|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | In situ cosmogenic ^(10)Be dating of the Quaternary glaciations in the southern Shaluli Mountain on the Southeastern Tibetan Plateau显示文摘It is generally considered that four-times ice age happened during the Quaternary epoch on the Tibetan Plateau. However, the research on the chronology of the four-times ice age is far from enough. The Shaluli Mountain on the Southeastern Tibetan Plateau is an ideal place for plaeo-glacier study, because there are abundant Quaternary glacial remains there. This paper discusses the ages of the Quaternary glaciations, based on the exposure dating of roche moutonnée, moraines and gla- cial erosion surfaces using in situ cosmogenic isotopes 10Be. It is found that the exposure age of the roche moutonnée at Tuershan is 15 ka, corresponding to Stage 2 of the deep-sea oxygen isotope, suggesting that the roche moutonnée at Tuershan is formed in the last glacial maximum. The expo- sure age of glacial erosion surface at Laolinkou is 130―160 ka, corresponding to Stage 6 of the deep-sea oxygen isotope. The oldest end moraine at Kuzhaori may form at 421―766 kaBP, corre- sponding to Stages 12―18 of the deep-sea oxygen isotope. In accordance with the climate charac- teristic of stages 12,14,16 and 18 reflected by the deep-sea oxygen isotope, polar ice cores and loess sequence, the oldest end moraine at Kuzhaori may form at stage 12 or stage 16, the latter is more possible. | Raisbeck Grand Yiou Francios | 2006 | Science China Earth Sciences2006，49，12： | 26 |
| 2 | Role of inflammatory response in liver diseases: Therapeutic strategies显示文摘Inflammation and tumorigenesis are tightly linked pathways impacting cancer development. Inflammasomes are key signalling platforms that detect pathogenic microorganisms, including hepatitis C virus(HCV) infection, and sterile stressors(oxidative stress, insulin resistance, lipotoxicity) able to activate pro-inflammatory cytokines interleukin-1β and IL-18. Most of the inflammasome complexes that have been described to date contain a NOD-like receptor sensor molecule. Redox state and autophagy can regulate inflammasome complex and, depending on the conditions, can be either pro-or antiapoptotic. Acute and chronic liver diseases are cytokinedriven diseases as several proinflammatory cytokines(IL-1α, IL-1β, tumor necrosis factor-alpha, and IL-6) are critically involved in inflammation, steatosis, fibrosis, and cancer development. NLRP3 inflammasome gain of function aggravates liver disease, resulting in severe liver fibrosis and highlighting this pathway in the pathogenesis of non-alcoholic fatty liver disease. On the other hand, HCV infection is the primary catalyst for progressive liver disease and development of liver cancer. It is well established that HCV-induced IL-1β production by hepatic macrophages plays a critical and central process that promotes liver inflammation and disease. In this review, we aim to clarify the role of the inflammasome in the aggravation of liver disease, and how selective blockade of this main pathway may be a useful strategy to delay fibrosis progression in liver diseases. | José A Del Campo Paloma Gallego Lourdes Grande | 2018 | World Journal of Hepatology2018，10，1： | 25 |
