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| 1 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 2 | Urodynamic assessment of bladder storage function after radical hysterectomy for cervical cancer显示文摘Background:After radical hysterectomy for cervical cancer,the most common complication is lower urinary tract symptoms.Post-operatively,bladder capacity can alter bladder function for a prolonged period.This study aimed to identify factors affecting bladder storage function.Methods:A multicenter,retrospective cohort study was conducted.Information of patients with stages IA2 to IIB cervical cancer with urodynamic study results were retrospectively collected from nine hospitals between June 2013 and June 2018 according to the inclusion criteria.Demographic,surgical,and oncological data were collected.The univariate and multivariate logistic regression was used to identify clinical factors associated with bladder storage function.Results:Two hundred and three patients with cervical cancer had urodynamic testing post-operatively.Ninety-five(46.8%)patients were diagnosed with stress urinary incontinence(SUI).The incidence of low bladder compliance(LBC)was 23.2%.Twenty-seven(13.3%)patients showed detrusor overactivity(DO).Fifty-seven patients(28.1%)presented with a decreased maximum cystometric capacity(DMCC).The probability of composite bladder storage dysfunction was 68.0%.Multivariate analysis confirmed that laparoscopy represents a protective factor for SUI with an odds ratio of 0.498(P=0.034).Patients who underwent a nerve-sparing procedure were less odds to experience SUI(P=0.014).A significant positive correlation between LBC and DO was observed(P<0.001).A greater length of the resected vagina and chemoradiotherapy were common risk factors for LBC and DO,while radiotherapy exerted a stronger effect than chemotherapy.Additionally,patients who received chemoradiotherapy frequently developed a DMCC.The follow-up time was not correlated with bladder storage function.Conclusion:A nerve-sparing procedure without longer resected vagina is recommended for protecting the bladder storage function. | Ting-Ting Cao Hong-Wu Wen Yu-Nong Gao Qiu-Bo Lyu Hui-Xin Liu Sha Wang Shi-Yan Wang Hua-Xin Sun Na Yu Hai-Bo Wang Yi Li Zhi-Qi Wang Olivia H.Chang Xiu-Li Sun Jian-Liu Wang | 2020 | Chinese Medical Journal2020，，19： | 7 |
| 3 | Effect of Mo on microstructural characteristics and coarsening kinetics of γ' precipitates in Co–Al–W–Ta–Ti alloys显示文摘The solvus temperature,volume fraction,coarsening behavior of Y' precipitates and the partitioning behavior of alloying elements as well as lattice misfit of Y/Y' phases influence the creep behavior of Ni-and Co-base superalloys.However,few investigations about the microstructural characteristics and the coarsening behavior of Y' precipitates were reported in multicomponent novel Co-base superalloys during thermal exposure.Two alloys containing different contents of molybdenum and tungsten have been investigated to explore the effect of molybdenum on Y' solvus temperature,Y + Y' microstructure and Y' coarsening in Co–Al–W–Ta–Ti-base alloys.The results showed that the Y' solvus temperature decreases with the addition of Mo.Mo addition reduces the Y' volume fractions after aging above 1000?C,but results in negligible influence on the Y' volume fractions aging at 900?C.Meanwhile,Y' coarsening is controlled by diffusion in experimental alloys after aging at 900?C and 1000?C,and the kinetics of Y'growth in experimental alloys are consistent with the predictions of LSW theory. | H.J.Zhou F.Xue H.Chang Q.Feng | 2018 | Journal of Materials Science & Technology2018，34，5： | 6 |
