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| 1 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 2 | Effect of cross-flow direction of coolant on film cooling effectiveness with one inlet and double outlet hole injection显示文摘In order to study the effect of cross-flow directions of an internal coolant on film cooling performance,the discharge coefficients and film cooling effectiveness with one inlet and double outlet hole injections were simulated.The numerical results show that two different cross-flow directions of the coolant cause the same decrease in the discharge coefficients as that in the case of supplying coolant by a plenum.The different proportion of the mass flow out of the two outlets of the film hole results in different values of the film cooling effectiveness for three different cases of coolant supplies.The film cooling effectiveness is the highest for the case of supplying coolant by the plenum.At a lower blowing ratio of 1.0,the film cooling effectiveness with coolant injection from the right entrance of the passage is higher than that from the left entrance of the passage.At a higher blowing ratio of 2.0,the opposite result is found. | Guangchao Lin Chaolin Wu Wei Zhang Zhihai Kou Dawei Peng | 2012 | Propulsion and Power Research2012，1，1： | 2 |
| 3 | Fine-tune chiroptical activity in discrete chiral Au nanorods显示文摘Accurate researches on the surface plasmon resonance(SPR)-based applications of chiral plasmonic metal nanoparticles(NPs)still remain a great challenge.Herein,a series of chiral plasmonic metal NPs,e.g.,chiral Au nanorods(c-Au NRs),c-Au@Ag core–shell,and c-Au@TiO_(2) core–shell NRs,with different chiroptical activities have been produced.Plasmonic circular dichroism(PCD)bands of c-Au NRs can be precisely tailored by tuning the longitudinal SPR(LSPR)and amount of Au NRs as seeds.Besides,a shift of PCD bands within ultraviolet–visible–near infrared ray(UV–vis–NIR)region can also be achieved through the functionalization of a shell of another metal or semiconductor.Interestingly,chirality transfer from c-Au core to Ag shell leads to new PCD bands at the near-UV region.The tuning of PCD bands and chirality transfer are confirmed by our developed theoretical model.Developing chiral Au NRs-based chiral plasmonic nanomaterials with tunable chiroptical activities will be helpful to understand the structure-direct PCD and to extend circularly polarized-based applications. | Guangchao Zheng Sulin Jiao Wei Zhang Shenli Wang Qinghua Zhang Lin Gu Weixiang Ye Junjun Li Xiaochen Ren Zhicheng Zhang Kwok-yin Wong | 2022 | Nano Research2022，15，7： | 2 |
| 4 | Therapeutic effects of a novel tylophorine analog, NK‐007, on collagen‐induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation显示文摘 | Ti Wen Yangguang Li Meng Wu Xiaolin Sun Xiucong Bao Yuquan Lin Jianlei Hao Lin Han Guangchao Cao Ziwen Wang Yuxiu Liu Zhenzhou Wu Zhangyong Hong Puyue Wang Liqing Zhao Zhanguo Li Qingmin Wang Zhinan Yin | 2012 | Arthritis & Rheumatism2012，，9： | 2 |
| 5 | trans-2-Enoyl-CoA Reductase Tecr-Driven Lipid Metabolism in Endothelial Cells Protects against Transcytosis to Maintain Blood-Brain Barrier Homeostasis显示文摘The transport and metabolism of lipids in cerebrovascular endothelial cells(ECs)have been hypothesized to regulate blood-brain barrier(BBB)maturation and homeostasis.Long-chain polyunsaturated fatty acids(LCPUFAs)as the important lipids components of cell membranes are essential for the development and function of BBB,but the direct links of lipid metabolism and ECs barrier function remain to be established.Here,we comprehensively characterize the transcriptomic phenotype of developmental cerebrovascular ECs in single-cell resolution and firstly find that trans-2-enoyl-CoA reductase(Tecr),a verylong-chain fatty acid synthesis,is highly expressed during barriergenesis and decreased after BBB maturation.EC-specific knockout of Tecr compromises angiogenesis due to delayed vascular sprouting.Importantly,EC-specific deletion of Tecr loss restrictive quality of vascular permeability from neonatal stages to adulthood,with high levels of transcytosis,but maintains the vascular tight junctions.Moreover,lipidomic analysis shows that the expression of Tecr in ECs is associated with the containing of omega-3 fatty acids,which directly suppresses caveolae vesicles formation.These results reveal a protective role for Tecr in BBB integrity and suggest that Tecr as a novel therapeutic target in the central nervous system(CNS)diseases associated with BBB dysfunction. | Jinxuan Wang Jianxiong Xu Guangchao Zang Tao Zhang Qi Wu Hongping Zhang Yidan Chen Yi Wang Weixi Qin Shuang Zhao Erdai Qin Juhui Qiu Xiaojuan Zhang Lin Wen Yeqi Wang Guixue Wang | 2022 | Research2022，，3： | 1 |
| 6 | Gas chro- matographic analysis of methanol and ethanol in marine sediment pore waters:Validation and implementation of three pretreatment techniques 显示文摘 | Zhuang GuangChao Lin Yushih Marcus E | 2014 | Marine Chemistry2014，160，： | 1 |
| 7 | Parameter Optimization via Orthogonal Experiment to Improve Accuracy of Metakaolin Ceramics Fabricated by Direct Ink Writing显示文摘Kaolin/metakaolin-insulating ceramic components fabricated using direct ink writing(DIW)have important ap-plication prospects in architecture and aerospace.The accuracy of the entire process including the forming and sintering accuracy of ceramics greatly limits the application scope,and high-accuracy ceramic samples can meet the usage requirements in many scenarios.The orthogonal experiment was designed with four process parame-ters,including nozzle internal diameter,filling rate,printing layer height/nozzle internal diameter,and printing speed,to investigate the evolution of the DIW forming accuracy,sintering shrinkage rate and surface roughness of metakaolin-based ceramics with different process parameters.The influence of each process parameter and its mechanism were analyzed to obtain the DIW parameters for high-accuracy metakaolin ceramics.Multiple linear regression models between the dimensional