| 3 | 桶基负压沉贯下粉土中水力梯度的变化过程显示文摘通过5个不同材料及其大小的桶基在粉土中的负压沉贯实验测定桶基内不同深度处孔隙水压力的产生和发展,计算出桶基作用下粉土中渗流梯度的大小,揭示出负压沉贯过程中渗流梯度的变化过程,表明土体在沉贯前后性质的变化,为桶基的设计提供依据。 | 杨少丽 Lars Grande 齐剑峰 李安龙 | 2003 | 岩土工程学报2003，25，6： | 18 |
| 4 | 利用陆面岩石中生成的宇生同位素重建冰川漂砾运动历史的尝试显示文摘冰川漂砾的形成年代通常难以直接测定,并且漂砾形成以后是否被再次搬运或者移动过,更是无法知道。本文研究发现,通过测试砾石不同部位的宇生同位素,不仅可以测定砾石形成的时代,而且可以确定砾石再次被搬运或者被翻转的年代,从而恢复砾石运动的历史。本文以石英中生成的宇生同位素^(10)Be,对青藏高原东南部海子山的冰川漂砾进行了探讨,结果表明该砾石形成于倒数第二次冰期(186~128 ka BP之间),在末次冰期中再次被冰川搬运,使之反转。该方法不局限于^(10)Be和冰川漂砾,也适用于其他陆面岩石中生成的宇生同位素以及其他成因的石块或者砾石。因此为探讨冰川作用、泥石流活动、重力崩塌等过程提供了一种重要的方法和技术途径。 | 王建 Francois Yiou Grand Raisbeck 徐孝彬 | 2003 | 地质学报2003，77，3： | 10 |
| 5 | Graphene for energy harvesting/storage devices and printed electronics显示文摘Graphene-based materials are intriguing from the perspective of fundamental science and technology because they are non-toxic, chemically and thermally tolerant, and mechanically robust. Graphene exhibits superior electrical conductivity, high surface area and a broad electrochemical window that may be particularly advantageous for their applications in energy storage devices. In addition, graphene can be prepared in the form of a colloidal suspension with adjustable solubility and thus is suitable for printing applications and offers both transparency and good conductivity at the same time. In this review, applications of graphene in solar cells, batteries, supercapacitors and fuel cells are summarized with the latest developments. Furthermore, graphene as a conductive ink for printed electronics is also discussed. | Lorenzo Grande Vishnu Teja Chundi Di Wei Chris Bower Piers Andrew TapaniRyhanen | 2012 | Particuology2012，10，1： | 8 |
| 6 | Modulation of faecal metagenome in Crohn's disease:Role of microRNAs as biomarkers显示文摘BACKGROUND The gut microbiota plays a key role in the maintenance of intestinal homeostasis and the development and activation of the host immune system. It has been shown that commensal bacterial species can regulate the expression of host genes. 16 S rRNA gene sequencing has shown that the microbiota in inflammatory bowel disease(IBD) is abnormal and characterized by reduced diversity. Micro RNAs(miRNAs) have been explored as biomarkers and therapeutic targets, since they are able to regulate specific genes associated with Crohn's disease(CD). In this work, we aim to investigate the composition of gut microbiota of active treatment-na?ve adult CD patients, with miRNA profile from gut microbiota.AIM To investigate the composition of gut microbiota of active treatment-na?ve adult CD patients, with miRNA profile from gut microbiota.METHODS Patients attending the outpatient clinics at Valme University Hospital without relevant co-morbidities were matched according to age and gender. Faecal samples of newonset CD patients, free of treatment, and healthy controls were collected. Faecal samples were homogenized, and DNA was amplified by PCR using primers directed to the 16 S bacterial rRNA gene. Pyrosequencing was performed using GS-Junior platform. For sequence analysis, MGRAST server with the database Ribosomal Project was used. MiRNA profile and their relative abundance were analyzed by quantitative PCR.RESULTS Microbial community was characterized using 16 S rRNA gene sequencing in 29 samples(n = 13 CD patients, and n = 16 healthy