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| 1 | New Insight in Ethylene Signaling: Autokinase Activity of ETR1 Modulates the Interaction of Receptors and EIN2显示文摘乙烯感觉迟钝 2 (EIN2 ) , ER 网络的不可分的膜蛋白质,作为发信号的乙烯的中央管理者被识别了小径。仍然,乙烯信号被从受体转移到 EIN2 的机制还没被解决。这里,我们证明蛋白质 phosphorylation 是关键机制控制 EIN2 和受体的相互作用。在 vivo 并且在 vitro,荧光研究表明受体的 kinase 领域为相互作用是必要的。氰化物,乙烯收缩筋,它被知道减少乙烯受体乙烯的 auto-phosphorylation 抵抗 1 (ETR1 ) 或在阻止 auto-phosphorylation (H353A ) 的 ETR1 的 kinase 领域的一个变化,为 EIN2 增加受体的亲密关系。在另一方面, mimicking 在异种, H353E 由植物荷尔蒙免除 EIN2ETR1 相互作用控制的 ETR1 的永久 auto-phosphorylation。基于我们的数据,我们在发信号的乙烯在 EIN2 的集成上建议一个新奇模型串联。 | Melanie M.A. Bisson Georg Groth | 2010 | Molecular Plant2010，3，5： | 18 |
| 2 | Efficacy of Bacillus subtilis MBI 600 Against Sheath Blight Caused by Rhizoctonia solani and on Growth and Yield of Rice显示文摘Rice sheath blight disease(ShB),caused by Rhizoctonia solani,gives rise to significant grain yield losses.The present study evaluated the efficacy of Integral?,the commercial liquid formulation of Bacillus subtilis strain MBI 600,against rice ShB and for plant growth promotion.In greenhouse studies,four log concentrations of Integral(from 2.2×106 to 2.2×109 cfu/mL) were used as seed treatment(ST).After 25 d,seedlings were dipped(SD) into Integral prior to transplanting.At 30 d after transplanting(DAT),leaf sheaths were inoculated with immature sclerotia of the pathogen.At 45 DAT,a foliar spray(FS) with Integral was applied to some treatments.The fungicide control was 50% carbendazim at 1.0 g/L,and a nontreated control was also included.Overall,there were 10 treatments,each with five replications.ShB severity was rated at 52 DAT,and seedling height and number of tillers per plant were rated at 60 DAT.In 2009,two field trials evaluated Integral at 2.2×108 and 2.2×109 cfu/mL.Integral was applied as ST,and seedlings were produced in a nursery bed.After 32 d,seedlings were treated with Integral as SD and transplanted into 10 m2 blocks.Foliar sprays were given at 45 and 60 DAT.There were seven treatments,each with eight replications arranged as a factorial randomized complete block design.At 20 DAT,the plots were broadcast inoculated with R.solani produced on rice grains.Seedling height before transplanting,ShB severity at 90 DAT,and grain yield at harvest were recorded.Integral at 2.2×109 cfu/mL provided significant increase of seedling heights over other treatments under greenhouse conditions.The Integral treatments of ST + SD + FS at 2.2×109 cfu/mL significantly suppressed ShB over other treatments.In field studies,Integral provided significant increase of seedling height in nursery,and number of tillers per plant,compared with the control.ShB severity was significantly suppressed with higher concentrations of Integral compared to lower concentrations.Grain yield were the highest at an Integral concentration of 2.2×109 cfu/mL.Overall,Integral significantly reduced ShB severity,enhanced seedling growth,number of tillers per plant and grain yield as ST + SD + FS at the concentration of 2.2×109 cfu/mL under the conditions evaluated. | K. VIJAY KRISHNA KUMAR S. KR. YELLAREDDYGARI M. S. REDDY J. W. KLOEPPER K. S. LAWRENCE X. G. ZHOU H. SUDINI D. E. GROTH S. KRISHNAM RAJU M. E. MILLER | 2012 | Rice science2012，19，1： | 11 |
| 3 | Ethylene Controls Autophosphorylation of the Histidine Kinase Domain in Ethylene Receptor ETR1显示文摘植物激素乙烯的感觉被不可分的膜受体的一个小家庭完成。在 Arabidopsis,五乙烯受体蛋白质被知道,包括乙烯抵抗 1 (ETR1 ) 。当 carboxyl 终端部分由一个 histidine kinase 领域和一个反应管理者领域组成时,这些受体的恐水病的氨基终端的领域包含乙烯绑定地点,它是在细菌的二部件的发信号发现的众所周知的元素。受体的可溶的膜外来的 carboxyl 终端部分,可能在信号 transduction 起一个重要作用,看了内在的 kinase 活动是否自己表示了并且净化。然而,在信号输入之间的关联和 autokinase 活动没在这些研究被建立,当受体正在错过 transmembrane 氨基终端的传感器领域。因此, autophosphorylation 是否响应乙烯信号的感觉发生,仍然是不清楚的。这里,我们在净化的全身的 ETR1 的 autophosphorylation 研究上报导。净化的受体的 Autokinase 活动被乙烯或由象领受人混合物氰化物一样的乙烯收缩筋控制。事实上,两个信号分子能完全关掉内在的 kinase 活动。而且,当乙烯对手 1-methyl-cyclopropene (MCP ) 被使用时,在由两个分子的 ETR1 的 autophosphorylation 的观察抑制能被阻止。 | Jan Voet-van-Vormizeele Georg Groth | 2008 | Molecular Plant2008，1，2： | 8 |
