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| 1 | Non-cirrhotic hepatocellular carcinoma in chronic viral hepatitis: Current insights and advancements显示文摘Primary liver cancers carry significant morbidity and mortality.Hepatocellular carcinoma(HCC)develops within the hepatic parenchyma and is the most common malignancy originating from the liver.Although 80%of HCCs develop within background cirrhosis,20%may arise in a non-cirrhotic milieu and are referred to non-cirrhotic-HCC(NCHCC).NCHCC is often diagnosed late due to lack of surveillance.In addition,the rising prevalence of non-alcoholic fatty liver disease and diabetes mellitus have increased the risk of developing HCC on noncirrhotic patients.Viral infections such as chronic Hepatitis B and less often chronic hepatitis C with advance fibrosis are associated with NCHCC.NCHCC individuals may have Hepatitis B core antibodies and occult HBV infection,signifying the role of Hepatitis B infection in NCHCC.Given the effectiveness of current antiviral therapies,surgical techniques and locoregional treatment options,nowadays such patients have more options and potential for cure.However,these lesions need early identification with diagnostic models and multiple surveillance strategies to improve overall outcomes.Better understanding of the NCHCC risk factors,tumorigenesis,diagnostic tools and treatment options are critical to improving prognosis and overall outcomes on these patients.In this review,we aim to discuss NCHCC epidemiology,risk factors,and pathogenesis,and elaborate on NCHCC diagnosis and treatment strategies. | Abhilash Perisetti Hemant Goyal Rachana Yendala Ragesh B Thandassery Emmanouil Giorgakis | 2021 | World Journal of Gastroenterology2021，27，24： | 6 |
| 2 | Secondary angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease: Results from the nationwide inpatient sample显示文摘BACKGROUND Chronic kidney disease is associated with angiodysplasia of gastrointestinal tract leading to increased risk of gastrointestinal bleeding.AIM To determine the nationwide prevalence,trends,predictors and resource utilization of angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease hospitalizations.METHODS The Nationwide Inpatient Sample database from 2009 to 2014,was utilized to conduct a retrospective study on patients with angiodysplasia associatedgastrointestinal bleeding and end-stage renal disease.Hospitalizations with endstage renal disease were included in the Nationwide Inpatient Sample database and a subset of hospitalizations with end-stage renal disease and angiodysplasiaassociated gastrointestinal bleeding were identified with International Classification of Diseases,9th revision,Clinical Modification codes for both endstage renal disease(585.6)and angiodysplasia(569.85,537.83).RESULTS The prevalence of angiodysplasia-associated gastrointestinal bleeding was 0.45%(n=24709)among all end-stage renal disease patients(n=5505252)that were hospitalized.Multivariate analysis indicated that the following were significant factors associated with higher odds of angiodysplasia associated-gastrointestinal bleeding in end-stage renal disease patients:an increasing trend from 2009-2014(P<0.01),increasing age(P<0.0001);African American race(P=0.0206);increasing Charlson-Deyo Comorbidity Index(P<0.01);hypertension(P<0.0001);and tobacco use(P<0.0001).Diabetes mellitus(P<0.0001)was associated with lower odds of angiodysplasia associated-gastrointestinal bleeding in end-stage renal disease patients.In comparison with urban teaching hospitals,rural and urban nonteaching hospitals were associated with decreased odds of angiodysplasia associated-gastrointestinal hemorrhage.CONCLUSION Angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease patients showed an increasing trend from 2009-2014.Advanced age,African American race,overall high comorbidities,hypertension and smoking were significant factors for angiodysplasia-associated gastrointestinal bleeding in bleeding in these patients. | Tooba Tariq Patrick Karabon Furqan B Irfan Sachin Goyal Matthew Masaru Mayeda Austin Parsons Stephanie Judd Murray Ehrinpreis | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，10： | 3 |
| 3 | Effect of chronic treatment with Enicostemma littorale in non-insulin-dependent diabetic (NIDDM) rats显示文摘 | B Murali U.M Upadhyaya R.K Goyal | 2002 | Journal of Ethnopharmacology2002，，2： | 2 |
| 4 | Data Models in Geographic Information Systems显示文摘 | Shekhar S Coyle M Goyal B | 1997 | Commun ACM1997，40，4： | 1 |
| 5 | Intracervical versus vaginal misoprostol for cervical dilatation prior to operative hys- teroscopy-a comparative study显示文摘 | GOYAL B ROY P BHAT P | 2012 | Med J Armed Forces India2012，68，2： | 1 |
| 6 | Positive pressure mechanical ventilation显示文摘 | GALI B GOYAL D G | 2003 | Emerg Med Clin North Am2003，21，2： | 1 |
| 7 | Analysis of junctional ectopy during radiofrequency ablation of the slow pathway in patients with atrioventricular nodal reentrant tachycardia 显示文摘 | JENTZER J H GOYAL R WILLIAMSON B D | 1994 | Circulation1994，90，： | 1 |
| 8 | Effects of doping concentration and annealing temperature on properties of highly-oriented Al-doped ZnO films显示文摘 | Goyal D J Agashe C M Marathe B R l | 1992 | Journal of Materials Science Letters1992，，11： | 1 |
| 9 | Growth Options, Beta, and the Cost of Capital 显示文摘 | BERNARDO A E CHOWDHRY B GOYAL A | 2007 | Financial Management2007，36，2： | 1 |
| 10 | Diabetic cardiornyopathy: Pathophysiological mechanisms and cardiac dysfunction 显示文摘 | Goyal B Mehta A | 2013 | Hum Exp Toxicol2013，32，6： | 1 |
| 11 | Recent trends in modeling of deteriorating inventory显示文摘 | Goyal S K Girl B C | 2001 | European J of Operational Research2001，134，1： | 1 |
| 12 | Podocyte depletion causes glomeruloselerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene显示文摘 | WHARRAM B L GOYAL M WIGGINS J E | 2005 | J Am Soc Nephrol2005，16，10： | 1 |
| 13 | Recent trends in modeling of deteriorating inventory显示文摘 | GOYAL S K GIRI B C | 2001 | European Journal of Operational Research2001，134，1： | 1 |
| 14 | Successful use of intra-aortic counterpulsation therapy for intractable ventricular arrhythmia in patient with severe left ventricular dysfunction and normal coronary arteries显示文摘 | Goyal D Nadar SK Wrigley B | 2010 | Cardiol J2010，17，4： | 1 |
| 15 | The production-inventory problem of a product with time varying demand, production and deterioration rates显示文摘 | Goyal S K Giri B C | 2003 | European Journal of Operational Research2003，147，3： | 1 |
| 16 | Recent trends in modeling of deteriorating inventory显示文摘 | Goyal S K Giri B C | 2001 | European Journal of Operational Research2001，，134： | 1 |
| 17 | Bio-fuels from thermochemical conversion of Renewable resources: A review显示文摘 | Goyal H B Seal D Saxena R C | 2008 | Renewable and Sustainable Energy Reviews2008，12，： | 1 |
| 18 | Podocyte depletion causes glomerulosclerosis: diphtheria toxin induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene 显示文摘 | WHARRAM B L GOYAL M WIGGINS J E | 2005 | J Am Soc Nephrol2005，16，10： | 1 |
| 19 | Sepsis : the inflammatory foun-dation of pathophysiology and therapy 显示文摘 | Li J Carr B Goyal M Gaieski DF | 2011 | Hosp Pract ( Minneap)2011，39，3： | 1 |
| 20 | Recent trends in modeling of deteriorating inventory 显示文摘 | Goyal S K Giri B C | 2001 | European Journal of Operational Research2001，134，1： | 1 |
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