controls). The mean Shannon diversity was higher in the healthy control population compared to CD group(5.5 vs 3.7). A reduction in Firmicutes and an increase in Bacteroidetes were found. Clostridia class was also significantly reduced in CD. Principal components analysis showed a grouping pattern, identified in most of the subjects in both groups, showing a marked difference between control and CD groups. A functional metabolic study showed that a lower metabolism of carbohydrates(P = 0.000) was found in CD group, while the metabolism of lipids was increased. In CD patients, three miRNAs were induced in affected mucosa: mir-144(6.2 ± 1.3 fold), mir-519(21.8 ± 3.1) and mir-211(2.3 ± 0.4). CONCLUSION Changes in microbial function in active non-treated CD subjects and three miRNAs in affected vs non-affected mucosa have been found. miRNAs profile may serve as a biomarker. | María Rojas-Feria Teresa Romero-García Jose Angel Fernández Caballero-Rico Helena Pastor Ramírez Marta Avilés-Recio Manuel Castro-Fernandez Natalia Chueca Porcuna Manuel Romero-Gomez Federico García Lourdes Grande JoséA Del Campo | 2018 | World Journal of Gastroenterology2018，24，46： | 7 |
| 7 | Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review显示文摘Although artificial intelligence(AI)was initially developed many years ago,it has experienced spectacular advances over the last 10 years for application in the field of medicine,and is now used for diagnostic,therapeutic and prognostic purposes in almost all fields.Its application in the area of hepatology is especially relevant for the study of hepatocellular carcinoma(HCC),as this is a very common tumor,with particular radiological characteristics that allow its diagnosis without the need for a histological study.However,the interpretation and analysis of the resulting images is not always easy,in addition to which the images vary during the course of the disease,and prognosis and treatment response can be conditioned by multiple factors.The vast amount of data available lend themselves to study and analysis by AI in its various branches,such as deeplearning(DL)and machine learning(ML),which play a fundamental role in decision-making as well as overcoming the constraints involved in human evaluation.ML is a form of AI based on automated learning from a set of previously provided data and training in algorithms to organize and recognize patterns.DL is a more extensive form of learning that attempts to simulate the working of the human brain,using a lot more data and more complex algorithms.This review specifies the type of AI used by the various authors.However,welldesigned prospective studies are needed in order to avoid as far as possible any bias that may later affect the interpretability of the images and thereby limit the acceptance and application of these models in clinical practice.In addition,professionals now need to understand the true usefulness of these techniques,as well as their associated strengths and limitations. | Miguel Jimenez Perez Rocio Gonzalez Grande | 2020 | World Journal of Gastroenterology2020，26，37： | 7 |
| 8 | 高频厚壁管焊接质量的影响因素显示文摘中、大壁厚钢管焊接热影响区的形状像个沙漏,管壁的内外表面热而中部低温会限制焊接最大速度,若简单升高管壁中部温度,则管壁的内外表面会过热,同样会降低焊接质量;另外,管壁内表面过热熔化金属掉入阻抗器,会降低阻抗器的寿命和性能。针对这个焊接难题,对焊接区横向温度分布的影响因素———V形角、感应线圈到焊接点的距离、结构应力、焊接速度和焊机功率进行了研究。研究结果表明,较小的V形角可以提高获得更高产量的潜能,从而提高整体焊接效率。 | John Inge Asperheim Bjrnar Grande 赵亚涛 | 2006 | 焊管2006，29，6： | 4 |
