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| 1 | Evaluation of diuretic and laxative activity of hydro-alcoholic extract of Desmostachya bipinnata(L.) Stapf in rats显示文摘OBJECTIVE: In continuation to the growing evidence for therapeutical potential of Desmostachya bipinnata(Linn) Stapf, the current pharmacological study was carried out to evaluate the diuretic and laxative activity of its hydro-alcoholic extract in rats.METHODS: The hydro-alcoholic extract of D. bipinnata whole plant was prepared by using Soxhlet extractor and subjected to analysis by standard preliminary phytochemical tests. Evaluation of both diuretic and laxative activity was carried out using standard methods as reported earlier. Frusemide(20 mg/kg) was served as positive control for diuretic activity and sennosides(10 mg/kg) served as negative control for laxative activity. RESULTS: The hydro-alcoholic extract showed signifi cant diuretic activity and was found to be the most potent in increasing the urinary output at 500 mg/kg when the effect was compared with that of the standard frusemide(P<0.01). Moreover, this extract was found to be most effective in increasing urinary electrolyte concentration(Na+, K+, and Cl-) at both doses tested. Whereas the results for laxative activity showed minimal increase of feces output at the dose of 500 mg/kg and the increase was negligible when compared with that of the standard drug sennosides.CONCLUSION: Altogether, the above signifi cant fi ndings validate and support its folkloric diuretic use and lend pharmacological credence to the ethno-medical use of this plant in traditional system of medicine, which demands further studies to investigate its active constituents, as well as its use and safety. | Upendarrao Golla Praveen Kumar Gajam Solomon Sunder Bhimathati | 2014 | Journal of Integrative Medicine2014，12，4： | 4 |
| 2 | Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate显示文摘Pantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor which is primarily used for the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD). The monographs of European Pharmacopoeia (Ph. Eur.) and United States Pharmacopoeia (USP) specify six impurities, viz.;impurities A, B, C, D, E and F, respectively for its active pharmaceutical ingredient (API). The identification and synthesis of all impurities except impurity E are well described in the literature;however, there is no report related to impurity E. The prospects to the formation and controlling of impurity E up to -0.03% in the synthesis of pantoprazole sodium sesquihydrate (PAN) were discussed in detail for the first time. The present work described the journey towards the successful development of an optimal preparation procedure of dimer impurity E. The most plausible mechanism involved in the formation of impurity E has been proposed. | Arun Kumar Awasthi Lalit Kumar Punit Tripathi Madhava Golla Cirandur Suresh Reddy Pramod Kumar | 2019 | Journal of Pharmaceutical Analysis2019，9，3： | 4 |
| 3 | Effect of organo-modified montmorillonite nanoclay on mechanical,thermal and ablation behavior of carbon fiber/phenolic resin composites显示文摘The mechanical,thermal and ablation properties of carbon phenolic(C-Ph)composites(Type-I)reinforced with different weight percentages of organo-modified montmorillonite(o-MMT)nanoclay have been studied experimentally.Ball milling was used to disperse different weight(wt)percentages(0,1,2,4,6 wt.%)of nanoclay into phenolic resin.Viscosity changes to resin due to nanoclay was studied.On the other hand,nanoclay added phenolic matrix composites(Type-II)were prepared to study the dispersion of nanoclay in phenolic matrix by small angle X-ray scattering and thermal stability changes to the matrix by thermogravimetric analyser(TGA).This data was used to understand the mechanical,thermal and ablation properties of Type-I composites.Inter laminar shear strength(ILSS),flexural strength and flexural modulus of Type I composites increased by about 29%,12%and 7%respectively at2 wt.