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| 1 | Platelet factor 4/heparin antibody (IgG/M/A) in healthy subjects: a literature analysis of commercial immunoassay results显示文摘 | Gowthami M. Arepally Marcie J. Hursting | 2008 | Journal of Thrombosis and Thrombolysis2008，，1： | 1 |
| 2 | Gastrointestinal tract and viral pathogens显示文摘Viral gastroenteritis is the most common viral illness that affects the gastro-intestinal(GI)tract,causing inflammation and irritation of the lining of the stomach and intestines.Common signs and symptoms associated with this condition include abdominal pain,diarrhea,and dehydration.The infections commonly involved in viral gastroenteritis are rotavirus,norovirus,and adenovirus,which spread through the fecal-oral and contact routes and cause non-bloody diarrhea.These infections can affect both immunocompetent and immunocompromised individuals.Since the pandemic in 2019,coronavirus gastroenteritis has increased in incidence and prevalence.Morbidity and mortality rates from viral gastroenteritis have declined significantly over the years due to early recognition,treatment with oral rehydration salts,and prompt vaccination.Improved sanitation measures have also played a key role in reducing the transmission of infection.In addition to viral hepatitis causing liver disease,herpes virus,and cytomegalovirus are responsible for ulcerative GI disease.They are associated with bloody diarrhea and commonly occur in im-munocompromised individuals.Hepatitis viruses,Epstein-Barr virus,herpesvirus 8,and human papillomavirus have been involved in benign and malignant diseases.This mini review aims to list different viruses affecting the GI tract.It will cover common symptoms aiding in diagnosis and various important aspects of each viral infection that can aid diagnosis and management.This will help primary care physicians and hospitalists diagnose and treat patients more easily. | Gowthami Sai Kogilathota Jagirdhar Yashwitha Sai Pulakurthi Himaja Dutt Chigurupati Salim Surani | 2023 | World Journal of Virology2023，12，3： | 1 |
| 3 | The congenital bicuspid aortic valve can experience high-frequency unsteady shear stresses on its leaflet surface显示文摘 | Choon Hwai Yap Neelakantan Saikrishnan Gowthami Tamilselvan Nikolai Vasilyev Ajit P. Yoganathan | 2012 | AJP: Heart and Circulatory Physiology2012，，6： | 1 |
| 4 | Comprehensive review on oral disintegrating films显示文摘 | NAGARAJU T GOWTHAMI R RAJASHEKAR M | 2013 | Curr Drug Deliv2013，10，1： | 1 |
| 5 | Heart failure in general and cardiac transplant patients with COVID-19显示文摘Coronavirus disease 2019(COVID-19)is primarily an infection of the respiratory tract,but it can have multisystem manifestations.Cardiac complications of COVID-19 can range from acute myocardial injury,cardiac arrhythmias,or heart failure,amongst others.Heart failure(HF)in COVID-19 can be a de novo process or due to worsening of pre-existing cardiovascular ailment.HF in a patient with COVID-19 not only poses challenges in clinical presentation and management of COVID-19 but also affect prognosis of the patient.This article aims to succinctly revisit the implications of this pandemic regarding pre-existing HF or new-onset HF based on prevailing data.It also focuses on the management and special recommendations from prior studies and guidelines. | Munish Sharma Gowthami Sai Kogilathota Jagirdhar Kalpalatha K Guntupalli Rahul Kashyap Salim Surani | 2022 | World Journal of Cardiology2022，14，7： | 1 |
| 6 | Production ofpullulan by Aureobasidium pullulans from Asian palm kemel:Anovel substrate显示文摘 | KR Sugumaran E Gowthami B Swathi | 2013 | Carbohydrate Polymers2013，，92： | 1 |
