|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Proteomic analysis of human epithelial ovarian cancer xenografts in immunodeficient mice exposed to chronic psychological stress显示文摘This work aims at comparing alterations in the proteomes of human epithelial ovarian cancer xenografts between stressed and non-stressed immunodeficient mice as well as exploring the molecular mechanisms linking chronic psychological stress to ovarian cancer oncogenesis and progression.SK-OV-3 cells were injected subcutaneously into nude mice.The stress group was subjected to a chronic physical restraint protocol for 6 h on 35 consecutive days,while the control group was unrestrained.All mice were sacrificed on day 36 after SK-OV-3 cell injection,and tumors were excised.Tumor tissues were processed for 2D gel electrophoresis,mass spectrometry(nanoUPLC-ESI-MS/MS) and Western blotting.The expression of 20 proteins was found to be significantly altered between the stress and control groups,of which 14 were up-regulated,five were down-regulated,and one protein was found only in the stress group.All proteins were identified by UPLC-ESI-MS/MS,and Western blotting results were consistent with those of proteomic methods.The present results provide new evidence relating to the molecular mechanism underlying the relationship between psychological stress and tumor progression. | GAO Jun GAO GuoLan ZHANG YanYu WANG Fen | 2011 | Science China(Life Sciences)2011，54，2： | 11 |
| 2 | Retrospective study of mycophenolate mofetil treatment in IgA nephropathy with proliferative pathological phenotype显示文摘 | Liang Yan Zhang Junjun Liu Dongwei Quan Songxia Xing Guolan Liu Zhangsuo | 2014 | Chinese Medical Journal2014，，1： | 7 |
| 3 | Blue revolution for food security under carbon neutrality: A case from the water-saving and drought-resistance rice显示文摘The increasing concentration of greenhouse gases(GHGs)in Earth's atmosphere leads to global warming,which further causes a series of climate changes and does great harm to both human society and natural ecosystems.Agricultural GHG emissions,mainly in theform of methane(CH4)and nitrous oxide(N2O),areasignificantsourceofGHGs,accountingfor~14%total global GHGs(Zhang et al.,2022).One major source of agricultural GHGs is CH4 emissions from rice paddies,which is responsiblefor~10%-12%ofhuman-inducedCH4emissions(van Groenigen et al.,2013)and contributes~2.40%to the enhanced global warming effect(Zhang et al.,2022).The global warming potential of GHGs emissions from rice systems is roughly four times higher than either wheat or maize(Linquist et al.,2012). | Hui Xia Xianxian Zhang Yi Liu Junguo Bi Xiaosong Ma Anning Zhang Hongyan Liu Liang Chen Sheng Zhou Huan Gao Kai Xu Haibin Wei Guolan Liu Feiming Wang Hongyang Zhao Xingxing Luo Danping Hou Qiaojun Lou Fangjun Feng Liguo Zhou Shoujun Chen Ming Yan Tianfei Li Mingshou Li LeiWang Zaochang Liu Xinqiao Yu HanweiMei Lijun Luo | 2022 | Molecular Plant2022，15，9： | 3 |
| 4 | Synthesis char- acterization and biological evaluation of some 16~-azolyl- 3/3-amino-Sa-androstane derivatives as potential antican- cer agents显示文摘 | Hao Guo Guolan Zhang Tac Zhang | 2011 | Eur J Med Chem2011，46，： | 1 |
| 5 | An environmentally-friendly technology of vanadium extraction from stone coal显示文摘 | He Dongsheng Feng Qiming Zhang Guolan | 2007 | Minerals Engineering2007，20，12： | 1 |
| 6 | Significant contribution of carbonyls to atmospheric oxidation capacity(AOC)during the winter haze pollution over North China Plain显示文摘Atmospheric carbonyl compounds play significant roles in the cycling of radicals and have exhibited surprisingly high levels in winter that were well correlated to particulate matter,for which the reason have not been clearly elucidated.Here we measured carbonyl compounds and other trace gasses together with PM_(2.5)over urban Jinan in North China Plain during the winter.Markedly higher carbonyl concentrations(average:14.63±4.21 ppbv)were found during wintertime haze pollution,about one to three-times relative to those on nonhaze days,with slight difference in chemical composition except formaldehyde(HCHO).HCHO(3.68 ppbv),acetone(3.17 ppbv),and acetaldehyde(CH_3CHO)(2.83 ppbv)were the three most