| 4 | FAIR Data Reuse-the Path through Data Citation显示文摘One of the key goals of the FAIR guiding principles is defined by its final principle-to optimize data sets for reuse by both humans and machines.To do so,data providers need to implement and support consistent machine readable metadata to describe their data sets.This can seem like a daunting task for data providers,whether it is determining what level of detail should be provided in the provenance metadata or figuring out what common shared vocabularies should be used.Additionally,for existing data sets it is often unclear what steps should be taken to enable maximal,appropriate reuse.Data citation already plays an important role in making data findable and accessible,providing persistent and unique identifiers plus metadata on over 16 million data sets.In this paper,we discuss how data citation and its underlying infrastructures,in particular associated metadata,provide an important pathway for enabling FAIR data reuse. | Paul Groth Helena Cousijn Tim Clark Carole Goble | 2020 | Data Intelligence2020，2，1： | 8 |
| 5 | 薄层层析指导下的嗜碱放线菌菌株YIMGQ-14次生代谢产物研究显示文摘在微生物资源的开发研究过程中 ,利用TLC方法 ,配合TLC数据库的检索 ,对嗜碱放线菌菌株YIMGQ1 4的次生代谢产物进行了研究。并从中分离纯化出两个具有生物活性的专利化合物“UmycinC”和“UmycinB”。结果证明 :相对于常规的生物活性筛选 ,TLC法在微生物次生代谢产物研究中具有快速、简便、经济的特点 ,适合于小量常规筛选的目的。通过进一步对相关的TLC数据库进行构建和补充 ,将能极大地改善该方法的使用效率。 | 李铭刚 Groth Ingrid 李一青 Sattler Isabel 文孟良 | 2003 | 微生物学报2003，43，4： | 7 |
| 6 | A Study of Melt Flow Analysis of an ABS-Iron Composite in Fused Deposition Modelling Process显示文摘Fused deposition modelling (FDM) is a filament based rapid prototyping system which offers the possibility of introducing new composite material for the FDM process as long as the new material can be made in feedstock filament form. Swinburne has been undertaking extensive research in development of new composite materials involving acrylonitrile-butadiene-styrene (ABS) and other materials including metals. In order to predict the behaviour of new ABS based composite materials in the course of FDM process, it is necessary to investigate the flow of the composite material in liquefier head. No such study is available considering the geometry of the liquefier head. This paper presents 2-D and 3-D numerical analysis of melt flow behaviour of a representative ABS-iron composite through the 90-degree bent tube of the liquefier head of the fused deposition modelling process using ANSYS FLOTRAN and CFX finite element packages. Main flow parameters including temperature, velocity, and pressure drop have been investigated. Filaments of the filled ABS have been fabricated and characterized to verify the possibility of prototyping using the new material on the current FDM machine. Results provide promising information in developing the melt flow modelling of metal-plastic composites and in optimising the FDM parameters for better part quality with such composites. | MOSTAFA Nikzad SYED Hasan Masood IGOR Sbarski ANDREW Groth | 2009 | Tsinghua Science and Technology2009，14，S1： | 6 |
| 7 | Targeting Plant Ethylene Responses by Controlling Essential Protein-Protein Interactions in the Ethylene Pathway显示文摘气体的植物荷尔蒙乙烯在整个植物的寿命调整高农学的关联的许多过程。在乙烯发信号的一个中央元素是 endoplasmic 蜂窝胃(嗯) 局部性的膜蛋白质乙烯 INSENSITIVE2 (EIN2 ) 。最近的研究显示响应乙烯, EIN2 的额外膜的 C 终端结束解朊地被处理并且从 ER 的 translocated 到原子核。这里,我们报导保存原子本地化发信号(NLS ) 调停 EIN2 C 终点的原子进口为复杂形成向一个重要领域提供乙烯受体乙烯 RESPONSE1 (ETR1 ) 。强烈缺乏 NLS 领域表演的 EIN2 为受体减少了亲密关系。EIN2 和 ETR1 的相互作用被 NLS 主题的合成的肽也堵住。相应的肽实质地在 planta 减少乙烯回答。我们的结果揭开禁止者防碍乙烯的新奇机制和类型在植物表明 transduction 和乙烯回答。在表明为 EIN2-ETR1 建筑群出现在我们的学习的小径的乙烯的必要蛋白质蛋白质相互作用的混乱有潜力为现代农业和园艺指导创新乙烯对手的发展。 | Melanie M.A. Bisson Georg Groth | 2015 | Molecular Plant2015，8，8： | 5 |
