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| 1 | Telomerase activity: An attractive target for cancer therapeutics显示文摘Telomeres are non-coding tandem repeats of 1000-2000 TTAGGG nucleotide DNA sequences on the 3' termini of human chromosomes where they serve as protective 'caps' from degradation and loss of genes. The 'cap' at the end of chromosome required to protect its integrity is a 150-200 nucleotide-long single stranded G-rich 3' overhang that forms two higher order structures, a T-loop with Sheltering complex, or a G-quadruplex complex. Telomerase is a human ribonucleoprotein reverse transcriptase that continually added single stranded TTAGGG DNA sequences onto the single strand 3' of telomere in the 5' to 3' direction. Telomerase activity is detected in male germ line cells, proliferative cells of renewal tissues, some adult pluripotent stem cells, embryonic cells, but in most somatic cells is not detected. Re-expression or up-regulation of telomerase in tumours cells is considered as a critical step in cell tumorigenesis and telomerase is widely considered as a tumour marker and a target for anticancer drugs. Different approaches have been used in anticancer therapeutics targeting telomerase. Telomerase inhibitors can block directly Human TElomerase Reverse Transcriptase(h TERT) or Human TElomerase RNA telomerase subunits activity, or G-quadruplex and Sheltering com-plex components, shortening telomeres and inhibiting cell proliferation. Telomerase can become an immune target and GV1001, Vx-001, I540 are the most widespread vaccines used with encouraging results. Another method is to use h TERT promoter to drive suicide gene expression or to control a lytic virus replication. Recently telomerase activity was used to activate pro-drugs such as Acycloguanosyl 5'-thymidyltriphosphate, a synthetic ACV-derived molecule when it is activated by telomerase it does not require any virus or host active immune response to induce suicide gene therapy. Advantage of all these therapies is that target only neoplastic cells without any effects in normal cells, avoiding toxicity and adverse effects of the current chemotherapy. However, as not all the approaches are equally efficient, further studies will be necessary. | Lucia Picariello Cecilia Grappone Simone Polvani Andrea Galli | 2014 | World Journal of Pharmacology2014，3，4： | 3 |
| 2 | Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells显示文摘 | M Pinzani S Milani R De Franco C Grappone A Caligiuri A Gentilini C Tosti- Guerra M Maggi P Failli C Ruocco P Gentilini | 1996 | Gastroenterology1996，，2： | 1 |
| 3 | Functions of fibrinolytic system in human ho cells and its control by basic fibroblas tand platelet-derived growth factor显示文摘 | Fibbi G Pucci M Grappone C | 1999 | Hepatology1999，29，3： | 1 |
| 4 | Thiazolidinediones inhibit growth and invasiveness of the human adrenocortical cancer cell line H295R显示文摘 | Ferruzzi P Ceni E Tarocchi M Grappone C Milani S Galli A | 2005 | J Clin Endocrinol Metab2005，90，3： | 1 |
| 5 | Expression of Monocyte Chemotactic Protein 1 Precedes Monocyte Recruitment in a Rat Model of Acute Liver Injury,and is Modulated by Vitamin E显示文摘 | MARRA F DE FRANCO R GRAPPONE C | 1999 | J Investig Med1999，47，1： | 1 |
| 6 | Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats显示文摘 | Cecilia Grappone Massimo Pinzani Maurizio Parola Giulia Pellegrini Alessandra Caligiuri Raffaella DeFranco Fabio Marra Hermann Herbst Gianfranco Alpini Stefano Milani | 1999 | Journal of Hepatology1999，，1： | 1 |
| 7 | Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells显示文摘 | M Pinzani S Milani R De Franco C Grappone A Caligiuri A Gentilini C Tosti- Guerra M Maggi P Failli C Ruocco P Gentilini | 1996 | Gastroenterology1996，，2： | 1 |
| 8 | Functions of fibrinolytic system in human Ito cells and its control by basic fibroblast and platelet-derived growth factor显示文摘 | Fibbi G Pucci M Grappone C | 1999 | Hepatology1999，29，3： | 1 |
| 9 | Expression of platelet- derived growth factor in a model of acute liver injury显示文摘 | Pinzani M Milani S Grappone C | 1994 | Hepatology1994，19，3： | 1 |
| 10 | Up-regulated expression of fractalkine and its receptor CX3CR1 during liver injury in humans显示文摘 | Efsen E Grappone C DeFranco RM | 2002 | J Hepato12002，37，1： | 1 |
| 11 | Up-regulated expression of fractalkine and its receptor CX3CRI during liver injury in humans显示文摘 | Efsen E Grappone C DeFranco RM | 2002 | J Hepatol2002，37，1： | 1 |
| 12 | Spatial and temporal pattern of expression of interstitial collagenase,stromelysin/transin,gelatinase A,and TIMP-1 during experimental gastric ulcer healing显示文摘 | A Calabro C Grappone G Pellegrini | 2004 | Digestion2004，70，2： | 1 |
| 13 | Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism显示文摘 | Galli A Svegliati-Baroni G Ceni E Milani S Ridolfi F Salzano R Tarocchi M Grappone C Pellegrini G Benedetti A Surrenti C Casini A | 2005 | Hepatology2005，41，5： | 1 |
| 14 | Expression of monocyte chemotactic protein-1 precedes monocyte recruitment in a rat model of acute liver injury, and is modulated by vitamin E显示文摘 | Marra F DeFranco R Grappone C | 1999 | J Investig Med1999，47，1： | 1 |
| 15 | Expression of monocyte chemotactic protein 1 precedes monocyte recruitment in a rat model of acute liver injury,and is modulated by vitamin E显示文摘 | De Franco R Grappone C | 1999 | J Investig Med1999，47，1： | 1 |
| 16 | Expression of the thrombin receptor in human liven up-regulation during acute and chronic injury显示文摘 | Marra F DeFranco R Grappone C | 1998 | Hepatology1998，27，2： | 1 |
| 17 | Functions of the fibrinolytic system in human Ito cells and its control by basic fibroblast and platelet-derived growth factor 显示文摘 | Fibbi G Pucei M Grappone C | 1999 | Hepatology1999，29，： | 1 |
| 18 | Expression of platelet-derived growth factor in a model of acute liver injury显示文摘 | Pinzani M Milani S Grappone C | 1994 | Hepatology1994，19，3： | 1 |
| 19 | Functions of fibrinolytic system in human Ito cells and its control by basic fibroblast and platelet-derived growth factor 显示文摘 | Fibbi G Pucci M Grappone C | 1999 | Hepatology1999，29，3： | 1 |
| 20 | Expression of platelet-derived growth factor in a model of acute liver injury显示文摘 | Pinzani M Milani S Grappone C | | 0，，03： | 1 |
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