abundant species,accounting for~75% of the total carbonylson both haze and non-haze days.Results from observational-based model(OBM)with atmospheric oxidation capacity(AOC)indicated that AOC significantly increased with the increasing carbonyls during the winter haze events.Carbonyl photolysis have supplied key oxidants such as RO_(2) and HO_(2),and thereby enhancing the formation of fine particles and secondary organic aerosols,elucidating the observed haze-carbonyls inter-correlation.Diurnal variation with carbonyls exhibiting peak values at early-noon and night highlighted the combined contribution of both secondary formation and primary diesel-fuel sources.1-butene was further confirmed to be the major precursor for HCHO.This study confirms the great contribution of carbonyls to AOC,and also suggests that reducing the emissions of carbonyls would be an effective way to mitigate haze pollution in urban area of the NCP region. | Xue Yang Gen Zhang Guang Pan Guolan Fan Houyong Zhang Xuan Ge Mingyue Du | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
| 7 | Highly Enantioselective Trapping of Carboxylic Oxonium Ylides with Imines for Direct Assembly of Enantioenriched γ-Butenolides显示文摘Enantioenrichedγ-butenolides are valuable structural cores in many pharmaceuticals and natural products,but their direct and catalytically asymmetric assembly remains rare.Here,we report an efficient,atom-economic synthetic strategy for enantioenrichedγ-butenolides via a unique enantioselective reaction of cyclopropene carboxylic acids with imines under the synergistic catalysis of Rh2(esp)2/chiral Brønsted acid system.The reaction involved trapping of carboxylic oxonium ylides,generated from cyclopropene carboxylic acids,which presented as the first asymmetric trapping reactive intermediate in the process. | Dan Zhang Xin Wang Mengchu Zhang Zhenghui Kang Guolan Xiao Xinfang Xu Wenhao Hu | 2020 | CCS Chemistry2020，2，4： | 0 |
| 8 | Evaluation and Genetic Classification of Rice Germplasm Resources Resistant to Rice Blast显示文摘[Objective]This study aimed to explore rice germplasm resources resistant to rice blast and provide theoretical basis for the modification of rice blastresistant germplasm resources. [Method]The resistance of 120 rice materials to rice blast was identified at three experimental areas. [Result]The resistance of120 experimental materials was at grade 0- 9 to panicle blast in Hainan Province,at grade 0- 9 to seedling blast in Fujian Province and at grade 3- 9 to panicle blast in Guangxi Zhuang Autonomous Region. Analysis of correlations between agronomic traits and rice blast resistance indicated that the resistance of experimental materials could not be simply determined based on agronomic traits. Furthermore,61 published SSR makers closely linked to rice blast were selected and synthesized for genotypic analysis of 120 experimental materials. The results of cluster analysis preliminarily divided 120 germplasms into resistant varieties and susceptible varieties. [Conclusion]These rice germplasm resources are of important value for breeding new materials resistant to rice blast. | Yuanyuan NIE Zhengshuai An Zhen ZHANG Linghua MAO Guolan LIU Manlian YAN Yaohui CAI | 2014 | Agricultural Biotechnology2014，3，2： | 0 |
| 9 | Direct evidence of CRISPR-Cas9-mediated mitochondrial genome editing显示文摘Pathogenic mitochondrial DNA(mtDNA)mutations can cause a variety of human diseases.The recent development of genome-editing technologies to manipulate mtDNA,such as mitochondria-targeted DNA nucleases and base editors,offer a promising way for curing mitochondrial diseases caused by mtDNA mutations.The CRISPR-Cas9 system is a widely used tool for genome editing;however,its application in mtDNA editing is still under debate.In this study,we developed a mito-Cas9 system by adding the mitochondria-targeted sequences and 30 untranslated region of nuclear-encoded mitochondrial genes upstream and downstream of the Cas9 gene,respectively. | Rui Bi Yu Li Min Xu Quanzhen Zheng Deng-Feng Zhang Xiao Li Guolan Ma Bolin Xiang Xiaojia Zhu Hui Zhao Xingxu Huang Ping Zheng Yong-Gang Yao | 2022 | The Innovation2022，3，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员