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10篇 您的检索式:作者名="Gu Fuqiang"
    题名 作者 年代 出处 被引量
1Ordered mesoporous polymers and homologous carbon frameworks: Amphiphilic surfactant templating and direct transformation 显示文摘MENG Yan GU Dong ZHANG Fuqiang 2005Angew Chem Int Ed2005,44,43:1
2Im- provement Schemes for Indoor Mobile Location Es- timation: A Survey 显示文摘Shang Jianga Hu Xuke Gu Fuqiang 2015Mathematical Problems in Engineering2015,,:1
3Ordered mesoporous polymers and homologous carbon frameworks Amphiphilic surfactant templating and direct transformation显示文摘Meng Yan Gu Dong Zhang Fuqiang 0,,43:1
4A family of highly ordered mesoporous polymer resin and carbon struc tures from organic organic selbassembly显示文摘Meng Yan Gu Dong Zhang Fuqiang 0,,18:1
5A family of highly ordered mesoporous polymer resin and carbon structures from organic-organic self-assembly显示文摘Meng Yan Gu Dong Zhang Fuqiang 2006Chem Mater2006,18,18:1
6Ordered mesoporous polymers and homologous carbon frameworks:Amphiphilic surfac- tant templating and direct transformation显示文摘Meng Yan Gu Dong Zhang Fuqiang 2005Angewandte Chemie2005,117,43:1
7A family of highly or- dered mesoporous polymer resin and carbon structures from organ- ic-organic self-assemb 显示文摘Meng Yah Gu Dong Zhang Fuqiang 2006Chemistry of Materia2006,,18:1
8Ordered mesoporous polymers and homologous carbon frameworks: am- phiphilic surfactant templating and direct transformation 显示文摘Yan Meng Dong Gu Fuqiang Zhang 2005Angew Chem2005,117,:1
9Polybenzimidazole/zwitterion-coated polyamidoamine dendrimer composite membranes for direct methanol fuel cell applications显示文摘ZongZong Gu Jianning Ding Ningyi Yuan Fuqiang Chu Bencai Lin 2013International Journal of Hydrogen Energy2013,,36:1
10Incorporation of a Toll-like receptor 2/6 agonist potentiates mRNA vaccines against cancer and infectious diseases显示文摘mRNA vaccines have emerged rapidly in recent years as a prophylactic and therapeutic agent against various diseases including cancer and infectious diseases.Improvements of mRNA vaccines have been underway,among which boosting of efficacy is of great importance.Pam2Cys,a simple synthetic metabolizable lipoamino acid that signals through Toll-like receptor(TLR)2/6 pathway,eliciting both humoral and cellular adaptive immune responses,is an interesting candidate adjuvant.To investigate the enhancement of the efficacies of mRNA vaccines by Pam2Cys,the adjuvant was incorporated into mRNA-lipid nanoparticles(LNPs)to achieve co-delivery with mRNA.Immunization with the resulting mRNA-LNPs(Pam2Cys)shaped up the immune milieu in the draining lymph nodes(dLNs)through the induction of IL-12 and IL-17,among other cytokines.Antigen presentation was carried out mainly by migratory and dLNresident conventional type 2 DCs(cDC2s)and significantly more potent antitumor responses were triggered in both prophylactic and therapeutic tumor models in a CD4^(+) and CD8^(+) T cell-dependent fashion.Accompanying memory antitumor immunity was also established.Moreover,the vaccine also stimulated much more robust humoral and cellular immunity in a surrogate COVID-19 prophylactic model.Last but not the least,the new vaccines exhibited good preliminary safety profiles in murine models.These facts warrant future development of Pam2Cys-incorporated mRNA vaccines or relevant mRNA therapeutics for clinical application.Yangzhuo Gu Jingyun Yang Cai He Tingmei Zhao Ran Lu Jian Liu Xianming Mo Fuqiang Wen Huashan Shi 2023Signal Transduction and Targeted Therapy2023,8,8:0
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