| 7 | Non-clostridium difficile induced pseudomembranous colitis显示文摘Pseudomembranous colitis is severe inflammation of the inner lining of the colon due to anoxia,ischemia,endothelial damage,and toxin production.The majority of cases of pseudomembranous colitis are due to Clostridium difficile.However,other causative pathogens and agents have been responsible for causing a similar pattern of injury to the bowel with the endoscopic appearance of yellow-white plaques and membranes on the mucosal surface of the colon.Common presenting symptoms and signs include crampy abdominal pain,nausea,watery diarrhea that can progress to bloody diarrhea,fever,leukocytosis,and dehydration.Negative testing for Clostridium difficile or failure to improve on treatment should prompt evaluation for other causes of pseudomembranous colitis.Bacterial infections other than Clostridium difficile,Viruses such as cytomegalovirus,parasitic infections,medications,drugs,chemicals,inflammatory diseases,and ischemia are other differential diagnoses to look out for in pseudomembranous colitis.Complications of pseudomembranous colitis include toxic megacolon,hypotension,colonic perforation with peritonitis,and septic shock with organ failure.Early diagnosis and treatment to prevent progression are important.The central perspective of this paper is to provide a concise review of the various etiologies for pseudomembranous colitis and management per prior literature. | Gowthami Sai Kogilathota Jagirdhar Salim Surani | 2023 | World Journal of Clinical Cases2023，11，5： | 1 |
| 8 | Comprehensive review on oral disintegrating films 显示文摘 | Nagaraju T Gowthami R Rajashekar M | 2013 | Curr DrugDeliv2013，10，1： | 1 |
| 9 | Acquired von Willebrand Syndrome in Continuous-Flow Ventricular Assist Device Recipients显示文摘 | Sheri Crow Dong Chen Carmelo Milano William Thomas Lyle Joyce Valentino Piacentino Riti Sharma Jogin Wu Gowthami Arepally Dawn Bowles Joseph Rogers Nestor Villamizar-Ortiz | 2010 | The Annals of Thoracic Surgery2010，，： | 1 |
| 10 | Association of non-alcoholic fatty liver and metabolic-associated fatty liver with COVID-19 outcomes:A systematic review and metaanalysis显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)and metabolic-associated fatty liver disease(MAFLD)are on the rise like any other liver disease,and tend to affect 25%of the United States population.The impact of NAFLD and MAFLD on patients with coronavirus disease 2019(COVID-19)remains unclear.AIM To identify the association of NAFLD and MAFLD with mortality,hospitalization,hospital length of stay,and supplemental oxygen utilization in COVID-19 patients.METHODS A systematic review of literature on Cochrane,Embase,PubMed,ScienceDirect,and Web of Science databases was conducted from January 2019 to July 2022.Studies that evaluated NAFLD/MAFLD using laboratory methods,noninvasive imaging,or liver biopsy were included.The study protocol was registered in PROSPERO(ID CRD42022313259)and PRISMA guidelines were followed.The National Institutes of Health quality assessment tool was used to assess the quality of the studies.Pooled analysis was conducted using software Rev Man version 5.3.The stability of the results was assessed using sensitivity analysis.RESULTS Thirty-two studies with 43388 patients were included in the meta-analysis of whom 8538(20%)patients were observed to have NAFLD.There were 42254 patients from 28 studies included in the mortality analysis.A total of 2008 patients died from COVID-19;837(10.52%)in the NAFLD group and 1171(3.41%)in the non-NAFLD group.The odds ratio(OR)was 1.38 for mortality with a 95%confidence interval(95%CI)=0.97-1.95 and P=0.07.A total of 5043 patients from eight studies were included in the hospital length of stay analysis.There were 1318 patients in the NAFLD group and 3725 patients in the non-NAFLD group.A qualitative synthesis showed that the mean difference in hospital length of stay was about 2 d between the NAFLD and non-NAFLD groups with a 95%CI=0.71-3.27 and P=0.002.For hospitalization rates,the OR was 3.25 with a 95%CI of 1.73-6.10 and P=0.0002.For supplemental oxygen utilization,the OR was 2.04 with a 95%CI of 1.17-3.53 and P=0.01.CONCLUSION Our meta-analysis suggests that there are increased odds of hospitalization,longer hospital length of stay,and increased use of supplemental oxygen in NAFLD/MAFLD patients. | Gowthami Sai Kogilathota Jagirdhar Rakhtan K Qasba Harsha Pattnaik Kaanthi Rama Akshat Banga Shiva Teja Reddy Anna Carolina Flumignan Bucharles Rahul Kashyap Praveen Reddy Elmati Vikas Bansal Yatinder Bains Theodore DaCosta Salim Surani | 2023 | World Journal of Gastroenterology2023，29，21： | 0 |
