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19篇 您的检索式:作者名="Gunaldi"
    题名 作者 年代 出处 被引量
1Cervical segment nervus vagus neurofibroma with associated neurofibromatosis type Ⅰ:a case report显示文摘Guler AK Gunaldi O Alis H 0,,:1
2Utility of peripheral blood parameters in predicting breast cancer risk显示文摘Okuturlar Y Gunaldi M Tiken EE 2015Asian Pac J Cancer Prev2015,16,6:1
3A new approach to the treatment of metastatic paraganglioma:sorafenib显示文摘GUNALDI M KARA I O DUMAN B B 2014Cancer Res Treat2014,46,4:1
4Efficacy of clinical prog- nostic factors on survival in patients with glioblastoma 显示文摘Tugcu B Postalci LS Gunaldi O 2010Turk Neurosurg2010,20,2:1
5Coexistence of tuberous sclerosis complex and malignant melanoma显示文摘Gunaldi M Paydas S Afsar CU 2013Singapore Med J2013,54,11:1
6Efficacy of clinical prognostic factors on survival in patients with glioblastoma 显示文摘Tugcu B Postalci LS Gunaldi O 2010Turk Neurosurg2010,20,3:1
7Efficacy of clinical prognostic factors on survival in patients with glioblasto-ma显示文摘Tugcu B Postalci LS Gunaldi O 0,,3:1
8Coexistence of tuberous sclerosis complex and malignant melanoma 显示文摘Gunaldi M Paydas S Afsar C U 2013Singapore Med J2013,54,11:1
9Lymphocytic hypo- physitis: an underestimated disease affecting the sellar region 显示文摘Tugcu B Gunaldi O Postalci L 2011Neurol Neurochir Pol2011,45,2:1
10Efficacy of clinical prognostic factors on survival in patients with glioblastoma显示文摘Tugeu B Postalei LS Gunaldi O 2010Turk Neurosurg2010,20,2:1
11Efficacy of clinical prognostic factors on survival in patients with glioblasto-ma显示文摘Tugcu B Postalci LS Gunaldi O 0,,2:1
12Primary intracerebral myeloid sarcoma显示文摘Gunaldi M Kara IO Duman BB 0,,11:1
13Primary intracerebral myeloid sarcoma 显示文摘Gunaldi M Kara IO Duman BB 2012Onkologie2012,35,11:1
14'Honey' can prevent epidural fibrosis development after laminectomy : an experimental study 显示文摘Gunaldi O Erdogan S Guclu DG 2014Turk Neurosurg2014,24,6:1
15Retrospective analysis of 498 primary soft tissue sarcomas in a single Turkish centre 显示文摘Duman BB Gunaldi M Ercolak V 2012Asian Pac J Cancer Prev2012,13,8:1
16Prognostic impact of plate- let/lymphocyte and neutrophil/lymphocyte ratios in patients with gastric cancer: a multieenter study 显示文摘Gunaldi M Goksu S Erdem D 2015Int J Clin Exp Med2015,8,4:1
17Efficacy of clinical prognostic factors on survival in patients with gliobastoma显示文摘Tugcu B Postalci LS Gunaldi O 2010Turk Neurosurg2010,20,2:1
18Efficacy of clinical prognos- tic factors on survival in patients with glioblastoma显示文摘Tugcu B Postalci LS Gunaldi O 2010Turk Neuro- surg2010,20,2:1
19Impact of sorafenib on epidural fibrosis: An immunohistochemical study显示文摘AIM To determine if sorafenib, an antineoplastic agent, could prevent the development of spinal epidural fibrosis(EF). METHODS The study used CD105 and osteopontin antibodiesin an immunohistochemical approach to quantify EF that occurred as a consequence of laminectomy in rats. Wistar albino rats(n = 16) were divided into two groups: control(L1-2 level laminectomy only) and sorafenib treatment(L1-2 level laminectomy + topical sorafenib). The animals were euthanatized after 6 wk, and the EF tissues were examined for histopathological changes after immunohistochemical staining. The EF grades were assigned to the tissues, and the treatment and control groups were compared. RESULTS The EF thickness, inflammatory cell density, and arachnoid adherences determined by light microscopy were significantly higher in the control group compared to the sorafenib-treated group. Based on fibrosis scores, the extent of EF in the treatment group was significantly lower than in the controls. Immunohistochemical staining for CD105 to identify microvessels revealed that the EF grades based on vessel count were significantly lower in the treatment group. Staining for osteopontin did not show any significant differences between the groups in terms of the extent of EF. The staging of EF based on vascular counts observed after immunohistochemical staining for CD105, but not for osteopontin, was compatible with conventional staging methods. Neither toxic effects on tissues nor systemic side effects were observed with the use of sorafenib. CONCLUSION Local administration of sorafenib significantly reduced post-laminectomy EF. Decreased neovascularization in spinal tissue may be due to the sorafenib-induced inhibition of vascular endothelial growth factor.Osman Tanriverdi Uzay Erdogan Canan Tanik Ilhan Yilmaz Omur Gunaldi Huseyin Utku Adilay Ayca Arslanhan Metehan Eseoglu 2018World Journal of Clinical Cases2018,6,9:0
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