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| 1 | Functional oesophago-gastric junction imaging显示文摘尽管有它在疾病的角色,仍然没有权威的方法估计 oesophago 胃的连接胜任(OGJ ) 。传统地, OGJ 作为指示物与更低的食道的括约肌压力用测压法被估计了。更最近,这被显示了不对倒流是括约肌功能和胜任的一个很可靠的标记。混乱象胃食道的倒流疾病那样并且到更小的 extend 弛缓不能仍然完成病人的一个重要数字。这评论看使用作为阻抗测面积池知道在一只袋子的扩张期间在 OGJ 介绍几何学和压力的一种新技术。收集的数据能被重建进 OGJ 行动的一个动态代表。这被显示了提供 OGJ 的一个有用代表并且由于 endoluminal 治疗以依从和膨胀性显示出变化到 OGJ 的胜任。 | Barry P McMahon Asbjφrn M Drewes Hans Gregersen | 2006 | World Journal of Gastroenterology2006，12，18： | 3 |
| 2 | Computation of flow through the oesophagogastric junction显示文摘Whilst methods exist to indirectly measure the effects of increased flow or gastro-oesophageal refluxing, they cannot quantitatively measure the amount of acid travelling back up into the oesophagus during reflux, nor can they indicate the flow rate through the oesophagogastric junction (OGJ). Since OGJ dysfunction affects flow it seems most appropriate to describe the geometry of the OGJ and its effect on the flow. A device known as the functional lumen imaging probe (FLIP) has been shown to reliably measure the geometry of and pressure changes in the OGJ. FLIP cannot directly measure flow but the data gathered from the probe can be used to model flow through the junction by using computational flow dynamics (CFD). CFD uses a set of equations known as the Navier-Stokes equations to predict flow patterns and is a technique widely used in engineering. These equations are complex and require appropriate assumptions to provide simplifications before useful data can be obtained. With the assumption that the cross-sectional areas obtained via FLIP are circular, the radii of these circles can be obtained. A cubic interpolation scheme can then be applied to give a high-resolution geometry for the OGJ. In the case of modelling a reflux scenario, it can be seen that at the narrowest section a jet of fluid squirts into the oesophagus at a higher velocity than the fluid surrounding it. This jet has a maximum velocity of almost 2 ms-1 that occurs where the OGJ is at its narrowest. This simple prediction of acid ‘squirting’ into the oesophagusillustrates how the use of numerical methods can be used to develop a better understanding of the OGJ. This initial work using CFD shows some considerable promise for the future. | Barry P McMahon Karl D Odie Kenneth W Moloney Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，9： | 2 |
| 3 | Leaf senescence and nutrient remobilisation in barley and wheat显示文摘 | Gregersen P L Holm P B Krupimka K | 2008 | Plant Biology2008，10，： | 1 |
| 4 | A comparison of eye movement behavior of inexperienced and experienced drivers in real traffic environments显示文摘 | Falkmer T Gregersen N P | 2005 | Optomet Vision Sci2005，82，8： | 1 |
| 5 | Stevioside induces antihyperglycaemic,insulinotropie and glueagonostatic effects in vivo:studies in the diabetic Goto-Kakizaki(GK) rats 显示文摘 | Jeppesen P B Gregersen S Alstrup K K eta! | 2002 | Phytomedicine2002，9，1： | 1 |
| 6 | DNA vaccines显示文摘 | GREGERSEN J P | 2001 | Naturwissenschaflen2001，88，12： | 1 |
| 7 | OpenMI:Open modelling interface显示文摘 | GREGERSEN J B GIJSBERS P L A and WESTEN S LP | 2007 | Journal ofHydroinformatics2007，9，3： | 1 |
| 8 | Stevioside includes an-tihyper-glycaemic,and glucagonostatic effects in vivo:studies in thediabetic Goto-Kakizaki(GK)rats显示文摘 | Jeppesen P B Gregersen S Alstrup K K | 2002 | Phytomedicine2002，9，1： | 1 |
| 9 | Clinical follow-up and immunogenetic studies of 32 patients with esoinophilia-myalgia syndrome显示文摘 | Kaufman L D Gruber B L Gregersen P K | 1991 | Lancet1991，337，： | 1 |
| 10 | Stevioside induces antihyper - glyeaemic , and glucagonostatic effects in vivo: studies in the diabetic Goto - Kakizaki (GK) rats显示文摘 | Jeppesen P B Gregersen S Alstrup K | 2002 | Phytomedicine2002，，9： | 1 |
| 11 | Water balance of willow dominated constructed wetlands显示文摘 | Brix H Gregersen P | 2002 | Proc Int Conf Wetland Syst Water Pollut Control2002，8，： | 1 |
| 12 | A ehaleone synthase with an unusual substrate preference is expressed in barley leaves in response to UV - light and pathogen attack 显示文摘 | CHRISTENSEN A B GREGERSEN P L SCHRODER J | 1998 | Plant Mol Biol1998，37，： | 1 |
| 13 | Zero-dlscharge of nutrients and water in a wil- low dominated constructed wetland 显示文摘 | Gregersen P Brix H | 2001 | Water Sci Techno2001，44，： | 1 |
| 14 | Plant senescence and crop productivity显示文摘 | Gregersen P L Culetic A Boschian L | 2013 | Plant Molecular Biology2013，82，： | 1 |
| 15 | Biogas plants in Demnark:successes and setbacks显示文摘 | RAVEN R P J M GREGERSEN K H | 2007 | Renewable & Sustainable Energy Reviews2007，11，1： | 1 |
| 16 | Do we really understand the role of the oesophagogastric junction in disease?显示文摘The role of the oesophago-gastric junction (OGJ) in gastro-oesophageal reflux disease is still not completely understood, and there is no clinically used method to assess the OGJ function in patients. Only indirect methods such as pH studies are carried out. The OGJ acts a valve controlling the flow of solids, liquids and gases between the oesophagus and the stomach. Manometry can determine if a sphincter is toned or relaxed; but, it cannot confirm that the sphincter region is actually open. Distension is a new technique for measuring function in the OGJ. By measuring the cross-sectional area through the narrow region in the junction during distension of a catheter mounted bag, much more information on the opening and closing patterns of the junction can be determined. This technique has already been demonstrated to show changes in the OGJ after surgical treatments for reflux disease. New measurement ideas around the concept of distending the OGJ offer new hope that a clinically useable test for compliance at the junction can be developed and could potentially help in determining appropriate therapy. | Barry P McMahon Blair A Jobe John E Pandolfino Hans Gregersen | 2009 | World Journal of Gastroenterology2009，15，2： | 1 |
| 17 | REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis 显示文摘 | Gregersen P K Amos C I Lee A T | 2009 | Nature Genetics2009，41，7： | 1 |
| 18 | Antihyperglycemic ef ects of stevioside in type 2 diabetic subjects显示文摘 | Gregersen S Jeppesen P B Holst J J | | 0，，： | 1 |
| 19 | Association of STAT4 with rheumatoid arthritis in the Korean population显示文摘 | Lee H S Remmers E F Le J M Kastner D L Bae S C Gregersen P K | 2007 | Mol Med2007，13，： | 1 |
| 20 | Molecular characterization of the oxalate oxidaze involved in the response of barley to the powdery mildew fungus显示文摘 | ZHANG Z GREGERSEN P L MIKKELSEN J D NEERGAARD E CCOLLINGE D B ThORDAL C H | 1998 | Plant Physiol1998，117，： | 1 |
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