| 9 | An in vitro prototype of a porcine biomimetic testis-like cell culture system: a novel tool for the study of reassembled Sertoli and Leydig cells显示文摘目前,有在 vitro 不可靠像睾丸的 biomimetic 机关文化系统设计了在 Sertoli 和 Leydig 房间上估计人的 gonadotropins 的功能的效果的装配 prepubertal。精子发生被调整由内分泌, paracrine,和 juxtacrine 因素(阴囊的串音) ,主要由象 luteinizing 荷尔蒙(LH ) 和由分别地刺激 Leydig 和 Sertoli 房间起一个枢轴的作用的刺激滤泡的荷尔蒙(FSH ) 那样的 gonadotropins 安排了。我们的学习的目的是建立一在里面 vitro prepubertal 是的猪的 bioengineered 构造为重新集合的 Sertoli 和 Leydig 房间上的试验性的研究的一个新模型。我们评估了从 15- 获得到 20-day-old 的 Sertoli 和 Leydig 房间新生的猪睾丸以纯净和功能。随后,净化了 Sertoli 并且充实 Leydig 房间受到 coincubation 获得一在里面 vitro prepubertal 猪的像睾丸的文化系统。我们为 anti-M 执行了连接酶的 immunosorbent 试金(ELISA ) | Iva Arato Giovanni Luca Francesca Mancuso Catia Bellucci Cinzia Lilli Mario Calvitti Barbara C Hansen Domenico Milardi Giuseppe Grande Riccardo Calafiore | 2018 | Asian Journal of Andrology2018，20，2： | 4 |
| 10 | Plasma phospholipid transfer protein (PLTP) modulates adaptive immune functions through alternation of T helper cell polarization显示文摘客观:血浆 phospholipid 转移蛋白质(PLTP ) 是脂蛋白新陈代谢的一个关键决定因素,并且动物和人的研究收敛显示 PLTP 支持 atherogenesis 和它的 thromboembolic 复杂并发症。而且, PLTP 调制发炎和有免疫力的回答,这最近被报导了。尽管从我们的组的更早的研究证明 PLTP 能修改巨噬细胞激活,在 T-cell-mediated 有免疫力的回答的调整的 PLTP 的含意从来没被调查过并且因此在现在的学习被探讨。途径和结果:在现在的学习,我们证明在老鼠的那 PLTP 缺乏在 CD4 + Th0 房间极化上有深刻效果,与向在正常、病理学的条件下面的反煽动性的 Th2 显型的移动。在接触超敏性的一个模型,对有 hapten-2,4-dinitrofluorobenzene (DNFB ) 的皮肤促进感受性的显著地损害的回答在 PLTP 缺乏的老鼠被观察与相比野类型(WT ) 老鼠。有趣地,在老鼠的 PLTP 缺乏没在外部血在全部的白血房间,淋巴细胞, granulocytes,或单核白血球的计数上施加效果。而且, PLTP 缺乏没修改 CD4 + 和 CD8 + T 淋巴细胞子集的数量。然而, PLTP 缺乏,与 Th2 显型的 upregulation 联系了,被重要减少在 pro-Th1 cytokine interleukin 的生产伴随 18 由附件房间。结论:第一次,这个工作向支持 inflammatory Th1 显型在 CD4 + T 房间的极化为 PLTP 报导一个生理的角色。 | Catherine Desrumau Stephanie Lemaire-Ewing Nicolas Ogier Akadiri Yessoufou Arlette Hammann Anabelle Sequeira-Le Grand Valerie Deckert Jean-Paul Pais de Barros Naig Le Guern Julien Guy Naim A Khan Laurent Lagrost | 2016 | Cellular & Molecular Immunology2016，13，6： | 3 |
| 11 | 肝硬化患者谷氨酰胺酶活性增加,其增加与轻微肝性脑病相关 | Romero-Gómez M. Ramos-Guerrero R. Grande L. 黎一兵 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，1： | 3 |
| 12 | Transrectal ultrasonography in infertile patients with persistently elevated bacteriospermia显示文摘瞄准:为了识别并且定义前列腺和精囊,在失败了到的有长期的男附件腺感染(东方三博士) 的病人的畸形对抗菌剂治疗作出回应。方法:我们与东方三博士选择了 67 个连续病人并且固执地提高了 bacteriospermia (≥
10 6 殖民地形成单位[CFU ]/mL ) 在三堂抗菌素功课以后。十四个不肥沃的病人与起始长期微生物引起(≥
10 6 CFU/mL ) 东方三博士对抗菌剂治疗作出回应(<
10 3 CFU/mL ) 担任了一个控制组。所有病人和控制经历了 transrectal ultrasonography (TRUS ) 扫描和精液分析。有低精液的血浆体积的病人(<
1.5 mL ) 经历 pre 射精并且 ejaculatory 以后 TRUS 检查。结果:TRUS 揭示了指示的多重畸形:(i) 双性人旁边地扩大了 prostato-vesiculitis (组 A:52 个盒子, 77.6%)( 九个这些病人也有 micro-emphyse-matous 前列腺脓肿) ;并且(i i ) 有射精管的单方或双边的亚阻塞的 prostato-vesiculitis (组 B:15 个盒子, 22.4%) 。吝啬的精子集中,全部的精子数字,精液体积和 pH 价值比在组 B 在组 A 是显著地更高的。另外,前面的活动性和正常的百分比形成的精子比在控制显著地更坏,而白血球集中在组 A 是显著地更高的。组 B 病人有所有精子参数,而是他们的 pH 值,与那些显著地不同控制。结论:尽管当微生物引起的东方三博士被怀疑时,抗菌素治疗被认为合适,根据常规标准仅仅说明对抗菌素的差的回答是不可能的(临床的历史,物理并且精液符号) 。因此, TRUS 可能在这些病人的后续是有用的。 | Sandro La Vignera Aldo E. Calogero Alessandro Arancio Roberto Castiglione Gaetano De Grande Enzo Vicari | 2008 | Asian Journal of Andrology2008，10，5： | 3 |
