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| 1 | Pediatric primary urolithiasis: Symptoms, medical management and prevention strategies显示文摘In the past few decades pediatric urolithiasis has become more frequent. The reason for this increase is not completely clear but has been attributed to changes in climate, nutritional habits and possibly other environmental factors. Although less frequent than adult stone disease, urolithiasis in the pediatric age group is also related to significant morbidity, particularly since stones tend to recur, and, thus, should not be underestimated. Most children with idiopathic stone disease have an underlying metabolic abnormality substantiating the importance of metabolic evaluation already following initial diagnosis of urolithiasis. Identification of the metabolic abnormality allows for more specific prescription of non pharmacological and pharmacological interventions aimed at preventing recurrent stone formation. A better understanding of the causes of kidney stone disease will provide better strategies for stone prevention in children. | Maria Goretti Moreira Guimar?es Penido Marcelo de Sousa Tavares | 2015 | World Journal of Nephrology2015，4，4： | 4 |
| 2 | Simplified and miniaturized procedure based on ultrasound-assisted cytosol preparation for the determination of Cd and Cu bound to metallothioneins in mussel tissue by ICP-MS显示文摘 | Isela Lavilla Marta Costas Sandra Gil Sandra Corderí Goretti Sánchez Carlos Bendicho | 2012 | Talanta2012，，： | 2 |
| 3 | Parathyroid ultrasonography and bone metabolic profile of patients on dialysis with hyperparathyroidism显示文摘AIM To evaluate the parathyroid ultrasonography and define parameters that can predict poor response to treatment in patients with secondary hyperparathyroidism due to renal failure.METHODS This cohort study evaluated 85 patients with chronic kidney disease stage V with parathyroid hormone levels above 800 pg/mL. All patients underwent ultrasonography of the parathyroids and the following parameters were analyzed: Demographic characteristics(etiology of chronic kidney disease, gender, age, dialysis vintage, vascular access, use of vitamin D), laboratory(calcium, phosphorus, parathyroid hormone, alkaline phosphatase, bone alkaline phosphatase), and the occurrence of bone changes, cardiovascular events and death. The χ~2 test were used to compare proportions or the Fisher exact test for small sample frequencies. Student t-test was used to detect differences between the two groups regarding continuous variables.RESULTS Fifty-three patients(66.4%) had parathyroid nodules with higher levels of parathyroid hormone, calcium and phosphorus. Sixteen patients underwent parathyroidectomy and had higher levels of phosphorus and calcium × phosphorus product(P = 0.03 and P = 0.006, respectively). They also had lower mortality(32% vs 68%, P = 0.01) and lower incidence of cardiovascular or cerebrovascular events(27% vs 73%, P = 0.02). Calcium × phosphorus product above 55 mg^2/dL^2 [RR 1.48(1.06, 2.08), P = 0.03], presence of vascular calcification [1.33(1.01, 1.76), P = 0.015] and previous occurrence of vascular events [RR 2.25(1.27, 3.98), P < 0.001] were risk factors for mortality in this population. There was no association between the occurrence of nodules and mortality.CONCLUSION The identification of nodules at ultrasonography strengthens the indication for parathyroidectomy in patients with secondary hyperparathyroidism due to renal failure. | Cláudia Ribeiro Maria Goretti Moreira Guimaraes Penido Milena Maria Moreira Guimaraes Marcelo de Sousa Tavares Bruno das Neves Souza Anderson Ferreira Leite Leonardo Martins Caldeira de Deus Lucas Joséde Campos Machado | 2016 | World Journal of Nephrology2016，5，5： | 2 |
| 4 | Cognitive impairment in pediatric multiple sclerosis显示文摘 | Ghezzi A Goretti B Portaccio E | | 0，，2： | 1 |
| 5 | Psychrophilic yeasts from worldwide glacial habitats: diversity, adaptation strategies and biotechno- logical potential显示文摘 | BUZZINI P BRANDA E GORETTI M | 2012 | FEMS Mierobioi Ecol2012，82，2： | 1 |