| 4 | Temporal features of magnetic resonance imaging and spectroscopy in non‐ketotic hyperglycemic chorea‐ballism patients显示文摘 | K. ‐H.Chang J. ‐C.Tsou S. ‐T.Chen L. ‐S.Ro R. ‐K.Lyu H. ‐S.Chang W. ‐C.Hsu C. ‐M.Chen Y. ‐R.Wu C. ‐J.Chen | 2010 | European Journal of Neurology2010，，4： | 1 |
| 5 | Impact of hepatitis C virus infection and other comorbidities on survival in patients on dialysis显示文摘 | A. A.Butt M.Skanderson K. A.McGinnis T.Ahuja C. L.Bryce A. E.Barnato C.‐C. H.Chang | 2007 | Journal of Viral Hepatitis2007，，10： | 1 |
| 6 | FK506 promotes melanocyte and melanoblast growth and creates a favourable milieu for cell migration via keratinocytes: possible mechanisms of how tacrolimus ointment induces repigmentation in patients with vitiligo显示文摘 | C‐C.E.Lan G‐S.Chen M‐H.Chiou C‐S.Wu C‐H.Chang H‐S.Yu | 2005 | British Journal of Dermatology2005，，3： | 1 |
| 7 | China's Policy Toward Iran:Arms for Oil显示文摘 | Parris H.Chang | | 0，，21： | 1 |
| 8 | A generalized double diamond approach to the global competitiveness of Korea and Singapore显示文摘 | Moon H.Chang A.M.Rugmau A.Verbeke | | 0，，07： | 1 |
| 9 | 难治性弥漫性大B细胞淋巴瘤临床结局:一项来自中国的多中心真实世界研究显示文摘背景与目的对以利妥昔单抗为基础的免疫化疗耐药的弥漫性大B细胞淋巴瘤(diffuse large B-celllymphoma,DLBCL)的患者预后较差。目前难治性DLBCL的定义仍存在争议,并缺少亚洲国家大样本队列研究的数据。为确定中国难治性DLBCL的定义及疾病结局,我们开展了这项多中心回顾性队列研究。方法利用来自中国8个中心的真实世界数据,进行了难治性DLBCL治疗反应的回顾性分析(REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL,REAL-TREND)。接受根治性化疗的DLBCL患者被纳入REAL-TREND数据集。用Kaplan-Meier法估计患者总生存(overallsurvival,OS),并用log-rank检验进行组间比较。由于不同研究中心之间的治疗缓解率存在差异,用随机效应模型对难治性患者的缓解率进行了汇总分析。用Cox回归模型进行多因素生存分析。结果2010年1月至2015年12月间确诊的、共2778例DLBCL患者被纳入本研究。对之前文献报道的定义进行验证后,SCHOLAR-1研究的定义适合界定难治性DLBCL。难治性患者的估计5年累积发生率为20%[95%置信区间(confidence interval,CI):18%–22%]。确定为难治性疾病后,总缓解率及完全缓解率分别为30%(95%CI:22%–38%)和9%(95%CI:4%–15%)。对免疫化疗无反应或干细胞移植后12个月以内复发的患者生存较差,中位OS为5.9个月(95%CI:5.5–7.1),2年OS率为16%(95%CI:12%–20%)。独立的不良预后因素包括国际预后评分4–5[风险比(hazard ratio,HR)=2.22;95%CI:1.47–3.35]、中枢神经系统复发(HR=1.43;95%CI:1.04–1.97)及最佳缓解状态(部分缓解,HR=2.68,95%CI:1.42–5.03;疾病稳定/疾病进展,HR=5.97,95%CI:3.21–11.11)。结论本研究是针对难治性DLBCL的第一个大样本亚洲队列研究。证实SCHOLAR-1研究中的难治性DLBCL定义筛选出的患者,预后最差,因此适用于作为难治性DLBCL的筛选标准。由于在利妥昔单抗时代的临床治疗结局较差,难治性DLBCL患者仍需新的治疗策略。 | 王硕 王黎 胡建达 钱文斌 张曦 胡豫 朱琦 陈波斌 吴德沛 Chung-Chou H.Chang 许彭鹏 郑晓云 韦菊英 刘耀 崔国惠 唐勇 马燕 黄海雯 易红梅 赵维莅 | 2021 | 癌症2021，40，12： | 1 |
| 10 | The surgical significance of residual mucosal abnormalities in rectal cancer following neoadjuvant chemoradiotherapy显示文摘 | F. M.Smith K. H.Chang K.Sheahan J.Hyland P. R.O’Connell D. C.Winter | 2012 | Br J Surg2012，，7： | 1 |
| 11 | Long-term effects of PM_(2.5) components on incident dementia in the northeastern United States显示文摘Growing evidence has linked long-term fine particulate matter(PM_(2.5))exposure to neurological disorders.Less is known about the individual effects of PM_(2.5) components.A population-based cohort study investigated the association between long-term(1-year average)exposure to PM_(2.5) components and dementia incidence among the elderly population(age,R65 years)in the United States. | Jing Li Yifan Wang Kyle Steenland Pengfei Liu Aaron van Donkelaar Randall V.Martin Howard H.Chang W.Michael Caudle Joel Schwartz Petros Koutrakis Liuhua Shi | 2022 | The Innovation2022，3，2： | 1 |
| 12 | Urban Air Pollution May Enhance COVID-19 Case-Fatality and Mortality Rates in the United States显示文摘BACKGROUND The novel human coronavirus disease 2019(COVID-19)pandemic has claimed more than 600,000 lives worldwide,causing tremendous public health,social,and economic damages.Although the risk factors of COVID-19 are still under investigation,environmental factors,such as urban air pollution,may play an important role in increasing population susceptibility to COVID-19 pathogenesis.METHODS We conducted a cross-sectional nationwide study using zero-inflated negative binomial models to estimate the association between longterm(2010–2016)county-level exposures to NO2,PM2.5,and O3 and county-level COVID-19 