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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Progress and records in the study of endogenetic mineralization during collisional orogenesis显示文摘To develop and perfect the theory of plate tectonics and regional metallogeny, metal-logenesis during collisional orogenesis should be thoroughly studied and will attract increasing at-tention of more and more scientists. This paper presents the main aspects of research and discus-sions on metallogenesis during collisional orogenesis after the development of plate tectonics, and accordingly divides the study history into two stages, i.e. the junior stage during 1971-1990 and the senior stage after 1990. Beginning with the negation of mineralization in the collision regime by Guild (1971), the focus of study was put on whether there occurred any mineralization during collisional orogenesis at the junior stage. At the senior stage, which is initiated by the advance of met-allogenic and petrogenic model for collisional orogenesis, scientists begin to pay their attention to the geodynamic mechanism of metallogenesis, spatial and temporal distribution of ore deposits, ore-forming fluidization, relationship | Yanjing Chen Huayong Chen Yulin Liu Guangjun Guo Yong Lai Shan Qin Baoling Huang Zengjie Zheng Yinghui Sui Chao Li et al. | 2000 | Chinese Science Bulletin2000，45，1： | 13 |
| 3 | CO_2 sensing properties and mechanism of PrFeO_3 and NdFeO_3 thick film sensor显示文摘The CO_2 sensing of PrFeO_3 and NdFeO_3 sensors were investigated. Experimental results show that the resistances for PrFeO_3 and NdFeO_3 in CO_2 gas are larger than those in air and the responses for PrFeO_3and NdFeO_3 sensors increase with an increase in room-temperature relative humidity. When exposed to1000 ppm CO_2, the response of PrFeO_3 thick film based on nano-powders annealed at 700℃can reach8.44 at 160℃for the background of wet air with 58%of room-temperature relative humidity (RH),which is much larger than the corresponding value (3.03) in wet air with 25%RH. The sensing response S of NdFeO_3 thick-film sensor based on nano-powders annealed at 600℃to 3000 ppm CO_2 at the operating temperature 200℃can reach 2.36 for the background of wet air with 72%RH, which is larger than the corresponding value (1.83) in the air with 25%RH. Compared with other CO_2 sensing materials, the PrFeO_3 sensor has larger response at lower operating temperature for CO_2 gas and may be used as a new CO_2 sensing material. | Yanping Chen Dandan Wang Hongwei Qin Heng Zhang Zhongli Zhang Guangjun Zhou Chengyong Gao Jifan Hu | 2019 | Journal of Rare Earths2019，37，1： | 2 |
| 4 | Fine-grained management of I/O optimizations based on workload characteristics显示文摘With the advent of new computing paradigms,parallel file systems serve not only traditional scientific computing applications but also non-scientific computing applications,such as financial computing,business,and public administration.Parallel file systems provide storage services for multiple applications.As a result,various requirements need to be met.However,parallel file systems usually provide a unified storage solution,which cannot meet specific application needs.In this paper,an extended tile handle scheme is proposed to deal with this problem.The original file handle is extended to record I/O optimization information,which allows file systems to specify optimizations for a file or directory based on workload characteristics.Therefore,fine-grained management of I/O optimizations can be achieved.On the basis of the extended file handle scheme,data prefetching and small file optimization mechanisms are proposed for parallel file systems.The experimental results show that the proposed approach improves the aggregate throughput of the overall system by up to 189.75%. | Bing WEI Limin XIAO Bingyu ZHOU Guangjun QIN Baicheng YAN Zhisheng HUO | 2021 | Frontiers of Computer Science2021，15，3： | 0 |
| 5 | Zeolite-encaged mononuclear copper centers catalyze CO_(2)selective hydrogenation to methanol显示文摘The selective hydrogenation of CO_(2) to methanol by renewable hydrogen source represents an attractive route for CO_(2) recycling and is carbon neutral.Stable catalysts with high activity and methanol selectivity are being vigorously pursued,and current debates on the active site and reaction pathway need to be clarified.Here,we report a design of faujasite-encaged mononuclear Cu centers,namely Cu@FAU,for this challenging reaction.Stable methanol space-time-yield(STY)of 12.8 mmol g_(cat)^(-1)h^(-1)and methanol selectivity of 89.5%are simultaneously achieved at a relatively low reaction temperature of 513 K,making Cu@FAU a potential methanol synthesis catalyst from CO_(2) hydrogenation.With zeolite-encaged mononuclear Cu centers as the destined active sites,the unique reaction pathway of stepwise CO_(2)hydrogenation over Cu@FAU is illustrated.This work provides a clear example of catalytic reaction with explicit structure-activity relationship and highlights the power of zeolite catalysis in complex chemical transformations. | Yuchao Chai Bin Qin Bonan Li Weili Dai Guangjun Wu Naijia Guan Landong Li | 2023 | National Science Review2023，10，7： | 0 |
| 6 | Efficient Heterogeneous Hydroformylation over Zeolite-Encaged Isolated Rhodium Ions显示文摘Alkene hydroformylation is an extremely important industry process currently accomplished via homogeneous catalysis.Heterogeneous hydroformylation is being avidly pursued as a more economical and sustainable process.Herein,we report the construction of zeolite-encaged rhodium catalyst for efficient hydroformylation.Through a facile in situ hydrothermal strategy,isolated Rh^(δ+)(δ=2.5)can be encaged in faujasite and efficiently stabilized via interaction with framework oxygen atoms,producing a Rh@Y model catalyst with well-defined rhodium sites and coordination environment.Rh@Y exhibits high catalytic activity,perfect chemoselectivity,and recyclability in 1-hexene hydroformylation under mild reaction conditions,making it a robust heterogeneous catalyst for potential applications.A state-of-the-art turnover frequency value of 6567 molC=C/molRh/h for Rh@Y can be achieved in 1-hexene hydroformylation at 393 K,outperforming all heterogeneous catalysts and most homogeneous catalysts under comparable conditions.With the well-defined structure of Rh@Y,the detailed mechanism of alkene hydroformylation can be interpreted via theoretical calculations,and the advantages of heterogeneous hydroformylation are well explained.This work provides a promising solution toward efficient heterogeneous noble metal catalysis by encaging stable isolated ions in a zeolite matrix. | Weixiang Shang Bin Qin Mingyang Gao Xuetao Qin Yuchao Chai Guangjun Wu Naijia Guan Ding Ma Landong Li | 2023 | CCS Chemistry2023，5，7： | 0 |