| 8 | Modification of tubular chitosan-based peripheral nerve implants: applications for simple or more complex approaches显示文摘Surgical treatment of peripheral nerve injuries is still a major challenge in human clinic.Up to now,none of the well-developed microsurgical treatment options is able to guarantee a complete restoration of nerve function.This restriction is also effective for novel clinically approved artificial nerve guides.In this review,we compare surgical repair techniques primarily for digital nerve injuries reported with relatively high prevalence to be valuable attempts in clinical digital nerve repair and point out their advantages and shortcomings.We furthermore discuss the use of artificial nerve grafts with a focus on chitosan-based nerve guides,for which our own studies contributed to their approval for clinical use.In the second part of this review,very recent future perspectives for the enhancement of tubular(commonly hollow)nerve guides are discussed in terms of their clinical translatability and ability to form three-dimensional constructs that biomimick the natural nerve structure.This includes materials that have already shown their beneficial potential in in vivo studies like fibrous intraluminal guidance structures,hydrogels,growth factors,and approaches of cell transplantation.Additionally,we highlight upcoming future perspectives comprising co-application of stem cell secretome.From our overview,we conclude that already simple attempts are highly effective to increase the regeneration supporting properties of nerve guides in experimental studies.But for bringing nerve repair with bioartificial nerve grafts to the next level,e.g.repair of defects>3 cm in human patients,more complex intraluminal guidance structures such as innovatively manufactured hydrogels and likely supplementation of stem cells or their secretome for therapeutic purposes may represent promising future perspectives. | Nina Dietzmeyer Maria F?rthmann Claudia Grothe Kirsten Haastert-Talini | 2020 | Neural Regeneration Research2020，15，8： | 4 |
| 9 | 【特刊综述】性腺功能低下在克氏综合征中的角色显示文摘克氏综合症(47,XXY)(KS)是最常见的性染色体异常,也是男性不育和性腺功能低下的常见原因。大部分KS患者终其一生都不知道自己患有这个疾病,只有25%的患者得到诊断,而在青春期前被诊断的更是少数。除了性腺功能低下和无精子症,大多数KS患者都有一定程度的学习障碍,并且可能有多种精神问题。长期性腺功能低下的影响可能使其难以与额外的x染色体引起的基因剂量效应相辨别。不管是什么原因,KS患者常出现身体成分的改变,包括脂肪增加、肌肉减少和骨矿物质流失,同时发生代谢障碍的风险也增加,例如患2型糖尿病和代谢综合征。这些发现应该引起我们的重视,因为他们不仅仅是简单的化验结果,流行病学调查表明KS患者因不同的疾病住院和死亡的风险均增加。KS患者应该在青春期早期就被给予睾丸激素治疗,尽管目前证据不足,因为至今仍未有随机对照试验的文章发表过。在这篇文章里,我们回顾了近期关于KS患者性腺功能低下症的研究进展和睾丸激素治疗的合理性,希望能为这个常见但往往被忽视的综合征提出我们的最佳建议。 | Christian Host Anne Skakkeb k Kristian A Groth Anders Bojesen | 2014 | Asian Journal of Andrology2014，16，2： | 3 |
| 10 | Surgery for Early-Stage Non-Small Cell Lung Cancer: A Systematic Review of the Video-Assisted Thoracoscopic Surgery Versus Thoracotomy Approaches to Lobectomy显示文摘 | Bryan A. Whitson Shawn S. Groth Susan J. Duval Scott J. Swanson Michael A. Maddaus | 2008 | The Annals of Thoracic Surgery2008，，6： | 3 |
| 11 | Survival of patients with distal esophageal and gastric cardia tumors: A population-based analysis of gastroesophageal junction carcinomas显示文摘 | Bryan A. Whitson Shawn S. Groth Zhongze Li Robert A. Kratzke Michael A. Maddaus | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，1： | 2 |