| 13 | Role of imaging in the evaluation of renal dysfunction in heart failure patients显示文摘Heart failure and kidney disease share common pathophysiological pathways which can lead to mutual dysfunction,known as cardiorenal syndrome.In heart failure patients,renal impairment is related to hemodynamic and nonhemodynamic factors.Both decreased renal blood flow and renal venous congestion due to heart failure could lead to impaired renal function.Kidney disease and worsening renal function are independently associated with poor prognosis in heart failure patients,both in acute and chronic clinical settings.The aim of this review is to assess the role of renal imaging modalities in the evaluation and management of heart failure patients.Renal imaging techniques could complete laboratory data,as estimated glomerular filtration rate,exploring different pathophysiological factors involved in kidney disease and adding valuable information about renal structure and function.In particular,Doppler examination of arterial and venous hemodynamics is a feasible and non invasive technique,which has proven to be a reliable method for prognostic stratification in patients with cardiorenal syndrome.The renal resistance index,a measure related to renal hemodynamics,can be calculated from the Doppler evaluation of arterial flow.Moreover,the analysis of Doppler venous flow patterns can integrate information from the arterial study and evaluate renal congestion.Other imaging modalities are promising,but still confined to research purposes. | Dario Grande Paola Terlizzese Massimo Iacoviello | 2017 | World Journal of Nephrology2017，6，3： | 3 |
| 14 | Resection of the uncinate process of the pancreas due to a ganglioneuroma显示文摘A 33-year-old woman who presented with epigastric discomfort and diarrhea underwent an abdominal ultrasound(US).This investigation and subsequent contrastenhanced computed tomography,magnetic resonance imaging and endoscopic US with fine needle aspiration (FNA)revealed a 40 mm well-circumscribed mass in the uncinate process of the pancreas.Findings were suggestive of a mucinous or solid-cystic pseudopapillary tumor of the pancreas,although other lesions such as a nonfunctioning neuroendocrine tumor could not be ruled out.FNA samples were negative for malignant cells,but of limited value due to poor cellularity.It was decided to surgically remove the tumor because malignancy could not be discounted.Multiple intraoperative biopsies were suggestive of mesenchymal tumor and consequently a conservative resection(uncinatectomy)was performed. The postoperative course was uneventful.The definitive diagnosis was ganglioneuroma.Immunocytochemistry showed positive staining with vimentin,S-100 protein, neurofilament and neuron-specific enolase.Ganglioneuroma is a rare benign tumor that can also present as a pancreatic tumor.Uncinatectomy is feasible,safe and a good surgical technique for the treatment of nonmalignant tumors located in the uncinate process of the pancreas. | Ignasi Poves Fernando Burdío Mar Iglesias María de los ángeles Martínez-Serrano Guadalupe Aguilar Luís Grande | 2009 | World Journal of Gastroenterology2009，15，34： | 3 |
