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| 1 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 2 | Cre-loxP-mediated gene replacement:a mouse strain producing humanized antibodies显示文摘 | Zou Y R Müller W Gu H | 1994 | Curr Biol1994，4，12： | 1 |
| 3 | Arachidonic acid inhibits K channels in basolateral membrane of the thick ascending limb显示文摘 | GU R M WANG W H | 2002 | Am J Physiol2002，283，3： | 1 |
| 4 | Suppressor of cytokine signaling - 3 is a biomechanical stress - inducible gene that suppresses gp130- mediated cardiac myocyte hypertrophy and survival pathways显示文摘 | Yasukawa H Hoshijima M Gu YS | 2001 | J Clin Invest2001，108，10： | 1 |
| 5 | Provenance and tectonic setting of the Proterozoic turbidites in Hunan, South China: Geochemical evi- dence显示文摘 | Gu X X Liu J M Zheng M H | 2002 | Journal of Sedimentary Research2002，72，39： | 1 |
| 6 | Which encodes a RNG- type ubiquitin ligase, disrupts the adaptability of Arabidopsis to nitrogen limitation显示文摘 | Peng M S Hannam C GU H | 2007 | Plant2007，50，： | 1 |
| 7 | Provenance and tectonic setting of the Proterozoie turbidites in Hunan, south China: Geochemical evidence 显示文摘 | Gu X X Liu J M Zheng M H Tang 3 X Qi L | 2002 | J Sediment Res2002，72，3： | 1 |
| 8 | A deadlock-free scheduling with sequence-dependent setup times显示文摘 | Zhang H Gu M Song X | 2009 | International Journal of Advanced Manufacturing System2009，45，56： | 1 |
| 9 | Nitrogen transfer of fuel-N in chemical looping combustion 显示文摘 | Song T Shen L H Xiao J Chen D Q Gu H M Zhang S W | 2012 | Combustion and Flame2012，159，3： | 1 |
| 10 | Diversity and abundance of ainmonia-oxidizing prokaryotes in sediments from the coastal Pearl River estuary to the South China Sea显示文摘 | CAO H HONG Y LI M GU J D | 2011 | Antonie Van Leeuwenhoek2011，100，4： | 1 |
| 11 | Kinetics and mechanism for oxi- dative desulfurization of fuels catalyzed by peroxo-molybdenum ami- no acid complexes in water-immiscible ionic liquids 显示文摘 | ZHU W S LI H M GU Q Q | 2011 | J Mol Catal A Chem2011，336，12： | 1 |
| 12 | Experiment of Bi-direction Pedestrian Flow with Three-dimensional Cellular Automata显示文摘 | Wei J Zhang H Gu M | 2015 | Physics Letters A2015，379，1617： | 1 |
| 13 | Superhydrophobic cotton fabric coating based on a complex layer of silica nanoparticles and perfluoro-octylated quaternary ammonium silane coupling agent显示文摘 | YU M H GU G T MENG W D | 2007 | Applied Sur-face Science2007，253，7： | 1 |
| 14 | Polymer monoliths wihh low hydrophobicity for strong cation-exchange capillary liquid chromatograpy of peptides and proteins显示文摘 | GU B H U Y LEE M L | 2007 | AnalChem2007，79，： | 1 |
| 15 | A typical and conventional antipsychotie drags in treatment naive first-episode schizophrenia:a 52 week randomized trial of elozapine vs ehlorpromazine显示文摘 | Lieberman JA Phillips M Gu H | 2003 | Neumpsychopharmacology2003，28，5： | 1 |
| 16 | Improvement of mechanical properties of forum lime stabilized soil with the addition of aluminum sludge显示文摘 | KAMON M GU H | 2001 | Materials Science Research International2001，7，1： | 1 |
| 17 | Two-dimensional traffic flow problems in inhomogeneous lattices显示文摘 | Gu G Q Chung K H Hui P M | 1995 | Physica A1995，217，34： | 1 |
| 18 | Identification of Flutter Derivatives of Bridge Decks 显示文摘 | GU M ZHANG R X XIANG H F | 2000 | Journal of Wind Engineering and Industrial Aerodynamics2000，84，2： | 1 |
| 19 | Generation of an axially super-resolved quasi-spherical focal spot using an amplitude-modulated radially polarized beam 显示文摘 | Lin H Jia B Gu M | 2011 | Opt Lett2011，36，13： | 1 |
| 20 | La and Ca co-doped ceriabased electrolyte materials for IT-SOFCs显示文摘 | Zheng Y F Shi Y M Gu H T | | 0，，： | 1 |
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