| 11 | Role of second look endoscopy in endoscopic submucosal dissection and peptic ulcer bleeding:Meta-analysis of randomized controlled trials显示文摘BACKGROUND Second-look endoscopy(SLE)to prevent recurrent bleeding in patients with peptic ulcer disease(PUD)and those undergoing endoscopic submucosal dissection(ESD)is routinely being performed.Conflicting evidence exists regarding efficacy,risk,benefit,and cost-effectiveness.AIM To identify the role and effectiveness of SLE in ESD and PUD,associated rebleeding and PUD-related outcomes like mortality,hospital length of stay,need for endoscopic or surgical intervention and blood transfusions.METHODS A systematic review of literature databases PubMed,Cochrane,and Embase was conducted from inception to January 5,2023.Randomized controlled trials that compared patients with SLE to those who did not have SLE or evaluated the role of prophylactic hemostasis during SLE compared to other conservative interventions were included.The study was conducted per PRISMA guidelines,and the protocol was registered in PROSPERO(ID CRD42023427555:).RevMan was used to perform meta-analysis,and Mantel-Haenszel Odds ratio(OR)were generated using random effect models.RESULTS A total of twelve studies with 2687 patients were included in our systematic review and meta-analysis,of which 1074 patients underwent SLE after ESD and 1613 patients underwent SLE after PUD-related bleeding.In ESD,the rates of rebleeding were 7%in the SLE group compared to 4.4%in the non-SLE group with OR 1.65,95%confidence intervals(CI)of 0.96 to 2.85;P=0.07,whereas it was 11%in the SLE group compared to 13%in the non-SLE group with OR 0.895%CI:0.50 to 1.29;P=0.36.The mean difference in the blood transfusion rates in the SLE and no SLE group in PUD was OR 0.01,95%CI:-0.22 to 0.25;P=0.91.In SLE vs non-SLE groups with PUD,the OR for Endoscopic intervention was 0.29,95%CI:0.08 to 1.00;P=0.05 while it was OR 2.03,95%CI:0.95 to 4.33;P=0.07,for surgical intervention.The mean difference in the hospital length of stay was-3.57 d between the SLE and no SLE groups in PUD with 95%CI:-7.84 to 0.69;P=0.10,denoting an average of approximately 3 fewer days of hospital stay among patients with PUD who underwent SLE.For mortality between SLE and non-SLE groups in PUD,the OR was 0.88,95%CI:0.45 to 1.72;P=0.70.CONCLUSION SLE does not confer any benefit in preventing ESD and PUD-associated rebleeding.SLE also does not provide any significant improvement in mortality,need for interventions,or blood transfusions in PUD patients.SLE decreases the hospital length of stay on average by 3.5 d in PUD patients. | Gowthami Sai Kogilathota Jagirdhar Jose Andres Perez Akshat Banga Rakhtan K Qasba Ruman K Qasba Harsha Pattnaik Muhammad Hussain Yatinder Bains Salim Surani | 2024 | World Journal of Gastrointestinal Endoscopy2024，16，4： | 0 |
| 12 | Integration and implementation of precision medicine in the multifaceted inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)is a complex disease with variability in genetic,environmental,and lifestyle factors affecting disease presentation and course.Precision medicine has the potential to play a crucial role in managing IBD by tailoring treatment plans based on the heterogeneity of clinical and temporal variability of patients.Precision medicine is a population-based approach to managing IBD by integrating environmental,genomic,epigenomic,transcriptomic,proteomic,and metabolomic factors.It is a recent and rapidly developing medicine.The widespread adoption of precision medicine worldwide has the potential to result in the early detection of diseases,optimal