剂溶液中泡囊相的形成。 | 郝京诚 黄建滨 徐桂英 郑利强 刘维民 H.Hoffmann | 2003 | 中国科学(B辑)2003，33，4： | 1 |
| 7 | Freeze-fracture transmission electron microscopy studies on the self-assemblies of amphiphilic solutions显示文摘Self-assemblies of amphiphiles in solutions were investigated by using freeze-fracture transmission electron microscopy(FF-TEM). Especially, vesicles were characterized by FF-TEM and the transition of self-assemblies was determined. The stacked lamellar Lα-phase was prepared without shear forces by a chemical reaction. The stacked lamellar Lα-phase can be transformed into multilamellar vesicles by the shearing forces that occur when the stacked lamellar Lα-phase sample is turned upside down a few times. The multilamellar vesicles can also be transformed into unilamellar vesicles by high shearing forces. These transitions were demonstrated by FF-TEM measurements. Zn2+-induced vesicle formation in the single-chain surfactant solutions was first achieved. | 郝京诚 黄建滨 徐桂英 郑利强 刘维民 H.Hoffmann | 2003 | Science China Chemistry2003，46，6： | 1 |
| 8 | Prevalence of extended‐spectrum β‐lactamases in isolates of the Enterobacter cloacae complex from German hospitals显示文摘 | H.Hoffmann E.Stürenburg J.Heesemann A.Roggenkamp | 2006 | Clinical Microbiology and Infection2006，，4： | 1 |
| 9 | The innovation impact of the EU Emission Trading System-Findings of company case studies in the German power sector显示文摘 | Karoline S.Rogge Malte Schneider Volker H.Hoffmann | | 0，，70： | 1 |
| 10 | Effects of regulatory uncertainty on corporate strategy-an analysis of firms' responses to uncertainty about post-Kyoto policy显示文摘 | CHRISTIAN ENGAU VOLKER H.HOFFMANN | | 0，，12： | 1 |
| 11 | A taxonomy for regulatory uncertainty-application to the European emission trading scheme显示文摘 | VOLKER H.HOFFMANN THOMAS TRAUTMANN MALTE SCHNEIDER | | 0，，11： | 1 |
| 12 | Corporate response strategies to regulatory uncertainty:evidence from uncertainty about post-Kyoto regulation显示文摘 | CHRISTIAN ENGAU VOLKER H.HOFFMANN | | 0，，44： | 1 |
| 13 | 应用多层CT观察他汀类药物治疗对冠状动脉粥样硬化的影响显示文摘目的应用多层CT(MDCT)冠状动脉血管成像,可以无创性评估非钙化性、钙化性和混合性斑块。冠状动脉斑块的发展可能会受到他汀类药物的影响。 | H.Hoffmann K.Frieler P.Schlattmann B.Hamm M.Dewey 华锐 | 2011 | 国际医学放射学杂志2011，，1： | 0 |
| 14 | 高选择性树脂和特殊处理工艺在水和溶液软化中的应用显示文摘目前,对水和冷凝液软化的特殊处理过程正向降低消耗和简化操作的方向发展;咸水、海水及采油回收水的软化,对树脂的高选择性提出了特殊的要求;尤其是饱和盐卤的除钙,要达到检测限度,树脂的任务就更艰巨了。糖溶液的软化是个特殊的领域。Cryllns过程巧妙地避免使用其他再生药物。有些糖汁软化工厂还增加了逆流软化床。 | H.HOffmann F.Martinolra 张贵珠 | 1989 | 净水技术1989，7，4： | 0 |
| 15 | Geographical vs. ecological diversification in Carex section Phacocystis (Cyperaceae): Patterns hidden behind a twisted taxonomy显示文摘Carex section Phacocystis(Cyperaceae)is one of the most diverse and taxonomically complex groups of sedges(between 116 and 147 species),with a worldwide distribution in a wide array of biomes.It has a very complicated taxonomic history,with numerous disagreements among different treatments.We studied the biogeography and niche evolution in a phylogenetic framework to unveil the relative contribution of geographical and ecological drivers to diversification of the group.We used a large species sampling of the section(82%of extant species)to build a phylogeny based on four DNA regions,constrained with a phylogenomic HybSeq tree and dated with six fossil calibrations.Our phylogenetic results recovered section Phacocystis s.s.(core Phacocystis)as sister to section Praelongae.Ancestral area reconstruction points toward the N Pacific as the cradle for the crown diversification of section Phacocystis during the Middle Miocene.Wide distributions were recurrently inferred across deep nodes.Large Northern Hemisphere lineages with geographical congruence were retrieved,pointing toward the importance of allopatric divergence at deep phylogenetic levels,whereas within-area speciation emerges as the predominant pattern at shallow phylogenetic level.The Southern Hemisphere(Neotropics,SW Pacific)was colonized several times from the Northern Hemisphere.The global expansion of Carex section Phacocystis did not entail major ecological changes along the inner branches of the phylogeny.Nevertheless,ecological differentiation seems to gain importance toward recent times. | Carmen Benitez-Benitez Santiago Martin-Bravo Charlotte S.Bjora Sebastian Gebauer Andrew L.Hipp Matthias H.Hoffmann Modesto Lucefio Tyril M.Pedersen Anton Reznicek Eric Roalson Polina Volkova Okihito Yano Daniel Spalink Pedro Jimenez-Mejias | 2021 | Journal of Systematics and Evolution2021，59，4： | 0 |
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