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| 1 | Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study显示文摘AIM To evaluate the ability of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 to colonize the intestinal environment of healthy subjects and modify the gut microbiota composition.METHODS Twenty healthy Italian volunteers, eight males and twelve females, participated in the study. Ten subjects took a sachet containing 4 × 109 colony-forming units(CFU) of Bifidobacterium longum BB536 and 109 CFU of Lactobacillus rhamnosus HN001, 30 min before breakfast(pre-prandial administration), while ten subjects took a sachet of probiotic product 30 min after breakfast(post-prandial administration). The ability ofLactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 to colonize human gut microbiota was assessed by means of quantitative real-time PCR, while changes in gut microbiota composition were detected by using Ion Torrent Personal Genome Machine.RESULTS Immediately after 1-mo of probiotic administration, B. longum BB536 and L. rhamnosus HN001 load was increased in the majority of subjects in both preprandial and post-prandial groups. This increase was found also 1 mo after the end of probiotic oral intake in both groups, if compared to samples collected before probiotic consumption. At phyla level a significant decrease in Firmicutes abundance was detected immediately after 1-mo of B. longum BB536 and L. rhamnosus HN001 oral intake. This reduction persisted up to 1 mo after the end of probiotic oral intake together with a significant decrease of Proteobacteria abundance if compared to samples collected before probiotic administration. Whereas, at species level, a higher abundance of Blautia producta, Blautia wexlerae and Haemophilus ducrey was observed, together with a reduction of Holdemania filiformis, Escherichia vulneris, Gemmiger formicilis and Streptococcus sinensis abundance. In addition, during follow-up period we observed a further reduction in Escherichia vulneris and Gemmiger formicilis, together with a decrease in Roseburia faecis and Ruminococcus gnavus abundance. Conversely, the abundance of Akkermansia muciniphila was increased if compared to samples collected at the beginning of the experimental time course CONCLUSION B. longum BB536 and L. rhamnosus HN001 showed the ability to modulate the gut microbiota composition, leading to a significant reduction of potentially harmful bacteria and an increase of beneficial ones. Further studies are needed to better understand the specific mechanisms involved in gut microbiota modulation. | Marco Toscano Roberta De Grandi Laura Stronati Elena De Vecchi Lorenzo Drago | 2017 | World Journal of Gastroenterology2017，23，15： | 14 |
| 2 | The Evaluation of Family Functioning by the Family Assessment Device: A Systematic Review of Studies in Adult Clinical Populations显示文摘 | Laura Staccini Elena Tomba Silvana Grandi Gabor I. Keitner | 2015 | Fam. Proc2015，，： | 2 |
| 3 | Amplification of an invA gene sequence of Salmonella typhimurium by polymerase chain reaction as a specific methad of detection of Salmonella显示文摘 | Rahn K Grandis S A Clarke R C | 1992 | Mol Cell Probes1992，6，4： | 1 |
| 4 | Business incubators and new venture creation: An assessment of incubating models显示文摘 | Grimaldi R and Grandi A | 2005 | Technovation2005，25，2： | 1 |
| 5 | Implications of recent clinical trials for the National Cholesterol Education Program Adult Panel Ⅲ Guidelines显示文摘 | Grandy SM Cleeman JI Merz CN | 2004 | J Am Coil Cardiol2004，44，： | 1 |
| 6 | 1,1 vivo antitumor effi cacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy显示文摘 | Xi S Gooding WE Grandis JR | 2005 | Oncogene2005，24，6： | 1 |
| 7 | Shear stress injury to arterial walls显示文摘 | Bhumanis OR Grandy PA | 1981 | Adv Neurol1981，30，： | 1 |
| 8 | Apical ballooning syndrome or Tako-Tsubo cardiomyopathy:a systematic review显示文摘 | Gianni M Dentali F Grandi AM | 2006 | Eur Heart J2006，27，： | 1 |
| 9 | Amplification of an invA gene sequence of Salmonella typhimurium by polymerase chain reaction as a specific method of detection of Salmonella显示文摘 | Rahn K De Grandis SA Clarke RC McEwen SA Galan JE Ginocchio C | 1992 | Mol Cell Probes1992，6，4： | 1 |
| 10 | Proteome survey reveals modularity of the yeast cell machinery 显示文摘 | GAVIN A C ALOY P GRANDI P | 2006 | Nature2006，440，7084： | 1 |
| 11 | Pelvic floor education after vaginal delivery显示文摘 | S Meyer P Hohlfeld C Achtari P De Grandi | 2001 | Obstetrics & Gynecology2001，，5： | 1 |
| 12 | Business incu- bators and new Venture creation: An assessment of incubafingmodels显示文摘 | Gmmldi R Grandi A | 2005 | Technovation2005，25，2： | 1 |
| 13 | Levels of TGF- alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival显示文摘 | Rubin Grandis J Melhem MF Gooding WE | 1998 | J Natl Cancer Inst1998，90，11： | 1 |
| 14 | Synthesis and complimentary complex formation properties of oligonucleotides covalently linked to new stabilizing agents显示文摘 | Sottofattori E Grandi T | 1994 | Tetrahedron1994，50，： | 1 |
| 15 | Prevalence of Theileriaequi and Babesia caballi Infection in Horses from Northern It-aly显示文摘 | Grandi G Molinari G Tittarelli M | 2011 | Vector Borne Zoonotic Dis?2011，23，1： | 1 |
| 16 | Epidermal growth factor receptor-mediated stat3 signaling blocks apoptosis in head and neck cancer显示文摘 | Rubin Grandis j Zeng Q Drenning SD | 2000 | Laryngoscope2000，110，51： | 1 |
| 17 | Role of bi-level positive airway pressure in the management of preterm newborns who have received surfactant 显示文摘 | Ancora G Maranella E Grandi S | 2010 | Acta Paediatr2010，99，12： | 1 |
| 18 | Surgical treatment of unstable intertrochanteric fractures by bipolar hip replacement or total hip replacement in elderly osteoporotic patients显示文摘 | Faldini G Grandi G Romagnoli M | | 0，，03： | 1 |
| 19 | Acute hemorrhagic leukoencephalitis with atypical features显示文摘 | Catalan M Naccarato M Grandi FC | 2009 | Neurol Sci2009，30，1： | 1 |
| 20 | Involvement of the receptor for advanced glycation-end products(RAGE)inβ-amyloid-induced toxic effects in rat cerebromicrovascular endothelial cells cultured in vitro显示文摘 | Baiguera S Fioravazo L Grandi C | 2009 | Int J Mol Med2009，24，1： | 1 |
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