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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 4 |
| 3 | Leitlinien für den Gebrauch von Ultraschallkontrastmitteln - Januar 2004显示文摘 | T Albrecht M Blomley L Bolondi M Claudon J.-M Correas D Cosgrove L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani L Solbiati L Thorelius F Tranquart H Weskott T Whittingham | 2004 | Ultraschall in Med2004，，04： | 3 |
| 4 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D'Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 3 |
| 5 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 6 | Correlation of fully developed heat transfer and pressure drop in a symmetrically grooved channel显示文摘 | Wirtz R A Huang F Greiner M | 1999 | ASME Journal of Heat Transfer1999，121，1： | 2 |
| 7 | Cerebral response to norepinephrine compared with fluid resuscitation in ovine traumatic brain injury and systemic inflammation 显示文摘 | Stubbe HD Greiner C Westphal M | 2006 | Crit Care Med2006，34，10： | 1 |
| 8 | Correlation of Fully Developed Heat Transfer and Pressure Dorp in a Symmetrically Grooved Channel显示文摘 | Wirtz R A Huang F Greiner M | 1999 | Journal of Heat Transfer1999，121，1： | 1 |
| 9 | Polymer core-shell fibers with metal nanoparticles as nanoreactor for catalysis 显示文摘 | Graeser M Pippel E Greiner A | 2007 | Macromolecules2007，40，17： | 1 |
| 10 | A hybrid approach using the analytic hierarchy process and integer programming to screen weapon systems projects 显示文摘 | Greiner M A Fowler J W Shunk D L | 2003 | IEEE Transactions on Engineering Management2003，50，2： | 1 |
| 11 | The effect of UV ozone treatment on poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)显示文摘 | Helander M G Wang Z B Greiner M T Liu Z W Lian K Lu Z H | | 0，，17： | 1 |
| 12 | Enhanced heat transfer/pressure drop measure from a flat surface in a grooved channel 显示文摘 | Greiner M Chen R F Wirtz R A | 1991 | ASME Journal of Heat Transfer1991，113，2： | 1 |
| 13 | Excluded vol- ume hadron gas model for particle number ratios in A+A collisions显示文摘 | Yen G D Gorenstein M I Greiner W | 1997 | Phys Rev C1997，56，： | 1 |
| 14 | Follow-up study on subjective quality of life for elderly persons with dementia using the Japanese version of Dementia Quality of Life Instrument(JDQoL)显示文摘 | Suzuki M Kanamori M Greiner C | 2006 | Nippon Ronen Igakkai Zasshi2006，43，4： | 1 |
| 15 | Correlation of lipid layer thickness measurements with fluorescein tear film break- up time and Schirmer's test显示文摘 | Isreb M A Greiner J V Korb D R | 2003 | Eye(Lond)2003，17，1： | 1 |
| 16 | Quantum phase transition from a Super fluid to a Mott insulator in a gas of ultracold atoms显示文摘 | GREINER M MANDEL O ESSLINGER T | 2002 | Nature ( London )2002，39，： | 1 |
| 17 | Polymer nanotubes by wetting of ordered porous template显示文摘 | Steinhart M Wendorff J H Greiner A | 2002 | Science2002，296，14： | 1 |
| 18 | WT1 mRNA expression of leukemia - associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies显示文摘 | GREINER J RINGHOFFER M TANIGUCHI M | 2004 | Int J Cancer2004，108，5： | 1 |
| 19 | Automatic reconstruction of personalized avatars from 3D face scans 显示文摘 | Zollhofer M Martinek M Greiner G | 2011 | Computer Animation and Virtual Worlds2011，22，23： | 1 |
| 20 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 1 |
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