case-fatality and mortality rates in the United States.We used both single-and multi-pollutant models and controlled for spatial trends and a comprehensive set of potential confounders,including state-level test positive rate,county-level health care capacity,phase of epidemic,population mobility,population density,sociodemographics,socioeconomic status,race and ethnicity,behavioral risk factors,and meteorology.RESULTS From January 22,2020,to July 17,2020,3,659,828 COVID-19 cases and 138,552 deaths were reported in 3,076 US counties,with an overall observed case-fatality rate of 3.8%.County-level average NO2 concentrations were positively associated with both COVID-19 case-fatality rate and mortality rate in single-,bi-,and tri-pollutant models.When adjusted for co-pollutants,per interquartile-range(IQR)increase in NO2(4.6 ppb),COVID-19 case-fatality rate and mortality rate were associated with an increase of 11.3%(95%CI 4.9%–18.2%)and 16.2%(95%CI 8.7%–24.0%),respectively.We did not observe significant associations between COVID-19 case-fatality rate and long-term exposure to PM2.5 or O3,although per IQR increase in PM2.5(2.6 mg/m3)was marginally associated,with a 14.9%(95%CI 0.0%–31.9%)increase in COVID-19 mortality rate when adjusted for co-pollutants.DISCUSSION Long-term exposure to NO2,which largely arises from urban combustion sources such as traffic,may enhance susceptibility to severe COVID-19 outcomes,independent of long-termPM2.5 and O3 exposure.The results support targeted public health actions to protect residents from COVID-19 in heavily polluted regions with historically high NO2 levels.Continuation of current efforts to lower traffic emissions and ambient air pollution may be an important component of reducing population-level risk of COVID-19 case fatality and mortality. | Donghai Liang Liuhua Shi Jingxuan Zhao Pengfei Liu Jeremy A.Sarnat Song Gao Joel Schwartz Yang Liu Stefanie T.Ebelt Noah Scovronick Howard H.Chang | 2020 | The Innovation2020，1，3： | 1 |
| 13 | RIPRAP STABILITY ON STEEP SLOPES显示文摘RIPRAPSTABILITYONSTEEPSLOPESHowardH.CHANG1ABSTRACTSteepchannelslopesareoftenlinedwithriprapasaprotectionagainstpotentialerosi... | Howard H.CHANG 1 | 1998 | International Journal of Sediment Research1998，13，2： | 0 |
| 14 | Plasticity Enhancement Processes in NiAl and MoSi_2显示文摘This paper demonstrates that plasticity enhancement processes previously observed in bcc metalsand associated with the presence of surface films and precipitates or dispersoids are operative in or-dered intermetallic compounds.’ Some specific results are given for NiAl-and MoSi2-basedmaterials.The plasticity of NiAl and related B2 ordered alloys at room temperature during monotonicdeformation can be enhanced by application of surface films such as electroless nickel platings.Sig-nificant effects are also observed during cyclic deformation.The presence of ductile second phasessuch as fcc γ or the ordered phase γ’ introduced by alloying also enhances the plasticity of NiAl.MoSi2 exhibits similar effects of surface films and second phases,but primarily at elevated tempera-tures,T>900℃.In this paper,we illustrate the effects of ZrO2 surface films deposited near roomtemperature and TiC particulate additions introduced by powder processing techniques.In all cases,the plasticity enhancement is associated with enhanced dislocation generation processes under theconditions of constrained deformation at the film-substrate or precipitate/dispersoid-matrix inter-face of the composite system. | R.Gibala H.Chang C.M.Czarnik K.M.Edwards A.Misra Department of Materials Science and Engineering,University of Michigan,Ann Arbor,Michigan 48109-2136,USA | 1993 | Journal of Materials Science & Technology1993，9，6： | 0 |
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