%addition of nanoclay beyond which these properties decreased.This was attributed to reduced fiber volume fraction(%Vf)of Type-I composites due to nanoclay addition at such high loadings.Mass ablation rate of Type-I composites was evaluated using oxy acetylene torch test at low heat flux(125 W/cm^(2))and high heat flux levels(500 W/cm^(2)).Mass ablation rates have increased at both flux levels marginally up to 2 wt.%addition of nanoclay beyond which it has increased significantly.This is in contrast to increased thermal stability observed for Type-I and Type-II composites up to 2 wt.%addition of nanoclay.Increased ablation rates due to nanoclay addition was attributed to higher insulation efficiency of nanolcay,which accumulates more heat energy in limited area behind the ablation front and self-propagating ablation mechanisms triggered by thermal decomposition of organic part of nanoclay. | Golla Rama Rao Ivautri Srikanth K.Laxma Reddy | 2021 | Defence Technology(防务技术)2021，17，3： | 2 |
| 4 | Mineralogical and Geochemical Constraints on Arsenic Mobility in a Philippine Geothermal Field显示文摘砷通常与硫醚矿物质在地热的环境形成了被联系。然而,在与在表面氧化下面的天落水的接触调节以后,硫醚矿物质对溶解敏感。第二等猛抛从主要硫化物的溶解的那种形式在地热的 environment.Fe 氢氧化物对砷活动性施加更大的影响与溶解砷酸盐有很好的亲密关系并且在大多数表面氧化条件下面是稳定的。两个都,非结晶的硅石直接从地热的液体并且可能猛抛一个高岭石改变罐头招待砷的小重要数量。这些硅酸盐在大量氢指数和氧化还原作用条件下面也是更稳定的。 | Chelo PASCUA Tsutomu SATO Glenn GOLLA | 2006 | Acta Geologica Sinica(English Edition)2006，80，2： | 2 |
| 5 | Corte,Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazoli-nethione derivatives as selective estrogen receptor beta modulators显示文摘 | Timur Güngor Chen Y Golla R | 2006 | J Med Chem2006，49，： | 1 |
| 6 | Insect resistance management of Bt maize - development of a GIS based decision making tool on farm sc- ale for planning refuges 显示文摘 | Hommel B Golla B Neukampf R | 2008 | Naehrichtenblattdes-Deutschen-Pflanzenschutzdienstes2008，60，1： | 1 |
| 7 | Virtual Design of Chemical Penetration Enhancers for Transdermal Drug Delivery显示文摘 | Golla S Neely BJ Whitebay E | | 0，，： | 1 |
| 8 | Genetic interactions between MTHFR(C677T),methionine synthase(A2756G,C2758G)variants with vitamin B12 and folic acid determine susceptibility to premature coronary arterydisease in Indian population显示文摘 | Kanth VV Golla JP Sastry BK | 2011 | J Cardiovasc Dis Res2011，2，3： | 1 |
| 9 | Electron- specimen interactions in low-voltage scanning electron mi- croscopy 显示文摘 | Bongeler R Golla U Kussens M | 1993 | Scanning1993，15，1： | 1 |
| 10 | High stable power aware multicast algorithm for mobile Ad Hoc networks显示文摘 | Golla Varaprasad | 2013 | IEEE Sensors Journal2013，13，： | 1 |
| 11 | First automated assay forthyrotropin receptor autoantibodies显示文摘 | Gassner D Stock W Golla R | 2009 | Clin Chem Lab Med2009，47，9： | 1 |
| 12 | A sensitive,robust high-throughput electro-chemiluminescence assay for rat insulin显示文摘 | Golla R Seethala R | 2004 | Biomol Screen2004，9，1： | 1 |
| 13 | The effects of cooling and emersion on total haemocyte count and phenoloxidase activity of the spiny lobster Panulirus interruptus 显示文摘 | GOMEZ - JIMENEZ S UGLOW R F GOLLAS - GALVAN T | 2000 | Fish & Shellfish lmmunol2000，，10： | 1 |
| 14 | scintigraphic and histological fea- tures of a vanishing scapular eosinophilic granuloma显示文摘 | Golla SK Kavanagh EC | 2009 | Ir J Med Sci2009，178，1： | 1 |
| 15 | Genotype-phenotype analysis in Apert syndrome suggests opposite effects of the two recurrent mutations on syndactyly and outcome of craniofacial surgery 显示文摘 | von Gemet S Golla A Ehrenfels Y | 2000 | Clin Genet2000，57，2： | 1 |
| 16 | 62-W CW TEM00 Nd:YAG laser side-pumped by fiber-coupled diode lasers 显示文摘 | D Golla M Bode S Knoke | 1996 | Opt Lett1996，21，3： | 1 |
| 17 | 查看详情显示文摘 | D Golla S Knoke W Schone G Ernst M Bode A Tunnermann H Welling | | 0，，： | 1 |
| 18 | MRI, CT, scintigraphic and histological features of a vanishing scapular eosinophilic granuloma显示文摘 | Golla SK Kavanagh EC | 2009 | Ir J Med Sci2009，178，： | 1 |
| 19 | Dynamics of viscoelastic structures-a time-domain finite element formulation显示文摘 | Golla D F Hughes P C | 1985 | Journal of Applied Mechanics1985，52，： | 1 |
| 20 | Activation of prophenoloxidase system of the brown shrimp (Penaeus californiensis Holmes)显示文摘 | Hem a ndez L J Gollas G T Vargas A F | 1996 | Comp Biochem Physiol1996，113，： | 1 |
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