| 7 | GCSS:a global collaborative scheduling strategy for wide-area high-performance computing显示文摘Wide-area high-performance computing is widely used for large-scale parallel computing applications owing to its high computing and storage resources.However,the geographical distribution of computing and storage resources makes efficient task distribution and data placement more challenging.To achieve a higher system performance,this study proposes a two-level global collaborative scheduling strategy for wide-area high-performance computing environments.The collaborative scheduling strategy integrates lightweight solution selection,redundant data placement and task stealing mechanisms,optimizing task distribution and data placement to achieve efficient computing in wide-area environments.The experimental results indicate that compared with the state-of-the-art collaborative scheduling algorithm HPS+,the proposed scheduling strategy reduces the makespan by 23.24%,improves computing and storage resource utilization by 8.28%and 21.73%respectively,and achieves similar global data migration costs. | Yao SONG Limin XIAO Liang WANG Guangjun QIN Bing WEI Baicheng YAN Chenhao ZHANG | 2022 | Frontiers of Computer Science2022，16，5： | 0 |
| 8 | A self-tuning client-side metadata prefetching scheme for wide area network file systems显示文摘Client-side metadata prefetching is commonly used in wide area network(WAN) file systems because it can effectively hide network latency. However, most existing prefetching approaches do not meet the various prefetching requirements of multiple workloads. They are usually optimized for only one specific workload and have no or harmful effects on other workloads. In this paper, we present a new self-tuning client-side metadata prefetching scheme that uses two different prefetching strategies and dynamically adapts to workload changes. It uses a directory-directed prefetching strategy to prefetch the related file metadata in the same directory, and a correlation-directed prefetching strategy to prefetch the related file metadata accessed across directories. A novel self-tuning mechanism is proposed to efficiently convert the prefetching strategy between directory-directed and correlation-directed prefetching. Experimental results using real system traces show that the hit ratio of the client-side cache can be significantly improved by our self-tuning client-side prefetching. With regards to the multi-workload concurrency scenario, our approach improves the hit ratios for the no-prefetching, directory-directed prefetching, variant probability graph algorithm, variant apriori algorithm, and variant semantic distance algorithm by up to 15.22%, 6.32%, 10.08%, 11.65%, and10.73%, corresponding to 25.24%, 18.11%, 23.53%, 24.94%, and 24.19% reductions in the average access time, respectively. | Bing WEI Limin XIAO Yao SONG Guangjun QIN Jinbin ZHU Baicheng YAN Chaobo WANG Zhisheng HUO | 2022 | Science China(Information Sciences)2022，65，3： | 0 |
| 9 | Pore-Fracture Distribution Heterogeneity of Shale Reservoirs Determined by using HPMI and LPN_(2 )GA Tests显示文摘The compressibility of shale matrix reflects the effects of reservoir lithology, material composition, pore structure and tectonic deformation. It is important to understand the factors that influence shale matrix compressibility(SMC) and their effects on pore size distribution(PSD) heterogeneity in order to evaluate the properties of unconventional reservoirs.In this study, the volumes of pores whose diameters were in the range 6–100 nm were corrected for SMC for 17 shale samples from basins in China using high-pressure mercury intrusion and low-temperature nitrogen gas adsorption analyses,in order to investigate the factors influencing the SMC values. In addition, the variations in fractal dimensions before and after pore volume correction were determined, using single and multifractal models to explain the effects of SMC on PSD heterogeneity. In this process, the applicability of each fractal model for characterizing PSD heterogeneity was determined using statistical analyses. The Menger and Sierpinski single fractal models, the thermodynamic fractal model and a multifractal model were all used in this study. The results showed the following. The matrix compression restricts the segmentation of the fractal dimension curves for the single fractal Menger and Sierpinski models, which leads to a uniformity of PSD heterogeneity for different pore diameters. However, matrix compression has only a weak influence on the results calculated using a thermodynamic model. The SMC clearly affects the multifractal value variations, showing that the fractal dimension values of shale samples under matrix compression are small. Overall PSD heterogeneity becomes small for pores with diameters below 100 nm and the SMC primarily affects the PSD heterogeneity of higher pore volume areas. The comparison of fractal curves before and after correction and the variance analysis indicate that the thermodynamic model is applicable to quantitatively characterize PSD heterogeneity of shale collected from this sampling area. The results show that PSD heterogeneity increases gradually as micro-pore volumes increase. | ZHANG Junjian QIN Zhengyuan HAN Yanning WANG Huaimeng HOU Maoguo YAN Gaoyuan FENG Guangjun ZHANG Xiaoyang YIN Tingting ZHANG Hainan WEN Shupeng | 2022 | Acta Geologica Sinica(English Edition)2022，96，5： | 0 |
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