| 15 | Early experience in human hybrid transgastric and transvaginal endoscopic cholecystectomy显示文摘 | Gustavo Salinas Lil Saavedra Hellen Agurto Rosa Quispe Edwin Ramírez José Grande Juan Tamayo Victoria Sánchez Daniel Málaga Jeffrey M. Marks | 2010 | Surgical Endoscopy2010，，5： | 2 |
| 16 | Activity of tea tree oil and nerolidol alone or in combination against Pediculus capitis (head lice) and its eggs显示文摘 | Emanuela Campli Soraya Bartolomeo Patricia Delli Pizzi Mara Giulio Rossella Grande Antonia Nostro Luigina Cellini | 2012 | Parasitology Research2012，，5： | 2 |
| 17 | Helicobacter pylori free‐living and biofilm modes of growth: behavior in response to different culture media显示文摘 | Lucinda J. Bessa Rossella Grande Donato DI Iorio Mara DI Giulio Emanuela DI Campli Luigina Cellini | 2012 | APMIS2012，，6： | 2 |
| 18 | 外科减肥手术后高血压缓解和复发的预测因素显示文摘目前,只有很少量研究涉及外科减肥手术后高血压得到缓解和复发的影响因素,没有可用于预测高血压复发相关因素的信息。该研究的目的是评估在外科减肥手术后第1年和第3年里高血压的缓解情况和复发率,并寻找可能的预测因素。 | Benaiges D Sagué M Flores-Le Roux JA Pedro-Botet J Ramón JM Villatoro M Chillarón JJ Pera M Más A Grande L Goday A 陈云 | 2016 | 中华高血压杂志2016，24，9： | 2 |
| 19 | Sentinel Lymph Node Mapping of the Gastrointestinal Tract by Using Invisible Light显示文摘 | Edward G. Soltesz Sungjee Kim Sang-Wook Kim Rita G. Laurence Alec M. De Grand Cherie P. Parungo Lawrence H. Cohn Moungi G. Bawendi John V. Frangioni | 2006 | Annals of Surgical Oncology2006，，3： | 2 |
| 20 | Severe immune thrombocytopenia after peg-interferonalpha2a, ribavirin and telaprevir treatment completion: a case report and systematic review of literature显示文摘Mild to moderate autoimmune thrombocytopenia(AITP) is a common finding in patients receiving interferonbased antiviral treatment, due to bone marrow suppression. Here we report the case of a patient with chronic genotype 1b hepatitis C virus(HCV) infection treated with pegylated-interferon alpha-2a, ribavirin and telaprevir for 24 wk; the patient developed severe AITP three weeks after treatment withdrawal. We performed a systematic literature search in order to review all published cases of AITP related to HCV antiviral treatment. To our knowledge, this is the second case of AITP observed after antiviral treatment withdrawal. In most published cases AITP occurred during treatment; in fact, among 24 cases of AITP related to interferonbased antiviral treatment, only one occurred after discontinuation. Early diagnosis of AITP is a key factor in order to achieve an early interferon discontinuation; in the era of new direct antiviral agents those patients have to be considered for interferon-free treatment regimens. Prompt prescription of immuno-suppressant treatment(i.e., corticosteroids, immunoglobulin infusion and even rituximab for unresponsive cases) leads to favourable prognosis in most of cases. Physicians using interferonbased treatments should be aware that AITP can occur both during and after treatment, specially in the new era of interferon-free antiviral treatment. Finally, in the case of suspected AITP, presence of anti-platelet antibodies should be checked not only during treatment but alsoafter discontinuation. | Rosario Arena Paolo Cecinato Andrea Lisotti Federica Buonfiglioli Claudio Calvanese Giuseppe Grande Marco Montagnani Francesco Azzaroli Giuseppe Mazzella | 2015 | World Journal of Hepatology2015，7，12： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员