| 12 | 22-gauge core vs 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses显示文摘AIM To compare the aspiration needle(AN) and core biopsy needle(PC) in endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) of abdominal masses.METHODS Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge(G) AN(Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22 G PC(Echo Tip Pro Core; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the PC group only. The main study endpoint was the overall diagnostic accuracy, including the contribution of histology to the final diagnosis. Secondary outcome measures included material adequacy, number of needle passes, and complications.RESULTS Fifty six consecutive patients(29 men; mean age 68 years) with pancreatic lesions(n = 38), lymphadenopathy(n = 13), submucosal tumors(n = 4), or others lesions(n = 1) underwent EUS-FNA using both of the needles in a randomized order. AN and PC reached similar overall results for diagnostic accuracy(AN: 88.9 vs PC: 96.1, P = 0.25), specimen adequacy(AN: 96.4% vs PC: 91.1%, P = 0.38), mean number of passes(AN: 1.5 vs PC: 1.7, P = 0.14), mean cellularity score(AN: 1.7 vs PC: 1.1, P = 0.058), and complications(none). A diagnosis on the basis of histology was achieved in the PC group in 36(64.3%) patients, and in 2 of those as the sole modality. In patients with available histology the mean cellularity score was higher for AN(AN: 1.7 vs PC: 1.0, P = 0.034); no other differences were of statistical significance.CONCLUSION Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle. | William Sterlacci Athanasios D Sioulas Lothar Veits Pervin G?nüllü Guido Schachschal Stefan Groth Mario Anders Christos K Kontos Theodoros Topalidis Andrea Hinsch Michael Vieth Thomas R?sch Ulrike W Denzer | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 13 | 66例原位肝脏移植及围手术期处理分析显示文摘目的 总结 6 6例肝移植及围手术期处理的经验 ,探讨适合我国目前及今后提高肝移植成活率和康复率的方法。方法 6 6例接受肝移植手术患者 ,12例行劈离式肝移植 (SL T)术 ,5 4例行原位肝移植 (OL T)术。结果 移植的 6 6例肝脏 ,术后无 1例发生肝脏功能衰竭 ,也无重大并发症发生 ,病人全部存活 ,多数已康复。结论 改善供肝条件 ,严格受体选择 ,提高手术水平 。 | 伍晓汀 严律南 Carl-Gustav Groth Bo-Gran Ericzon 周勇 庄文 张明鸣 | 2002 | 华西医科大学学报2002，33，4： | 2 |
| 14 | A standardized injection technique and regimen ensures success and safety of N-butyl-2-cyanoacrylate injection for the treatment of gastric fundal varices (with videos)显示文摘 | Stefan Seewald Tiing Leong Ang Hiroo Imazu Mazen Naga Salem Omar Stefan Groth Uwe Seitz Yan Zhong Frank Thonke Nib Soehendra | 2008 | Gastrointestinal Endoscopy2008，，3： | 2 |
| 15 | 钢纤维在自密实混凝土中的应用显示文摘在自密实混凝土中使用钢纤维,提供了一种提高生产率的方法,并兼有免振及减少钢筋配置所带来的正面效应。本文提供了对这个课题正在进行的一个项目的实验结果的综述。结果表明,用钢纤维加筋自密实混凝土是可能的。测出的韧性相当于或者好于普通的纤维增强混凝土。纤维的方位受混凝土流向的影响以及纤维是否较好地分布。在本项目中,钢纤维增强自密实混凝土(简称SFRSCC)用于足尺的墙及楼板。 | Patrik Groth Dirk Nemegeet 张金强 | 2002 | 石家庄铁路工程职业技术学院学报2002，1，3： | 2 |
| 16 | Population Diversity of Puccinia graminis is Sustained Through Sexual Cycle on Alternate Hosts显示文摘A high degree of virulence diversity has been maintained in the population of Puccinia graminis f.sp.tritici(Pgt)in northwestern United States.Although Berberis vulgaris is present in the region and Pgt has been isolated from aecial infections on B.vulgaris,the population is too diverse to be explained by the limited presence of B.vulgaris alone.Since2008,we have isolated P.graminis from aecial infections on fruits of Ma honia repens and Mahonia aquifolium from northwestern United States.These two native woody shrub species,widely distributed in western North America,were once classified as resistant to P.graminis based on artif icial inoculations.By isolating P.graminis from aecia,we established that M.repens and M.aquifolium along with B.vulgaris(albeit infrequent)serve as the alternate hosts of P.graminis in the region.The isolates of P.graminis from Mahonia of North America had diverse virulence patterns and most of the isolates could be