utilization of healthcare resources,enhanced patient outcomes,and,ultimately,improved quality of life for individuals with IBD.Though precision medicine is promising in terms of better quality of patient care,inadequacies exist in the ongoing research.There is discordance in study conduct,and data collection,utilization,interpretation,and analysis.This review aims to describe the current literature on precision medicine,its multiomics approach,and future directions for its application in IBD. | Gowthami Sai Kogilathota Jagirdhar Jose Andres Perez Andrea Belen Perez Salim Surani | 2023 | World Journal of Gastroenterology2023，29，36： | 0 |
| 13 | The growth of biopolymers and natural earthen sources as membrane/separator materials for microbial fuel cells:A comprehensive review显示文摘Microbial fuel cell(MFC)technology has emerged as an effective solution for energy insecurity and bioremediation.However,identifying suitable components(particularly separators or membranes)with the required properties,such as low cost and high performance,remains challenging and restricts practical application.Commercial membranes,such as Nafion,exhibit excellent performance in MFC.However,these membranes have high production costs,which considerably increase the overall MFC unit cell cost.Among the numerous types,the separators or membranes developed from biopolymers and naturally occurring earthen sources have proven to be a novel and efficient concept due to their natural abundance,cost-effectiveness(approximately$20 m^(-2),$5 m^(-2),and$1 kg-1for biopolymers,ceramics,and earthensources,respectively),structural properties,proton transportation,manufacturing and modification ease,and environmental friendliness.In this review,we emphasize cost-effective renewable green materials(biopolymers,bio-derived materials,and naturally occurring soil,clay,ceramics or minerals)for MFC applications for the first time.Biopolymers with good thermal,mechanical,and water retention properties,sustainability,and environmental friendliness,such as cellulose and chitosan,are typically preferred.Furthermore,the modification or introduction of various functional groups in biopolymers to enhance their functional properties and scale MFC power density is explored.Subsequently,separator/membrane development using various bio-sources(such as coconut shells,banana peels,chicken feathers,and tea waste ash)is described.Additionally,naturally occurring sources such as clay,montmorillonite,and soils(including red,black,rice-husk,and Kalporgan soil)for MFC were reviewed.In conclusion,the existing gap in MFC technology was filled by providing recommendations for future aspects based on the barriers in cost,environment,and characteristics. | Gowthami Palanisamy Sadhasivam Thangarasu Ranjith Kumar Dharman Chandrashekar S.Patil Thakur Prithvi Pal Singh Negi Mahaveer D.Kurkuri Ranjith Krishna Pai Tae Hwan Oh | 2023 | Journal of Energy Chemistry2023，，5： | 0 |
| 14 | Removal of intrahepatic bile duct stone could reduce the risk of cholangiocarcinoma显示文摘Hepatolithiasis(HL)poses a significant risk for cholangiocarcinoma(CCA)development,with reported incidences ranging from 5%-13%.Risk factors include older age,smoking,hepatitis B infection,and prolonged HL duration.Chronic inflammation and mechanical stress on the biliary epithelium contribute to CCA pathogenesis.Hepatectomy reduces CCA risk by removing stones and atrophic liver segments.However,residual stones and incomplete removal increase CCA risk.Kim et al identified carbohydrate antigen 19-9,carcinoembryonic antigen,and stone laterality as CCA risk factors,reaffirming the importance of complete stone removal.Nonetheless,challenges remain in preventing CCA recurrence post-surgery.Longer-term studies are needed to elucidate CCA risk factors further. | Gowthami Sai Kogilathota Jagirdhar Yatinder Bains Salim Surani | 2024 | World Journal of Clinical Cases2024，12，11： | 0 |
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