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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Increased insulin-like growth factor-1 gene expression precedes left ventricular cardiomyocyte hypertrophy in a rapidly-hypertrophying rat model system 显示文摘 | Huang CY Buchanan DL Gordon RL Jr | 2003 | Cell Biochem Funct2003，21，4： | 1 |
| 3 | UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelial cells显示文摘 | Black AT Gordon MK Heck DE Gallo MA Laskin DL Laskin JD | | 0，，07： | 1 |
| 4 | Simulation and new learning technologies显示文摘 | Issenberg SB Gordon MS Gordon DL | 2001 | Med Teach2001，23，： | 1 |
| 5 | Dopaminergic dysregulation in mice selectively bred for excessive exercise or obesity显示文摘 | Mathes WF Nehrenberg DL Gordon R Hua K Garland T Jr Pomp D | 2010 | Behav Brain Res2010，210，2： | 1 |
| 6 | Use of mesenchymal stem cellsin a collagen matrix for Achilles tendon repair显示文摘 | Young RG Butler DL Weber W Caplan AI Gordon SL Fink DJ | 1998 | J Orthop RES1998，16，： | 1 |
| 7 | Correlation between cognitive deficits and AI3 deposits in transganic APP/PSI mice 显示文摘 | Gordon MN King DL Diamond DM | 2001 | Neurobiol Aging2001，22，： | 1 |
| 8 | Role of TLR-4 in liv- er maerophage and endothelial cell responsiveness dudng acute en- dotoxemia显示文摘 | Chen LC Gordon RE Laskin JD Laskin DL | 2007 | Exp Mol Pathol2007，83，3： | 1 |
| 9 | Regulation of TREM ex- pression in hepatic macrophages and endothelial cells during acute en- dotoxemia显示文摘 | Chen LC Laskin JO Gordon MK LaskJn DL | 2008 | Fxp Mol Pathol2008，84，2： | 1 |
| 10 | Dopaminergic dys- regulation in mice selectively bred for excessive exercise or obesity 显示文摘 | Mathes WF Nehrenberg DL Gordon R | 2010 | Behav Brain Res2010，210，2： | 1 |
| 11 | Fea-tures and uses of high-fidelity medical simulations that lcad to effective learning:a BEME systemic review显示文摘 | Issenberg SB Mcgaghie WC Petmsa ER Gordon DL Scalse AJ | | 0，，： | 1 |
| 12 | Up-regulation of human neutrophil CD59, a regulator of the membrane attack complex of complement, following cell activation 显示文摘 | Gordon DL Papazaharoudakis H Sadlon TA | 1994 | Immunol Cell Bid1994，72，3： | 1 |
| 13 | Increased insulin-like growth factor-1 gene expression precedes left ventricular eardiomyocyte hypertrophy in a rapidly hypertrophying rat model system 显示文摘 | Huang CY Buchanan DL Gordon RL | 2003 | Cell Biochem Funct2003，21，4： | 1 |
| 14 | Swallow syncope associated with paroxysmal atrial fibrillation显示文摘 | Gordon J Saleem SM Ngaage DL | 2002 | Eur J Cardiothorac Surg2002，21，3： | 1 |
| 15 | Early onset prosthetic valve endocarditis: the Cleveland Clinic experience 1992-1997 显示文摘 | Gordon SM Serkey JM Longworth DL | 2000 | Ann Thorac Surg2000，69，5： | 1 |
| 16 | Cerebral microbleeds in nonla- cunar brain infarction are associated with lower coated-platelet levels显示文摘 | Prodan CI Stoner JA Gordon DL | 2014 | Journal of stroke and cerebravascular diseases2014，56，5： | 1 |
| 17 | Upregulation of human neutrophil CD59,a regulator of the membrane attack complex of complement, following cell activation 显示文摘 | Gordon DL Papazaharoudakis H Sadlon TA | 1994 | Immunol Cell Riol1994，72，3： | 1 |
| 18 | Which arterial conduit?Radial artery versus free right internal thoracic artery:six-year clinical results of a randomized controlled trial显示文摘 | Hayward PA Hare DL Gordon I | 2007 | Ann Thorac Surg2007，84，2： | 1 |
| 19 | Comparable patencies of the radial artery and right internal thoracic artery or saphenoas vein beyond 5 years:results from the Radial Artery Patency and Clinical Outcomes trial显示文摘 | Hayward PA Gordon IR Hare DL | 2010 | J Thorac Cardiovasc Surg2010，139，1： | 1 |
| 20 | Identificationof complement regulatory domains inhuman factor H 显示文摘 | Gordon DL Kaufman HM Blackmore TK | 1995 | J Immunol1995，155，1： | 1 |
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