differentiated on Morocco,Line E,Chinese Spring,Little Club,LMPG-6,Rusty,and other genotypes that are considered to be universally susceptible to most Pgt isolates.This discovery explained the persistence of virulence diversity of Pgt observed in isolates derived from uredinia on cereal crops in the region.In addition to cereal crops,uredinial stage of the P.graminis population is sustained by wild grasses,especially Elymus glaucus,a native grass sharing the same habitat with the rusted Mahonia spp.Although virulence to some important stem rust resistance genes was observed in some isolates derived from Mahonia of North America when tested against single stem rust resistance gene stocks,the overall virulence is very limited in these isolates.This is likely a result of limited selection pressure on the rust population.In contrast to northwestern United Sates,the Pgt population in east of the Rocky Mountains of North America has declined steadily with a single race,QFCSC,being predominant in the last decade.This decline is likely due to a combination of factors,of which a lack of sexual recombination in the region is perhaps the most important one. | Yue Jin Matt Rouse Jim Groth | 2014 | Journal of Integrative Agriculture2014，13，2： | 2 |
| 17 | Chemotherapy for advanced gastric cancer显示文摘 | Wagner AD Unverzagt S Grothe W | | 0，，03： | 2 |
| 18 | Prospective evaluation of the short access cholangioscopy for stone clearance and evaluation of indeterminate strictures显示文摘BACKGROUND: Peroral cholangioscopy facilitates diagnosis and therapy of biliary disorders. This study prospectively evaluated a new short access cholangioscopy. METHODS: Consecutive patients were included as follows: difficult stones(group 1) underwent cholangioscopy with electrohydraulic lithotripsy and indeterminate biliary strictures(group 2) were evaluated with macroscopic assessment and cholangioscopy guided biopsy sampling. We evaluated the complete stone clearance rate(group 1) and diagnostic accuracy(group 2). Follow-up was performed over a median of 13 and 16 months, respectively.RESULTS: Group 1(n=21): complete stone clearance defined as lack of stones in cholangiography and stone removal during cholangioscopy was achieved in 15(71.4%) patients. Clinical stone clearance defined as lack of symptoms, laboratory abnormalities and hospital visits during follow-up, irrespective of stone clearance was evident in 17(81.0%) patients. One serious adverse event occurred(bile duct perforation). Group 2(n=28): malignancy was confirmed in 15 patients. Sensitivity, specificity and diagnostic accuracy of cholangioscopy were 85.7%, 75.0% and 80.7%, respectively. Sensitivity, specificity and diagnostic accuracy of biopsies were 54.5%, 100.0% and 72.2%, respectively. No serious adverse events occurred, and one patient was lost to follow-up.CONCLUSIONS: The novel system enabled complex stone treatment and biliary stricture diagnosis. Cholangioscopy outperformed direct biopsy regarding characterization of indeterminate strictures. | Athanasios D Sioulas Muhammad A El-Masry Stefan Groth Guido Schachschal Mario Anders Thomas Rosch Ulrike Denzer | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，1： | 2 |
| 19 | Randomized phase Ⅱ trialgemcitabine-cisplatin with or without trastuzumab in HER- 2-positive non-small-cell lung cancer显示文摘 | Gatzemeier U Groth G Butts C | 2004 | Ann Onco2004，15，1： | 1 |
| 20 | Effect of recombinant tissue plasminogen activator on clot lysis and ventricular dilatation in the treatment of severe intraventricular haemorrhage 显示文摘 | Mayfrank L Lippitz B Groth M | 1993 | Acta Neurochir(Wien)1993，122，1： | 1 |
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