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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 3 | Angiotensin-(1-7) potentiates re- sponses to bradykinin but does not change responses to angiotensin I 显示文摘 | Greco AJ Master RG Fokin A Jr | 2006 | Can J Physiol Pharmacol2006，84，11： | 1 |
| 4 | Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-beta显示文摘 | Patel SA Meyer JR Greco SJ | 2010 | J Immunol2010，184，10： | 1 |
| 5 | Enzyme stabilization towards thermal chemical,and proteolytic deactivation显示文摘 | Gianfreda L Modafferi M Greco Jr G | | 0，，02： | 1 |
| 6 | Use of double gloves to protect the surgeon from blood contact during anesthetic procedures显示文摘 | Greco RJ Garza JR | 1995 | Aesthetic Plast Surg1995，19，3： | 1 |
| 7 | Preoperative therapy withconcurrent paclitaxel/carboplatin/infusional 5-FU and radiationtherapy in locoregional esophageal cancer:final results of a MinniePearl Cancer Research Network phaseⅡtrial显示文摘 | Meluch AA Greco FA Gray JR | 2003 | Cancer J2003，9，4： | 1 |
| 8 | Prospective randomized study of four novel chemotherapy regimens in patients with advanced non-small cell lung carcinoma显示文摘 | Greco FA Gray JR Jr Thompson DS | 2002 | Cancer2002，95，6： | 1 |
| 9 | The lateral notch sign associated with acute anterior cruciate ligament disruption显示文摘 | Garth WP Jr Greco J House MA | 2000 | Am J Sports Med2000，28，1： | 1 |
| 10 | Mesenchymal stem cells pro- tect breast cancer cells through regulatory T cells: role of mesen- chymal stem cell-derived TGF-beta 显示文摘 | Patel SA Meyer JR Greco SJ | 2010 | J Immunol2010，184，10： | 1 |
| 11 | Prospective randomized study of four novel chemotherapy regimens in patiets with advanced nonsmall cell lung carcinoma:a minnie pearl cancer research network trial显示文摘 | Greco FA Gray JR Jr Thompson DS | 2002 | Cancer2002，95，： | 1 |
| 12 | Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-beta显示文摘 | Patel SA Meyer JR Greco S J | 2010 | J Immunol2010，184，10： | 1 |
| 13 | Effectiveness of sodium fluoride on tooth hypersensitivity with and without iontophoresis显示文摘 | Lutins ND Greco GW McFall WT Jr | 1984 | J Periodontol1984，55，5： | 1 |
| 14 | Lipase- catalyzed transformations for the synthesis of butyl lactate: A comparison between esterification and transesterification 显示文摘 | PIROZZI D GRECO G JR | | Biotechnol Prog0，22，2： | 1 |
| 15 | Activity and stability of lipases in the synthesis of butyl lactate显示文摘 | Pirozzi D Greco Jr G | 2004 | Enzyme and Microbial Technology2004，34，： | 1 |
| 16 | Mesenchymal stem cells protect breast cancer cells through regulatory T cells : role of mes- enehymal stem cell-derived TGF-beta显示文摘 | Patel SA Meyer JR Greco SJ | 2010 | J Immunol2010，184，10： | 1 |
| 17 | Preoperative therapy with concurrent paclitaxel/carboplatin/infusional 5 FU and radiation therapy in locoregional esophageal cancer:final results of a Minnie Pearl Cancer Research Network phase Ⅱ trial显示文摘 | Meluch AA Greco FA Gray JR | 2003 | Cancer J2003，9，4： | 1 |
| 18 | Motor-evoked potentials recorded from lumbar erector spinae muscles:a study of corticospinal excitability changes associated with spinal manipulation显示文摘 | Dishman JD Greco DS Burke JR | 2008 | J Manipulatioe Physiol Ther2008，31，4： | 1 |
| 19 | Mesenchymal stem cells protect breast cancer cells through regulatory T cells:role of mesenchymal stem cell-derived TGF-beta显示文摘 | Patel SA Meyer JR Greco SJ | | 0，，： | 1 |
| 20 | Prospective randomized study of four novel chemotherapy regimens in patients with advanced nonsmall cell lung carcinoma: a minnie pearl cancer research network trial显示文摘 | Greco FA Gray JR Jr Thompson DS | 2002 | Cancer2002，95，6： | 1 |
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