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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Primary cancers of the small bowel : analysis of prognostic factors and results of surgical management显示文摘 | TALAMONTI MS GOETZ LH RAO S | 2002 | Arch Surg2002，137，5： | 1 |
| 3 | New developments in acoustic and electroacoustic spectroscopy for characterizing concentrated dispersions 显示文摘 | DUKHIN A S GOETZ P J | 2001 | Colloids and Surfaces: A Physicochemical and Engineering Aspects2001，192，3： | 1 |
| 4 | Hypoxia activates beta (1) -integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells显示文摘 | Blaschke F Stawowy P Goetze S | 2002 | Biochem Biophys Res Commun2002，296，4： | 1 |
| 5 | Cavitation and failure during hot forging of Ti-6A1-4V显示文摘 | Semiatin S L Goetz R L Shell E B | 1999 | Metallurgical and Materials Transactions1999，，： | 1 |
| 6 | Pro-brain natriuretic peptide as marker of cardiovascular or pulmonary causes of dyspnea in patients with terminal parenchymal lung disease显示文摘 | GOETZE J P VIDEBAEK R BOESGAARD S | 2004 | J Heart Lung Transplant2004，23，1： | 1 |
| 7 | Expression and function of PPARgamma in rat and human vascular smooth muscle cells显示文摘 | Law RE Goetze S Xi XP | 2000 | Circulation2000，101，： | 1 |
| 8 | Expession and function of PPAR-γ in rat and human vascular smooth muscle cell 显示文摘 | Law RE Goetze S Xi XP | 2000 | Circulation2000，101，11： | 1 |
| 9 | Molecular imaging in endoscopy 显示文摘 | Hoetker M S Goetz M | 2013 | United European Gastroenterol J2013，1，2： | 1 |
| 10 | Pro-brain natriuretic peptide as marker of cardiovascular or pulmonary causes of dyspnea in patients with terminal parenchymal lung disease显示文摘 | Goetze JP Videbaek R Boesgaard S | 2004 | J Heart Lung Transplant2004，23，1： | 1 |
| 11 | Central role of the MAPK pathway in Ang Ⅱ mediated DNA synthesis and migration in rat vascular smooth muscle cells显示文摘 | Xi X P Graf K Goetze S | 1999 | ATVB1999，19，1： | 1 |
| 12 | Troglitazone inhibits angiotensionⅡ-induced extracellular signal-regulated kinase 1/2 nuclear translocation and activation in vascular smooth muscle cells显示文摘 | Goetze S Xi XP Graf K | 1999 | FEBS Lett1999，452，： | 1 |
| 13 | Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes显示文摘 | Kintscher U Goetze S Wakino S | 2000 | Eur J Pharmacol2000，401，3： | 1 |
| 14 | Chronic diarrhea as a result of intestinal microsposidiosis in a liver transplant recipient显示文摘 | Goetz M Eichenlaub S Pape GR | 2001 | Transplantation2001，71，2： | 1 |
| 15 | The adiabatic correction factor for deformation heating during the uniaxial compression test显示文摘 | Goetz R L Semiatin S L | 2001 | Journal of Materials Engineering and Performance2001，10，6： | 1 |
| 16 | A method for a more complete in vitro Parkinson's model:slice culture bioassay for modeling maintenance and repair of the nigrostriatal circuit显示文摘 | Kearns S M Scheffler B Goetz AK | 2006 | J Neurosci Methods2006，157，1： | 1 |
| 17 | Obesity prevention inearly adolescence:Student parent and teacher views显示文摘 | POWER TG BINDLER RC GOETZ S et ai | 2010 | J SchHealth2010，80，1： | 1 |
| 18 | Self-employment in rural America:The new economic reality显示文摘 | GOETZ S J | 2008 | Rural realities2008，2，3： | 1 |
| 19 | Viability and virulence of pneumolysin,pneumococcal surface protein A,andpneumolysin/pneumococcal surface protein A mutants in the ear显示文摘 | Schachern PA Tsuprun V Goetz S | 2013 | JAMA Otolaryngol Head Neck Surg2013，139，9： | 1 |
| 20 | BNP and N-terminal proBNP are both extracted in the normal kidney显示文摘 | Goetze JP Jensen G Moller S | 2006 | Eur J Clin Investig2006，36，： | 1 |
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