共被期刊论文引用了4次
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| 1 | 肿瘤多药耐药性及其逆转策略显示文摘 | 赵艳飞 于跃利 兰明阳 贾志勇 | 2009 | 包头医学院学报2009，25，6： | 3 |
| 2 | 结肠癌耐药细胞株LoVo/L-OHP的建立及其耐药机制显示文摘目的:建立获得性奥沙利铂(L-OHP)耐药的结肠癌细胞模型LoVo/L-OHP,并初步研究其耐药机制。方法:采用L-OHP浓度递增法建立人结肠癌细胞耐药模型LoVo/L-OHP,观察其生长规律并绘制细胞生长曲线;用MTT法鉴定耐药细胞株耐药性并计算耐药指数(RI);用半定量RT-PCR方法对部分耐药相关基因在耐药细胞及其亲本细胞中的表达情况进行分析。结果:成功建立了耐药的结肠癌细胞模型LoVo/L-OHP,LoVo/L-OHP细胞与LoVo细胞相比,生长缓慢,触角增多。通过RT-PCR半定量分析,P-gp、bcl-2、ERCC-1在LoVo/L-OHP中的表达上调,而p53基因表达下调。结论:LoVo/L-OHP细胞株耐药性稳定,耐药机制可能与P-gp、bcl-2、ERCC-1基因上调、p53基因下调多因素有关。 | 李敏 方明治 | 2011 | 现代肿瘤医学2011，19，10： | 2 |
| 3 | 肿瘤多药耐药机制的研究进展显示文摘肿瘤的多药耐药(MDR)是肿瘤化疗失败的主要原因之一,其机制复杂,为多因素作用的结果,故克服肿瘤耐药性也是十分棘手的课题。本文就MDR的不同机制作一综述,以期为更进一步的研究逆转肿瘤MDR作一指导。 | 靳君华 杨成旺 孟兴凯 乌新林 | 2007 | 内蒙古医学院学报2007，29，3： | 1 |
| 4 | Mechanism of Suppression on Proliferation of QGY Cell by Oxaliplatin显示文摘Objective:To observe the effects of oxaliplatin(L-OHP)on proliferation of human hepatoma cell line QGY in vitro and to investigate the mechanism.Methods:The inhibition of proliferation in QGY cell was assayed by MTT-test.Morphologic changes were observed under light microscope and electronic microscope.Distribution of cell cycle and apoptosis were analyzed using flow cytometry.The expressions of cell cycle proteins and apoptosis-associated proteins were detected with immuno-histochemical technique.Results:Oxaliplatin could inhibit the proliferation of QGY cells and the inhibition depended on the exposure time and dose.The cells showed morphologic changes of the early stage of apoptosis under the light microscope:the shrunk round cells,condensed cytoplasma and pycnosis of nucleus.Apoptotic cells and apoptotic body could be found under the transmission electronic microscope.The analysis of cell cycle indicated that oxaliplatin blocked cells at S and G2/M phases and the cells of G0/Gl phase reduced.When treated with oxaliplatin for 72h,the expressions of cyclin A and Bax were up-regulated,mutant type P53,Bcl-2 and Myc were down-regulated,and Fas was not changed.Conclusion:Oxaliplatin could inhibit the proliferation of the hepatoma cell lines.Cells were blocked at S and G2/M phases.The apoptosis was related to the up-regulation of Bax and down-regulation of mutant type P53,Bcl-2 and Myc.Oxaliplatin could not induce apoptosis through the Fas pathway. | 何松 左国庆 张燕 汤为学 刘长安 | 2007 | Chinese Journal of Cancer Research2007，19，4： | 0 |
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