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| 1 | Cerebral sinus thrombosis in patients with inflammatory bowel disease: A case report显示文摘Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease of the gastrointestinal tract. The pathophysiology of IBD is probably the result of the complex interaction of genetic susceptibility and environmental influences. There is a well-known risk of thrombosis in patients with IBD. We present the case of a 53-year-old man with ulcerative colitis, who spontaneously developed intracranial sinus thrombosis that was treated with low molecular weight heparin. Literature was searched to assess the frequency and characteristics of cerebral sinus thrombosis in IBD and the role of certain etiopathological factors in such thrombotic patients. | Hasan Umit Talip Asil Yahya Celik Ahmet Tezel Gulbin Dokmeci Nermin Tuncbilek Ufuk Utku Ali Riza Soylu | 2005 | World Journal of Gastroenterology2005，11，34： | 6 |
| 2 | Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats显示文摘AIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bili- ary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly as- signed to 5 groups (10 rats in each). Bile duct was liga- ted in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, he- patic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 μg collagen/mg protein, respectively) compared to BDL (48.3 ± 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supp-lementation prevented the increase in hepatic collagen surface density (7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively) compared to BDL (17.4% ± 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treat- ment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 ± 0.8 vs BDL: 3.1 ± 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obs- tructed rats. Oxidative stress may play a role in the patho- genesis of hepatic fibrosis in secondary biliary cirrhosis. | Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak | 2006 | World Journal of Gastroenterology2006，12，42： | 4 |
| 3 | ACTN3 genotype is associated with human elite athletic performance显示文摘 | Yang N MaeArthur DG Gulbin JP | 2003 | Am J Hum Genet2003，73，3： | 1 |
| 4 | Ion channels and membrane rafts in apoptosis显示文摘 | Szabò I Adams C Gulbins E | 2004 | Pflugers Arch2004，448，3： | 1 |
| 5 | Physiology of apoptosis显示文摘 | Gulbins E Jekle A Ferlinz K | 2000 | Am J Physiol Renal Physiol2000，279，4： | 1 |
| 6 | Secular trends in physi- cal performance of Australian children:Evidence from the Talent Search program 显示文摘 | Tomkinson GR Olds TS Gulbin J | 2003 | J Sports Med Phys Fitness2003，43，4： | 1 |
| 7 | Eryptosis, a window to systemic disease 显示文摘 | Lang F Gulbins E Lerche H | 2008 | Cell Physiol Biochem2008，22，： | 1 |
| 8 | Physiological and pathophysiological aspects of ceramide显示文摘 | Gulbins E Li PL | 2006 | Am J Physiol Regul Integr Comp Physiol2006，290，1： | 1 |
| 9 | Chemosensitivity of human malignant glioma: modulation by p53 gene transfer显示文摘 | Martin Trepel Peter Groscurth Ursula Malipiero Erich Gulbins Johannes Dichgans Michael Weller | 1998 | Journal of Neuro - Oncology1998，，1： | 1 |
| 10 | Clarication of issuse on the close-form Green's functions in stratified media 显示文摘 | Aksun M I Gulbin D | 2005 | IEEE Trans - AP2005，53，11： | 1 |
| 11 | ACTN3genotype is associated with human elite athletic performance显示文摘 | YANG N MACARTHUR D G GULBIN J P | 2003 | Am J Hum Genet2003，73，3： | 1 |
| 12 | Cell transplantation-a potential therapy for cardiac repair in the future?显示文摘 | Gulbins H Meiser B M Reichenspurner H | 2002 | Heart Surg Forum2002，5，4： | 1 |
| 13 | Ceramide,membrane rafts and infections显示文摘 | Gulbins E Dreschers S Wilker B | 2004 | Mol Med2004，82，6： | 1 |
| 14 | Seeding of human vascular cells onto small diameter polyurethane vascular grafts 显示文摘 | Gulbins H Pritisanac A Dauner M Petzold R Goldemund A Doser M | 2006 | Thorac Cardiovasc Surg2006，54，2： | 1 |
| 15 | Pore volume and surface area of the carboniferous coals from the Zonguldak basin ( NW Turkey) and their variations with rank and maceral composition 显示文摘 | Gulbin Gilrdal M Namik Yaliin | 2001 | Int J Coal Geol2001，48，12： | 1 |
| 16 | Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs显示文摘 | Gulbins E Palmada M Reichel M Lüth A B?hmer C Amato D | 2013 | Nat Med2013，19，7： | 1 |
| 17 | Role of mitochondria in apoptosis显示文摘 | Gulbins E Dreschers S Bock J | 2003 | Exp Physiol2003，88，1： | 1 |
| 18 | Tumors of the cardiac valves:imaging findings in magnatic resonance imaging显示文摘 | Wintersperger BJ Becker CR Gulbins H | 2000 | Eur Radiol2000，10，3： | 1 |
| 19 | A low-flow adaptation phase improves shear-stress resistance of artificially seeded endothelial cells显示文摘 | Gulbins H Pritisanac A Petzold R | 2005 | Thorac Cardiovasc Surg2005，53，2： | 1 |
| 20 | Improving anaerobic biodegradability of biological sludges by Fenton pre-treatment: Effects on single stage and two-stage anaerobic digestion显示文摘 | Gulbin Erden A. Filibeli | 2009 | Desalination2009，，1： | 1 |
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