change rate,surface roughness,and process parameters of the ceramic samples were established and validated.The results show that comprehensively considering the forming accuracy of the ceramic green bodies,sintering shrinkage rate and surface roughness,the optimal DIW process parameters were a 0.41 mm nozzle internal diameter,100%filling rate,50%printing layer height/nozzle inter-nal diameter,and a 15 mm/s printing speed.Multiple linear regression models were developed for the process parameters and the printing accuracy,sintering shrinkage rate and surface roughness.The error rates between the theoretical results obtained by substituting the optimal process parameters into the multiple linear regression models and the actual results obtained by printing the samples with the optimal parameters were extremely small,all less than 0.8%.This verified the correctness and predictability of the multiple linear regression models.This work provides a reference basis for rapid fabrication of high-accuracy ceramics via DIW and accuracy prediction with different process parameters. | Ming Wu Fuchu Liu Yuxiao Lin Miao Wang Shilin Zhou Chi Zhang Yingpeng Mu Guangchao Han Liang Hao | 2023 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2023，2，4： | 0 |
| 8 | CFTR is a negative regulator ofγδT cell IFN-γproduction and antitumor immunity显示文摘CFTR,a chloride channel and ion channel regulator studied mostly in epithelial cells,has been reported to participate in immune regulation and likely affect the risk of cancer development.However,little is known about the effects of CFTR on the differentiation and function ofγδT cells.In this study,we observed that CFTR was functionally expressed on the cell surface ofγδT cells.Genetic deletion and pharmacological inhibition of CFTR both increased IFN-γrelease by peripheralγδT cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in vivo.Interestingly,the molecular mechanisms underlying the regulation ofγδT cell IFN-γproduction by CFTR were either TCR dependent or related to Ca^(2+)influx.CFTR was recruited to TCR immunological synapses and attenuated Lck-P38 MAPK-c-Jun signaling.In addition,CFTR was found to modulate TCR-induced Ca^(2+)influx and membrane potential(Vm)-induced Ca^(2+)influx and subsequently regulate the calcineurin-NFATc1 signaling pathway inγδT cells.Thus,CFTR serves as a negative regulator of IFN-γproduction inγδT cells and the function of these cells in antitumor immunity.Our investigation suggests that modification of the CFTR activity ofγδT cells may be a potential immunotherapeutic strategy for cancer. | Yuanyuan Duan Guangqiang Li Miaomiao Xu Xiaofei Qi Mingxia Deng Xuejia Lin Zhiwei Lei Yi Hu Zhenghu Jia Quanli Yang Guangchao Cao Zonghua Liu Qiong Wen Zhenhua Li Jie Tang Wei Kevin Zhang Pingbo Huang Limin Zheng Richard A.Flavell Jianlei Hao Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，8： | 0 |
| 9 | A quantitative study on source rocks in the western Leidong depression, northern South China Sea显示文摘The Leidong depression is one of the secondary tectonic units and the least explored part of the Beibu Gulf Basin,northern South China Sea.Exploration activities in the basin reveal that the Middle Eocene deposition was controlled by NE-SW-striking faults and the second member of the Eocene Liushagang Formation(LII)consists of high-quality source rocks.The nature and origin of this depression has remained enigmatic due to the complex fault structures as compared to those in other basins.It is important to identify whether LII occurs in the Leidong depression in the context of exploration.Here we analyze available geological,seismic,and drilling data of the depression and the controlling factors among faults,deposition,lithology,and hydrocarbon distribution in the basin.Measures such as stress fracture analysis,fault growth index analysis,and sedimentary strata characterization were used to construct an Eocene sedimentary model controlled by NW-SE striking faults.The model with integrated seismic profile characteristics comparison and velocity analysis results was then used to determine whether the Eocene strata in the west of the depression contain the high-quality source rocks that are widely distributed elsewhere in the basin.Finally,calculations were performed to quantify the intensity of hydrocarbon generation and amount of hydrocarbon generated in the depression based on available data of the source rocks,including their distribution and thickness.The results confirmed the assumption that the Middle Eocene strata in the Leidong depression were controlled by NW-SE strike-slip faults and contain high-quality LII source rocks,thus providing an important foundation for future exploration. | Tao Wu Lie Li Wentuo Li Yonghao Gai Yu Qiu Guangchao Pan Lin Chen | 2021 | Energy Geoscience2021，2，1： | 0 |
| 10 | Filtration performance and modeling of granular bed for dust removal from coal pyrolytic vapors显示文摘Dust removal from pyrolytic vapors at high temperatures is an obstacle to the industrialization of the coal pyrolysis process.In this work,a granular bed with expanded perlites as filtration media was designed and integrated into a 10 t·d^(–1)coal pyrolysis facility.The testing results showed that around 97.56%dust collection efficiency was achieved.As a result,dust content in tar was significantly lowered.The pressure drop of the granular bed maintained in the range of 356 Pa to 489 Pa.The dust size in the effluent after filtration exhibited a bimodal distribution,which was attributed to the heterogeneity of the dust components.The effects of filtration bed on pyrolytic product yields were also discussed.A modified filtration model based on the macroscopic phenomenological theory was proposed to describe the performance of the granular bed.The computation results were well agreed with the experimental data. | Shuaiqiang Yang Lin Du Guangchao Ding Runguo Liu Wenli Song Songgeng Li | 2024 | Chinese Journal of Chemical Engineering2024，65，1： | 0 |
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