| 6 | Cognitive and psychosocial features of childhood and juvenile MS显示文摘 | Amato MP Goretti B Ghezzi A | | 0，，20： | 1 |
| 7 | Cognitive and psychosocial features in childhood and juvenile MS:two-year follow-up显示文摘 | Amato MP Goretti B Ghezzi A | | 0，，13： | 1 |
| 8 | Cognitive and psychosocial features in childhood and juvenile MS: Twu-year follow-up显示文摘 | Amato MP Goretti B Ghezzi A Lori S Zipoli V Moiola L | 2010 | Neurology2010，75，13： | 1 |
| 9 | Psychosocial issue in children and adolescents with multiple sclerosis显示文摘 | Goretti B Ghezzi A Portaccio E | | 0，，04： | 1 |
| 10 | Fatigue and its relationships with cognitive functioning and depression in pediatric multiple sclerosis显示文摘 | Goretti B Portaccio E Ghezzi A | | 0，，03： | 1 |
| 11 | Use of circulating microRANs to diag- nose acute myocardial infarction显示文摘 | Devaux Y Vausort M Goretti E | 2012 | Clin Chem2012，，3： | 1 |
| 12 | Benign multiple sclerosis: cognitive,psychological and social aspects in a clinical cohort显示文摘 | Amato MP Zipoli V Goretti B | 2006 | J Neurol2006，253，8： | 1 |
| 13 | Use of circulating microRNAs to diagnose acute myocardial infarction 显示文摘 | Devaux Y Vausort M Goretti E | 2012 | Clinical chemistry2012，58，3： | 1 |
| 14 | Use of circulating microRNAs to diagnose acute myocardial infarction 显示文摘 | Devaux Y Vausort M Goretti E | 2012 | Clin Chem2012，58，3： | 1 |
| 15 | Psychrophilic yeasts in glacial environments of Alpine glaciers 显示文摘 | TURCHETTI B BUZZINI P GORETTI M | 2008 | FEMS Microbiol Ecoi2008，63，1： | 1 |
| 16 | Use of circu- lating microRNAs to diagnose acute myocardial in- farction显示文摘 | Devaux Y Vausort M Goretti E | 2012 | Clin Chem2012，58，3： | 1 |
| 17 | Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors显示文摘 | Renato F. Freitas Igor M. Prokopczyk Aderson Zottis Glaucius Oliva Adriano D. Andricopulo Maria Teresa S. Trevisan Wagner Vilegas Maria Goretti V. Silva Carlos A. Montanari | 2009 | Bioorganic & Medicinal Chemistry2009，，6： | 1 |
| 18 | Cognitive impair-ment in early stages of multiple sclerosis 显示文摘 | Amato MP Portaccio E Goretti B | 2010 | Neurol Sci2010，31，2： | 1 |
| 19 | Evaluation of post and cores in the laboratory: rationale for developing a fatigue test and preliminary results 显示文摘 | Dietschi D Romelli M Goretti A | 1996 | Compend Contin Educ Dent Suppl1996，20，： | 1 |
| 20 | Bone disease in pediatric idiopathic hypercalciuria显示文摘Idiopathic hypercalciuria(IH) is the leading metabolic risk factor for urolithiasis and affects all age groups without gender or race predominance. IH has a high morbidity with or without lithiasis and reduced bone mineral density(BMD), as described previously in pediatric patients as well as in adults. The pathogenesis of IH is complex and not completely understood, given that urinary excretion of calcium is the end result of an interplay between three organs(gut, bone and kidney), which is further orchestrated by hormones, such as 1,25 dihydroxyvitamin D, parathyroid hormone, calcitonin and fosfatonins(i.e., fibroblast growth-factor-23). Usually, a primary defect in one organ induces compensatory mechanisms in the remaining two organs, such as increased absorption of calcium in the gut secondary to a primary renal loss. Thus, IH is a systemic abnormality of calcium homeostasis with changes in cellular transport of this ion in intestines, kidneys and bones. Reduced BMD has been demonstrated in pediatric patients diagnosed with IH. However, the precise mechanisms of bone loss or failure of adequate bone mass gain are still unknown. The largest accumulation of bone mass occurs during childhood and adolescence, peaking atthe end of the second decade of life. This accumulation should occur without interference to achieve the peak of optimal bone mass. Any interference may be a risk factor for the reduction of bone mass with increased risk of fractures in adulthood. This review will address the pathogenesis of IH and its consequence in bone mass. | Maria Goretti Moreira Guimares Penido Marcelo de Sousa Tavares | 2012 | World Journal of Nephrology2012，1，2： | 1 |
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