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32篇 您的检索式：作者名="Grutzner"

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	题名	作者	年代	出处	被引量
1	PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation显示文摘AIM:To investigate the in vivo effect of atrial natriureticpeptide(ANP)and its signaling pathway during ortho-topic rat liver transplantation.METHODS:Rats were infused with NaCl,ANP(5 μg/kg),wortmannin(WM,16 μg/kg),or a combination ofboth for 20 min.Livers were stored in UW solution(4°C)for 24 h,transplanted and reperfused.Apoptosis wasexamined by caspase-3 activity and TUNEL staining.Phosphorylation of Akt and Bad was visualized by West-ern blotting and phospho-Akt-localization by confocalmicroscopy.RESULTS:ANP-pretreatment decreased caspase-3activity and TUNEL-positive cells after cold ischemia,indicating antiapoptotic effects of ANP in vivo.The an-tiapoptotic signaling of ANP was most likely caused byphosphorylation of Akt and Bad,since pretreatment withPI 3-kinase inhibitor WM abrogated the ANP-inducedreduction of caspase-3 activity.Interestingly,analysis ofliver tissue by confocal microscopy showed translocationof phosphorylated Akt to the plasma membrane of hepa-tocytes evoked by ANP.CONCLUSION:ANP activates the PI-3-kinase pathwayin the liver in vivo leading to phosphorylation of Bad, an event triggering antiapoptotic signaling cascade inischemic liver.	Uwe Grutzner Melanie Keller Michael Bach Alexandra K Kiemer Herbert Meissner Manfred Bilzer Stefan Zahler Alexander L Gerbes Angelika M Vollmar	2006	World Journal of Gastroenterology2006，12，7：	3
2	Tumor-associated proteases and inhibitors in gastric cancer:analysis of prognostic impact and individual risk protease patters显示文摘	Allgayer H Babic R Grutzner KU	1998	Clin Exp Metastasis1998，16，1：	1
3	Computer aided long bone fracture treatment显示文摘	Grutzner PA Suhm N		0，，：	1
4	Development of a new industrial process for trioxane production显示文摘	Thomas Grutzner Hans Hasse Neven Lang	2007	Chemical Engineering Science2007，62，18：	1
5	Effect of injury on pulpal leveds of immunoreactive substance P and immunoreactive calcitioin gene-related peptide显示文摘	Grutzner EH Garry MC Hargreaves KM	1992	J Endod1992，18，11：	1
6	The condylar plate for treatment of distal femoral fractures: a long-term follow-up study显示文摘	Kolb K Grutzner P Koller H	2009	Injury2009，40，：	1
7	Limb dominance as a potential etiologic factor in noncontact anterior cruciate ligament tears显示文摘	Matava MJ Freehil AK Grutzner S		0，，01：	1
8	Tumor-associated proteases and inhibitor singa stric cancer:analysis of prognostic impact and in dividual risk protease patters显示文摘	All gayer H Babic R Grutzner KU etal	1998	Clin Exp Metastasis1998，16，1：	1
9	Effect of injury on pulpal levels of immunoreactive Substance P and immunoreactive calcitonin gene-related peptide显示文摘	Grutzner E Garry M Hargreaves K	1992	Endod1992，18，11：	1
10	Effect of injury on pulpal levels of immunoreactive substance P and immunoreactive calctionin gene-relared peptice显示文摘	Grutzner EH Garry MG Hargreaves KM	1992	J Endod1992，18，11：	1
11	Tumor associated proteases and inhibitors in gastric cancer: Analysis of prognostic impact and individual risk protease pattern 显示文摘	Allayer H Babic R Grutzner KU	1998	Clin Exp Metast1998，16，1：	1
12	Computer aided long bone fracture treatment显示文摘	Grutzner P A Suhm N	2004	Injury2004，35，1：	1
13	Ultra-fast CAD scan chain highlighting for failureanalysis assistance显示文摘	Grutzner M	2010	Microelectronics Reliability2010，，50：	1
14	Computer-assisted LISS plate osteosynthesis of proximaml tibia fractures: feasibility study and first clinical results显示文摘	Grutzner PA Langlotz F Zheng G	2005	Comput Aided2005，10，：	1
15	Robinlin:a novel bioactive homo-monoterpene from Robinia pseudoacacia L显示文摘	Tian F Chang C J Grutzner J B	2001	Bioorganic & Medicinal Chemistry Letters2001，11，19：	1
16	Tumor-associatede proteases and inhibitors in gastric cancer:analysis of prognostic impact and individual risk protease patterns显示文摘	Allgayer H Babic R Grutzner KU	1998	Clin Exp Metastasis1998，16，1：	1
17	Tumor-associated proteases and inhibitors in gastrc cancer:analysis of prognostic impact and indi- vidual risk protease patters显示文摘	Allgayer H Babic R Grutzner KU	1998	Clin Exp Metassis1998，16，1：	1
18	Accuracy considerations in navigated cup placement for total hip arthroplasty显示文摘	Langlotz U Grutzner PA Bernsmann K		0，，07：	1
19	Second malignancies after Hodgkin's disease:the Munich experience显示文摘	Grutzner S Hiller E	1999	Ann Hemato L1999，78，12：	1
20	An immunohistochemical assessment of Cathepsin D in gastric carcinoma:its impact on clinical prognosis显示文摘	Allgayer H Bahic R Grutzner KU	1997	Cancer1997，80，1：	1

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