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| 1 | Protein O-mannosyltransferases partici- pate in ER protein quality control 显示文摘 | Goder V Melero A | 2011 | J Cell Sei2011，124，1： | 1 |
| 2 | Impairment of sleep-related memory consolidation in schizophrenia:relevance of sleep spindles?显示文摘 | Goder R Graf A Ballhausen F | 2015 | Sleep Med2015，16，5： | 1 |
| 3 | Membrane protein integration and the role of the translocation channel 显示文摘 | Rapoport TA Goder V Heinrieh SU | 2004 | Trends Cell Biol2004，14，： | 1 |
| 4 | Effects of olanzapine on slowwave sleep,sleep spindles and sleep-related memory consolidation in schizophrenia显示文摘 | Goder R Fritzer G Gottwald B | 2008 | Pharmacopsychiatry2008，41，3： | 1 |
| 5 | Evaluation of friction conditions in powder compaction for admixed and die wall lubrication显示文摘 | TURENNE S GODERE C THOMAS Y | 1999 | Powder Metallurgy1999，42，： | 1 |
| 6 | Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins 显示文摘 | CARVALHO P GODER V RAPOPORT T A | 2006 | Cell2006，126，： | 1 |
| 7 | Serial analysis of troponin I levels with ischemic and nonischemin dilated cardiomyopathy显示文摘 | Nellessen U Goder S Schobre R | | 0，，05： | 1 |
| 8 | Polysomnographic findings in nights preceding a migraine attack显示文摘 | R Goder G Fritzer A Kapsokalyvas | 2001 | Cephalalgia2001，21，1： | 1 |
| 9 | Design Criteria for Particle Attrition显示文摘 | Kalman H Goder D | 1998 | Advanced Powder Technology1998，，9： | 1 |
| 10 | Laparoscopic Parial nephrectomy:initial case report for benign disease显示文摘 | Winfield HN Donovan JF Goder AS | 1993 | J Endourol1993，7，： | 1 |
| 11 | FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells显示文摘 | Qian X Davis AA Goderic SK Temple S | 1997 | Neuron1997，18，1： | 1 |
| 12 | Sleep and cognition at baseline and the effects of REM sleep dimi- nution aider 1 week of antidcpressive treatment in patients with depression显示文摘 | GODER R SEECK H M STINGELE K | 2011 | J Sleep Res2011，20，4： | 1 |
| 13 | Serial analysis of troponin I levels in patients with ischemic and nonis-chemic dilated cardiomyopathy显示文摘 | Nellessen U Goder S Schobre R | | 0，，05： | 1 |
| 14 | The prevalence of retinal and optical coherence tomography findings in preeclamptic women 显示文摘 | Neudorfer M Spierer O Goder M | 2014 | Retina2014，34，7： | 1 |
| 15 | Reduced sleep-associated consolidation of declarative memory in attention-deficit/hyperactivity disorder显示文摘 | Prehn-Kristensen A Goder R Fischer J | 2011 | Sleep Med2011，12，7： | 1 |
| 16 | Establishment,functional and genetic characterization of three novel patient-derived rectal cancer cell lines显示文摘AIM To establish patient-individual tumor models of rectal cancer for analyses of novel biomarkers, individual response prediction and individual therapy regimens.METHODS Establishment of cell lines was conducted by direct in vitro culturing and in vivo xenografting with subsequent in vitro culturing. Cell lines were in-depth characterized concerning morphological features, invasive and migratory behavior, phenotype, molecular profile including mutational analysis, protein expression, and confirmation of origin by DNA fingerprint. Assessment of chemosensitivity towards an extensive range of current chemotherapeutic drugs and of radiosensitivity was performed including analysis of a combined radioand chemotherapeutic treatment. In addition, glucose metabolism was assessed with 18 F-fluorodeoxyglucose(FDG) and proliferation with 18 F-fluorothymidine.RESULTS We describe the establishment of ultra-low passage rectal cancer cell lines of three patients suffering from rectal cancer. Two cell lines(HROC126, HROC284 Met) were established directly from tumor specimens while HROC239 T0 M1 was established subsequent to xenografting of the tumor. Molecular analysis classified all three cell lines as CIMP-0/non-MSI-H(sporadic standard) type. Mutational analysis revealed following mutational profiles: HROC126: APC^(wt), TP53^(wt), KRAS^(wt), BRAF^(wt), PTEN^(wt); HROC239 T0 M1: APC^(mut), P53^(wt), KRAS^(mut), BRAF^(wt), PTEN^(mut) and HROC284 Met: APC^(wt), P53^(mut), KRAS^(mut), BRAF^(wt), PTEN^(mut). All cell lines could be characterized as epithelial(EpCAM+) tumor cells with equivalent morphologic features and comparable growth kinetics. The cell lines displayed a heterogeneous response toward chemotherapy, radiotherapy and their combined application. HROC126 showed a highly radio-resistant phenotype and HROC284 Met was more susceptible to a combined radiochemotherapy than HROC126 and HROC239 T0 M1. Analysis of 18 F-FDG uptake displayed a markedly reduced FDG uptake of all three cell lines after combined radiochemotherapy. CONCLUSION These newly established and in-depth characterized ultra-low passage rectal cancer cell lines provide a useful instrument for analysis of biological characteristics of rectal cancer. | Michael Gock Christina S Mullins Carina Bergner Friedrich Prall Robert Ramer Anja Goder Oliver H Kramer Falko Lange Bernd J Krause Ernst Klar Michael Linnebacher | 2018 | World Journal of Gastroenterology2018，24，43： | 1 |
| 17 | Serial analysis of troponin I levels in patients with ischemie and nonischemic dilated cardiomyopathy 显示文摘 | Nellessen U Goder S Schobre R | 2006 | Clin Cardiol2006，29，5： | 1 |
| 18 | Comparison of 3 bonded lingual appliances by auditive analysis and subjective assessment显示文摘 | Hohoff A Stamm T Goder G | 2003 | Am J Orthod Dentofacial Orthop2003，124，6： | 1 |
| 19 | Visual declarative memory is associated with non-rapid eye movement sleep and sleep cycles in patients with chronic non-restorative sleep 显示文摘 | Goder R Scharffetter F Aldenhoff JB | 2007 | Sleep Med2007，8，5： | 1 |
| 20 | Reduced olfactory performance in patients with major depression显示文摘 | PAUSE B M MIRANDA A GODER R | 2001 | Psychiatry Res2001，35，5： | 1 |
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